Polymeric Films for Prevention of Recurrent Lung Cancer
Poly(glycerol monostearate-co-ε-caprolactone) films have been designed to provide prolonged, low dose release of paclitaxel at the site of tumor resection to prevent local tumor recurrence following surgery in vivo.
Cationic CT Contrast Agents for Cartilage Imaging
The synthesis and evaluation of new cationic iodinated contrast agents for CT imaging of cartilage are described which give higher x-ray attenuation values and specific imaging of the cartilage tissue.
Expansile Nanoparticles
Polymeric nanoparticles that swell and release their contents as a result of a hydrophobic to hydrophilic transition at pH 5 are found to be efficaceous in vitro and in vivo.
Amphiphiles for Gene Delivery
Charge reversal amphiphiles, that undergo an electrostatic transtion from cationic to anionic, are described for DNA and siRNA delivery...
Supramolecular Ionic Networks
New supramolecular assemblies are created using multi-cationic and multi-anionic molecules and this noncovalent synthetic strategy complements those approaches using hydrogen and metal-ligand bonding.
Biodendrimers
Polyester based dendrimers based on biocompatible building blocks are synthesized and these polymers are of interest for ...
Prevention of Local Tumor Recurrence Following Surgery Using Low-Dose Chemotherapeutic Polymer Films
The in vivo efficacy of a polymer film, designed for prolonged paclitaxel release at surgical margins, was demonstrated ...Read More
The cationic contrast agent article in C&E news
New CT contrast agents, developed by Boston University researchers, highlight cartilage ... Read More
Welcome to the Grinstaff Group
The Grinstaff Group pursues highly interdisciplinary research in the areas of biomedical engineering and macromolecular chemistry. The major goal in these research projects is to elucidate the underlying fundamental chemistry and engineering principles and to use that insight to direct our creative and scientific efforts.
