My CV in PDF

I completed my requirements for the PhD in Bioinformatics from Boston University in Dec 2008. I am currently seeking a post-doctoral fellowship.

For my PhD dissertation, I collaborated to develop a novel microarray prove-level algorithm and applied it to a mouse leukemia model to discriminate histologically similar subtypes of mouse lymphoma samples based on differences in the 3'-untranslated region. I demonstrated the critical importance of measuring changes in the distribution of alternative isoforms, as well as overall transcript levels and provided a possible link between genotoxic stress and alternative 3'-processing.

Some of my research interests involve investigating role of miRNA activity in cancer system, developing diagnostic algorithms using microarray or next-generation deep sequencing for early diagnosis of cancer, developing statistical methods to unravel deep-sequencing mRNA data and exploring gene-protein, protein-protein networks in cancer.

Publications
Liu D**, Brockman JM**, Dass B, Hutchins LN, Singh P, McCarrey J, MacDonald C, Graber JH.** Co-first authors
Systematic variation in mRNA 3'-processing signals during mouse spermatogenesis.
Nucleic Acids Research, 2007 Jan 12; 35(1): 234-246. PDF TEXT

Evsikov AV, Graber JH,Brockman JM,Singh P, Holbrook AE, Hampl A, Oh B, Eppig JJ, Solter D, Knowles BB.
Cracking the egg: developmental dynamics and molecular transitions from the fully grown oocyte to embryo.
Genes and Development, 2006 Oct 1; 20(19): 2713-2727. PDF TEXT

Brockman JM**, Singh P**, Liu D, Quinlan S, Salisbury J, Graber JH. ** Co-first authors
PACdb: PolyA Cleavage Site and 3'-UTR Database.
Bioinformatics. 2005 Sep 15;21(18):3691-3. Epub 2005 Jul 19. PMID: 16030070 PDF TEXT

Singh P, Alley TL, Wright SM, Kamdar S, Schott W, Wilpan RY, Mills KD, Graber JH
Global changes in processing of mRNA 3' untranslated regions characterize clinically distinct cancer subtypes
In Review (Cancer Research).

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