-
- L
T Zhou, D Liu, H C Kang, L Lu, H Z huang, W Q Ai, Y
Zhou, M F Deng, H Li, Z Q Liu, W F Zhang, Y Z Hu, Z T
Han, H H Zhang, J J Jia, A K Sarkar, S Sharaydeh, J
Wang, H Y Man, M Schilling, L Bertram, Y Lu, Z Guo, L
Q Zhu (2023) Tau pathology epigenetically remodels the
neuron-glial cross-talk in Alzheimer's disease. Science
Advances, 2023 Apr
21;9(16):eabq7105.doi:10.1126.
-
-
W Hu, Z Liuyang, J Liang, Y Tian, J Liang X Zhang, H
Zhang, G Wang, Y Huo, Y Shentu, J Wang, X Wang, Y Lu,
J Westermarck*, H Y Man*, R Liu* (2022) CIP2A
deficiency promotes depression through inhibition of
dendritic arborization. (*corresponding authors) EMBO
Reports, 2022 Oct 28; e54911.doi:10.15252/embr.202254911.
PMID: 36305222
-
-
J Zhang, D Liu, P Fu, Z Q Liu, C Lai, C Q Yang, K
Chen, W D Bao, F Hu, H Y Du, W Yang, J Wang, H Y Man,
Y Lu, L Q Zhu (2022) Social isolation reinforces
aging-related behavioral inflexibility by promoting
neuronal necroptosis in basolateral amygdyla. Mol
Psychiatry. 2022 Jul 15;. DOI:
10.1038/s41380-022-01694-5. PMID:35840795
-
H Qiao, Y Tian, Y Huo, H Y Man (2022) Role of the DUB
enzyme USP7 in dendritic arborization, neuronal
migration and autisitic-like behaviors in mice. iScience
2022 Jul 15; 25(7):104595. DOI:
10.1016/j.isci.2022.104595. PMID: 35800757; PMCID:
PMC925496 .
-
R C McNaughton, Y Huo, G Li, A D Via Loschpe, L Yan, H
Y Man*, X Zhang*(2022) Regulatory effects of gradient
microtopographies on synapse formation and neurite
growth in hippocampal neurons. (*corresponding
authors) J. Micromechanics and Microengineering,
2022 Jul; 32(7). DOI:
10.1088/1361-6439/c73d7. PMID: 814808; PMCID:
PMC9262107.
-
Y Huo, Y Tian, W Lu, Q Huo, H Y Man (2022)
Prkn-knockout mice show autistic-like behaviors and
aberrant synapse formation. iScience, 2022
Jul 15; 25(7):104573. DOI:10.1016/j.isci.2022.104573.
PMID:35789851; PMCID: PMC9249611.
- S
Xiao, E Lowet, H J Gritton, P Fabris, Y Wang, J
Sherman, R A Mount, H Tseng, H Y Man, C Straub, K D
Piatkevich, E S Boyden, J Mertz, X Han (2021)
Large-scale voltage imaging in behaving mice using
targeted illumination. iScience. 2021 Oct
12;24(11):103263. doi: 10.1016/j.isci.2021.103263
- L
Shi, Y Jiang, F R Fernandez, G Chen, L Lan, H Y Man, J
A White, J X Cheng, C Yang (2021) Non-genetic
photoacoustic stimulation of single neurons by a
tapered fiber optoacoustic emitter. Light Sci Appl.
2021 Jul 14;10(1):143. doi:
10.1038/s41377-021-00580-z.
- L
Perez-Sisqu ́es, N Martín-Flores, M Masana, J
Solana-Balaguer, A Llobet, J Romaní-Aumedes, M Canal,
G Campoy-Campos, E García-García, N S ́anchez-Fern
́andez, S Fern ́andez-García, J P Gilbert, M J
Rodríguez, H Y Man, E Feinstein, D L Williamson, D
Soto, X Gasull, J Alberch, Cristina Malagelad (2021)
RTP801 regulates motor cortex synaptic transmission
and learning. Experimental Neurology, 342, 113755.
