Publications

 

2013 2012 2011 2010 2009 2008  
2007 2006 2005 2004 2003 2002  
2001 2000          

Click here to go to the publications page without graphical abstracts

2013

(158) "Biomimetic Dehydrogenative Diels-Alder Cycloadditions: Total Syntheses of Brosimones A and B" Qi, C.; Cong, H.; Cahill, K. J.; Muller, P.; Johnson, R. P.; Porco, J. A. Jr., Angew. Chem. Int. Ed. 2013, Early View. [link]

(157) "Evidence for a Functionally Relevant Rocaglamide Binding Site on the elF4A-RNA Complex" Sadlish, H.; Galicia-Vazquez, G.; Paris, C.G.; Aust, T.; Bhullar, B.; Chang, L.; Helliwell, S.B.; Hoepfner, D.; Knapp, B.; Ridel, R.; Roggo, S.; Schuierer, S.; Studer, C.; Porco, J. A. Jr.; Pelletier, J.; Movva, N.R., ACS Chem. Biol. 2013, ASAP. [link]

(156) "Metal-Catalyzed Cascade Rearrangements of 3-Alkynyl Flavone Ethers " Xiong, Y.; Schaus, S.E.; Porco, J. A. Jr., Org. Lett. 2013, ASAP. [link]

(155) "Polycyclic xanthone natural products: structure, biological activity and chemical synthesis" Winter, D.K.; Sloman, D.L.; Porco, J. A. Jr., Nat. Prod. Rep. 2013, 30, 382-391. [link]

(154) "eIF4F suppression in breast cancer affects maintenance and progression" Nasr, Z.; Robert, F.; Porco, J.A. Jr.; Muller, W.J.; Pelletier, J., Oncogene 2013, 1-11. [link]

2012

(153) "Synthesis of Chamaecypanone C Analogues from in Situ-Generated Cyclopentadienones and Their Biological Evaluation " Dong, S.; Qin, T.; Hamel, E.; Beutler, J. A.; Porco, J. A. Jr., J. Am. Chem. Soc. 2012, 134, 19782-19787. [link]

(152) "Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations " Leng, B.; Chichetti, S.; Su, S.; Beeler, A. B.; Porco, J. A. Jr., Beilstein Journal of Org. Chem. 2012, 8, 1338-1343.[link]

(151) "Development of an Alkaloid-Pyrone Annulation: Synthesis of Pleiomaltinine" Ziegler, R.E.; Tan, S.J.; Kam, T.S.; Porco, J.A. Jr., Angew. Chem. Int. Ed. 2012, 51, 9348-9351. [link]

(150) Enantioselective Photocycloaddition of 3-Hydroxyflavones: Total Syntheses and Absolute Configuration Assignments of (+)-Ponapensin and (+)-Elliptifoline " Lajkiewicz, N.J.; Roche, S.P.; Gerard, B.; Porco, J.A. Jr., J. Am. Chem. Soc. 2012, ASAP. [link] Highlights: synfacts: [link]

(149) "Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein " Jin, C.; Rodrigo, C.M.; Porco, J.A. Jr.; Kufe, D., Oncogene 2012, 1-10. [link]

(148) "Total Synthesis of Graphisin A and Sydowinin B" Little, A.; Porco, J.A. Jr., Org. Lett. 2012, 14, 2862-2865. [link]

(147) "Targeting Synthetic Lethal Interactions between Myc and the eIF4F Complex Impedes Tumorigenesis" Lin, C.J.; Nasr, Z.; Premsrirut, P.K.; Porco, J.A. Jr.; Hippo, Y.; Lowe, S.W.; Pelletier, J., Cell Rep. 2012, 4, 325-333. [link]

(146) "Studies Toward the Synthesis of the Epoxykinamycin FL-120B': Discovery of a Decarbonylative Photocyclization" Scully, S.S.; Porco J.A. Jr., Org. Lett. 2012, Article ASAP. [link]

(145) "Total Synthesis of (±)-Sorocenol B Employing Nanoparticle Catalysis" Cong, H.; Porco J.A. Jr., Org. Lett. 2012, 14, 2516-2519. [link]

(144) "Total Synthesis of (±)-7-epi-Nemorosone" Zhang, Q.; Porco J.A. Jr., Org. Lett. 2012, 14, 1797-1799. [link]

(143) "Synthesis of Azaphilone-Based Chemical Libraries" Achard, M.; Beeler, A.B.; Porco, J.A. Jr.; ACS Comb. Sci 2012, 14, 236-244. [link]

(142) "Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosis " Yeo, A. T.; Porco, J. A. Jr.; Gilmore, T. D. Cancer Letters 2012, 318, 53-60. [link]

2011

(141) "Development of a Photochemical microfluidics Platform " Pimparkar, K.; Yen, B.; Goodell, J.R.; Martin, V.I.; Lee, W.H.; Porco, J. A. Jr.; Beeler, A.B.; Jensen, K.F. J. Flow Chem. 2011, 2, 53-55. [link]

