Grinstaff Group - BME/Chemistry - Boston University

Biodendrimer Drug Delivery Vehicles

The container properties of dendrimers contribute to their use as vehicles for drug delivery. Recently, we have reported biocompatible polyester dendrimers composed of glycerol and succinic acid for the encapsulation of two anticancer agents: 10-hydroxycamptothecin (10HCPT) and 7-butyl-10-aminocamptothecin (BACPT). NMR experiments confirmed the encapsulation of the compounds within the dendrimer structure. The cytotoxicity of the dendrimer-drug complex toward four different human cancer cell lines (human breast adenocarcinoma (MCF-7), colorectal adenocarcinoma (HT-29), non-small cell lung carcinoma (NCI H460), and glioblastoma (SF-268)) was determined, and low IC50s were measured for both camptothecins (see Figures). Cellular uptake and efflux measurements in MCF-7 cells also showed an increase of 16-fold and a 50% increase in drug retention within the cell when using the dendrimer vehicle.

Selected Publications

© Copyright 2009. Grinstaff Group. All rights reserved. Boston University / BME / Chemistry

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