Jie Wu
2002-2006 B.S. Beijing Normal University
2006-now Ph.D.Boston University
Hometown: Sichuan
Leiodelide A, which was isolated from Leiodermatium sponges in 2006, showed significant cytotoxicity in the National Cancer Institute’s 60 cell line panel with enhanced activity against HL-60 leukemia and OVCAR-3 ovarian cancer cell lines. The goal of this project is to achieve an efficient and enantioselective synthesis of Leiodelide A through the use of new silane reagents. This total synthesis will provide a highly convergent synthetic route and will allow for the determination of its absolute stereochemistry of the molecule.
Study towards the synthesis and Stereochemical Assignment of Marine Metabolite Leiodelide A