PMID: 33984337, doi: 10.1016/j.expneurol.2021.113755
- Y
Jiang, Y Huang, X Luo, J Wu, H Zong, L Shi, R Cheng, Y
Zhu, S Jiang, L Lan, X Jia, J Mei, H Y Man, J X Cheng,
C Yang (2021) Neural stimulation in vitro and in vivo
by photoacoustic nanotransducers. Matter, 4(2),
654-674
- W
D Bao, P Pang, X T Zhou, F Hu, W Xiong, K Chen, J
Wang, F Wang, D Xie, Y Z Hu, Z T Han, H H Zhang, W X
Wang, P Nelson, J Chen, Y Lu, H Y Man, D Liu, and L Q
Zhu (2021) Loss of ferroportin induces memory
impairment via promoting ferroptosis in Alzheimer’s
disease. Cell Death and Differentiation, 2021 Jan 4.
doi: 10.1038/s41418-020-00685-9
- M
O’Connor, Y-P Shentu, G Wang, W-T Hu, R Liu, H Y Man
(2020) Acetylation of AMPA receptors regulates
receptor trafficking and rescues memory deficits in
Alzheimer’s Disease. iScience, 2020 Aug
15;23(9):101465. doi: 10.1016/j.isci.2020.101465
- Kantak
KM, Gauthier JM, Mathieson E, Knyazhanskaya E,
Rodriguez-Echemendia P, Man HY (2020) Sex differences
in the effects of a combined behavioral and
pharmacological treatment strategy for cocaine relapse
prevention in an animal model of cue exposure therapy.
Behav Brain Res. 2020 Aug 2;395:112839. doi:
10.1016/j.bbr.2020.112839.
-
Bensussen S, Shankar S, Ching KH, Zemel D, Ta TL,
Mount RA, Shroff SN, Gritton HJ, Fabris P,
Vanbenschoten H, Beck C, Man HY, Han X (2020) A Viral
Toolbox of Genetically Encoded Fluorescent Synaptic
Tags. iScience, 2020 Jul 24;23(7):101330.
doi:10.1016/j.isci.2020.101330.
- W
Tang, X Xin, M O’Connor, N Zhang, B Lai, H Y Man*, Y
Xie*, Y Wei* (2020). Transient sublethal hypoxia in
neonatal rats causes reduced dendritic spines,
aberrant synaptic plasticity and impairments in memory
(*corresponding authors). J Neurosci Res,
98(8):1588-1604.
- M
Hastings, JM. Gauthiera, K Mabrya, A Tranb, H Y Man,
KM Kantak (2020) Facilitative effects of environmental
enrichment for cocaine relapse prevention are
dependent on extinction training context and involve
increased TrkB signaling in dorsal hippocampus and
ventromedial prefrontal cortex. Behavioural Brain
Research, 386, 112596
- Y
Jiang, H J Lee, L Lan, H Tseng, C Yang, H Y Man, X
Han, J-X Cheng (2020) Optoacoustic Brain Stimulation
at Submillimeter Spatial Precision. Nat Commun. 2020
Feb 14;11(1):881. doi: 10.1038/s41467-020-14706-1.
- M
Ma, W Xiong, F Hu, M F Deng, X Huang, JG Chen, H Y
Man, Y Lu, D Liu, L Q Zhu (2020). A novel pathway
regulates social hierarchy via lncRNA AtLAS and
postsynaptic synapsin IIb. Cell Research. 2020
Feb;30(2):105-118
- T
Y Hou, Y Zhou, L S Zhu, X Wang, P Pang, D Q Wang, Z Y
Liuyang, H Y Man, Y Lu, L Q Zhu, D Liu (2020)
Correcting abnormalities in miR-124/PTPN1 signaling
rescues tau pathology in Alzheimer's disease. J
Neurochem. 154(4):441-457.
- Gilbert
James*, Margaret O'Connor*, S Templet, M Moghaddam, A
Di Via Ioschpe, A Sinclair, L Q Zhu, W Xu, and H Y Man
(2019) NEXMIF/KIDLIA knockout mouse demonstrates
autistic behavior, memory defects, and impairments in
synapse formation and function. (*Equal Contribution)
J Neuroscience, 40(1):237-254.
