Studies Directed Toward the Total
Synthesis of Geldanamycin

Geldanamycin (yellow) bonded in receptor cite

Hua-Li Qin Boston University Fall 2004


Isolation and Structure

De Boer, C.; Meulman, P. A.; Wnuk, R. J.; Peterson, D. H. J.Antibiot. 1970 , 23 , 442. Rinehart, K. L.; Sasaki, K.; Slomp, G.; Grostic, M. F.; Olson, E. C. J. Am. Chem. Soc. 1970 , 92 , 7591

Biological Activity

Broad activity with a unique profileof action within the NCI 60 cell-line panel with an average ED50 value of 180 nM Great potential as therapeutic lead compounds for new anti-cancer agents Kuduk, S. D. et al. J. Bioorg. Med. Chem. Lett. 2000 , 10 , 1303. Whitesell, L.; Shifrin, S. D.; Schwab, G.; Neckers, L. M. Cancer.Res. 1992 , 52 , 1721.