(140) "Synthesis of Rocaglamide Hydroxamates and Related Compounds as Eukaryotic Translation Inhibitors: Synthetic and Biological Studies " Rodrigo, C.M.; Cencic, R.; Roche, S.P.; Pelletier, J.; Porco, J. A. Jr. J. Med. Chem. 2011, 558-562. [link]

(139) "Chemical Synthesis of Complex Molecules Using Nanoparticle Catalysis" Cong, H.; Porco, J. A. Jr. ACS Catal. 2011, 2, 65-70. [link]

(138) "Synthetic cyclohexenyl chalcone natural products possess cytotoxic activities against prostate cancer cells and inhibit cysteine cathepsins in vitro" Majumdara, I.D.; Devanabandaa, A.; Foxa, B.; Schwartzmana, J.; Cong, H.; Porco, J. A. Jr.; Weber, H.C. Biochem. Biophys. Res. Commun. 2011, 416, 397-402. [link]

(137) "Synthesis and Reactivity of Bicyclo[3.2.1] octanoid-Derived Cyclopropanes" Goodell, J. R.; Poole, J. L.; Beeler, A. B.; Aube, J.; Porco, J. A. Jr.; J. Org. Chem. 2011, 76, 9792-9800. [link]

(136) "Remodelling of the natural product fumagillol employing a reaction discovery approach" Balthaser, B. R.; Maloney, M. C.; Beeler, A. B.; Porco, J. A. Jr.; Snyder, J. K. Nature Chemistry 2011, 3, 969-973. [link]

(135) "Microwave-Based Reaction Screening: Tandem Retro-Diels–Alder/Diels–Alder Cycloadditions of o-Quinol Dimers", Dong, S.; Cahill, K.J.; Kang, M.I.; Colburn, N.H.; Henrich, C.J.; Wilson, J.A.; Beutler, J.A.; Johnson, R.P.; Porco, J.A. Jr. J. Org. Chem., 2011, 76, 8944-8954. [link]

(134) "Chemistry and biology of rocaglamides (= flavaglines) and related derivatives from aglaia species (meliaceae)", Ebada, S.S.; Lajkiewicz, N.; Porco, J.A. Jr.; Li-Weber, M.; Proksch, P. Progress in the Chemistry of Organic Natural Products, 2011, 94, 1-58.

(133) "Asymmetric Total Synthesis of the Epoxykinamycin FL-120 B' ", Scully, S.S.; Porco, J.A. Jr. Angew. Chem. Int. Ed., 2011, 50, 9722-9726. [link]

(132) "Targeting Cap-dependent Translation Blocks Converging Survival Signals by AKT and PIM Kinases in Lymphoma ", Schatz, J. H.; Orcchio E.; Wolfe A. L.; Jiang, M.; Linkov I.; Maragulia J.; Shi, W.; Zhang, Z.; Vinagolu, R. K.; Pagano, N. C.; Porco, J.A. Jr.; Teruya-Feldstein, J.; Rosen, N.; Pelletier, J.; Wendel, H.-G. J. Exp. Med., 2011, 208, 1799-1807. [link]

(131) "Gold Catalyzed Cyclization of Alkynes-Tethered Dihydropyrimidones", Brown, L. E.; Dai, P.; Porco, J. A. Jr.; Schaus, S. E. Org. Lett., 2011, 13, 4228-4231. [link]

(130) "A Cycloisomerization/Friedel–Crafts Alkylation Strategy for the Synthesis of Pyrano[3,4-b]indoles", Medeiros, M.R.; Schaus, S.E.; Porco, J.A. Jr. Org. Lett., 2011, 13, 4012-4015. [link]

(129) "Total synthesis and Absolute Stereochemical Assignment of Kibdelone C ", Sloman, D.L.; Bacon, J.W.;Porco, J.A. Jr. J. Am. Chem. Soc., 2011, 133, 9952-9955. [link] Featured in C&EN, 2011, 89, 31. [link]

(128) "Sequential Transformations to Access Polycyclic Chemotypes: Asymmetric Crotylation and Metal Carbenoid Reactions", Wu, J.; Becerril, J.; Lian, Y.; Davies, H.M.L.; Porco, J.A. Jr.; Panek, J.S. Angew. Chem. Int. Ed., 2011, 50, 5938-5942. [link]

(127) "Dearomatization Strategies in the Synthesis of Complex Natural Products", Roche, S.P.; and Porco, J.A. Jr. Angew. Chem. Int. Ed., 2011, 50, 4068-4093. [link]

