Publications

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2008

(101) "Applying Computer-Assisted Structure Elucidation Algorithms for the Purpose of Structure Validation: Revisiting the NMR Assignments of Hexacyclinol" Williams, A. J.; Elyashberg, M. E.; Blinov, K. A.; Lankin, D. C.; Martin, G. E.; Reynolds, W. F.; Porco, J. A., Jr.; Singleton, C. A.; Su, S. J. Nat. Prod. 2008, 71, 581-588. [link]

(100) "Enantioselective Synthesis of Bicyclo[2.2.2]octenones Using a Copper-Mediated Oxidative Dearomatization/[4 + 2] Dimerization Cascade" Dong, S.; Zhu, J.; Porco, J. A., Jr. J. Am. Chem. Soc. 2008, 130, 2738-2739. [link]

2007

(99) "Structure-Activity Relationship Study of [1,2,3]thiadiazole Necroptosis Inhibitors" Teng, X.; Keys, H.; Jeevanandam, A.; Porco, J. A., Jr.; Degterev, A.; Yuan, J.; Cuny, G. D. Bioorg. Med. Chem. Lett. 2007, 17, 6836-6840. [link]

(98) "Preparation of Alkylidene Indane and Related Scaffolds and Their Further Elaboration to Novel Chemotypes"
Kesavan, S.; Panek, J. S.; Porco, J. A., Jr. Org. Lett. 2007, 9, 5203-5206. [link]

(97) "1,2-Dihydroisoquinolines as Templates for Cascade Reactions To Access Isoquinoline Alkaloid Frameworks"
Su, S.; Porco, J. A., Jr. Org. Lett. 2007, 9, 4983-4986 . [link]

(96) "Identification of Novel Epoxide Inhibitors of Hepatitis C Virus Replication Using a High-Throughput Screen." Peng, L. A.; Kim, S. S.; Matchacheep, S.; Lei, X.; Su, S.; Lin, W.; Runguphan, W.; Choe, W-H.; Sakamoto, N.; Ikeda, M.; Kato, N.; Beeler, A. B.; Porco, J. A., Jr.; Schreiber, S. L.; Chung, R. T. Antimicrob. Agents Chemother. 2007, 51, 3756-3759. [link]

(95) "Rapid Access to Polyprenylated Phloroglucinols via Alkylative Dearomatization-Annulation: Total Synthesis (±)-Clusianone." Qi, J.; Porco, J. A., Jr. J. Am. Chem. Soc. 2007, 129, 12682-12683. [link]

(94) "Enantioselective Synthesis of the Complex Rocaglate (-)-Silvestrol." Gerard, B.; Cencic, R.; Pelletier, J.; Porco, J.A., Jr. Angew. Chem. Int. Ed. Engl. 2007, 46, 7831-7834. [link]

(93) "Skeletal Diversity Through p-Radical Cyclization of Tetrahydropyridine Scaffolds." Dandapani, S.; Dudata, M.; Panek, J. S.; Porco, J. A., Jr. Org. Lett. 2007, 9, 3849-3852. [link]

(92) "Nucleophilic Addition to N-Phosphinylimines via Rare Earth Metal Triflate / Trifluoroacetic Anhydride Activation." Ong, W. W.; Beeler, A. B.; Kesavan, S.; Panek, J. S.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2007, 46, 7470-7472. [link]

(91) "Synthesis of Pyrrolo-isoquinolines Related to the Lamellarins Using Silver-Catalyzed Cycloisomerizaton/Dipolar Cycloaddition." Su, S.; Porco, J. A., Jr. J. Am. Chem. Soc. 2007, 129, 7744-7745. [link]

(90) "An Approach to Skeletal Diversity Using Functional Group Pairing of Multifunctional Scaffolds."
Comer, E.; Rohan, E.; Deng, L.; Porco, J. A., Jr. Org. Lett. 2007, 9, 2123-2126. [link]

(89) "Organic Chemistry: Synthesis Undressed." Porco, J. A., Jr. Nature 2007, 446 (7134), 383-385. [link]

(88) " Stereochemical and Skeletal Diversity Employing Pipecolate Ester Scaffolds", Yu, C.; Panek, J. S.; Porco, J. A. Jr, Org. Lett, 2007, 9, 1529-1532. [link]

