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Click here to go to the publications page with graphical abstracts
(158) "Biomimetic Dehydrogenative Diels-Alder Cycloadditions: Total Syntheses of Brosimones A and B" Qi, C.; Cong, H.; Cahill, K. J.; Muller, P.; Johnson, R. P.; Porco, J. A. Jr., Angew. Chem. Int. Ed. 2013, Early View. [link]
(157) "Evidence for a Functionally Relevant Rocaglamide Binding Site on the elF4A-RNA Complex" Sadlish, H.; Galicia-Vazquez, G.; Paris, C.G.; Aust, T.; Bhullar, B.; Chang, L.; Helliwell, S.B.; Hoepfner, D.; Knapp, B.; Ridel, R.; Roggo, S.; Schuierer, S.; Studer, C.; Porco, J. A. Jr.; Pelletier, J.; Movva, N.R., ACS Chem. Biol. 2013, ASAP. [link]
(156) "Metal-Catalyzed Cascade Rearrangements of 3-Alkynyl Flavone Ethers " Xiong, Y.; Schaus, S.E.; Porco, J. A. Jr., Org. Lett. 2013, ASAP. [link]
(155) "Polycyclic xanthone natural products: structure, biological activity and chemical synthesis" Winter, D.K.; Sloman, D.L.; Porco, J. A. Jr., Nat. Prod. Rep. 2013, 30, 382-391. [link]
(154) "eIF4F suppression in breast cancer affects maintenance and progression" Nasr, Z.; Robert, F.; Porco, J.A. Jr.; Muller, W.J.; Pelletier, J., Oncogene 2013, 1-11. [link]
(153) "Synthesis of Chamaecypanone C Analogues from in Situ-Generated Cyclopentadienones and Their Biological Evaluation " Dong, S.; Qin, T.; Hamel, E.; Beutler, J. A.; Porco, J. A. Jr., J. Am. Chem. Soc. 2012, 134, 19782-19787. [link]
(152) "Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations " Leng, B.; Chichetti, S.; Su, S.; Beeler, A. B.; Porco, J. A. Jr., Beilstein Journal of Org. Chem. 2012, 8, 1338-1343. [link]
(151) "Development of an Alkaloid-Pyrone Annulation: Synthesis of Pleiomaltinine" Ziegler, R.E.; Tan, S.J.; Kam, T.S.; Porco, J.A. Jr., Angew. Chem. Int. Ed. 2012, 51, 9348-9351. [link]
(150) "Enantioselective Photocycloaddition of 3-Hydroxyflavones: Total Syntheses and Absolute Configuration Assignments of (+)-Ponapensin and (+)-Elliptifoline " Lajkiewicz, N.J.; Roche, S.P.; Gerard, B.; Porco, J.A. Jr., J. Am. Chem. Soc. 2012, 134, 13108-13113. [link] Highlights: synfacts: [link]
(149) "Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein " Jin, C.; Rodrigo, C.M.; Porco, J.A. Jr.; Kufe, D., Oncogene 2012, 1-10. [link]
(148) "Total Synthesis of Graphisin A and Sydowinin B" Little, A.; Porco, J.A. Jr., Org. Lett. 2012, 14, 2862-2865. [link]
(147) "Targeting Synthetic Lethal Interactions between Myc and the eIF4F Complex Impedes Tumorigenesis" Lin, C.J.; Nasr, Z.; Premsrirut, P.K.; Porco, J.A. Jr.; Hippo, Y.; Lowe, S.W.; Pelletier, J., Cell Rep. 2012, 4, 325-333. [link]
(146) "Studies Toward the Synthesis of the Epoxykinamycin FL-120B': Discovery of a Decarbonylative Photocyclization" Scully, S.S.; Porco J.A. Jr., Org. Lett. 2012, 14, 2646-2649. [link]
(145) "Total Synthesis of (±)-Sorocenol B Employing Nanoparticle Catalysis" Cong, H.; Porco, J.A. Jr., Org. Lett. 2012, 14, 2516-2519. [link]
(144) "Total Synthesis of (±)-7-epi-Nemorosone" Zhang, Q.; Porco, J.A. Jr., Org. Lett. 2012, 14, 1797-1799. [link]
(143) "Synthesis of Azaphilone-Based Chemical Libraries" Achard, M.; Beeler, A.B.; Porco, J.A. Jr., ACS Comb. Sci 2012, 14, 236-244. [link]
(142) "Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosis" Yeo, A. T.; Porco, J. A. Jr.; Gilmore, T. D. Cancer Letters 2012, 318, 53-60. [link]
(141) "Development of a Photochemical microfluidics Platform " Pimparkar, K.; Yen, B.; Goodell, J.R.; Martin, V.I.; Lee, W.H.; Porco, J. A. Jr.; Beeler, A.B.; Jensen, K.F. J. Flow Chem. 2011, 2, 53-55. [link]
