Selected Publications:


Russo, A. L., A. Thiagalingam, H. Pan, J. Califano, K-h. Cheng, J.F. Ponte, D. Chinnappan, P. Nemani, D. Sidransky, and S. Thiagalingam. 2005. Differential DNA hypermethylation of critical genes mediate the stage specific tobacco smoke induced neoplastic progression of lung cancer. Clin. Cancer Res. 11 : 2466-2470.

Pan, H., J. Califano, J. F. Ponte, A.L. Russo, K-h. Cheng, A. Thiagalingam, P. Nemani, D. Sidransky and S. Thiagalingam. 2005. Loss of Heterozygosity Patterns Provide Fingerprints for Genetic Heterogeneity in Multistep Cancer Progression of Tobacco Smoke Induced Non Small Cell Lung Cancer. Cancer Res. 65 : 1664-1669.

Abdolmaleky, H. M ., S. Thiagalingam and M. Wilcox. 2005. Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications and future scope. Am J Pharmacogenomics. 5 : 1175-2203.

Abdolmaleky, H., K-h. Cheng, A. Russo, C.L. Smith, S.V. Faraone, R. Shafa, M. Wilcox, S. Glatt, W.S. Stone, G. Nguyen, J.F. Ponte, S. Thiagalingam* and M. Tsuang*. 2005. Hypermethylation of the Reelin ( RELN ) Promoter in the Brain of Schizophrenic Patients: A Preliminary Report. Am J Med Genet B Neuropsychiatr Genet. 134B : 60-66. (*These authors co-directed and contributed equally to this work)

Cheng, K-h., J. F. Ponte and S. Thiagalingam. 2004. Elucidation of epigenetic inactivation of SMAD8 in cancer using Targeted Expressed Gene Display. Cancer Res. 64: 1639-1646.

Kugathasan S, Cheng K-h, Johnson NA, Ogawa H, Rafiee P, Binion DG, and S. Thiagalingam. 2003. Inactivation of mucosal SMAD signaling is associated with the progression from early to late Crohn's disease (Cd). Gastroenterology 124 (4) : Suppl. A313-A313

Thiagalingam, S., K-h.Cheng, H. J. Lee, N. Mineva, and J. F. Ponte. 2003. Histone deacetylases: Unique players in shaping the epigenetic histone code, Annal. New York Acad. Sci. 983 : 86-100.

Thiagalingam, S. , K-h.Cheng, R. L. Foy, H. J. Lee, D. Chinnappan, and J. F. Ponte. 2002. TGF- b and its Smad connection to cancer. Current Genomics 3 : 449-476.

Thiagalingam, S., R. L. Foy, K-h.Cheng, H. J. Lee, A. Thiagalingam, and J. F. Ponte. 2002. Loss of heterozygosity as a predictor to map tumor suppressor genes in cancer: molecular basis of its occurrence. Current Opinion in Oncology 14 (1): 65-72.

Thiagalingam, S. , S. Laken, J. K. V. Willson, S. Markowitz, K. W. Kinzler, B. Vogelstein and C. Lengauer. 2001. The mechanisms underlying losses of heterozygosity in human colorectal cancers. Proc. Natl. Acad. Sci. USA. 98 : 2698-2702.

Thiagalingam, S. 2001. Molecular detection of Smad4/Smad2 alterations in colorectal tumors: Colorectal Cancer Methods and Protocols. In Methods in Molecular Medicine . S. M. Powell (Ed) Humana Press Inc., New Jersey, 50 : 149-165.

Fink, S. P., S. E. Swindler, R. S. Brady, J. D. Lutterbaugh, J. Massague, S. Thiagalingam , K. W. Kinzler, B. Vogelstein. J. K. V. Willson, and S. Markowitz. 2000. TGF- b induced inhibition in a Smad4 mutant colon adenoma cell line. Cancer Res. 61 : 256-260.

Grady, W. M., L. L. Myeroff, S. E. Swindler, A. Rajput, S. Thiagalingam , J. D. Lutterbaugh, A. Neumann, M. G. Brattain, J. Chang, S.-J. Kim, K. W. Kinzler, B. Vogelstein. J. K. V. Willson, and S. Markowitz. 1999. Mutational inactivation of TGF- b receptor type II in microsatellite stable colon cancers. Cancer Res. 59 : 320-324.

Hermeking, H, C. Lengauer, K. Polyak, T.-C. He, L. Zhang, S. Thiagalingam , K. W. Kinzler and B. Vogelstein. 1997. 14-3-3- s mediates a p53 induced G2 arrest. Molecular Cell 1 : 3-11.

Riggins, J. G., K. W. Kinzler, B. Vogelstein and S. Thiagalingam. 1997. Frequency of Smad gene mutations in human cancers. Cancer Res. 57 : 2578-2580.

Riggins, J. G., S. Thiagalingam, E. Rozenblum, C. L. Weinstein, S. E. Kern, S. R. Hamilton, J. K. V. Willson, S. Markowitz, K. W. Kinzler and B. Vogelstein. 1996. MAD -related genes in the human. Nature Genet. 13 : 347-349.

Thiagalingam, S., C. Lengauer, F. S. Leach, M. Schutte, S. A. Hahn, J. Overhauser, J. K. V. Willson, S. Markowitz, S. R. Hamilton, S. E. Kern, K. W. Kinzler and B. Vogelstein. 1996. Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nature Genet. 13 : 343-346.

Thiagalingam, S . , N. A. Lisitsyn, M. Hamaguchi, M. H. Wigler, J. K. V. Willson, S. D. Markowitz, F. S. Leach, K. W. Kinzler and B. Vogelstein. 1996. Evaluation of FHIT gene in colorectal cancers. Cancer Res. 56 : 2936-2939.

Thiagalingam, S., K. W. Kinzler and B. Vogelstein. 1995. PAK1 , a gene that can regulate p53 activity in yeast. Proc. Natl. Acad. Sci. USA. 92 : 6062-6066.

Tokino, T., S. Thiagalingam, W. S. El-Deiry, T. Waldman, K. W.Kinzler, and B. Vogelstein.1994. p53 -tagged sites from human genomic DNA. Human Mol. Genet. 3 : 1537-1542.

Pietenpol, J. A., T. Tokino, S. Thiagalingam, W. S. El-Deiry, K. W. Kinzler, and B. Vogelstein. 1994. Sequence-specific transcriptional activation is essential for growth suppression by p53. Proc. Natl. Acad. Sci. 91 :1998-2002.

Oliner, J. D., J. A. Pietenpol , S. Thiagalingam, K. W. Kinzler, and Vogelstein, B. 1993. Oncoprotein MDM2 conceals the activation domain of p53. Nature 362 : 857-862

Grossman, L., and S. Thiagalingam . 1993. Nucleotide excision repair, a tracking mechanism in search of damage. J. Biol. Chem. 268 : 16871-16874.

Thiagalingam, S., and L. Grossman. 1993. The multiple roles for ATP in the Escherichia coli UvrABC catalyzed incision reaction. J. Biol. Chem. 268 : 18382-18389.

Kern, S. E., J. A. Pietenpol, S. Thiagalingam, A. Seymour, K. W. Kinzler and B. Vogelstein. 1992. Oncogenic forms of p53 inhibit p53-regulated gene expression. Science 256 : 827-830.

Thiagalingam, S., and L. Grossman. 1991. Both ATPase sites of Escherichia coli UvrA have functional roles in nucleotide excision repair. J. Biol. Chem. 268 : 18382-18389.