(87) " Synthesis of Carbamates and Ureas Using Zr(IV)-Catalyzed Exchange Processes." Han, C.; Porco, J. A, Jr. Org. Lett. 2007, 9, 1517-1520. [link]

(86) " Discovery of Chemical Reactions through Multidimensional Screening." Beeler, A. B.; Su, S.; Singleton, C. A.; Porco, J. A, Jr. J. Am. Chem. Soc. 2007, 129, 1413-1419. [link]

(85) " Synthesis of 5,6,7,8-Tetrahydro-1,6-naphthyridines and Related Heterocycles by Cobalt-Catalyzed [2 + 2 + 2] Cyclizations." Zhou, Y.; Porco, J. A, Jr.; Snyder, J. K. Org. Lett. 2007, 9, 393-396. [link]

2006

(84) " Convergent Synthesis of Complex Diketopiperazines Derived from Pipecolic Acid Scaffolds and Parallel Screening against GPCR Targets." Dandapani, S.; Lan, P.; Beeler, A. B.; Beischel, S.; Abbas, A.; Roth, B. L.; Porco, J. A, Jr., Panek, J. S. J. Org. Chem. 2006, 71, 8934-8945. [link]

(83) " Total Synthesis of the Diazobenzofluorene Antibiotic (-)-Kinamycin C1." Lei, X.; Porco, J. A, Jr. J. Am. Chem. Soc. 2006, 128, 14790-14791 . [link]

(82) "Exploring Skeletal Diversity via Ring Contraction of Glycal-Derived Scaffolds." Yeager, A. R.; Min, G. K.; Porco, J. A, Jr.; Schaus. S. E. Org. Lett. 2006, 8, 5065-5068. [link]

(81) "Asymmetric Syntheses of (-)-Mitorubrin and Related Azaphilone Natural Products." Zhu, J.; Porco, J. A., Jr. Org. Lett. 2006, 8, 5169-5171. [link]

(80) "Total Synthesis and Structure Assignment of (+)-Hexacyclinol." Porco, J. A., Jr.; Su, S.; Lei, X.; Bardhan, S.; Rychnovsky, S. D. Angew. Chem. Int. Ed. Engl. 2006, 45, 5790-5792. [link]

(79) "Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity - and high glucose-induced b cell dysfunction in isolated pancreatic islets." Zhang, C-Y.; Parton, L. E.; Ye, C-P.; Krauss, S.; Shen, R.; Lin, C-T.; Porco, J. A., Jr.; Lowell.B. B. Cell Metabolism, 2006, 3, 417-427. [link]

(78) "Total Synthesis of the Interleukin-1 Converting Enzyme Inhibitor EI-1941-2 Using Tandem Oxa-electrocyclization/Oxidation 1." Kleinke, A. S.; Li, C.; Rabasso, N.; Porco, J. A., Jr. Org. Lett, 2006, 8, 2857-2850. [link]

(77) "Enantioselective Photocycloaddition Mediated by Chiral Br nsted Acids: Asymmetric Synthesis of the Rocaglamides." Gerard, B.; Sangji, S.; O'Leary, D. J.; Porco, J. A., Jr. J. Am. Chem. Soc, 2006, 128, 7754-7755. [link]

(76) "Synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by copper-catalyzed cycloaddition-coupling of azides and terminal alkynes." Gerard, B.; Ryan, J.; Beeler, A. B.; Porco, J. A., Jr. Tetrahedron 2006, 62, 6405-6411. [link]

(75) "Targeting Heat Shock Response to Sensitize Cancer Cells to Proteasome and Hsp90 Inhibitors." Zaarur, N.; Gabai, V. L.; Porco, J. A., Jr.; Calderwood, S.; Sherman, M. Y. Cancer Research 2006, 66, 1783-1791. [link]

(74) "Total Synthesis and Stereochemical Assignment of the Spiroisoxazoline Natural Product (+)-Calafianin." Bardhan, S.; Schmitt, D. C.; Porco, J. A., Jr. Org. Lett. 2006, 8, 927-930. [link]