(126) "Discovery of New Antimalarial Chemotypes Through Chemical Methodology and Library Development", Brown, L.E.; Cheng, K.C.; Wei, W.; Yuan, P.; Dai, P.; Trillesa, R.; Ni, F.; Yuan, J.; MacArthur, R.; Guha, R.; Johnson, R.L.; Su, X.; Dominguez, M.M.; Snyder, J.K.; Beeler, A.B.; Schaus, S.E.; Inglese, J.; and Porco, J.A. Jr. P.N.A.S., 2011, 6775-6780. [link]

 

(125) "Synthesis of the Azaphilones (+)-Sclerotiorin and (+)-8-O-Methylsclerotiorinamine Utilizing (+)-Sparteine Surrogates in Copper-Mediated Oxidative Dearomatization", Germain, A.R.; Bruggemeyer, D.M.; Zhu, J.; Genet, C.; O'Brien, P.; and Porco, J.A. Jr. J. Org. Chem., 2011, 76, 2577- 2584. [link]

(124) " ESIPT-Mediated Photocycloadditions of 3-Hydroxyquinolinones: Development of a Fluoroescence Quenching Assay for Reaction Screening ", Xia, B.; Gerard, B.; Solano, D.M.; Wan, J.; Jones, G. II; and Porco, J.A. Jr. Org. Lett., 2011, 13, 1346-1349. [link]

(123) " Synthesis and Biological Evaluation of ABCD Ring Fragments of the Kibdelones", Sloman, D.L.; Mitasev, B.; Scully, S.S.; Beutler, J.A.; and Porco, J.A. Jr. Angew. Chem. Int. Ed ., 2011, 50, 2511-215. [link]

(122) " Vinylogous Addition of Siloxyfurans to Benzopyryliums: A Concise Approach to the Tetrahydroxanthone Natural Products", Qin, T.; Johnson, R. P.; and Porco, J.A. Jr. J. Am. Chem. Soc., 2011, 133, 1714–1717. [link]

2010

(121) " Total Synthesis of Plukenetinoe A", Zhang, Q; Mitasev, B.; Qi, J.; and Porco, J.A., Jr. J. Am. Chem. Soc. 2010, 132, 14212-14215. [link]

(120) " Catalytic Enantioselective Alkylative Dearomatization-Annulation: Total Synthesis and Absolute Configuration Assignment of Hyperibone K", Qi, J.; Beeler, A. B.; Zhang, Q. and Porco, J. A., Jr. J. Am. Chem. Soc. 2010, 132, 13642-13644. [link]

(119) " Biomimetic Photocycloaddition of 3-Hydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation ", Roche, S. P.; Cencic, R.; Pelletier, J. and Porco, J. A. Jr. Angew. Chem. Int. Ed. 2010, 49, 6533-6538. [link]

(118) "Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones", Goodell, John R.; Leng, Bo; Snyder, Tracy K.; Beeler, A. B; Porco, J. A., Jr. Synthesis 2010, 13, 2254-2270. [link]

(117) "Enantioselective Synthesis of 3,4-Chromanediones via Asymmetric Rearrangement of 3-Allyloxyflavones", Marie, Jean-Charles; Xiong, Yuan; Min, Genna K.; Yeager, Adam R.; Taniguchi, Tohru; Berova, Nina; Schaus, Scott E.; Porco, J. A., Jr. J. Org. Chem. 2010, 75 ,4584–4590. [link] Highlights: synfacts [link]

(116) " "Skeletal Diversity via Cationic Rearrangements of Substituted Dihydropyrans", Medeiros, Matthew, R.; Narayan, Radha S.; McDougal,
Nolan T.; Schaus, Scott E.; Porco, J. A., Jr.Org. Lett. 2010, 12 , pp 3222–3225. [link]

(115) "Silver Nanoparticle-Catalyzed Diels-Alder Cycloadditions of 2'-Hydroxychalcones." Cong, H.; Becker, C. F.; Elliott, S. J.; Grinstaff, M. W.; Porco, J. A., Jr. J. Am. Chem. Soc. 2010, 132, 7514-7518. [link]

(114) "Tandem Processes Identified from Reaction Screening: Nucleophilic Addition to Aryl N-Phosphinylimines Employing La(III)-TFAA Activation." Kinoshita, H.; Ingham, J. O.; Ong, W. W.; Beeler, B. A.; Porco, J. A., Jr. J. Am. Chem. Soc. 2010, 132, 6412–6418. [link]

(113) "Reaction Discovery Using Microfluidic-Based Multidimensional Screening of Polycyclic Iminium Ethers." Treece, L. J. ; Goodell, R. J. ; Vender Velde, D. ; Porco, J. A., Jr.; Aube, J. J. Org. Chem. 2010, 75, 2028-2038. [link]

(112) "Multicomponent Reaction Discovery: Three-Component Synthesis of Spirooxindoles." Liang, B.; Kalidindi, S.; Porco, J. A., Jr.; Stephenson, C. R. Org. Lett. 2010, 12, 572-575 . [link]

