2014 NSF Workshop on Noninvasive Imaging of Brain Function

	2014 NSF Workshop on Noninvasive Imaging of Brain Function
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	Workshop Speakers Jeffrey Anderson Jeffrey Anderson is an Assistant Professor of Neuroradiologyat the University of Utah.He received a BS in Mathematics, Brigham Young University and MD/PhDin Neurobiology, Northwestern University. His research concerns neurophysiology of distributed brain networks, brain synchrony, and functional connectivity. He studies distributed brain networks using functional imaging techniques such as fMRI, diffusion tensor imaging, and MEG. A primary emphasisof his work is to develop methods for studying brain synchrony and functional connectivity, and apply these techniques to diagnose neurological and psychiatric disorders of the brain. Thomas Bifano Thomas Bifano directs the Boston University Photonics Center (BUPC), an academic center of excellence comprised of forty faculty members from many academic disciplines. He directs BUPC programs for education, scholarly research and development of advanced photonic device prototypes for commercial and military applications. Dr. Bifano also serves as a Professor of Mechanical Engineering. He is a founder and Chief Technical Officer of Boston Micromachines Corporation. He earned B.S. and M.S. degrees in mechanical engineering and materials science from Duke University, and a Ph.D. in mechanical engineering from North Carolina State University. His research focuses on design and manufacturing of microelectromechanical systems (MEMS) for optical applications. Most recently, he has engineered a class of deformable mirror systems that have led to significant advances in high-resolution imaging for telescopes, microscopes, and ophthalmoscopes. John George John S. George is Deputy Group Leader in P21, the Applied Modern Physics Group at Los Alamos National Laboratory, and a principal investigator in biophysics and neuroscience. After undergraduate studies in computer science and art, he received his PhD in Physiology from Vanderbilt University based on dissertation research on biophysical mechanisms of visual transduction, conducted at the NIH. Experimental and modeling studies of neural mechanisms of visual processing remain a cornerstone of his scientific interest, along with development of technologies to image and modulate neural function. George has become an international leader in the development of high performance techniques for noninvasive imaging of neural function including Magnetoencephalography (MEG), MRI, and functional MRI. He developed modeling and analytical methods and software tools for MEG source localization, segmentation and geometrical modeling based on anatomical MRI, and pioneered the development of multi-modality techniques for functional neuroimaging integrating MEG, and anatomical and functional MRI. He was involved in early demonstrations of fMRI, and MR diffusion imaging with hyperpolarized noble gases. George pioneered dynamic optical methods for imaging neural function, based on calcium fluorescent indicators and fast intrinsic optical signals. He was a leader of the Los Alamos component of a large consortium to develop a retinal prosthetic implant (for which the team won an R&D100 award), and has developed novel devices for high density neural interfaces based on electrical and optical sensor arrays. He was PI of a DARPA project on Ultra Low Field (ULF) MRI, and co-PI of a project to develop ULF MRI technology and techniques for functional neuroimaging. The mapping of applied currents by MRI (Electrical Impedance Tomography, MR EIT) and detection of endogenous neural currents by MRI is a principal focus of recent work. George has also led several projects to develop software and hardware systems that mimic the architecture and function of the brain, especially the information processing functions of the early visual system. Lee Goldstein Lee Goldstein is a Professor of Psychiatry, Neurology, Ophthalmology, Pathology and Laboratory Medicine, & Biomedical Engineering at Boston University. He has received honors from numerous organizations, including the Harvard Medical School, National Institute of Mental Health, National Alliance for Research on Schizophrenia and Affective Diseases, Alzheimer’s Association, the American Psychiatric Association, and the Optical Society of America. His work focuses on understanding the role of abnormal protein aggregation in chronic degenerative disorders of aging. His laboratory concentrates on Alzheimer’s disease, age-related cataracts, and other common diseases of aging that involve pathogenic protein aggregation. His team recently discovered the first evidence of Alzheimer’s disease-associated amyloid pathology outside the brain as well as a new transcription factor that plays a crucial role in cellular differentiation within the lens and brain. He and his laboratory are developing a laser-based diagnostic technology that will hopefully detect Alzheimer’s disease years before the first symptoms emerge. Xue Han Xue Han is a Peter Paul Career Development Professor and an assistant professor of Biomedical Engineering at Boston University. She received her Ph.D. degree from University of Wisconsin-Madison. Her neuroengineering lab is developing radical new genetic, molecular, and optical neurotechnologies and application protocols to treat neurological and psychiatric