Phone: 617-353-2621

E-mail: jsnyder@chem.bu.edu

Snyder Group

Boston University Chemistry Department

                                            Research Papers

1. Strosberg, A. D.; Kota, S.; Takahashi, V. Snyder, J. K. “Core as a Novel Viral
Target for Hepatitis C Drugs.” Viruses 2010, 2, 1734-1751.

2. Jones, A. L.; Snyder J. K. “Synthesis of Unique Scaffolds via Diels-Alder Cycloadditions of Tetrasubstituted Cyclohexadienes”. Org. Lett. 2010, 12, 1592-1595.

3. Jones, A. L.; Liu, X.; Snyder, J. K. “Enantioselective Syntheses of Candenatenins B and C Using a Chiral Anthracene Auxiliary”. Tetrahedron Lett. 2010, 51, 1091-1094.

4. Kota, S.; Scampavia, L.; Spicer, T.; Beeler, A. B.; Takahashi, V.; Snyder, J. K.;
Porco, J. A., Jr.; Hodder, P.; Strosberg, A. D. “A Time-Resolved Fluorescence-Resonance
Energy Transfer Assay for Identifying Inhibitors of Hepatitis C Virus Core
Dimerization.” ASSAY Drug Dev. Tech.  2010, 8, 96-105.

5. Wei, W.; Cai, C.; Kota, S.; Takahasi, V.; Ni, F.; Strosberg, A. D.; Snyder, J. K. “New Small Molecule Inhibitors of Hepatitus C Virus”. Bioorg. Med. Chem. Lett. 2009, 19, 6926-6930.

6. Jones, A. L.; Snyder, J. K. “Intramolecular Rhodium-Catalyzed [2+2+2] Cyclizations of Diynes with Enones”.  J. Org. Chem. 2009, 74, 2907-2910.

7. Liu, X.; Snyder, J. K. “Anthracene Cycloadducts as Highly Selective Chiral Auxiliaries”. J. Org.  Chem. 2008, 73, 2935-2938.

8.    Zhou, Y.; Porco, J. A., Jr.; Snyder, J. K. “Synthesis of 5,6,7,8-Tetrahydro-1,6-napthyridines and Related Heterocycles by Cobalt-Catalyzed [2+2+2] Cyclizations”. Org. Lett. 2007, 9(3), 393-396.

9.      Hours, A. E.; Snyder, J. K. “PtCl₂-Promoted Cyclopropane Opening in [4 + 2 + 2] Homo Diels-Alder Cycloadducts”. Tetrahedron Lett. 2006, 47, 675-678.

10.      Burgess, K. L.; Corbett, M. S.; Eugenio, P.; Lajkiewicz; N. J.; Liu, X.; Sanyal, A.; Yan, W.; Yuan, Q.; Snyder, J. K. “ Chiral Anthracene and Anthrone templates as Stereocontrolling Elements in Diels-Alder/Retro Diels-Alder Sequences”. Bioorg, Med. Chem. 2005, 13, 5299-5309. (Special issue honoring Koji Nakanishi’s Tetrahedron award.)

11.      Su, S.; Acquilano, D. E.; Arumugasamy, J.; Beeler, A. B.; Eastwood, E. L.; Giguere, J.; Lan, P.; Lei, X.; Min, G. K.; Yeager, A. R.; Zhou, Y.; Panek, J. S.; Snyder, J. K.; Schaus, S. E.*, Porco, J. A., Jr.* “Convergent Synthesis of a Complex Oxime Library Using Chemical Domain Shuffling”. Org. Lett. 2005, 7(15), 2751-2754.

12.     Sanyal, A.; Yuan, Q.; Snyder, J. K. “A new, chiral anthracene for the Diels-Alder/retro-Diels-Alder sequence in lactam and butenolide synthesis”. Tetrahedron Lett. 2005, 46, 2475-2478.

13.      Ma, B.; Snyder, J. K. “Homo Diels-Alder Chemistry in the Synthesis of Portulal: Construction of the Functionalized Hydroazulene Core” Tetrahedron Lett. 2005, 46, 703-706.

14.      Burgess, K. L.; Lajkiewicz, N. J.; Sanyal, A.; Yan, W.; Snyder, J. K. “A New Chiral Anthracene for the Asymmetric Diels-Alder/Retro Diels-Alder Sequence”. Org. Lett. 2005, 7, 31-34.