(111) "Synergistic Effect of Inhibiting Translation Initiation in Combination with Cytotoxic Agents in Acute Myelogenous Leukemia Cells" Cencic, R.; Carrier, M.; Trnkus, A.; Porco, J. A., Jr.; Minden, M.; Pelletier, J. Leukemia Res. 2010, 34, 535-541. [link]

2009

 

(110) "Development of an Automated Microfluidic Reaction Platform for Multidimensional Screening: Reaction Discovery Employing Bicyclo[3.2.1]octanoid Scaffolds" Goodell, J.R.; McMullen, J. P.; Zaborenko, N.; Maloney, J. R.; Ho, C.-X.; Jensen, K. F.; Porco, J. A., Jr.; Beeler, A. B. J. Org. Chem. 2009, 74, 6169-6180. [link]

(109) "Stereoselective Synthesis of Spirocyclic Oxindoles via Prins Cyclizations." Castaldi,M.P.; Troast,D.M.; Porco, J. A., Jr. Org. Lett. 2009, 11, 3362-3365..[link]

(108) "Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol." Cencic, R.; Carrier, M.; Galicia-Vázquez, G.; Bordeleau, M. E.; Sukarieh, R.; Bourdeau, A.; Brem, B.; Teodoro, J. G.; Greger, H.; Tremblay, M. L.; Porco, J. A., Jr.; Pelletier, J. PLoS ONE. 2009, 4, e5223. [link]

(107) "Manganese(III)-Mediated Transformations of Phloroglucinols: A Formal Oxidative [4 + 2] Cycloaddition Leading to Bicyclo[2.2.2]octadiones" Mitasev, B.; Porco, J. A., Jr. Org Lett. 2009, 11, 2285-2288. [link]

(106) "Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor" Dong, S.; Hamel, E.; Bai, R.; Covell, D. G.; Beutler, J. A.; Porco, J. A., Jr. Angew. Chem. Int. Ed. 2009, 48, 1494-1497. [link]

(105) "Reaction Discovery Employing Macrocycles: Transannular Cyclizations of Macrocyclic Bis-lactams " Han, C.; Rangarajan, S.; Voukides, A. C.; Beeler, A. B.; Johnson, R.; Porco, J. A., Jr. Org. Lett. 2009, 11, 413-416. [link]

2008

(104) "Studies toward the Synthesis of (-)-Zampanolide: Preparation of the Macrocyclic Core" Troast, D. M.; Yuan, J.; Porco, J. A., Jr. Adv. Synth. Catal. 2008, 350, 1701-1711. [link]

(103) "Electron Transfer-Initiated Diels-Alder Cycloadditions of 2'-Hydroxychalcones" Cong, H.; Ledbetter, D.; Rowe, G. T.; Caradonna, J. P.; Porco, J. A., Jr. J. Am. Chem. Soc. 2008, 130, 9214-9215.. [link]

(102) "Therapeutic Suppression of Translation Initiation Modulates Chemosensitivity in a Mouse Lymphoma Model" Bordeleau, M-E.; Robert, F.; Gerard, B.; Lindqvist, L.; Chen, S. M. H.; Wendel, H-G.; Brem, B.; Greger, H.; Lowe, S. W.; Porco, J. A., Jr.; Pelletier, J. J. Clin. Invest. 2008, 118, 2651-2660. [link]

(101) "Applying Computer-Assisted Structure Elucidation Algorithms for the Purpose of Structure Validation: Revisiting the NMR Assignments of Hexacyclinol" Williams, A. J.; Elyashberg, M. E.; Blinov, K. A.; Lankin, D. C.; Martin, G. E.; Reynolds, W. F.; Porco, J. A., Jr.; Singleton, C. A.; Su, S. J. Nat. Prod. 2008, 71, 581-588. [link]

(100) "Enantioselective Synthesis of Bicyclo[2.2.2]octenones Using a Copper-Mediated Oxidative Dearomatization/[4 + 2] Dimerization Cascade" Dong, S.; Zhu, J.; Porco, J. A., Jr. J. Am. Chem. Soc. 2008, 130, 2738-2739. [link]

2007

(99) "Structure-Activity Relationship Study of [1,2,3]thiadiazole Necroptosis Inhibitors" Teng, X.; Keys, H.; Jeevanandam, A.; Porco, J. A., Jr.; Degterev, A.; Yuan, J.; Cuny, G. D. Bioorg. Med. Chem. Lett. 2007, 17, 6836-6840. [link]

(98) "Preparation of Alkylidene Indane and Related Scaffolds and Their Further Elaboration to Novel Chemotypes"
Kesavan, S.; Panek, J. S.; Porco, J. A., Jr. Org. Lett. 2007, 9, 5203-5206. [link]

(97) "1,2-Dihydroisoquinolines as Templates for Cascade Reactions To Access Isoquinoline Alkaloid Frameworks"
Su, S.; Porco, J. A., Jr. Org. Lett. 2007, 9, 4983-4986 . [link]