(73) "A µ-η²:η² -Disulfide Dicopper( II ) Complex from Reaction of S₈ with a Copper( I ) Precursor: Reactivity of the Bound Disulfur Moiety." Helton, M. E.; Maiti, D; Zakharov, L. N.; Rheingold, A. L.; Porco, J. A., Jr.; Karlin, K. D. Angew. Chem. Int. Ed. Engl. 2006, 45, 1138-1141. [link]

(72) "Inhibition of transcription factor NF-kB signaling proteins IKKb and p65 through specific cysteine residues by epoxyquinone A monomer: Correlation with its anti-cancer cell growth activity." Liang, M-C.; Bardhan, S.; Pace, E. A.; Rosman, D.; Beutler, J. A.; Porco, J. A., Jr.; Gilmore, T. D. Biochemical Pharmacology 2006, 71, 634-645. [link]

(71) "The synthetic epoxyquinoids jesterone dimer and epoxyquinone A monomer induce apoptosis and inhibit REL (human c-Rel) DNA binding in an I[kappa]B[alpha]-deficient diffuse large B-cell lymphoma cell line." Liang, M-C. Bardhan, S.; Porco, J. A., Jr.; Gilmore, T. D.  Cancer Letters 2006, 241, 69-78. [link]

2005

(70) "Enantioselective Synthesis of Linear Polypropionate Arrays Using Anthracene-Tagged Organosilanes." Kesavan, S.; Su, Q.; Shao, J.; Porco, J. A., Jr.; Panek, J. S. Org. Lett. 2005, 7, 4435-4438. [link]

(69) "Synthesis of a Library of Complex Macrodiolides Employing Cyclodimerization of Hydroxy Esters." Beeler, A. B.; Acquilano, D. E.; Su, Q.; Yan, F.; Roth, B. L.; Panek, J. S.; Porco, J. A., Jr. J. Comb. Chem. 2005, 7, 673-681. [link]

(68) "Stereocontrolled Synthesis of a Complex Library via Elaboration of Angular Epoxyquinol Scaffolds." Lei, X.; Zaarur, N.; Sherman, M. Y.; Porco, J. A., Jr. J. Org. Chem. 2005, 70, 6474-6483. [link]

(67) "Synthesis of Epoxyquinol A and Related Molecules: Probing Chemical Reactivity of Epoxyquinol Dimers and 2H-Pyran Precursors." Li, C.; Porco, J. A., Jr. J. Org. Chem. 2005, 70, 6053-6065. [link]

(66) "Catalytic Ester-Amide Exchange Using Group(IV) Metal Alkoxide-Activator Complexes." Han, C.; Lee, J. P.; Lobkovsky, E.; Porco, J. A., Jr. J. Am. Chem. Soc. 2005, 127, 10039-10044. [link]

(65) "Synthesis of the Azaphilones Using Copper-Mediated Enantioselective Oxidative Dearomatization." Zhu, J.; Grigoriadis, N. P.; Lee, J. P.; Porco, J. A., Jr. J. Am. Chem. Soc. 2005, 127, 9342-9343. [link]

(64) "Convergent Synthesis of a Complex Oxime Library Using Chemical Domain Shuffling." Su, S.; Acquilano, D. E.; Arumugasamy, J.; Beeler, A. B.; Eastwood, E. L.; Giguere, J. R.; Lan, P.; Lei, X.; Min, G. K.; Yeager, A. R.; Zhou, Y.; Panek, J. S.; Snyder, J. K.; Schaus, S. E.; Porco, J. A., Jr. Org. Lett. 2005, 7, 2751-2754. [link]

(63) "Synthesis of the Tetracyclic Core of the Tetrapetalones through Transannular Oxidative [4+3] Cyclization." Wang, X.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2005, 44, 3067-3071. [link]

(62) "Synthesis of Photoactivatable Acyclic Analogues of the Lobatamides." Shen, R.; Inoue, T.; Forgac, M.; Porco, J. A., Jr. J. Org. Chem. 2005, 70, 3686-3692. [link]

2004

(61) "A Biomimetic Approach to the Rocaglamides Employing Photogeneration of Oxidopyryliums Derived from 3-Hydroxyflavones." Gerard, B.; Jones, G., II.; Porco, J. A., Jr. J. Am. Chem. Soc. 2004, 126, 13620-13621. [link]

