Population Genetics - Fall 2014
Course Description: This course is designed to provide students with a general introduction to population genetics, which examines the interaction of basic evolutionary processes (including mutation, natural selection, genetic drift, inbreeding, recombination, and gene flow) in determining the genetic composition and evolutionary trajectories of natural populations. An understanding of the mechanisms shaping genetic variation within and between populations is critical to understanding the course of adaptive evolution and is increasingly being recognized as a critical component of medical research and the development of effective treatments for disease. Both the classic models and insights of the modern evolutionary synthesis and more recently developed approaches based on coalescent theory are considered.
Excel and Python Files
11 September - Genetic Polymorphisms and HW-Equilibrium
Kreitman M (1983) Nucleotide polymorphism at the alcohol-dehydrogenase locus of Drosophila melanogaster. Nature 304, 412-417.
Hishimoto A, Fukutake M, Mouri K, Nagasaki Y, Asano M, Ueno Y, Nishiguchi N, Shirakawa O (2010) Alcohol and aldehyde dehydrogenase polymorphisms and risk for suicide: a preliminary observation in the Japanese male population. Genes, Brain and Behavior 9, 498-502.
18 September - Effective Population Size
Charlesworth, B (2009) Effective population size and patterns of molecular evolution and variation. Nature Reviews Genetics 10, 195-205.
25 September - The Coalescent
Rosenberg NA, Nordborg M (2002) Genealogical trees, coalescent theory and the analysis of genetic polymorphisms. Nature Reviews Genetics, 3, 380-390.