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Publications and Patents:

Click here for a complete publication list:

Recent Reviews and Perspectives:

  1. S. Heydrick, E.G. Roberts, J. Kim, S. Emani, and J.Y. Wong (2016) “Pediatric Cardiovascular Grafts: Historical Perspective and Future Directions” Current Opinion in Biotechnology 40: 119-124. doi: 10.1016/j.copbio.2016.03.013
  2. H. Kong and J.Y. Wong, Guest Editors (2014) “Materials for Biological Modulation, Sensing, and Imaging” MRS Bulletin 39 (1): 12-14. 
  3. E.G. Roberts, Elaine L. Lee, Daniel Backman, Jo Ann Buczek-Thomas, Sitaram Emani, and Joyce Y. Wong (2015) “Engineering Myocardial Tissue Patches with Hierarchical Structure-Function” Annals of Biomedical Engineering, 43(3): 762-773. DOI: 10.1007/s10439-014-1210-6. Epub 2014 Dec 17. 


  1. Kim, J. and J.Y. Wong, "Multi-layered Cell Constructs and Methods of Use and Production using Enzymatically Degradable Natural Polymers", US Serial No. 14/891,713, filed November 13, 2015, Claiming priority to PCT/US14/37946
  2. J.Y. Wong, V.M. Herrera, N. Ruiz-Opazo, and R.D. Whiaker, U.S. Provisional Patent Application No. 62/157,623, "Theranostic compositions and uses thereof", Filing Date: May 6, 2015
  3. Nagy, J.O., J.Y. Wong, A. Luce, R.D. Whitaker, R.O. Cleveland, Y. Park, "Polymerized shell lipid microbubbles and uses thereof", Pub. No.: WO/2011/149985; International Application No.: PCT/US2011/037801; Publication Date: 01.12.2011; International Filing Date: 24.05.2011. (US 61/347,524)
  4. Wong, J.Y., Ingber, D.E., and Langer, R. "Control of cell function on electrically conducting polymers", U.S. Patent 5,843,741 issued December 1, 1998.


Cell-Biomaterial Interactions (cardiovascular; cancer):

  1. C.D. Hartman, B.C. Isenberg, S.G. Chua, and J.Y. Wong (2016) “Vascular smooth muscle cell durotaxis depends on extracellular matrix composition,” PNAS, 113(40): 11190-11195. doi: 10.1073/pnas.1611324113 
  2. C. Zhang, M. Barrios, R.M. Alani, M. Cabodi, and J.Y. Wong (2016) “A microfluidic Transwell to study chemotaxis” Experimental Cell Research 342(2):159-65.
  3. C. Zhang, E. Shenk, L. Blaha, B.Ryu, R. Alani, M. Cabodi, and J.Y. Wong (2015) "A Simple Engineered Platform Reveals Different Modes of Tumor-Environmental Cell Interaction" Biofabrication 8(1): 015001. 
  4. O.V. Sazonova, B.C. Isenberg, J. Herrmann, K. Lee, A. Purwada, A. Valentine, J. Buczek-Thomas, J.Y. Wong*, and M. Nugent* (2015) “Extracellular matrix presentation modulates vascular smooth muscle cell mechanotransduction,” (*co-corresponding authors) Matrix Biology, 41: 36-43.
  5. B.C. Isenberg*, P.A. DiMilla*+, M. Walker, S. Kim, and J.Y. Wong+ (2009) “Vascular smooth muscle cell durotaxis depends on substrate stiffness gradient strength,” Biophys. J., 97: 1313-1322 (*co-first authors) (co-corresponding authors+) 

Vascular Tissue Engineering:

  1. E.L. Lee, H. Bendre, A. Kalmykov, and J.Y. Wong (2015) “Surface modification of uniaxial cyclic strain cell culture platform with temperature-responsive polymer for cell sheet detachment,” Journal of Materials Chemistry B 3:7899-7902
  2. J.B. Lin, B.C. Isenberg, Y. Shen, K. Schorsch, O.V. Sazonova, and J.Y. Wong (2012) “Thermo-responsive poly(N-isopropylacrylamide) Grafted onto Microtextured Poly(dimethylsiloxane) for Aligned Cell Sheet Engineering,” Colloids and Surfaces B: Biointerfaces 99: 108-115
  3. B.C. Isenberg, D.E. Backman, M.E.Kinahan, R. Jesudason, B. Suki, P.J. Stone, E.C. Davis, and J.Y. Wong (2012) “Micropatterned cell sheets with defined cell and extracellular matrix orientation exhibit anisotropic mechanical properties,” J Biomechanics 45: 756-761 57
  4. C. Williams, A. Xie, M. Yamato, T. Okano, and J.Y. Wong (2011) “Stacking of aligned cell sheets for layer-by-layer control of complex tissue structure,” Biomaterials 32: 5625-5632

