
We now are using deuterium kinetic isotope effect experiments to reveal even finer details of how the hydroxyl radical cleavage pattern relates to the structure of a DNA or an RNA molecule.
We participated in the ENCODE Pilot Project sponsored by the National Human Genome Research Institute of the NIH. The aim of our work is to produce a map of the structure of the human genome, to better understand how the genome functions.
CH724: Special Topics in the Chemical Biology of Nucleic Acids. Fall 2006