(96) "Identification of Novel Epoxide Inhibitors of Hepatitis C Virus Replication Using a High-Throughput Screen." Peng, L. A.; Kim, S. S.; Matchacheep, S.; Lei, X.; Su, S.; Lin, W.; Runguphan, W.; Choe, W-H.; Sakamoto, N.; Ikeda, M.; Kato, N.; Beeler, A. B.; Porco, J. A., Jr.; Schreiber, S. L.; Chung, R. T. Antimicrob. Agents Chemother. 2007, 51, 3756-3759. [link]

(95) "Rapid Access to Polyprenylated Phloroglucinols via Alkylative Dearomatization-Annulation: Total Synthesis (±)-Clusianone." Qi, J.; Porco, J. A., Jr. J. Am. Chem. Soc. 2007, 129, 12682-12683. [link]

(94) "Enantioselective Synthesis of the Complex Rocaglate (-)-Silvestrol." Gerard, B.; Cencic, R.; Pelletier, J.; Porco, J.A., Jr. Angew. Chem. Int. Ed. Engl. 2007, 46, 7831-7834. [link]

(93) "Skeletal Diversity Through p-Radical Cyclization of Tetrahydropyridine Scaffolds." Dandapani, S.; Dudata, M.; Panek, J. S.; Porco, J. A., Jr. Org. Lett. 2007, 9, 3849-3852. [link]

(92) "Nucleophilic Addition to N-Phosphinylimines via Rare Earth Metal Triflate / Trifluoroacetic Anhydride Activation." Ong, W. W.; Beeler, A. B.; Kesavan, S.; Panek, J. S.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2007, 46, 7470-7472. [link]

(91) "Synthesis of Pyrrolo-isoquinolines Related to the Lamellarins Using Silver-Catalyzed Cycloisomerizaton/Dipolar Cycloaddition." Su, S.; Porco, J. A., Jr. J. Am. Chem. Soc. 2007, 129, 7744-7745. [link]

(90) "An Approach to Skeletal Diversity Using Functional Group Pairing of Multifunctional Scaffolds."
Comer, E.; Rohan, E.; Deng, L.; Porco, J. A., Jr. Org. Lett. 2007, 9, 2123-2126. [link]

(89) "Organic Chemistry: Synthesis Undressed." Porco, J. A., Jr. Nature 2007, 446 (7134), 383-385. [link]

(88) " Stereochemical and Skeletal Diversity Employing Pipecolate Ester Scaffolds", Yu, C.; Panek, J. S.; Porco, J. A. Jr, Org. Lett, 2007, 9, 1529-1532. [link]

(87) " Synthesis of Carbamates and Ureas Using Zr(IV)-Catalyzed Exchange Processes." Han, C.; Porco, J. A, Jr. Org. Lett. 2007, 9, 1517-1520. [link]

 

(86) " Discovery of Chemical Reactions through Multidimensional Screening." Beeler, A. B.; Su, S.; Singleton, C. A.; Porco, J. A, Jr. J. Am. Chem. Soc. 2007, 129, 1413-1419. [link]

 

(85) " Synthesis of 5,6,7,8-Tetrahydro-1,6-naphthyridines and Related Heterocycles by Cobalt-Catalyzed [2 + 2 + 2] Cyclizations." Zhou, Y.; Porco, J. A, Jr.; Snyder, J. K. Org. Lett. 2007, 9, 393-396. [link]

2006

(84) " Convergent Synthesis of Complex Diketopiperazines Derived from Pipecolic Acid Scaffolds and Parallel Screening against GPCR Targets." Dandapani, S.; Lan, P.; Beeler, A. B.; Beischel, S.; Abbas, A.; Roth, B. L.; Porco, J. A, Jr., Panek, J. S. J. Org. Chem. 2006, 71, 8934-8945. [link]

(83) " Total Synthesis of the Diazobenzofluorene Antibiotic (-)-Kinamycin C1." Lei, X.; Porco, J. A, Jr. J. Am. Chem. Soc. 2006, 128, 14790-14791 . [link]


(82) "Exploring Skeletal Diversity via Ring Contraction of Glycal-Derived Scaffolds." Yeager, A. R.; Min, G. K.; Porco, J. A, Jr.; Schaus. S. E. Org. Lett. 2006, 8, 5065-5068. [link]

(81) "Asymmetric Syntheses of (-)-Mitorubrin and Related Azaphilone Natural Products." Zhu, J.; Porco, J. A., Jr. Org. Lett. 2006, 8, 5169-5171. [link]

(80) "Total Synthesis and Structure Assignment of (+)-Hexacyclinol." Porco, J. A., Jr.; Su, S.; Lei, X.; Bardhan, S.; Rychnovsky, S. D. Angew. Chem. Int. Ed. Engl. 2006, 45, 5790-5792. [link]

