NIH defines bioinformatics
as "Research, development, or application of computational
tools and approaches for expanding the use of biological, medical,
behavioral or health data, including those to acquire, store, organize,
archive, analyze, or visualize such data".
The problems I work on are the analysis of gene expression data
produced with microarrays,
and the identification of genes responsible for diseases by using
Gene expression data. I develop Bayesian
methods for the automated identification of differentially expressed
Gene profiling. The goal is to identify
genes which behave similarly when subjected to the same conditions.
Typically, the data to analyze are short time series of expression
data of thousands of genes. Caged
is the new software that I have developed for this task, with Marco
Phenotyping. I work
on methods for discovering the genetic bases of complex traits using
polymorphisms. This research is supported by NSF.