(60) "Synthesis of complex alkoxyamines using a polymer-supported N-hydroxyphthalimide." Su, S.; Giguere, J. R.; Schaus, S. E.; Porco, J. A., Jr. Tetrahedron 2004, 60, 8645-8657. [link]

(59) "Total Synthesis of the Salicylate Enamide Macrolide Oximidine III: Application of Relay Ring-Closing Metathesis." Wang, X.; Bowman, E. J.; Bowman, B. J.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2004, 43, 3601-3605. [link]

(58) "Synthesis of Azaphilones and Related Molecules by Employing Cycloisomerization of o-Alkynylbenzaldehydes." Zhu, J.; Germain, A. R.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2004, 43, 1239-1243. [link]  

(57) "Synthesis of a Polymer-Supported Anthracene and Its Application as a Dienophile Scavenger." Lei, X.; Porco, J. A., Jr.; Org. Lett. 2004, 6, 795-798. [link]  

(56) "Synthesis of the Epoxyquinol Dimer RKB-3564 D : Utilization of an Alkoxysilanol To Promote [4 + 4] Dimerization." Li, C.; Porco, J. A., Jr.; J . Am. Chem. Soc. 2004, 126, 1310-1311. [link]

(55) "Copper-Mediated Synthesis of N-Acyl Vinylogous Carbamic Acids and Derivatives: Synthesis of the Antibiotic CJ-15,801." Han, C.; Shen, R.; Su, S.; Porco, J. A., Jr.; Org. Lett. 2004, 6, 27-30. [link]

2003

(54) "Polymer-Assisted Solution-Phase (PASP) Suzuki Couplings Employing an Anthracene-Tagged Palladium Catalyst." Lan, P.; Berta, D.; Porco, J. A., Jr.; South, M. S.; Parlow, J. J.; J. Org. Chem. 2003; 68, 9678-9686. [link]

(53) "The Development of a Chromatography-Free Mitsunobu Reaction: Synthesis and Applications of an Anthracene-Tagged Phosphine Reagent." Lan, P.; Porco, J. A., Jr.; South, M. S.; Parlow, J. J. J. Comb. Chem. 2003, 5, 660-669. [link]

(52) "Total Synthesis of the Ubiquitin-Activating Enzyme Inhibitor (+)-Panepophenanthrin." Lei, X.; Johnson, R. P.; Porco, J. A., Jr. Angew. Chem. Int. Ed. Engl. 2003, 42, 3913-3917. [link]

(51) "Stereochemical Diversity through Cyclodimerization: Synthesis of Polyketide-like Macrodiolides." Su, Q.; Beeler, A. B.; Lobkovsky, E.; Porco, J. A., Jr.; Panek, J. S. Org. Lett, 2003, 5, 2149-2152. [link]

(50) "Synthesis and Cell Cycle Inhibition of the Peptide Enamide Natural Product Terpeptin and the Aspergillamides." Su, S.; Kakeya, H.; Osada, H.; Porco, J. A., Jr. Tetrahedron, 2003, 59, 8931-8946. [link]

(49 ) "Jesterone Dimer, a Synthetic Derivative of the Fungal Metabolite Jesterone, Blocks Activation of Transcription Factor Nuclear Factor kB by Inhibiting the Inhibitor of kB Kinase," Liang, M.-C.; Bardhan, S.; Li, C.; Pace, E. A.; Porco, J. A., Jr.; Gilmore, T. D. Molecular Pharmacology, 2003, 64, 123-131. [link]

(48) "Lobatamide C: Total Synthesis, Stereochemical Assignment, Preparation of Simplified Analogues, and V-ATPase Inhibition Studies." Shen, R.; Lin, C. T.; Bowman, E. J.; Bowman, B. J.; Porco, J. A., Jr. J. Am. Chem. Soc. 2003, 125, 7889-7901. [link]

(47) "Total Synthesis of the Salicylate Enamide Macrolide Oximidine II." Wang, X.; Porco, J. A., Jr. J. Am. Chem. Soc. 2003, 125, 6040-6041. [link]

(46) "Total Synthesis of the Quinone Epoxide Dimer (+)-Torreyanic Acid: Application of a Biomimetic Oxidation/Electrocylization/Diels-Alder Dimerization Cascade." Li, C.; Johnson, R. P.; Porco, J. A., Jr. J. Am. Chem. Soc. 2003, 125, 5095-5106. [link]

