NIH defines bioinformatics as "Research, development, or application of computational tools and approaches for expanding the use of biological, medical, behavioral or health data, including those to acquire, store, organize, archive, analyze, or visualize such data".

The problems I work on are the analysis of gene expression data produced with microarrays, and the identification of genes responsible for diseases by using genetic markers.

Gene expression data. I develop Bayesian methods for the automated identification of differentially expressed genes.

Gene profiling. The goal is to identify genes which behave similarly when subjected to the same conditions. Typically, the data to analyze are short time series of expression data of thousands of genes. Caged is the new software that I have developed for this task, with Marco Ramoni.

Phenotyping. I work on methods for discovering the genetic bases of complex traits using polymorphisms. This research is supported by NSF.




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