Cardiac Troponin I in Rhabdomyolysis |
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Clinical Chemistry 48: 1112-1114, 2002
Differential Detection of Skeletal Troponin I Isoforms in Serum of a Patient with Rhabdomyolysis: Markers of Muscle Injury?
Jeremy A. Simpson1,2,1, Ralf Labugger1,2,1, Geoffrey G. Hesketh1, Christine D’Arsigny3,5, Denis O’Donnell3,5, Nobuko Matsumoto6, Christine P. Collier2,5, Steve Iscoe1 and Jennifer E. Van Eyk1,4a
Study evaluated new antibodies to assess skeletal troponin I changes in chemically induced rhabdomyolysis. Below is their data with respect to CK level and cardiac troponin I, which they assumed to be negligible (relative to levels seen in acute MI).
Table 1. Serum CK and cTnI from 20 samples taken over the time course of 8 days from a patient with drug-induced rhabdomyolysis.
| Sample |
Day |
Time, h |
CK, U/L |
cTnI, µg/L |
|
| 1 |
1 |
1540 |
16 021 |
0.46 |
| 2 |
2 |
0530 |
18 300 |
ND1 |
| 3 |
3 |
0210 |
29 412 |
0.69 |
| 4 |
3 |
0500 |
20 375 |
ND |
| 5 |
3 |
1225 |
20 899 |
0.71 |
| 6 |
3 |
2100 |
21 969 |
ND |
| 7 |
4 |
0643 |
27 350 |
ND |
| 8 |
4 |
1542 |
34 220 |
ND |
| 9 |
4 |
2349 |
38 890 |
ND |
| 10 |
5 |
0550 |
32 240 |
ND |
| 11 |
5 |
1700 |
35 630 |
ND |
| 12 |
6 |
0600 |
39 622 |
ND |
| 13 |
6 |
1028 |
ND |
ND |
| 14 |
6 |
1630 |
42 350 |
ND |
| 15 |
6 |
2139 |
34 460 |
ND |
| 16 |
7 |
0320 |
41 900 |
1.13 |
| 17 |
7 |
0600 |
ND |
ND |
| 18 |
7 |
1740 |
23 711 |
ND |
| 19 |
8 |
0545 |
ND |
ND |
| 20 |
8 |
1700 |
10 113 |
ND |
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