(140) "Synthesis of Rocaglamide Hydroxamates and Related Compounds as Eukaryotic Translation Inhibitors: Synthetic and Biological Studies" Rodrigo, C.M.; Cencic, R.; Roche, S.P.; Pelletier, J.; Porco, J. A. Jr. J. Med. Chem. 2011, 558-562. [link]
(139) "Chemical Synthesis of Complex Molecules Using Nanoparticle Catalysis" Cong, H.; Porco, J. A. Jr. ACS Catal. 2011, 2, 65-70. [link]
(138) "Synthetic cyclohexenyl chalcone natural products possess cytotoxic activities against prostate cancer cells and inhibit cysteine cathepsins in vitro" Majumdara, I.D.; Devanabandaa, A.; Foxa, B.; Schwartzmana, J.; Cong, H.; Porco, J. A. Jr.; Weber, H.C. Biochem. Biophys. Res. Commun. 2011, 416, 397-402. [link]
(137) "Synthesis and Reactivity of Bicyclo[3.2.1] octanoid-Derived Cyclopropanes" Goodell, J. R.; Poole, J. L.; Beeler, A. B.; Aube, J.; Porco, J. A. Jr.; J. Org. Chem. 2011, 76, 9792-9800. [link]
(136) "Remodelling of the natural product fumagillol employing a reaction discovery approach" Balthaser, B. R.; Maloney, M. C.; Beeler, A. B.; Porco, J. A. Jr.; Snyder, J. K. Nature Chemistry 2011, 3, 969-973. [link]
(135) "Microwave-Based Reaction Screening: Tandem Retro-Diels–Alder/Diels–Alder Cycloadditions of o-Quinol Dimers", Dong, S.; Cahill, K.J.; Kang, M.I.; Colburn, N.H.; Henrich, C.J.; Wilson, J.A.; Beutler, J.A.; Johnson, R.P.; Porco, J.A. Jr. J. Org. Chem., 2011, 76, 8944-8954. [link]
(134) "Chemistry and biology of rocaglamides (= flavaglines) and related derivatives from aglaia species (meliaceae)", Ebada, S.S.; Lajkiewicz, N.; Porco, J.A. Jr.; Li-Weber, M.; Proksch, P. Progress in the Chemistry of Organic Natural Products, 2011, 94, 1-58.
(133) "Asymmetric Total Synthesis of the Epoxykinamycin FL-120 B' ", Scully, S.S.; Porco, J.A. Jr. Angew. Chem. Int. Ed., 2011, 50, 9722-9726. [link]
(132) "Targeting Cap-dependent Translation Blocks Converging Survival Signals by AKT and PIM Kinases in Lymphoma ", Schatz, J. H.; Orcchio E.; Wolfe A. L.; Jiang, M.; Linkov I.; Maragulia J.; Shi, W.; Zhang, Z.; Vinagolu, R. K.; Pagano, N. C.; Porco, J. A. Jr.; Teruya-Feldstein, J.; Rosen, N.; Pelletier, J.; Wendel, H.-G. J. Exp. Med., 2011, 208, 1799-1807. [link]
(131) "Gold Catalyzed Cyclization of Alkynes-Tethered Dihydropyrimidones", Brown, L. E.; Dai, P.; Porco, J.A. Jr.; Schaus, S.E. Org. Lett., 2011, 13, 4228-4231. [link]
(130) "A Cycloisomerization/Friedel–Crafts Alkylation Strategy for the Synthesis of Pyrano[3,4-b]indoles", Medeiros, M.R.; Schaus, S.E.; Porco, J.A. Jr. Org. Lett., 2011, 4012-4015. [link]
(129) "Total Synthesis and Absolute Stereochemical Assignment of Kibdelone C ", Sloman, D.L.; Bacon, J.W.; Porco, J.A. Jr. J. Am. Chem. Soc., 2011, 133, 9952-9955. [link] Featured in C&EN, 2011, 89, 31. [[link]]
(128) "Sequential Transformations to Access Polycyclic Chemotypes: Asymmetric Crotylation and Metal Carbenoid Reactions", Wu, J.; Becerril, J.; Lian, Y.; Davies, H.M.L.; Porco, J.A. Jr.; Panek, J.S. Angew. Chem. Int. Ed., 2011, 50, 5938-5942. [link]
(127) "Dearomatization Strategies in the Synthesis of Complex Natural Products", Roche, S.P.; and Porco, J.A. Jr. Angew. Chem. Int. Ed., 2011, 50, 4068-4093. [link]
(126) "Discovery of New Antimalarial Chemotypes Through Chemical Methodology and Library Development", Brown, L.E.; Cheng, K.C.; Wei, W.; Yuan, P.; Dai, P.; Trillesa, R.; Ni, F.; Yuan, J.; MacArthur, R.; Guha, R.; Johnson, R.L.; Su, X.; Dominguez, M.M.; Snyder, J.K.; Beeler, A.B.; Schaus, S.E.; Inglese, J.; and Porco, J.A. Jr. P.N.A.S., 2011, 6775-6780. [link]
