Motivated by potentially significant benefits in diagnosis and treatment of eye disease, the goal of this project is to develop a compact MEMS-based adaptive optics scanning laser ophthalmoscope (AOSLO) for high-resolution in vivo, confocal imaging of mouse retinas. With an adaptive optics system, aberrations in the mouse eye are measured and corrected using a real time control system and a deformable mirror. The Boston University micromachined deformable mirror (µDM) is the enabling component for this system. A testbed AOSLO system has been designed, constructed, and tested, with the support of a Biomedical Research Partnership Grant from the National Institutes of Health. Collaborators include Dr. Charles Lin, of the Masachusetts General Hospital's Wellman Laboratories of Photomedicine, and Drs. Steven Burns and Rob Webb of the Schepen's Eye Research Institute.