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  Micro/Nanoengineered Multi-Spectral Contrast Agents for MRI and CT

The objective of this research is to develop a biocompatible, fabricated magnetic resonance imaging (MRI) or computed tomography (CT) contrast agent platform with novel properties, including sensory capability, and potential for wide application to biomedical research. The approach is to employ both top-down and self assembly approaches, incorporating environmentally responsive materials, to develop a class of contrast agents which address major limitations of currently available agents. In collaboration with Dr. Stephan Anderson (MD, Radiologist), this project addresses the development of next generation MRI and CT contrast agents using micro- and nanofabrication techniques incorporating biocompatible magnetic materials to develop a series of geometrically precise, particulate contrast agents yielding distinct spectral signatures with multiplexing capability. In addition, the incorporation of biocompatible hydrogels, tunable to respond to myriad environmental stimuli, into the fabrication process will yield in vivo biological sensing capability.

Representative Publications (#denotes graduate students/postdocs supervised by X. Zhang; *denotes corresponding author by X. Zhang; +denotes contributed equally.)

C. Wang#, X. Wang#, S.W. Anderson, and X. Zhang*, "Biocompatible, Micro- and Nano-fabricated Magnetic Cylinders for Potential Use as Contrast Agents for Magnetic Resonance Imaging," Sensors and Actuators B: Chemical, 2014, 196: 670-675. [DOI]

C. Wang#, X. Wang#, S.W. Anderson, and X. Zhang*, "Fabrication and Characterization of Composite Hydrogel Particles with X-Ray Attenuating Payloads," Journal of Vacuum Science & Technology B, 2014, 32(3): 032001(7pp). [DOI]

X. Wang#, C. Wang#, S.W. Anderson, and X. Zhang*, "Microfabricated Iron Oxide Particles for Tunable, Multispectral Magnetic Resonance Imaging," Materials Letters, 2013, 110: 122-126. [DOI]

Ph.D. Dissertation

Xiaoning Wang, "Size and Shape Specific Particles Toward Biomedical Imaging: Design, Fabrication, and Characterization," Ph.D. Dissertation, Boston University. (Advisor: Xin Zhang; September 2014)

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