BI515: Population Genetics - Fall 2014

Course Description: This course is designed to provide students with a general introduction to population genetics, which examines the interaction of basic evolutionary processes (including mutation, natural selection, genetic drift, inbreeding, recombination, and gene flow) in determining the genetic composition and evolutionary trajectories of natural populations. An understanding of the mechanisms shaping genetic variation within and between populations is critical to understanding the course of adaptive evolution and is increasingly being recognized as a critical component of medical research and the development of effective treatments for disease. Both the classic models and insights of the modern evolutionary synthesis and more recently developed approaches based on coalescent theory are considered.


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Final Exam: TBD

Powerpoint Presentations

Excel and Python Files

Discussion Readings

11 September - Genetic Polymorphisms and HW-Equilibrium

Kreitman M (1983) Nucleotide polymorphism at the alcohol-dehydrogenase locus of Drosophila melanogaster. Nature 304, 412-417.

Hishimoto A, Fukutake M, Mouri K, Nagasaki Y, Asano M, Ueno Y, Nishiguchi N, Shirakawa O (2010) Alcohol and aldehyde dehydrogenase polymorphisms and risk for suicide: a preliminary observation in the Japanese male population. Genes, Brain and Behavior 9, 498-502.

18 September - Effective Population Size

Charlesworth, B (2009) Effective population size and patterns of molecular evolution and variation. Nature Reviews Genetics 10, 195-205.

25 September - The Coalescent

Rosenberg NA, Nordborg M (2002) Genealogical trees, coalescent theory and the analysis of genetic polymorphisms. Nature Reviews Genetics, 3, 380-390.



Web of Science





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