diseases. She has received a number of awards, including a Presidential Early Career Awards for Scientists and Engineers (PECASE) and a NIH innovator award. Cort Johnson Cort Johnson is a senior member of the technical staff, Sandia National Laboratories. He received a B.S. in physics from Brigham Young University in 2001 and a Ph.D. from Massachusetts Institute of Technology in 2008. His doctoral work focused on developing cryogenic techniques for cooling and trapping neutral atoms with potential applicability to precision measurement and quantum information. From 2008-2013, Dr. Johnson was a postdoctoral researcher/Senior Member of Technical Staff in the Photonic Microsystems Technologies department at Sandia National Laboratories (Albuquerque, NM) where his focus was developing atomic magnetometers for biomagnetic applications. He was a primary contributor to the first published demonstration of MEG signal detection with fiber-coupled atomic magnetometers (single-sensor and multi-sensor). This work led to an NIH R01 grant (ongoing) to scale up the system to enable partial-head coverage and source localization. In 2013 Dr. Johnson transitioned to Draper Laboratories (Cambridge, MA) and continues to develop atomic magnetometer technology for a variety of applications. Svenja Knappe Svenja Knappe is a physicist working for the National Institute of Standards and Technology and an associate professor adjunct in the Department of Psychology and Neuroscience at the University of Colorado in Boulder. In 2005, Knappe worked alongside colleagues to invent chip-scale atomic magnetometers and in 2014 she was the distinguished recipient of a Rank Prize in optoelectronics. Her current research involves work centered on microfabricated atomic devices. Srikanth Nagarajan Srikantan Nagarajan is a Professor in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. He also has an appointment in the Department of Bioengineering and Therapeutic Sciences at UCSF, and is an active member in the UCB-UCSF Graduate Program in Bioengineering. He is the Director of the Biomagnetic Imaging Laboratory, a shared research and clinical resource at UCSF. Dr. Nagarajan’s research interests focuses on (1) understanding brain plasticity associated with learning, (2) determining neural mechanisms of auditory feedback processing during speech motor control and, (3) developing novel and power algorithms of functional imaging of brain activity, brain connectivity and brain computer interfaces. Yoshio Okada Yoshio Okadais a Professor at Boston Children's Hospital. He has worked in the field of MEG and EEG for over 30 years, studying these signals from different animal preparations in vitro and in vivo (turtle cerebellum in vitro, guinea pig hippocampal slice, swine in vivo, ferret in vivo, rabbit in vivo, chick retina in vitro) as well as from human adults, newborns and children. Dr. Okada has also used a mathematical model of the hippocampus written by Roger Traub and extended his model to explain intracellular potential, extracellular field potential and MEG signals from brain slices. He has also worked on models of realistically shaped cortical principal neurons to understand the genesis of magnetic fields by these neurons. Thus he is quite familiar with the issues of electrophysiology modeling. Dr. Okada began the study in ncMRI in turtle cerebellum in 2007 while he was at the University of New Mexico. His group were not successful during this initial attempt. He then resumed the ncMRI study with the same preparation when he arrived in Boston. He established a collaboration with Dr. Padma Sundaram Patel and together they started the work in 2011 and succeeded in measuring the ncMRI tightly coupled with the simultaneously measured evoked potential in the cerebellum in 2013. Thus he has been intimately involved in ncMRI research. Aude Oliva Aude Oliva joined the MIT faculty in the Department of Brain and Cognitive Sciences in 2004 and the MIT Computer Science and Artificial Intelligence Laboratory in 2012. Her research is cross-disciplinary, spanning human perception and cognition, computer vision, and neuroscience, focusing on research questions at the intersection of the three domains. She is the recipient of a National Science Foundation CAREER Award (2006) in Computational Neuroscience, an elected Fellow of the Association for Psychological Science (APA), and the recipient of the 2014 Guggenheim fellowship in Computer Science. Michael Romalis Michael Romalis is a professor of Physics at Princeton University. His research is focused on development of sensors using spin-polarized atoms for a range of applications, such as detection of very weak magnetic fields and searches for physics beyond the Standard Model. His group has developed very sensitive atomic magnetometers and was the first to demonstrate MEG recording with atomic sensors. He is an author of over 70 publications and several patents. Matthew Rosen Matthew S. Rosen, PhD, holds appointments at the MGH/A.A. Martinos Center for Biomedical Imaging (Department of Radiology), Harvard Medical School (Department of Radiology), and Harvard University (Department of Physics). Dr. Rosen is a physicist with extensive experience as a tool-builder for NMR and MRI. His career over the past decade has bridged the spectrum from fundamental physics to applied bioimaging work. He established the Low-Field MRI and Hyperpolarized Media Laboratory at the Athinoula