Overview
Recent Projects
Amphiphiles for Gene Delivery
Charge reversal amphiphiles, that undergo an electrostatic transtion from cationic to anionic, are described for DNA and siRNA delivery...
Expansile Nanoparticles
Polymeric nanoparticles that swell and release their contents as a result of a hydrophobic to hydrophilic transition at pH 5 are found to be efficaceous in vitro and in vivo...
Cationic CT Contrast Agents for Cartilage Imaging
The synthesis and evaluation of a new class of cationic iodinated contrast agents for the CT imaging of cartilage are described...
Polymeric Films for Prevention of Recurrent Lung Cancer
Poly(glycerol monostearate-co-ε-caprolactone) films have been designed to provide prolonged, low dose release of paclitaxel at the site of tumor resection to prevent local tumor recurrence following surgery in vivo...
Supramolecular Ionic Networks
New supramolecular assemblies are created using multi-cationic and multi-anionic molecules...
Biodendrimer Ophthalmic Corneal Sealant
Hydrogel-based tissue adhesives can effectively seal corneal wounds in vitro and in vivo and are superior to sutures...
Interfacial Biomaterials
In the extracellular matrix chemical cues are present that control all aspects of cell biology.
Supramolecular Assemblies of Nucleoside-based Amphiphiles
New nucleoside-amphiphiles that possess the molecular recognition information of nucleic acids and the compartmentalization characteristics of lipids have been synthesized and these amphiphiles form a diverse range of supramolecular structures...