(79) "Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity - and high glucose-induced b cell dysfunction in isolated pancreatic islets." Zhang, C-Y.; Parton, L. E.; Ye, C-P.; Krauss, S.; Shen, R.; Lin, C-T.; Porco, J. A., Jr.; Lowell.B. B. Cell Metabolism, 2006, 3, 417-427. [link]

(78) "Total Synthesis of the Interleukin-1 Converting Enzyme Inhibitor EI-1941-2 Using Tandem Oxa-electrocyclization/Oxidation 1." Kleinke, A. S.; Li, C.; Rabasso, N.; Porco, J. A., Jr. Org. Lett, 2006, 8, 2857-2850. [link]

(77) "Enantioselective Photocycloaddition Mediated by Chiral Br nsted Acids: Asymmetric Synthesis of the Rocaglamides." Gerard, B.; Sangji, S.; O'Leary, D. J.; Porco, J. A., Jr. J. Am. Chem. Soc, 2006, 128, 7754-7755. [link]

(76) "Synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by copper-catalyzed cycloaddition-coupling of azides and terminal alkynes." Gerard, B.; Ryan, J.; Beeler, A. B.; Porco, J. A., Jr. Tetrahedron 2006, 62, 6405-6411. [link]

(75) "Targeting Heat Shock Response to Sensitize Cancer Cells to Proteasome and Hsp90 Inhibitors." Zaarur, N.; Gabai, V. L.; Porco, J. A., Jr.; Calderwood, S.; Sherman, M. Y. Cancer Research 2006, 66, 1783-1791. [link]

(74) "Total Synthesis and Stereochemical Assignment of the Spiroisoxazoline Natural Product (+)-Calafianin." Bardhan, S.; Schmitt, D. C.; Porco, J. A., Jr. Org. Lett. 2006, 8, 927-930. [link]

(73) "A µ-η22 -Disulfide Dicopper( II ) Complex from Reaction of S8 with a Copper( I ) Precursor: Reactivity of the Bound Disulfur Moiety." Helton, M. E.; Maiti, D; Zakharov, L. N.; Rheingold, A. L.; Porco, J. A., Jr.; Karlin, K. D. Angew. Chem. Int. Ed. Engl. 2006, 45, 1138-1141. [link]

(72) "Inhibition of transcription factor NF-kB signaling proteins IKKb and p65 through specific cysteine residues by epoxyquinone A monomer: Correlation with its anti-cancer cell growth activity." Liang, M-C.; Bardhan, S.; Pace, E. A.; Rosman, D.; Beutler, J. A.; Porco, J. A., Jr.; Gilmore, T. D. Biochemical Pharmacology 2006, 71, 634-645. [link]

(71) "The synthetic epoxyquinoids jesterone dimer and epoxyquinone A monomer induce apoptosis and inhibit REL (human c-Rel) DNA binding in an I[kappa]B[alpha]-deficient diffuse large B-cell lymphoma cell line." Liang, M-C. Bardhan, S.; Porco, J. A., Jr.; Gilmore, T. D.  Cancer Letters 2006, 241, 69-78. [link]

 

2005

(70) "Enantioselective Synthesis of Linear Polypropionate Arrays Using Anthracene-Tagged Organosilanes." Kesavan, S.; Su, Q.; Shao, J.; Porco, J. A., Jr.; Panek, J. S. Org. Lett. 2005, 7, 4435-4438. [link]

(69) "Synthesis of a Library of Complex Macrodiolides Employing Cyclodimerization of Hydroxy Esters." Beeler, A. B.; Acquilano, D. E.; Su, Q.; Yan, F.; Roth, B. L.; Panek, J. S.; Porco, J. A., Jr. J. Comb. Chem. 2005, 7, 673-681. [link]

(68) "Stereocontrolled Synthesis of a Complex Library via Elaboration of Angular Epoxyquinol Scaffolds." Lei, X.; Zaarur, N.; Sherman, M. Y.; Porco, J. A., Jr. J. Org. Chem. 2005, 70, 6474-6483. [link]

(67) "Synthesis of Epoxyquinol A and Related Molecules: Probing Chemical Reactivity of Epoxyquinol Dimers and 2H-Pyran Precursors." Li, C.; Porco, J. A., Jr. J. Org. Chem. 2005, 70, 6053-6065. [link]

(66) "Catalytic Ester-Amide Exchange Using Group(IV) Metal Alkoxide-Activator Complexes." Han, C.; Lee, J. P.; Lobkovsky, E.; Porco, J. A., Jr. J. Am. Chem. Soc. 2005, 127, 10039-10044. [link]

(65) "Synthesis of the Azaphilones Using Copper-Mediated Enantioselective Oxidative Dearomatization." Zhu, J.; Grigoriadis, N. P.; Lee, J. P.; Porco, J. A., Jr. J. Am. Chem. Soc. 2005, 127, 9342-9343. [link]