(125) "Synthesis of the Azaphilones (+)-Sclerotiorin and (+)-8-O-Methylsclerotiorinamine Utilizing (+)-Sparteine Surrogates in Copper-Mediated Oxidative Dearomatization", Germain, A.R.; Bruggemeyer, D.M.; Zhu, J.; Genet, C.; O'Brien, P.; and Porco, J.A. Jr. J. Org. Chem., 2011, 76, 2577- 2584. [link]
(124) " ESIPT-Mediated Photocycloadditions of 3-Hydroxyquinolinones: Development of a Fluoroescence Quenching Assay for Reaction Screening ", Xia, B.; Gerard, B.; Solano, D.M.; Wan, J.; Jones, G. II; and Porco, J.A. Jr. Org. Lett., 2011, 13, 1346-1349. [link]
(123) " Synthesis and Biological Evaluation of ABCD Ring Fragments of the Kibdelones", Sloman, D.L.; Mitasev, B.; Scully, S.S.; Beutler, J.A.; and Porco, J.A. Jr. Angew. Chem. Int. Ed ., 2011, 50, 2511-2515. [link]
(122) " Vinylogous Addition of Siloxyfurans to Benzopyryliums: A Concise Approach to the Tetrahydroxanthone Natural Products", Qin, T.; Johnson, R. P.; and Porco, J.A. Jr. J. Am. Chem. Soc., 2011, 133, 1714–1717. [link]
(121) " Total Synthesis of Plukenetione A", Zhang, Q; Mitasev, B.; Qi, J.; and Porco, J.A., Jr. J. Am. Chem. Soc. 2010, 132, 14212-14215. [link]
(120) " Catalytic Enantioselective Alkylative Dearomatization-Annulation: Total Synthesis and Absolute Configuration Assignment of Hyperibone K", Qi, J.; Beeler, A. B.; Zhang, Q.; and Porco, J.A., Jr. J. Am. Chem. Soc. 2010, 132, 13642-13644. [link]
(119) " Biomimetic Photocycloaddition of 3-Hydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation ", Roche, S.P.; Cencic, R.; Pelletier, J.; and Porco, J.A., Jr. Angew. Chem. Int. Ed. 2010, 49, 6533-6538. [link]
(118) "Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones", Goodell, J.R.; Leng, B.; Snyder, T. K.; Beeler, A. B; Porco, J. A., Jr. Synthesis 2010, 13, 2254-2270. [link]
(117) "Enantioselective Synthesis of 3,4-Chromanediones via Asymmetric Rearrangement of 3-Allyloxyflavones", Marie, J.C.; Xiong, Y.; Min, G. K.; Yeager, A.R.; Taniguchi, T.; Berova, N.; Schaus, S.E.; Porco, J. A., Jr. J. Org. Chem. 2010, 75 ,4584–4590. [link] Highlights: synfacts [link]
(116) "Skeletal Diversity via Cationic Rearrangements of Substituted Dihydropyrans", Medeiros, M.R.; Narayan, R.S.; McDougal,
N.T.; Schaus, S.E.; Porco, J. A., Jr. Org. Lett. 2010, 12 , pp 3222–3225. [link]
(115) "Silver Nanoparticle-Catalyzed Diels-Alder Cycloadditions of 2'-Hydroxychalcones." Cong, H.; Becker, C. F.; Elliott, S. J.; Grinstaff, M. W.; Porco, J. A., Jr. J. Am. Chem. Soc. 2010, 132, 7514-7518. [link] Highlights: C&EN [link] and Science [link]
(114) "Tandem Processes Identified from Reaction Screening: Nucleophilic Addition to Aryl N-Phosphinylimines Employing La(III)-TFAA Activation." Kinoshita, H.; Ingham, J. O.; Ong, W. W.; Beeler, B. A.; Porco, J. A., Jr. J. Am. Chem. Soc. 2010, 132, 6412–6418. [link](
(113) "Reaction Discovery Using Microfluidic-Based Multidimensional Screening of Polycyclic Iminium Ethers." Treece, L. J. ; Goodell, R. J. ; Vender Velde, D. ; Porco, J. A., Jr.; Aube, J. J. Org. Chem. 2010, 75, 2028-2038. [link]
(112) "Multicomponent Reaction Discovery: Three-Component Synthesis of Spirooxindoles." Liang, B.; Kalidindi, S.; Porco, J. A., Jr.; Stephenson, C. R. Org. Lett. 2010, 12, 572-575. [link]
(111) "Synergistic Effect of Inhibiting Translation Initiation in Combination with Cytotoxic Agents in Acute Myelogenous Leukemia Cells" Cencic, R.; Carrier, M.; Trnkus, A.; Porco, J. A., Jr.; Minden, M.; Pelletier, J. Leukemia Res. 2010, 34, 535-541. [link]