Theranostics / Drug Delivery / Imaging Contrast Agents:

  1. Y. Park, C. Zhang, S. Kim, G. Mohamedi, C. Beigie, J. Nagy, R.G. Holt, R.O. Cleveland, N.L. Jeon, and J.Y. Wong (in press) “Microvessels-on-a-Chip to Assess Targeted Ultrasound-Assisted Drug Delivery,” ACS Applied Materials & Interfaces    
  2. Y. Park, T.A. Pham, C. Beigie, M. Cabodi, R.O. Cleveland, J.O. Nagy, and J.Y. Wong (2015) “Monodisperse micro-oil droplets stabilized by polymerizable phospholipid coatings as potential drug carriers” Langmuir 31 (36): 9762-70. 
  3. Y. Park, J.B. Smith, T. Pham, R.D. Whitaker. C. Sucato, J.A. Hamilton, E. Bartolak-Suki, and J.Y. Wong (2014) “Effect of PEG Molecular Weight on Stability, T2 contrast, Cytotoxicity, and Cellular Uptake of Superparamagnetic Iron Oxide Nanoparticles (SPIONs)” Colloids and Surfaces B: Biointerfaces, 119: 106–114.
  4. Y. Park, J. Paulsen, R.J. Nap, R.D. Whitaker, V. Mathiyazhagan, Y.-Q. Song, M. Hürlimann, I. Szleifer, and J.Y. Wong (2014) “Adsorption of Superparamagnetic Iron Oxide Nanoparticles on Silica and Calcium Carbonate Sand,” Langmuir, 30 (3): 784–792. DOI: 10.1021/la404387t
  5. Y. Park, A.C. Luce, R.D. Whitaker, B. Amin, M. Cabodi, R. Nap, I. Szleifer, R.O. Cleveland, J.O. Nagy, and J.Y. Wong (2012) “Tunable diacetylene polymerized shell microbubbles as ultrasound contrast agents,” Langmuir 28: 3766-3772. 

Biomimetic Materials Engineering:

  1. S. Lin, S. Ryu, O. Tokareva, G. Gronau, M.M. Jacobsen, W. Huang, D. Rizzo, D. Li, C. Staii, N. Pugno, J.Y. Wong, D.L. Kaplan and M.J. Buhler (2015) “Predictive Modelling-Based Design for Synthesis and Spinning of Bioinspired Silk Fibres” Nature Communications 6: 6892. doi: 10.1038/ncomms7892. PubMed PMID: 26017575.
  2. M.E. Kinahan, E. Filippidi, S. Koester, H.M. Evans, T. Pfohl, D.L. Kaplan, and J.Y. Wong (2011) “Tunable silk: Using microfluidics to fabricate silk fibers with controllable properties,” Biomacromolecules, 12: 1504-1511, DOI: 10.102/bm1014624 (

Computer Science meets Cell Imaging:

  1. S.K. Kim, D. Gurari, C. Yang, C.D. Hartman, M. Jacobsen, J.Y. Wong, and M. Betke (2014) “I’mCell: A Touch Pad Tool for Annotating Cell Images,” Biomedical Signal Analysis (BSA): 3-D Imaging in Medicine, Florianopolis, Brazil, 3 pages.
  2. Gurari, D., S-K Kim, E. Yang, B. Isenberg, T. Pham, A. Purwada, P. Solski, M. Walker, J.Y. Wong, and M. Betke (2013) “SAGE: A Principled Approach and Implementation Empowering Quick and Reliable Quantitative Analysis of Segmentation Quality,” IEEE Workshop on the Applications of Computer Vision (WACV) 2013, Clearwater Beach, Florida
  3. Wu, Z., D. Gurari, J.Y. Wong, and M. Betke (2012) “Hierarchical Partial Matching and Segmentation of Interacting Cells,” Med Image Comput Comput Assist Interv,15( Pt I): 389-396.