A. Martinos Center for Biomedical Imaging to focus on the continued development of new hyperpolarization methods, and MRI-based tools. Dr. Rosen leads an effort to rethink conventional approaches to MRI scanner construction, and develops tools and techniques for robust low-magnetic-field implementations of MRI focused on brain imaging, including new opportunities provided by free-radical injury markers paired with in vivo Overhauser DNP at low magnetic field. Mikhail Shapiro Mikhail Shapiro is an Assistant Professor of Chemical Engineering at the California Institute of Technology. His research is focused on the development of technologies to image and control brain function non-invasively at the molecular level. Dr. Shapiro received his PhD in Biological Engineering from the Massachusetts Institute of Technology and his BSc in Neuroscience from Brown. He conducted post-doctoral research in biophysics at the University of Chicago and was a Miller Fellow at the University of California, Berkeley. Among his research accomplishments, Dr. Shapiro developed the first genetically engineered functional sensors for magnetic resonance imaging of the brain, discovered fundamental mechanisms by which infrared light stimulates neurons, and introduced the first protein-based molecular imaging agents for ultrasound. Dr. Shapiro is a fellow of the Defense Sciences Research Council and served on the National Academy of Sciences' committee on Technology Insight (TIGER). He has been awarded the Hertz, Soros, Miller and Life Science Research Foundation fellowships, the Hertz PhD Thesis Prize and the Burroughs Wellcome Career Award at the Scientific Interface. In 2010, the Technology Review recognized him as one of the world's top 35 innovators under age 35. Nian Sun Nian X. Sun is a Professor of Electrical and Computer Engineering at Northeastern University. He received the Ph.D. degree from Stanford University in 2002. He is a professor at the Electrical and Computer Engineering Department, Northeastern University. He received his Ph.D. degree from Stanford University. Prior to joining Northeastern University, he was a scientist at IBM and Hitachi Global Storage Technologies. Dr. Sun was the recipient of the NSF CAREER Award, ONR Young Investigator Award, the Søren Buus Outstanding Research Award, etc. His research interests include novel magnetic, ferroelectric and multiferroic materials, devices and subsystems for sensing, memory, power, RF and microwave applications. He has over 170 publications and over 20 patents and patent disclosures. One of his papers was selected as the “Ten most outstanding full papers in the past decade (2001~2010) in Advanced Functional Materials”. Dr. Sun has given over 80 invited or keynote presentations in national and international conferences and universities. He is an editor of IEEE Transactions on Magnetics, and a fellow of the Institute of Physics, and of the Institution of Engineering and Technology. Ron Walsworth Ronald Walsworth holds faculty appointments at Harvard University in the Department of Physics and Center for Brain Science. He is also a senior physicist at the Smithsonian Institution. He leads an interdisciplinary laboratory research group with a focus on developing precision measurement tools and applying them to problems in both the physical and life sciences — ranging from quantum physics, astrophysics, and nanoscience to bioimaging, brain science, and medical diagnostics. He currently serves as Chair of NASA’s Fundamental Physics Standing Review Board; and for more than a decade has been a Distinguished Traveling Lecturer for the American Physical Society (APS), giving public and scientific lectures at college and universities throughout the country. He has co-founded and serves on the scientific advisory board of several technology companies. Eric Wong Eric C. Wong, MD, PhD is a biophysicist working on the development of new hardware and imaging methods for MRI. He is a professor of radiology at the University of California, San Diego. His current areas of interest include arterial spin labeling techniques for noninvasive measurement of tissue perfusion, high speed and high resolution imaging techniques, including spiral techniques and contrast optimization, diffusion imaging, local gradient coils, application specific RF coils, and local shim coils. Chris Xu Chris Xu is Professor of Applied Physics at Cornell University. His current research areas are fiber optics and biomedical imaging, with major thrusts in multiphoton microscopy, multiphoton endoscopy, and ultrafast and nonlinear fiber optics. Prior to Cornell, he was a member of technical staff in Advanced Photonic Research at Bell Laboratories from 1999 to 2002. He joined Bell Laboratories as a postdoctoral member in Biological Computation Research in 1997. He received his Ph.D. from Applied Physics, Cornell University, working on multiphoton microscopy. Awards and honors include the Tau Beta Pi and two other teaching excellence awards at Cornell, Bell Labs team research award, and the NSF CAREER award. He is a fellow of the Optical Society of America. Workshop point of contact: Thomas Bifano, 617-353-8908, tgb@bu.edu	Workshop Date July 23-24, 2104 Location The Westin Arlington Gateway 801 North Glebe Rd. Arlington, VA 22209 Tel. 703-717-6200 www.westinarlingtongateway.com Website tinyurl.com/NSF-Brain Workshop Report

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