(110) "Development of an Automated Microfluidic Reaction Platform for Multidimensional Screening: Reaction Discovery Employing Bicyclo[3.2.1]octanoid Scaffolds" Goodell, J.R.; McMullen, J. P.; Zaborenko, N.; Maloney, J. R.; Ho, C.-X.; Jensen, K. F.; Porco, J. A., Jr.; Beeler, A. B. J. Org. Chem. 2009, 74, 6169-6180. [link]
(109) "Stereoselective Synthesis of Spirocyclic Oxindoles via Prins Cyclizations." Castaldi,M.P.; Troast,D.M.; Porco, J. A., Jr. Org. Lett. 2009, 11, 3362-3365. [link]
(108) "Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol." Cencic, R.; Carrier, M.; Galicia-Vázquez, G.; Bordeleau, M. E.; Sukarieh, R.; Bourdeau, A.; Brem, B.; Teodoro, J. G.; Greger, H.; Tremblay, M. L.; Porco, J. A., Jr.; Pelletier, J. PLoS ONE. 2009, 4, e5223. [link]
(107) "Manganese(III)-Mediated Transformations of Phloroglucinols: A Formal Oxidative [4 + 2] Cycloaddition Leading to Bicyclo[2.2.2]octadiones" Mitasev, B.; Porco, J. A., Jr. Org Lett. 2009, 11, 2285-2288. [link]
(106) "Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor" Dong, S.; Hamel, E.; Bai, R.; Covell, D. G.; Beutler, J. A.; Porco, J. A., Jr. Angew. Chem. Int. Ed. 2009, 48, 1494-1497. [link]
(105) "Reaction Discovery Employing Macrocycles: Transannular Cyclizations of Macrocyclic Bis-lactams" Han, C.; Rangarajan, S.; Voukides, A. C.; Beeler, A. B.; Johnson, R.; Porco, J. A., Jr. Org. Lett. 2009, 11, 413-416. [link]
(104) "Studies toward the Synthesis of (-)-Zampanolide: Preparation of the Macrocyclic Core" Troast, D. M.; Yuan, J.; Porco, J. A., Jr. Adv. Synth. Catal. 2008, 350, 1701-1711. [link]
(103) "Electron Transfer-Initiated Diels-Alder Cycloadditions of 2'-Hydroxychalcones" Cong, H.; Ledbetter, D.; Rowe, G. T.; Caradonna, J. P.; Porco, J. A., Jr. J. Am. Chem. Soc. 2008, 130, 9214-9215.. [link]
(102) "Therapeutic Suppression of Translation Initiation Modulates Chemosensitivity in a Mouse Lymphoma Model" Bordeleau, M-E.; Robert, F.; Gerard, B.; Lindqvist, L.; Chen, S. M. H.; Wendel, H-G.; Brem, B.; Greger, H.; Lowe, S. W.; Porco, J. A., Jr.; Pelletier, J. J. Clin. Invest. 2008, 118, 2651-2660. [link]
(101) "Applying Computer-Assisted Structure Elucidation Algorithms for the Purpose of Structure Validation: Revisiting the NMR Assignments of Hexacyclinol" Williams, A. J.; Elyashberg, M. E.; Blinov, K. A.; Lankin, D. C.; Martin, G. E.; Reynolds, W. F.; Porco, J. A., Jr.; Singleton, C. A.; Su, S. J. Nat. Prod. 2008, 71, 581-588. [link]
(100) "Enantioselective Synthesis of Bicyclo[2.2.2]octenones Using a Copper-Mediated Oxidative Dearomatization/[4 + 2] Dimerization Cascade" Dong, S.; Zhu, J.; Porco, J. A., Jr. J. Am. Chem. Soc. 2008, 130, 2738-2739. [link]
(99) "Structure-Activity Relationship Study of [1,2,3]thiadiazole Necroptosis Inhibitors" Teng, X.; Keys, H.; Jeevanandam, A.; Porco, J. A., Jr.; Degterev, A.; Yuan, J.; Cuny, G. D. Bioorg. Med. Chem. Lett. 2007, 17, 6836-6840. [link]
(98) "Preparation of Alkylidene Indane and Related Scaffolds and Their Further Elaboration to Novel Chemotypes" Kesavan, S.; Panek, J. S.; Porco, J. A., Jr. Org. Lett. 2007, 9, 5203-5206. [link]
(97) "1,2-Dihydroisoquinolines as Templates for Cascade Reactions To Access Isoquinoline Alkaloid Frameworks" Su, S.; Porco, J. A., Jr. Org. Lett. 2007, 9, 4983-4986 . [link]