(64) "Convergent Synthesis of a Complex Oxime Library Using Chemical Domain Shuffling." Su, S.; Acquilano, D. E.; Arumugasamy, J.; Beeler, A. B.; Eastwood, E. L.; Giguere, J. R.; Lan, P.; Lei, X.; Min, G. K.; Yeager, A. R.; Zhou, Y.; Panek, J. S.; Snyder, J. K.; Schaus, S. E.; Porco, J. A., Jr. Org. Lett. 2005, 7, 2751-2754. [link]

(63) "Synthesis of the Tetracyclic Core of the Tetrapetalones through Transannular Oxidative [4+3] Cyclization." Wang, X.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2005, 44, 3067-3071. [link]

(62) "Synthesis of Photoactivatable Acyclic Analogues of the Lobatamides." Shen, R.; Inoue, T.; Forgac, M.; Porco, J. A., Jr. J. Org. Chem. 2005, 70, 3686-3692. [link]

 

2004

(61) "A Biomimetic Approach to the Rocaglamides Employing Photogeneration of Oxidopyryliums Derived from 3-Hydroxyflavones." Gerard, B.; Jones, G., II.; Porco, J. A., Jr. J. Am. Chem. Soc. 2004, 126, 13620-13621. [link]

(60) "Synthesis of complex alkoxyamines using a polymer-supported N-hydroxyphthalimide." Su, S.; Giguere, J. R.; Schaus, S. E.; Porco, J. A., Jr. Tetrahedron 2004, 60, 8645-8657. [link]

(59) "Total Synthesis of the Salicylate Enamide Macrolide Oximidine III: Application of Relay Ring-Closing Metathesis." Wang, X.; Bowman, E. J.; Bowman, B. J.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2004, 43, 3601-3605. [link]

(58) "Synthesis of Azaphilones and Related Molecules by Employing Cycloisomerization of o-Alkynylbenzaldehydes." Zhu, J.; Germain, A. R.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2004, 43, 1239-1243. [link]  

(57) "Synthesis of a Polymer-Supported Anthracene and Its Application as a Dienophile Scavenger." Lei, X.; Porco, J. A., Jr.; Org. Lett. 2004, 6, 795-798. [link]  

(56) "Synthesis of the Epoxyquinol Dimer RKB-3564 D : Utilization of an Alkoxysilanol To Promote [4 + 4] Dimerization." Li, C.; Porco, J. A., Jr.; J . Am. Chem. Soc. 2004, 126, 1310-1311. [link]

(55) "Copper-Mediated Synthesis of N-Acyl Vinylogous Carbamic Acids and Derivatives: Synthesis of the Antibiotic CJ-15,801." Han, C.; Shen, R.; Su, S.; Porco, J. A., Jr.; Org. Lett. 2004, 6, 27-30. [link]

 

2003

(54) "Polymer-Assisted Solution-Phase (PASP) Suzuki Couplings Employing an Anthracene-Tagged Palladium Catalyst." Lan, P.; Berta, D.; Porco, J. A., Jr.; South, M. S.; Parlow, J. J.; J. Org. Chem. 2003; 68, 9678-9686. [link]

(53) "The Development of a Chromatography-Free Mitsunobu Reaction: Synthesis and Applications of an Anthracene-Tagged Phosphine Reagent." Lan, P.; Porco, J. A., Jr.; South, M. S.; Parlow, J. J. J. Comb. Chem. 2003, 5, 660-669. [link]

(52) "Total Synthesis of the Ubiquitin-Activating Enzyme Inhibitor (+)-Panepophenanthrin." Lei, X.; Johnson, R. P.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2003, 42, 3913-3917. [link]

(51) "Stereochemical Diversity through Cyclodimerization: Synthesis of Polyketide-like Macrodiolides." Su, Q.; Beeler, A. B.; Lobkovsky, E.; Porco, J. A., Jr.; Panek, J. S. Org. Lett, 2003, 5, 2149-2152. [link]

(50) "Synthesis and Cell Cycle Inhibition of the Peptide Enamide Natural Product Terpeptin and the Aspergillamides." Su, S.; Kakeya, H.; Osada, H.; Porco, J. A., Jr. Tetrahedron, 2003, 59, 8931-8946. [link]

(49 ) "Jesterone Dimer, a Synthetic Derivative of the Fungal Metabolite Jesterone, Blocks Activation of Transcription Factor Nuclear Factor kB by Inhibiting the Inhibitor of kB Kinase," Liang, M.-C.; Bardhan, S.; Li, C.; Pace, E. A.; Porco, J. A., Jr.; Gilmore, T. D. Molecular Pharmacology2003, 64, 123-131. [link]

(48) "Lobatamide C: Total Synthesis, Stereochemical Assignment, Preparation of Simplified Analogues, and V-ATPase Inhibition Studies." Shen, R.; Lin, C. T.; Bowman, E. J.; Bowman, B. J.; Porco, J. A., Jr. J. Am. Chem. Soc. 2003, 125, 7889-7901. [link]

