There was a war in 1675-1676 between the the settlers and the Native Americans, led by a Pokanoket warrior called Metacomet, nicknamed King Philip by the English. It ended with the loss of the Native Americans.

Metacomet (King Philip)

Map of the Theater of King Philip's War
(from Bourne's The Red King's Rebellion)

 

Links

http://members.aol.com/netpotato/king_philips_war.htm

http://www.georgetown.edu/users/arsenauj/kpw.html