(96) "Identification of Novel Epoxide Inhibitors of Hepatitis C Virus Replication Using a High-Throughput Screen." Peng, L. A.; Kim, S. S.; Matchacheep, S.; Lei, X.; Su, S.; Lin, W.; Runguphan, W.; Choe, W-H.; Sakamoto, N.; Ikeda, M.; Kato, N.; Beeler, A. B.; Porco, J. A., Jr.; Schreiber, S. L.; Chung, R. T. Antimicrob. Agents Chemother. 2007, 51, 3756-3759. [link]
(95) "Rapid Access to Polyprenylated Phloroglucinols via Alkylative Dearomatization-Annulation: Total Synthesis (±)-Clusianone." Qi, J.; Porco, J. A., Jr. J. Am. Chem. Soc. 2007, 129, 12682-12683. [link]
(94) "Enantioselective Synthesis of the Complex Rocaglate (-)-Silvestrol." Gerard, B.; Cencic, R.; Pelletier, J.; Porco, J.A., Jr. Angew. Chem. Int. Ed. Engl. 2007, 46, 7831-7834. [link]
(93) "Skeletal Diversity Through p-Radical Cyclization of Tetrahydropyridine Scaffolds." Dandapani, S.; Dudata, M.; Panek, J. S.; Porco, J. A., Jr. Org. Lett. 2007, 9, 3849-3852. [link]
(92) "Nucleophilic Addition to N-Phosphinylimines via Rare Earth Metal Triflate / Trifluoroacetic Anhydride Activation." Ong, W. W.; Beeler, A. B.; Kesavan, S.; Panek, J. S.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2007, 46, 7470-7472. [link]
(91) "Synthesis of Pyrrolo-isoquinolines Related to the Lamellarins Using Silver-Catalyzed Cycloisomerizaton/Dipolar Cycloaddition." Su, S.; Porco, J. A., Jr. J. Am. Chem. Soc. 2007, 129, 7744-7745. [link]
(90) "An Approach to Skeletal Diversity Using Functional Group Pairing of Multifunctional Scaffolds." Comer, E.; Rohan, E.; Deng, L.; Porco, J. A., Jr. Org. Lett. 2007, 9, 2123-2126. [link]
(89) "Organic Chemistry: Synthesis Undressed." Porco, J. A., Jr. Nature 2007, 446 (7134), 383-385. [link]
(88) " Stereochemical and Skeletal Diversity Employing Pipecolate Ester Scaffolds", Yu, C.; Panek, J. S.; Porco, J. A. Jr, Org. Lett, 2007, 9, 1529-1532. [link]
(87) " Synthesis of Carbamates and Ureas Using Zr(IV)-Catalyzed Exchange Processes." Han, C.; Porco, J. A, Jr. Org. Lett. 2007, 9, 1517-1520. [link]
(86) " Discovery of Chemical Reactions through Multidimensional Screening." Beeler, A. B.; Su, S.; Singleton, C. A.; Porco, J. A, Jr. J. Am. Chem. Soc. 2007, 129, 1413-1419. [link]
(85) " Synthesis of 5,6,7,8-Tetrahydro-1,6-naphthyridines and Related Heterocycles by Cobalt-Catalyzed [2 + 2 + 2] Cyclizations." Zhou, Y.; Porco, J. A, Jr.; Snyder, J. K. Org. Lett. 2007, 9, 393-396. [link]
(84) " Convergent Synthesis of Complex Diketopiperazines Derived from Pipecolic Acid Scaffolds and Parallel Screening against GPCR Targets." Dandapani, S.; Lan, P.; Beeler, A. B.; Beischel, S.; Abbas, A.; Roth, B. L.; Porco, J. A, Jr., Panek, J. S. J. Org. Chem. 2006, 71, 8934-8945. [link]
(83) " Total Synthesis of the Diazobenzofluorene Antibiotic (-)-Kinamycin C1." Lei, X.; Porco, J. A, Jr. J. Am. Chem. Soc. 2006, 128, 14790-14791 . [link]
(82) "Exploring Skeletal Diversity via Ring Contraction of Glycal-Derived Scaffolds." Yeager, A. R.; Min, G. K.; Porco, J. A, Jr.; Schaus. S. E. Org. Lett. 2006, 8, 5065-5068. [link]
(81) "Asymmetric Syntheses of (-)-Mitorubrin and Related Azaphilone Natural Products." Zhu, J.; Porco, J. A., Jr. Org. Lett. 2006, 8, 5169-5171. [link]
(80) "Total Synthesis and Structure Assignment of (+)-Hexacyclinol." Porco, J. A., Jr.; Su, S.; Lei, X.; Bardhan, S.; Rychnovsky, S. D. Angew. Chem. Int. Ed. Engl. 2006, 45, 5790-5792. [link]
(79) "Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity - and high glucose-induced b cell dysfunction in isolated pancreatic islets." Zhang, C-Y.; Parton, L. E.; Ye, C-P.; Krauss, S.; Shen, R.; Lin, C-T.; Porco, J. A., Jr.; Lowell.B. B. Cell Metabolism, 2006, 3, 417-427. [link]