15.      Lahue, B. R.; Lo, S.-M.; Wan, Z.-K.; Woo, G. H. C.; Snyder, J. K. “Intramolecular Inverse Electron Demand Diels-Alder Reactions of Imidazoles with 1,2,4-Triazines: A New Route to 1,2,3,4-Tetrahydro-1,5-naphthyridines and Related Heterocycles”. J. Org. Chem. 2004, 69, 7171-7182.

16.        Lahue, B. R.; Wan, Z.-K.; Snyder, J. K. “Dienophilicity of Imidazole in Inverse Electron Demand Diels-Alder Reactions. IV. Intermolecular Reactions with 1,2,4-Triazines.” J. Org. Chem. 2003, 68, 4345 - 4354.

17.        Corbett, M. S.; Liu, X.; Sanyal, A.; Snyder, J. K. “Cycloadditions of chiral anthracenes: effect of the trifluoromethyl group.” Tetrahedron Lett. 2003, 44, 931 - 935.

18.    Ma, B.; Snyder, J. K. “Development of a New Cobalt Catalyst System for the [4 + 2 + 2] Cycloadditions of Functionalized Norbornadienes and Butadiene.” Organometallics 2002, 21, 4688 - 4695.

19.        Ma, B.; Snyder, J. K. “A Homo Diels-Alder Approach to Bicyclo[4.2.1]nonanes.” Org. Lett. 2002, 4, 2731 - 2734.

20.       Deng, Y.; Snyder, J. K. “Preparation of a 24-Nor-1,4-dien-3-one Triterpene Derivative from Betulin; A New Route to 24-Nortriterpene Analogues.” J. Org. Chem. 2002, 67, 2864 - 2873.

21.     Nomak, R.; Snyder, J. K. “Inverse Electron Demand Diels-Alder Chemistry in the Synthesis of a Regioselectively Protected Analogue of the Staurosporine Aglycone” Tetrahedron Lett. 2001, 42, 7929 - 7933.

22.    Deng, Y.; Tianasoa-Ramamonjy, M.; Snyder, J. K. “Remangilone D: A New Bisnoroleanane Triterpene, and A New Flavone from Physena madagascariensis” Z. Naturforsch. B 2001, 56B, 1079 - 1083.

23.     Chen, Y.; Snyder, J. K. “Opening the [4 + 2 + 2] Cycloadducts of Bicyclo[2.2.1]hepta-2,5-dienes (Norbornadienes) to Cis-Fused Bicyclo[5.3.0]decanes” J. Org. Chem. 2001, 66, 6943 - 6957.

24.   Chen, Y.; Kiattansakul, R.; Ma, B.; Snyder, J. K. “Transition Metal-Catalyzed [4 + 2 + 2] Cyclcoadditions of Bicyclo[2.2.1]hepta-2,5-dienes (Norbornadienes) and Bicyclo[2.2.2]octa-2,5-dienes” J. Org. Chem. 2001, 66, 6932 - 6942.

25.   Deng, Y.; Scott, L.; Swanson, D.; Snyder, J. K.; Sari, N.; Dogan, H. “Guaianolide Sesquiterpene Lactones from Cichorium intybus (Asteraceae)” Z. Naturforsch. B 2001, 56B, 787 - 796.

26.   Wan, Z.-K.; Woo, G. H. C.; and Snyder, J. K. “Dienophilicity of Imidazole in Inverse Electron Demand Diels-Alder Reactions; Cycloadditions with 1,2,4,5-Tetrazines and the Synthesis of Zarzissine” Tetrahedron 2001, 57, 5497 - 5507.

27.     Sanyal, A.; Snyder, J. K. “Stereoselective Diels-Alder Reactions of Chiral Anthracenes” Org. Lett. 2000, 2527 - 2530.

28.      Deng, Y.; Lee, J. P.; Tianasoa-Ramamonjy, M.; Snyder, J. K.; Des Etages, S. A.; Kanada, D.; Snyder, M. P.; Turner, C. J. “New Antimicrobial Flavanones from Physena madagascariensis” J. Nat. Prod.  2000, 63, 1082 - 1089.

29.     Benson, S. C.; Lee, L.; Yang, L.; Snyder, J. K. “Intramolecular Inverse Electron Demand Diels-Alder Reactions of Tryptamine with Tethered Heteroaromatic Azadienes”, Tetrahedron 2000, 56, 1165 - 1180.

