Wednesday December 8, 2004 t u 4 : 3 0 - 6:00 PM 4:00-6:30 PM

At Boston University Medical Campus (BUMC)
715 Albany Street, Boston, MA
The Leonard S. Gottlieb Conference Room,
Instructional (L) Building Room L804

4:00 Welcome – Jackie Sharon

4:05 Regulation of MMP-9 Expression in Cancers by Gene Promoter Region Methylation: Preliminary Studies
Mary Jo Murnane, Karen Morgan, Kuang-Hung Cheng, Jinguo Cai, Supraja Narasimhan, Shi Yang, Sam Thiagalinham, Michael J. O'Brien, Barbara Smith and David McAneny
Pathology & Laboratory Medicine, Medicine, and Biochemistry, Boston University School of Medicine

4:20 Molecular Network Aberrations Define Subtypes of Non Small Cell Lung Cancer
Sam Thiagalingam*1-3, Jose F. Ponte1,2, Andrea L. Russo1, Kuang-Hung Cheng1,2,3, Pratima Nemani1, and Hongjie Pan1,2
Departments of Medicine (Genetics Program and Cancer Research Center)1, Genetics & Genomics2 and Pathology & Laboratory Medicine3, Boston University School of Medicine

4:35 The Retinoblastoma Protein Pathway in Differentiation, Senescence and Cancer
Phil Hinds, Nelson Brown, Amit Deshpande, Gabriel Gutierrez, Bin He, Miao Hu, Elizabeth Kong, Mark Landis, Daqin Mao, Pedro Santiago, and Haisu Yang
Molecular Oncology Research Institute, Tufts-New England Medical Center

4:50 Mechanism of Degradation of the Mitotic Kinase Aurora-B: Identification of an Aneuploidy and Transformation-Promoting Property
Hao G. Nguyen, D. Chinnapan, Takeshi Urano and Katya Ravid
Department of Biochemistry, Cancer Research Center, Boston University School of Medicine

5:05 Refreshment Break

5:25 Recruitment of Stromal Stem Cells by Breast Carcinomas
Antoine E. Karnoub1, Melody Baddoo2, Tan A. Ince1, Donald G. Phinney2, and Robert A. Weinberg1
1Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, and 2Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana

5:40 Kinase Inactive GSK3? Promotes Wnt Signaling and Mammary Tumorigenesis
Marganit Farago, Isabel Dominguez, Esther Landesman, and David C. Seldin
Section of Hematology-Oncology and Program in Molecular Medicine, Department of Medicine, Boston University School of Medicine

5:55 Apoptosis Factor EI24/PIG8 is a Novel Endoplasmic Reticulum-Localized Bcl-2-Binding Protein which is Associated with Suppression of Breast Cancer Invasiveness
Remco A. Spanjaard,1 Xiansi Zhao,1 Robert E. Ayer,1 Shannon L. Davis,1 Sarah J. Ames,1 Brian Florence,2 Cyrus Torchinsky,1 James S. Liou,2 and Ling Shen1
Departments of 1Otolaryngology and Biochemistry, and 2Department of Medicine, Cancer Research Center, Boston University School of Medicine

6:10 General Discussion