Wang,
Guan, J Zhong, D Guttieres, and H Y Man (2019)
Non-scaling regulation of AMPA receptors in homeostatic
synaptic plasticity. Neuropharmacology,
158: 107700.
- Khatri,
Natasha and H Y Man (2019) The Autism and Angelman
Syndrome Protein Ube3A/E6AP: The Gene, E3 Ligase
Ubiquitination Targets and Neurobiological Functions. Front
Mol Neurosci, 12:109.
-
- Xie,
A J, T‐Y Hou, W Xiong, H‐Z Huang, J Zheng, K Li, H Y
Man, Y Z Hu, Z T Han, H H Zhang, N Wei, J Z Wang, D
Liu, Y Lu, L Q Zhu (2019) Tau overexpression impairs
neuronal endocytosis by decreasing the GTPase dynamin
1 through the miR‐132/MeCP2 pathway. Aging
Cell.
Shentu,
Y P, W T Hu, Q Zhang, Y Huo, J W Liang, Z Y Liuyang, H
Zhou, H Wei, D Ke, X C Wang, J Z Wang, H Y Man, J
Westermarck, R Liu (2019) CIP2A-promoted astrogliosis
induces AD-like synaptic degeneration and cognitive
deficits. Neurobiol Aging, 75: 198-208.
- Tang,
H, M Ma, Y Wu, M F Deng, F Hu, HAMM Almansoub, H Z
Huang, D Q Wang, L T Zhou, N Wei, H Y Man, Y Lu, D
Liu, L Q Zhu (2019) Activation of MT2 receptor
ameliorates dendritic abnormalities in Alzheimer's
disease viaC/EBPα/miR-125b pathway. Aging
Cell, 18(2).
- Su
Y, Deng MF, Xiong W, Xie AJ, Guo J, Liang ZH, Hu B,
Chen JG, Zhu X, Man H Y, Lu Y, Liu D, Tang B, and Zhu
LQ (2018) MicroRNA-26a/Death-Associated Protein
Kinase 1 Signaling Induces Synucleinopathy and
Dopaminergic Neuron Degeneration in Parkinson's
Disease. Biol Psychiatry, 85(9):
769-781.
- Hastings,
M H and H Y Man(2018) Synaptic Capture of Laterally
Diffusing AMPA Receptors – An Idea That Stuck. Trends
in Neurosciences, 41(6): 330-332.
- Shentu,
Y P, X L Feng, Y Huo, J Gilbert, Q Zhang, X L Wang, Z
Y Liuyang, G Wang, H Zhou, X C Wang, J Z Wang, Y M Lu,
J Westermarck, H Y Man†
and R Liu† (†corresponding
authors) (2018) CIP2A-PP2A signaling causes Tau/APP
phosphorylation, synaptopathy and memory deficits in
Alzheimer’s disease. Cell Reports,
24(3):713-723
-
- Zhang,
Yamin, O Guo, Y Huo, G Wang, and Heng-Ye Man. (2018)
Amyloid-β Induces AMPA Receptor Ubiquitination and
Degradation in Primary Neurons and Human Brains of
Alzheimer’s Disease. Journal of Alzheimer's
Disease. 62(4):1789-1801..
- Khatri,
Natasha, James Gilbert, Yuda Huo, Hui Qiao, Roozhin
Sharaflari, Micheal Nee, and Heng-Ye Man. (2018) The
maternal imprinted autism protein Ube3A/E6AP remodels
dendritic arborization via XIAP ubiquitination and
caspase 3-mediated pruning. Journal of
Neuroscience. 38 (2) 363-378.
-
Wang,
Xiong, D Liu, H Huang, Z Wang, T Y Hou, X Yang, N Wei, Y
Zhou, M J Dupras, F Calon, Y T Wang, H Y Man, J Chen, J
Wang, S S Hébert, Y M Lu, L Q Zhu. (2017) A Novel
MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and
Memory Deficits in Alzheimer's Disease. Biological
Psychiatry. 3223(17)31853-X.