30.    Deng, Y.; Jiang, T. Y.; Sheng, S.; Tianasoa-Ramomonjy, M.; Snyder, J. K. “Remangilones A - C: New Cytotoxic Triterpenes from Physena madagascariensis”, J. Nat. Prod. 1999, 62, 471.

31.   Kiattansakul, R.; Snyder, J. K. “Cobalt-Catalyzed [4 + 2 + 2] Cycloadditions of Bicyclo[2.2.2]octadienes”, Tetrahedron Lett. 1999, 40, 1079. 

32.   Girardot, M.; Nomak, R.; Snyder, J. K. “Direct Conversion of Heteroaromatic Esters to Methyl Ketones with Trimethylaluminum; Nonsymmetrically Disubstituted 1,2,4,5-Tetrazines”, J. Org. Chem. 1998, 63, 10063.

33.    Chen, Y.; Snyder, J. K. “Metal Catalyzed [4 + 2 + 2] Cycloadditions: Cycloadducts of Substituted Norbornadienes and Their Opening with Zeise’s Dimer”, J. Org. Chem. 1998, 63, 2060.

34.    Wan, Z.; Snyder, J. K. “Inverse Electron Demand Diels-Alder Reactions of Indole . VI. A Fully Removable Tether for Intramolecular Reactions with 1,2,4-Triazines”, Tetrahedron Lett. 1998, 39, 2487.

35.   Daly, K.; Nomak, R.; Snyder, J. K. “A Facile Preparation of Pyrrolo[3,4-b]indoles”, Tetrahedron Lett. 1997, 38, 8611.

36.   Neipp, C. E.; Ranslow, P. B.; Wan, Z.; Snyder, J. K. “Dienophilicity of Imidazole in Inverse Electron Demand Diels-Alder Reactions; Intramolecular Reactions with 1,2,4-Triazines”, Tetrahedron Lett. 1997, 38, 7499.

37.   Wan, Z.; Snyder, J. K. “Dienophilicity of Imidazole in Inverse Electron Demand Diels-Alder Reactions; Intermolecular Reactions with 1,2,4-Triazines”, Tetrahedron Lett. 1997, 38, 7495.

38.    Haiza, M. A.; Sanyal, A.; Snyder, J. K. “O-Nitromandelic: A Chiral Solvating Agent for the NMR Determination of Chiral Diamine Enantiomeric Purity”, Chirality 1997, 9, 556. (Special issue comemorating Koji Nakanishi’s 70th birthday.)

39.    Chen, Y.; Snyder, J. K. “Opening Norbornadiene Homo Diels-Alder Adducts to Bicyclic Systems”, Tetrahedron Lett. 1997, 38, 1477.

   Selected Book Chapters and Reviews

1.        G. H. C. Woo, Z.-K. Wan, and J. K. Snyder, “Six-Membered Ring Systems: Diazines and Benzo Derivatives”, in Progress in Heterocyclic Chemistry, Vol. 14; T. L. Gilchrist and G. Gribble, ed.; Pergamon; NY, 2002, pp 279 - 309.

2.         B. R. Lahue, G. H. C. Woo and J. K. Snyder, “Six-Membered Ring Systems: Diazines and Benzo Derivatives”, in Progress in Heterocyclic Chemistry, Vol. 13; T. L. Gilchrist and G. Gribble, ed.; Pergamon; NY, 2001, pp 261 - 295.

3.           B. R. Lahue and J. K. Snyder, “Six-Membered Ring Systems: Diazines and Benzo Derivatives”, in Progress in Heterocyclic Chemistry, Vol. 12; T. L. Gilchrist and G. Gribble, ed.; Pergamon; NY, 2000, pp 263 - 293.

4.         L. Lee and J. K. Snyder, “Indole as a Dienophile in Inverse Electron Demand Diels-Alder and Related Reactions”, in Advances in Cycloadditions, Vol 6; M. Harmata, ed.; JAI Press: Stamford, CT, 1999, pp 119 - 171.

                                                                                         Books

1.        R. Cooper and J. K. Snyder, eds. The Biology - Chemistry Interface, A Tribute to Koji   Nakanishi, Marcel Dekker; 1999, NY.

                                                                Patents 

1.      N. Sari, H. Dogan and J. K. Snyder, “Methods and Compositions for Treating Neoplastic Disorders”, US Patent No. 08/116,689; 1996.

Publications