BI515: Population Genetics - Fall 2014

Course Description: This course is designed to provide students with a general introduction to population genetics, which examines the interaction of basic evolutionary processes (including mutation, natural selection, genetic drift, inbreeding, recombination, and gene flow) in determining the genetic composition and evolutionary trajectories of natural populations. An understanding of the mechanisms shaping genetic variation within and between populations is critical to understanding the course of adaptive evolution and is increasingly being recognized as a critical component of medical research and the development of effective treatments for disease. Both the classic models and insights of the modern evolutionary synthesis and more recently developed approaches based on coalescent theory are considered.



Powerpoint Presentations

RAD-seq data sets

Excel and Python Files

Discussion Readings

11 September - Genetic Polymorphisms and HW-Equilibrium

Kreitman M (1983) Nucleotide polymorphism at the alcohol-dehydrogenase locus of Drosophila melanogaster. Nature 304, 412-417.

Hishimoto A, Fukutake M, Mouri K, Nagasaki Y, Asano M, Ueno Y, Nishiguchi N, Shirakawa O (2010) Alcohol and aldehyde dehydrogenase polymorphisms and risk for suicide: a preliminary observation in the Japanese male population. Genes, Brain and Behavior 9, 498-502.

18 September - Effective Population Size

Charlesworth, B (2009) Effective population size and patterns of molecular evolution and variation. Nature Reviews Genetics 10, 195-205.

25 September - The Coalescent

Rosenberg NA, Nordborg M (2002) Genealogical trees, coalescent theory and the analysis of genetic polymorphisms. Nature Reviews Genetics, 3, 380-390.

16 October - Population Structure

Novembre J, Johnson T, Bryc K, Kutalik Z, Boyko AR, Auton A, Indap A, King KS, Bergmann S, Nelson MR, Stephens M, Bustamante CD (2008) Genes mirror geography within Europe. Nature 456, 98-101.

23 October - Coalescent Analyses of Population Structure

Carstens BC, Brennan RS, Chua V, Duffie CV, Harvey MG, Koch RA, Mcmahan CD, Nelson BJ, Newman CE, Satler JD, Seeholzer G, Posbic K, Tank DC, Sullivan J (2013) Model selection as a tool for phylogeographic inference: an example from the willow Salix melanopsis. Molecular Ecology 22, 4014–4028.

30 October - Rapid Evolution

Stuart YE, Campbell TS, Hohenlohe PA, Reynolds RG, Revell LJ, Losos JB (2014) Rapid evolution of a native species following invasion by a congener. Science 346, 463-466.

6 November - Selctive Sweeps

Hernandez RD, Kelley JL, Elyashiv E, Melton SC, Auton A, McVean G, Sella G, Przeworski M, 1000 Genomes Project (2011) Classic selective sweeps were rare in recent human evolution. Science 331: 920–924.



Web of Science





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