(78) "Total Synthesis of the Interleukin-1 
Converting Enzyme Inhibitor EI-1941-2 Using Tandem Oxa-electrocyclization/Oxidation 1." Kleinke, A. S.; Li, C.; Rabasso, N.; Porco, J. A., Jr. Org. Lett, 2006, 8, 2857-2850. [link]
(77) "Enantioselective Photocycloaddition Mediated by Chiral Br 
nsted Acids: Asymmetric Synthesis of the Rocaglamides." Gerard, B.; Sangji, S.; O'Leary, D. J.; Porco, J. A., Jr. J. Am. Chem. Soc, 2006, 128, 7754-7755. [link]
(76) "Synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by copper-catalyzed cycloaddition-coupling of azides and terminal alkynes." Gerard, B.; Ryan, J.; Beeler, A. B.; Porco, J. A., Jr. Tetrahedron 2006, 62, 6405-6411. [link]
(75) "Targeting Heat Shock Response to Sensitize Cancer Cells to Proteasome and Hsp90 Inhibitors." Zaarur, N.; Gabai, V. L.; Porco, J. A., Jr.; Calderwood, S.; Sherman, M. Y. Cancer Research 2006, 66, 1783-1791. [link]
(74) "Total Synthesis and Stereochemical Assignment of the Spiroisoxazoline Natural Product (+)-Calafianin." Bardhan, S.; Schmitt, D. C.; Porco, J. A., Jr. Org. Lett. 2006, 8, 927-930. [link]
(73) "A µ-η2:η2 -Disulfide Dicopper( II ) Complex from Reaction of S8 with a Copper( I ) Precursor: Reactivity of the Bound Disulfur Moiety." Helton, M. E.; Maiti, D; Zakharov, L. N.; Rheingold, A. L.; Porco, J. A., Jr.; Karlin, K. D. Angew. Chem. Int. Ed. Engl. 2006, 45, 1138-1141. [link]
(72) "Inhibition of transcription factor NF-kB signaling proteins IKKb and p65 through specific cysteine residues by epoxyquinone A monomer: Correlation with its anti-cancer cell growth activity." Liang, M-C.; Bardhan, S.; Pace, E. A.; Rosman, D.; Beutler, J. A.; Porco, J. A., Jr.; Gilmore, T. D. Biochemical Pharmacology 2006, 71, 634-645. [link]
(71) "The synthetic epoxyquinoids jesterone dimer and epoxyquinone A monomer induce apoptosis and inhibit REL (human c-Rel) DNA binding in an I[kappa]B[alpha]-deficient diffuse large B-cell lymphoma cell line." Liang, M-C. Bardhan, S.; Porco, J. A., Jr.; Gilmore, T. D. Cancer Letters 2006, 241, 69-78. [link]
(70) "Enantioselective Synthesis of Linear Polypropionate Arrays Using Anthracene-Tagged Organosilanes." Kesavan, S.; Su, Q.; Shao, J.; Porco, J. A., Jr.; Panek, J. S. Org. Lett. 2005, 7, 4435-4438. [link]
(69) "Synthesis of a Library of Complex Macrodiolides Employing Cyclodimerization of Hydroxy Esters." Beeler, A. B.; Acquilano, D. E.; Su, Q.; Yan, F.; Roth, B. L.; Panek, J. S.; Porco, J. A., Jr. J. Comb. Chem. 2005, 7, 673-681. [link]
(68) "Stereocontrolled Synthesis of a Complex Library via Elaboration of Angular Epoxyquinol Scaffolds." Lei, X.; Zaarur, N.; Sherman, M. Y.; Porco, J. A., Jr. J. Org. Chem. 2005, 70, 6474-6483. [link]
(67) "Synthesis of Epoxyquinol A and Related Molecules: Probing Chemical Reactivity of Epoxyquinol Dimers and 2H-Pyran Precursors." Li, C.; Porco, J. A., Jr. J. Org. Chem. 2005, 70, 6053-6065. [link]
(66) "Catalytic Ester-Amide Exchange Using Group(IV) Metal Alkoxide-Activator Complexes." Han, C.; Lee, J. P.; Lobkovsky, E.; Porco, J. A., Jr. J. Am. Chem. Soc. 2005, 127, 10039-10044. [link]
(65) "Synthesis of the Azaphilones Using Copper-Mediated Enantioselective Oxidative Dearomatization." Zhu, J.; Grigoriadis, N. P.; Lee, J. P.; Porco, J. A., Jr. J. Am. Chem. Soc. 2005, 127, 9342-9343. [link]
