Grinstaff Group - BME/Chemistry - Boston University

Biodendrimers

Dendrimers are highly branched macromolecules possessing three main structural components: a core, internal branching layers, and peripheral groups (see Figure). Unlike linear polymers where growth is accomplished by adding single monomers to the chain (1:1 growth), a dendrimer grows exponentially where each monomer is branched leading to multiple additions (1:2, 1:3, etc. growth). Each layer in a dendrimer is termed a generation (G) and thus as a dendrimer grows through the addition of new monomers, the generation number increases (G0, G1, … Gn). We are synthesizing, characterizing, and evaluating a class of dendritic polymers termed "Biodendrimers". These dendrimers are comprised of building blocks known to be biocompatible or degradable in vivo to natural metabolites. We have reported the synthesis of these macromolecules using either a divergent or convergent strategy. The introduction of biocompatible building blocks augments the favorable physical properties of dendrimers and facilitates the design and development of new polymer and materials for basic and applied studies.

 

Selected Publications

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Boston University College of Engineering Department of Biomedical Engineering Boston University Department of Chemistry Boston University