2002

(45) "Angiogenesis Inhibitor Epoxyquinol A: Total Synthesis and Inhibition of Transcription Factor NF-kB." Li, C.; Bardhan, S.; Pace, E. A.; Liang, M.-C.; Gilmore, T. D.; Porco, J. A., Jr. Org. Lett.  2002,  4,  3267-3270. [link]

(44) "Synthesis and V-ATPase Inhibition of Simplified Lobatamide Analogues." Shen, R; Lin, C. T.; Bowman, E. J.; Bowman, B. J.; Porco, J. A., Jr. Org. Lett.  2002, 4, 3103-3106. [link]

(43) "Polymer-assisted parallel solution phase synthesis of substituted benzimidazoles." Yun, Y. K.; Porco, J. A., Jr.; Labadie, J. Synlett. 2002, 5, 739-742. [link]

(42) "Total Synthesis and Stereochemical Assignment of the Salicylate Antitumor Macrolide Lobatamide C."  Shen, R.; Lin, C. T.; Porco, J. A., Jr. J. Am. Chem. Soc. 2002, 124, 5650-5651. [link]

(41) "Studies Toward the Synthesis of (-)-Zampanolide: Preparation of N-Acyl Hemiaminal Model Systems." Troast, D. M.; Porco, J. A., Jr. Org. Lett. 2002, 4, 991-994. [link]

2001

(40) "Total Synthesis of the NF-kB Inhibitor (-)-Cycloepoxydon: Utilization of Tartrate-Mediated Nucleophilic Epoxidation." Li, C.; Pace, E. A.; Liang, M-C.; Lobkovsky, E.; Gilmore, T. D.;. Porco, J. A., Jr. J. Am. Chem. Soc. 2001, 123, 11308-11309. [link]

(39) "Combinatorial synthesis of natural product-like molecules using a first-generation spiroketal scaffold." Kulkarni, B. A.; Roth, G. P.; Lobkovsky, E.; Porco, J. A., Jr.  J. Comb. Chem. 2002, 4, 56-72. [link]

(38) "Modification of C-Terminal Peptides for Form Peptide Enamides: Synthesis of Chondriamides A and C.” Wang, X.; Porco, J. A., Jr. J. Org. Chem.. 2001, 66, 8215-8221. [link]

(37) “Exploring Chemical Diversity of Epoxyquinoid Natural Products: Synthesis and Biological Activity of (-)-Jesterone and Related Molecules.” Hu, Y.; Li, C.; Kulkarni, B.; Strobel, G.; Lobkovsky, E.; Porco, J. A. , Jr. Org. Lett. 2001, 3, 1649-1652. [link]  

2000

(36) "Total Synthesis of (±) Torreyanic Acid." Li, C.; Lobkovsky, E.; Porco, J. A., Jr. J. Am. Chem. Soc. 2000, 122, 10484-10485. [link]

(35) "Parallel Synthesis and Purification using Anthracene-Tagged Substrates." Wang, X.; Parlow, J. J.; Porco, J. A., Jr. Org. Lett. 2000, 2, 3509-3512. [link]

(34) "Multistep Synthesis of 1,2,3-Thiadiazoles using 'Catch and Release'." Hu, Y.; Baudart, S.; Porco, Jr., J. A. High Throughput Synthesis: Theory and Practice, Chapter 6, Section 5, (Sucholeiki, I., editor), Marcel Dekker, NY, 2000."

(33) "Synthesis of Enamides Related to the Salicylate Antitumor Macrolides Using Copper-mediated Vinylic Substitution." Shen, R.; Porco, J. A., Jr. Org. Lett. 2000, 2, 1333-1336. [link]

(32) "Organic Synthesis Using Chemical Tags: The 'Third Leg' of Parallel Synthesis." Porco, J. A., Jr. Combinatorial Chemistry and High Throughput Screening, 2000, 3, 93-102.

(31) "Streamlined Synthesis of Substituted 2-Aminothiazoles Using Tandem Precipitative and Polymer-Assisted Reactions." Yun, Y. K.;  Leung, S. S. W.; Porco, J. A., Jr. Biotechnol. Bioeng. 2000, 71, 9-18.