(64) "Convergent Synthesis of a Complex Oxime Library Using Chemical Domain Shuffling." Su, S.; Acquilano, D. E.; Arumugasamy, J.; Beeler, A. B.; Eastwood, E. L.; Giguere, J. R.; Lan, P.; Lei, X.; Min, G. K.; Yeager, A. R.; Zhou, Y.; Panek, J. S.; Snyder, J. K.; Schaus, S. E.; Porco, J. A., Jr. Org. Lett. 2005, 7, 2751-2754. [link]
(63) "Synthesis of the Tetracyclic Core of the Tetrapetalones through Transannular Oxidative [4+3] Cyclization." Wang, X.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2005, 44, 3067-3071. [link]
(62) "Synthesis of Photoactivatable Acyclic Analogues of the Lobatamides." Shen, R.; Inoue, T.; Forgac, M.; Porco, J. A., Jr. J. Org. Chem. 2005, 70, 3686-3692. [link]
(61) "A Biomimetic Approach to the Rocaglamides Employing Photogeneration of Oxidopyryliums Derived from 3-Hydroxyflavones." Gerard, B.; Jones, G., II.; Porco, J. A., Jr. J. Am. Chem. Soc. 2004, 126, 13620-13621. [link]
(60) "Synthesis of complex alkoxyamines using a polymer-supported N-hydroxyphthalimide." Su, S.; Giguere, J. R.; Schaus, S. E.; Porco, J. A., Jr. Tetrahedron 2004, 60, 8645-8657. [link]
(59) "Total Synthesis of the Salicylate Enamide Macrolide Oximidine III: Application of Relay Ring-Closing Metathesis." Wang, X.; Bowman, E. J.; Bowman, B. J.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2004, 43, 3601-3605. [link]
(58) "Synthesis of Azaphilones and Related Molecules by Employing Cycloisomerization of o-Alkynylbenzaldehydes." Zhu, J.; Germain, A. R.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2004, 43, 1239-1243. [link]
(57) "Synthesis of a Polymer-Supported Anthracene and Its Application as a Dienophile Scavenger." Lei, X.; Porco, J. A., Jr.; Org. Lett. 2004, 6, 795-798. [link]
(56) "Synthesis of the Epoxyquinol Dimer RKB-3564 D : Utilization of an Alkoxysilanol To Promote [4 + 4] Dimerization." Li, C.; Porco, J. A., Jr.; J . Am. Chem. Soc. 2004, 126, 1310-1311. [link]
(55) "Copper-Mediated Synthesis of N-Acyl Vinylogous Carbamic Acids and Derivatives: Synthesis of the Antibiotic CJ-15,801." Han, C.; Shen, R.; Su, S.; Porco, J. A., Jr.; Org. Lett. 2004, 6, 27-30. [link]
(54) "Polymer-Assisted Solution-Phase (PASP) Suzuki Couplings Employing an Anthracene-Tagged Palladium Catalyst." Lan, P.; Berta, D.; Porco, J. A., Jr.; South, M. S.; Parlow, J. J.; J. Org. Chem. 2003; 68, 9678-9686. [link]
(53) "The Development of a Chromatography-Free Mitsunobu Reaction: Synthesis and Applications of an Anthracene-Tagged Phosphine Reagent." Lan, P.; Porco, J. A., Jr.; South, M. S.; Parlow, J. J. J. Comb. Chem. 2003, 5, 660-669. [link]
(52) "Total Synthesis of the Ubiquitin-Activating Enzyme Inhibitor (+)-Panepophenanthrin." Lei, X.; Johnson, R. P.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2003, 42, 3913-3917. [link]
(51) "Stereochemical Diversity through Cyclodimerization: Synthesis of Polyketide-like Macrodiolides." Su, Q.; Beeler, A. B.; Lobkovsky, E.; Porco, J. A., Jr.; Panek, J. S. Org. Lett, 2003, 5, 2149-2152. [link]
(50) "Synthesis and Cell Cycle Inhibition of the Peptide Enamide Natural Product Terpeptin and the Aspergillamides." Su, S.; Kakeya, H.; Osada, H.; Porco, J. A., Jr. Tetrahedron, 2003, 59, 8931-8946. [link]
(49 ) "Jesterone Dimer, a Synthetic Derivative of the Fungal Metabolite Jesterone, Blocks Activation of Transcription Factor Nuclear Factor kB by Inhibiting the Inhibitor of kB Kinase," Liang, M.-C.; Bardhan, S.; Li, C.; Pace, E. A.; Porco, J. A., Jr.; Gilmore, T. D. Molecular Pharmacology, 2003, 64, 123-131. [link]
