>> Zhang Lab: Publications

BioMEMS: Microsystems for Cellular Force Measurement

Archival Journal Papers

Investigation of Cellular Contraction Forces in the Frequency Domain Using PDMS Micropillar Force Transducers,
P. Du, C. Chen, H. Lu, and X. Zhang, submitted for publication.

The Use of Controlled Surface Topography and Flow-induced Shear Stress to Influence Renal Epithelial Cell Function,
E.M. Frohlich, X. Zhang, and J.L. Charest, Integrative Biology, 2012, 4(1): 75-83. [DOI; PDF]

Effect of Loading Rates on Cellular Force Measurements by Polymer Micropillar based Transducers,
P. Du, X. Zheng, I-K Lin, and X. Zhang, Applied Physics Letters, 2011, 99(8): 083701(3pp). [DOI; PDF]

Opto-Mechanical Platforms for Cell Force Study,
X. Zheng and X. Zhang, Micro and Nano Letters, 2011, 6(5): 332-336. [DOI; PDF]

Microsystems for Cellular Force Measurement: A Review,
X. Zheng and X. Zhang, Journal of Micromechanics and Microengineering, 2011, 21(5): 054003(13pp). [DOI; PDF]

Whole Field Decoupling of Predistortion on Polymeric Cell Force Transducer,
X. Zheng and X. Zhang, Applied Physics Letters, 2011, 98(17): 173701(3pp). [DOI; PDF]

Extension of the Beam Theory for Polymer Bio-Transducers with Low Aspect Ratios and Viscoelastic Characteristics,
P. Du, I-Kuan Lin, H. Lu, and X. Zhang, Journal of Micromechanics and Microengineering, 2010, 20(9): 095016(13pp). [DOI; PDF]

A Versatile Cell Contractility Mapping Transducer Utilizing Moire-Based Technique,
X. Zheng, H.K. Surks, and X. Zhang, Journal of Microelectromechanical Systems, 2010, 19(4): 764-773. [DOI; PDF]

Single Cell Contractility Studies Based On Compact Moire System Over Periodic Gratings,
X. Zheng, H.K. Surks, and X. Zhang, Applied Physics Letters, 2010, 96(21): 213705(3pp). [DOI; PDF]

Viscoelastic Characterization and Modeling of Polymer Transducers for Biological Applications,
I-K Lin, K-S Ou, Y-M Liao, Y. Liu, K-S Chen, and X. Zhang, Journal of Microelectromechanical Systems, 2009, 18(5): 1087-1099. [DOI; PDF]

ROCK Isoform Regulation of Myosin Phosphatase and Contractility in Vascular Smooth Muscle Cells,
Y. Wang, X. Zheng, N. Riddick, M. Bryden, W. Baur, X. Zhang, and H.K. Surks, Circulation Research, 2009, 104(4): 531-540. [DOI; PDF]

Viscoelastic Mechanical Behavior of Soft Microcantilevers-Based Force Sensors,
I-K Lin, Y-M Liao, Y. Liu, K-S Ou, K-S Chen, and X. Zhang, Applied Physics Letters, 2008, 93(25): 251907(3pp). [DOI; PDF]

An Optical Moire Technique for Cell Traction Force Mapping,
X. Zheng and X. Zhang, Journal of Micromechanics and Microengineering, 2008, 18(12): 125006(10pp). [DOI; PDF]

Optical Moire as a Visualization Tool for Living Vascular Cell Contraction Force Mapping,
X. Zheng and X. Zhang, Applied Physics Letters, 2008, 93(16): 164106(3pp). [DOI; PDF]

Simultaneous Orientation and Cellular Force Measurements in Adult Cardiac Myocytes Using Three-Dimensional Polymeric Microstructures,
Y. Zhao, C.C. Lim, D.B. Sawyer, R. Liao, and X. Zhang, Cell Motility and the Cytoskeleton, 2007, 64(9): 718-725. [DOI; PDF]

Adaptation of Myofibrils to a Microstructured Polymeric Substrate,
Y. Zhao and X. Zhang, Sensors and Actuators A: Physical, 2007, 136(2): 491-495. [DOI; PDF]

Determination of the Deformations in Polymeric Nanostructures Using Geometric Moire Techniques for Biological Applications,
Y. Zhao and X. Zhang, Sensors and Actuators B: Chemical, 2006, 117(2): 376-383. [DOI; PDF]

Microchip for Subcellular Mechanics Study in Living Cells,
Y. Zhao, C.C. Lim, D.B. Sawyer, R. Liao, and X. Zhang, Sensors and Actuators B: Chemical, 2006, 114(2): 1108-1115. [DOI; PDF]

An Approach for Creating Polymeric Microstructures with Various Aspect Ratios for Cellular Analysis Applications,
Y. Zhao and X. Zhang, Sensors and Actuators A: Physical, 2006, 127(2): 216-220. [DOI; PDF]

Cellular Mechanics Study in Cardiac Myocytes Using PDMS Pillars Array,
Y. Zhao and X. Zhang, Sensors and Actuators A: Physical, 2006, 125(2): 398-404. [DOI; PDF]

Adaptation of Flexible Polymer Fabrication to Cellular Mechanics Study,
Y. Zhao and X. Zhang, Applied Physics Letters, 2005, 87(14): 144101(3pp). [DOI; PDF]

Cellular Force Measurements Using Single-Spaced Polymeric Microstructures: Isolating Cells from Base Substrate,
Y. Zhao, C.C. Lim, D.B. Sawyer, R. Liao, and X. Zhang, Journal of Micromechanics and Microengineering, 2005, 15(9): 1649-1656. [DOI; PDF]

Conference Proceeding Papers

Polymer Opto-Mechanical Transducer for Abnormal Cell Contraction Diagnostics,
X. Zheng and X. Zhang, Proceeding of the 16th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers '11), Beijing, China, June 5-9, 2011, pp. 2243-2246.