-
- Zhu,
Houze, Huanhuan Yan, Na Tang, Xinyan Li, Pei Pang, Hao
Li, Wenting Chen, Yu Guo, Shu Shu, You Cai, Lei Pei,
Dan Liu, Min-Hua Luo, Heng-Ye Man, Qing Tian, Yangling
Mu, Ling-Qiang Zhu, and Youming Lu. (2017) Impairments
of spatial memory in an Alzheimer's disease model via
degeneration of hippocampal cholinergic synapses. Nature
Communications. 8(1):1676.
- Gilbert,
James and Heng-Ye Man. (2017) Fundamental elements in
autism: from neurogenesis and neurite growth to
synaptic plasticity. Front. Cellular Neuroscience.
11:359.
Wang,
Guan, Shaomin Li, James Gilbert, Howard J. Gritton, Zemin
Wang, Zhangyuan Li, Xue Han, Dennis J. Selkoe, and Heng-Ye
Man. (2017) Crucial Roles for SIRT2 and AMPA Receptor
Acetylation in Synaptic Plasticity and Memory. Cell
Reports. 20(6):1335-1347.
- Qiu,
Mei, Yang-Ping Shentu, Ji Zeng, Xiao-Chuan Wang, Xiong
Yan, Xin-Wen Zhou, Xiao-Peng Jing, Qun Wang, Heng-Ye Man,
Jian-Zhi Wang, and Rong Liu. (2017) Zinc mediates the
neuronal activity–dependent anti-apoptotic effect. PLOS
ONE. 12(8): e0182150.
- Zhu,
Jiuhe, Kwan Young Lee, Kathryn Jewett, Heng-Ye Man, Hee
Jung Chung, and Nien-Pei Tsai. (2017) Epilepsy-associated
gene Nedd4-2 mediates neuronal activity and seizure
susceptibility through AMPA receptors. PLOS Genetics.
13(2): e1006634.
- Gauthier,
Jamie, Amy Lin, Bríd Nic Dhonnchadha, Roger Spealman,
Heng-Ye Man, and Kathleen Kantak. (2017) Environmental
enrichment facilitates cocaine-cue extinction, deters
reacquisition of cocaine self-administration and alters
AMPAR GluA1 expression and phosphorylation. Addiction
Biology. 22(1):152-162.
- Gilbert,
James, Shu Shu, Xin Yang, Youming Lu, Ling-Qiang Zhu, and
Heng-Ye Man. (2016) β-Amyloid triggers aberrant
over-scaling of homeostatic synaptic plasticity. Acta
Neuropathologica Communications. 4:131.
- Gilbert,
James and Heng-Ye Man. (2016) The X-linked autism protein
KIAA2022/KIDLIA regulates neurite outgrowth via N-cadherin
and δ-catenin signaling. eNeuro 10.1523.
- Li,
Li-Jun, Rong Hu, Brendan Lujan, Juan Chen, Jian-Jian
Zhang, Yasuko Nakano, Tian-Yuan Cui, Ming-Xia Liao,
Jin-Cao Chen, Heng-Ye Man, Hua Feng, and Qi Wan. (2016)
Glycine Potentiates AMPA Receptor Function through
Metabotropic Activation of GluN2A-Containing NMDA
Receptors. Frontiers in Molecular Neuroscience.
10.3389.
- Canal,
Mercè, Núria Martín-Flores, Leticia Pérez-Sisqués, Joan
Romaní-Aumedes, Bekir Altas, Heng-Ye Man, Hiroshi Kawabe,
Jordi Alberch, and Cristina Malagelada. (2016) Loss of
NEDD4 contributes to RTP801 elevation and neuron toxicity:
implications for Parkinson's disease. Oncotarget
10.18632.
- Kohman,
Richie E., Susie S. Cha, Heng-Ye Man, and Xue Han. (2016)
Light-Triggered Release of Bioactive Molecules from DNA
Nanostructures. Nano Letters 16.4:2781-785.