(47) "Total Synthesis of the Salicylate Enamide Macrolide Oximidine II." Wang, X.; Porco, J. A., Jr. J. Am. Chem. Soc. 2003, 125, 6040-6041. [link]

(46) "Total Synthesis of the Quinone Epoxide Dimer (+)-Torreyanic Acid: Application of a Biomimetic Oxidation/Electrocylization/Diels-Alder Dimerization Cascade." Li, C.; Johnson, R. P.; Porco, J. A., Jr. J. Am. Chem. Soc. 2003, 125, 5095-5106. [link]

 

2002

(45) "Angiogenesis Inhibitor Epoxyquinol A: Total Synthesis and Inhibition of Transcription Factor NF-kB." Li, C.; Bardhan, S.; Pace, E. A.; Liang, M.-C.; Gilmore, T. D.; Porco, J. A., Jr. Org. Lett.  20024,  3267-3270. [link]

(44) "Synthesis and V-ATPase Inhibition of Simplified Lobatamide Analogues." Shen, R; Lin, C. T.; Bowman, E. J.; Bowman, B. J.; Porco, J. A., Jr. Org. Lett.  2002, 4, 3103-3106. [link]

(43) "Polymer-assisted parallel solution phase synthesis of substituted benzimidazoles." Yun, Y. K.; Porco, J. A., Jr.; Labadie, J. Synlett. 2002, 5, 739-742. [link]

(42) "Total Synthesis and Stereochemical Assignment of the Salicylate Antitumor Macrolide Lobatamide C."  Shen, R.; Lin, C. T.; Porco, J. A., Jr. J. Am. Chem. Soc. 2002, 124, 5650-5651. [link]

(41) "Studies Toward the Synthesis of (-)-Zampanolide: Preparation of N-Acyl Hemiaminal Model Systems." Troast, D. M.; Porco, J. A., Jr. Org. Lett. 2002, 4, 991-994. [link]

 

2001

(40) "Total Synthesis of the NF-kB Inhibitor (-)-Cycloepoxydon: Utilization of Tartrate-Mediated Nucleophilic Epoxidation." Li, C.; Pace, E. A.; Liang, M-C.; Lobkovsky, E.; Gilmore, T. D.;. Porco, J. A., Jr. J. Am. Chem. Soc. 2001, 123, 11308-11309. [link]

(39) "Combinatorial synthesis of natural product-like molecules using a first-generation spiroketal scaffold." Kulkarni, B. A.; Roth, G. P.; Lobkovsky, E.; Porco, J. A., Jr.  J. Comb. Chem. 2002, 4, 56-72. [link]

(38) "Modification of C-Terminal Peptides for Form Peptide Enamides: Synthesis of Chondriamides A and C.” Wang, X.; Porco, J. A., Jr. J. Org. Chem.. 2001, 66, 8215-8221. [link]

(37) “Exploring Chemical Diversity of Epoxyquinoid Natural Products: Synthesis and Biological Activity of (-)-Jesterone and Related Molecules.” Hu, Y.; Li, C.; Kulkarni, B.; Strobel, G.; Lobkovsky, E.; Porco, J. A. , Jr. Org. Lett. 2001, 3, 1649-1652. [link]  

 

2000

(36) "Total Synthesis of (±) Torreyanic Acid." Li, C.; Lobkovsky, E.; Porco, J. A., Jr. J. Am. Chem. Soc. 2000, 122, 10484-10485. [link]

(35) "Parallel Synthesis and Purification using Anthracene-Tagged Substrates." Wang, X.; Parlow, J. J.; Porco, J. A., Jr. Org. Lett. 2000, 2, 3509-3512. [link]

(34) "Multistep Synthesis of 1,2,3-Thiadiazoles using 'Catch and Release'." Hu, Y.; Baudart, S.; Porco, Jr., J. A. High Throughput Synthesis: Theory and Practice, Chapter 6, Section 5, (Sucholeiki, I., editor), Marcel Dekker, NY, 2000."

(33) "Synthesis of Enamides Related to the Salicylate Antitumor Macrolides Using Copper-mediated Vinylic Substitution." Shen, R.; Porco, J. A., Jr. Org. Lett. 2000, 2, 1333-1336. [link]

(32) "Organic Synthesis Using Chemical Tags: The 'Third Leg' of Parallel Synthesis." Porco, J. A., Jr. Combinatorial Chemistry and High Throughput Screening, 2000, 3, 93-102.

(31) "Streamlined Synthesis of Substituted 2-Aminothiazoles Using Tandem Precipitative and Polymer-Assisted Reactions." Yun, Y. K.;  Leung, S. S. W.; Porco, J. A., Jr. Biotechnol. Bioeng. 2000, 71, 9-18.