Effect of Loading Rates on Polymer Micropillar-Based Force Transducers,
P. Du, X. Zheng, I-K Lin, H. Lu, and X. Zhang, Proceeding of the 16th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers '11), Beijing, China, June 5-9, 2011, pp. 1432-1435.

A Micro Moire Chip for Automated Whole Field Cell Analysis,
X. Zheng and X. Zhang, Proceeding of the 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS '10), Groningen, Netherlands, October 3-7, 2010, pp. 1625-1627.

Extended Timoshenko Beam Formula for Cellular Contraction Force Calculation,
P. Du, X. Zheng, I-K Lin, H. Lu, and X. Zhang, Proceeding of the 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS '10), Groningen, Netherlands, October 3-7, 2010, pp. 509-511.

Sensing Single Cell Contractility Utilizing Moire Fringes,
X. Zheng, H.K. Surks, and X. Zhang, Technical Digest of IEEE Solid-State Sensor and Actuator Workshop (Hilton Head '10), Hilton Head Island, SC, USA, June 6-10, 2010, pp. 274-277.

Quantifying Contractility in Migrational Vascular Smooth Muscle Cells Regulated by Contractile Proteins Using a Novel Microfluidic Force Mapping Chip,
X. Zheng and X. Zhang, Proceeding of the 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS '09), Jeju, Korea, November 1-5, 2009, pp. 475-477.

Cellular Force Measurement in Cardiac Myocytes Using Polymer Micropillar Array with Viscoelastic Characterization,
I-K Lin, K-S Ou, K-S Cen, and X. Zhang, Proceeding of the 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS '09), Jeju, Korea, November 1-5, 2009, pp. 269-271.

Diffraction Moire: Decoupling Distortions in Periodic Polymeric Post Arrays,
X. Zheng and X. Zhang, Proceeding of the 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS '08), San Diego, CA, USA, October 12-16, 2008, pp. 991-993.

A Novel Versatile Biomechano-Sensor for Real Time Vascular Cell Contractility Mapping,
X. Zheng and X. Zhang, Proceeding of the 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS '08), San Diego, CA, USA, October 12-16, 2008, pp. 510-512.

Viscoelastic Characterization of Soft Micropillars for Cellular Mechanics Study,
I-K Lin, Y-M Liao, K-S Chen, and X. Zhang, Proceeding of the 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS '08), San Diego, CA, USA, October 12-16, 2008, pp. 278-280.

A Diffraction Moire Based Micro Double Layered Chip for Cellular Mechanics Study,
X. Zheng and X. Zhang, Proceeding of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS '07), Paris, France, October 7-11, 2007, pp. 1649-1651.

A MEMS Based Optical Moire Approach for in situ Cardiac Myocyte Force Probing,
X. Zheng and X. Zhang, Proceeding of the 14th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers '07), Lyon, France, June 10-14, 2007, pp. 1119-1122.

Pressure-Assisted Micropatterning of Non-Photodefinable Polymers,
Y. Zhao, D. Mabius, J. Regis, and X. Zhang, Proceeding of the 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS '06), Tokyo, Japan, November 5-9, 2006, pp. 164-166.

Directional Reassembly of Myofibrils in Cultured Cardiac Myocytes Using a Three-Dimensional Polymeric Substrate,
Y. Zhao and X. Zhang, Technical Digest of IEEE Solid-State Sensor and Actuator Workshop (Hilton Head '06), Hilton Head Island, SC, USA, June 4-8, 2006, pp. 410-411.

A Three-Dimensional Substrate for Cardiac Myocyte Orientation and Contraction Force Measurements,
Y. Zhao and X. Zhang, Proceeding of the 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS '05), Boston, MA, USA, October 9-13, 2005, pp. 166-168.

Determination of Deformations in Polymeric Nanostructures Using Geometric Moire Techniques for Biological Applications,
Y. Zhao, F. Li, and X. Zhang, Proceeding of the 13th International Conference on Solid-State Sensors and Actuators and Microsystems (Transducers '05), Seoul, Korea, June 5-9, 2005, pp. 1748-1751.

Creating Polymer-Based Microstructures with Various Aspect Ratios from a Single Template for Cellular Force Measurements,
Y. Zhao, H. Yu, and X. Zhang, Proceeding of the 18th IEEE International Conference on Micro Electro Mechanical Systems (MEMS '05), Miami Beach, FL, USA, January 30 - February 3, 2005, pp. 496-499.

Contraction Force Measurements in Cardiac Myocytes Using PDMS Pillar Array,
Y. Zhao and X. Zhang, Proceeding of the 18th IEEE International Conference on Micro Electro Mechanical Systems (MEMS '05), Miami Beach, FL, USA, January 30 - February 3, 2005, pp. 834-837.

In Situ Force Probing for Cardiac Myocyte Using Micro PDMS Pillar Array,
Y. Zhao and X. Zhang, Proceeding of the 8th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS '04), Malmo, Sweden, September 26-30, 2004, Volume I, pp. 430-432.

Micro Molded PDMS Structures for Cardiac Myocyte Restoring Force Measurements,
Y. Zhao, H. Yu, B. Li, and X. Zhang, Technical Digest of IEEE Solid-State Sensor and Actuator Workshop (Hilton Head '04), Hilton Head Island, SC, USA, June 6-10, 2004, pp. 394-395.

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