(48) "Lobatamide C: Total Synthesis, Stereochemical Assignment, Preparation of Simplified Analogues, and V-ATPase Inhibition Studies." Shen, R.; Lin, C. T.; Bowman, E. J.; Bowman, B. J.; Porco, J. A., Jr. J. Am. Chem. Soc. 2003, 125, 7889-7901. [link]
(47) "Total Synthesis of the Salicylate Enamide Macrolide Oximidine II." Wang, X.; Porco, J. A., Jr. J. Am. Chem. Soc. 2003, 125, 6040-6041. [link]
(46) "Total Synthesis of the Quinone Epoxide Dimer (+)-Torreyanic Acid: Application of a Biomimetic Oxidation/Electrocylization/Diels-Alder Dimerization Cascade." Li, C.; Johnson, R. P.; Porco, J. A., Jr. J. Am. Chem. Soc. 2003, 125, 5095-5106. [link]
(45) "Angiogenesis Inhibitor Epoxyquinol A: Total Synthesis and Inhibition of Transcription Factor NF-kB." Li, C.; Bardhan, S.; Pace, E. A.; Liang, M.-C.; Gilmore, T. D.; Porco, J. A., Jr. Org. Lett. 2002, 4, 3267-3270. [link]
(44) "Synthesis and V-ATPase Inhibition of Simplified Lobatamide Analogues." Shen, R; Lin, C. T.; Bowman, E. J.; Bowman, B. J.; Porco, J. A., Jr. Org. Lett. 2002, 4, 3103-3106. [link]
(43) "Polymer-assisted parallel solution phase synthesis of substituted benzimidazoles." Yun, Y. K.; Porco, J. A., Jr.; Labadie, J. Synlett. 2002, 5, 739-742. [link]
(42) "Total Synthesis and Stereochemical Assignment of the Salicylate Antitumor Macrolide Lobatamide C." Shen, R.; Lin, C. T.; Porco, J. A., Jr. J. Am. Chem. Soc. 2002, 124, 5650-5651. [link]
(41) "Studies Toward the Synthesis of (-)-Zampanolide: Preparation of N-Acyl Hemiaminal Model Systems." Troast, D. M.; Porco, J. A., Jr. Org. Lett. 2002, 4, 991-994. [link]
(40) "Total Synthesis of the NF-kB Inhibitor (-)-Cycloepoxydon: Utilization of Tartrate-Mediated Nucleophilic Epoxidation." Li, C.; Pace, E. A.; Liang, M-C.; Lobkovsky, E.; Gilmore, T. D.;. Porco, J. A., Jr. J. Am. Chem. Soc. 2001, 123, 11308-11309. [link]
(39) "Combinatorial synthesis of natural product-like molecules using a first-generation spiroketal scaffold." Kulkarni, B. A.; Roth, G. P.; Lobkovsky, E.; Porco, J. A., Jr. J. Comb. Chem. 2002, 4, 56-72. [link]
(38) "Modification of C-Terminal Peptides for Form Peptide Enamides: Synthesis of Chondriamides A and C.” Wang, X.; Porco, J. A., Jr. J. Org. Chem.. 2001, 66, 8215-8221. [link]
(37) “Exploring Chemical Diversity of Epoxyquinoid Natural Products: Synthesis and Biological Activity of (-)-Jesterone and Related Molecules.” Hu, Y.; Li, C.; Kulkarni, B.; Strobel, G.; Lobkovsky, E.; Porco, J. A. , Jr. Org. Lett. 2001, 3, 1649-1652. [link]
(36) "Total Synthesis of (±) Torreyanic Acid." Li, C.; Lobkovsky, E.; Porco, J. A., Jr. J. Am. Chem. Soc. 2000, 122, 10484-10485. [link]
(35) "Parallel Synthesis and Purification using Anthracene-Tagged Substrates." Wang, X.; Parlow, J. J.; Porco, J. A., Jr. Org. Lett. 2000, 2, 3509-3512. [link]
(34) "Multistep Synthesis of 1,2,3-Thiadiazoles using 'Catch and Release'." Hu, Y.; Baudart, S.; Porco, Jr., J. A. High Throughput Synthesis: Theory and Practice, Chapter 6, Section 5, (Sucholeiki, I., editor), Marcel Dekker, NY, 2000."
(33) "Synthesis of Enamides Related to the Salicylate Antitumor Macrolides Using Copper-mediated Vinylic Substitution." Shen, R.; Porco, J. A., Jr. Org. Lett. 2000, 2, 1333-1336. [link]
(32) "Organic Synthesis Using Chemical Tags: The 'Third Leg' of Parallel Synthesis." Porco, J. A., Jr. Combinatorial Chemistry and High Throughput Screening, 2000, 3, 93-102.
(31) "Streamlined Synthesis of Substituted 2-Aminothiazoles Using Tandem Precipitative and Polymer-Assisted Reactions." Yun, Y. K.; Leung, S. S. W.; Porco, J. A., Jr. Biotechnol. Bioeng. 2000, 71, 9-18.