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CURRICULUM VITAE NAME: Jinghua YANG, Ph.D. DATE OF BIRTH: June 12, 1959 ADDRESS: TELEPHONE: (857)-364-6398 FAX: (857) 364-5627 Cell: (203) 214-8757 E-MAIL: jyang@bu.edu;
jinghua.yang@va.gov EDUCATION
and PROFESSIONAL EXPERIENCE: 2006.11 – present, Associate
Professor, Director Surgical
Oncology Laboratory Boston
VA Medical Center 2004.7 – 2006.10, Head of
Surgical Oncology Research Laboratory. Department
of Surgery 1998 – 2004 Assistant Professor Department
of Surgery 1994 - 1998, Post-doctoral
fellow with Dr. Tom Maniatis Department
of Molecular and Cellular Biology 1992 - 1994, Post-doctoral
fellow with Dr. Bernado Nadal-Ginard Howard
Hughes Medical Institute, Dept of Cell. & Mole. Physiology, 1988 - 1992, Graduate
Student (Ph.D.) with Dr. Robert. Cedergren Department
of Biochemistry, 1985 - 1988, Assistant
Lecturer & Lecturer in Biochemistry Department
of Biochemistry, 4th 1982 - 1985, Graduate
Student (M.Sc.) in Catalysis Beijing
Research Institute of Chemical Engineering, 1978 -
1982, Undergraduate student (B.Sc.) in Chemistry AWARDS
and OTHER PROFESSIONAL ACTIVITIES: Awards and honors: 1988
- Fellowship, 1992,
Outstanding NSERC Young
Researcher Award. National
Science and Engineering Research Council of 1992, MRC Fellowship from Medical Research
Council of Grant
number: 9204FEN-1328-41318 1996,
Outstanding Young Scientist
Award from National Science Foundation of 1996- Guest professor in Xian International
BioMedical Institute, 1999,
Hellman Fellowship Award Other professional activities: Ad hoc Reviewer for the American Associate member of RNA society, 1996- Guest professor in Xian
International BioMedical Research Institute, Xian,
1996 - present: Founder, Vice president of Chinese-American
Science and Technology Society, 2001-; RESEARCH
GRANT SUPPORTS DURING LAST 5 YEARS: Currently
active: KO2 AI060701, Yang (PI), 07/15/04 –
4/31/09 ($524,485, total) NIH/NIAID Title: Role of RNA editing by
ADAR1 in infection This support is to elucidate the
role of the RNA editing enzyme ADAR1 in modulating cellular responses to
infection. Role: PI. R01 GM 60426, Yang (PI), 01/01/00 –
12/31/05 extended to 10/31/07; ($1,207,707 total) NIH/NIGMS,
This support is to study the
mechanism of A-to-I RNA editing enzyme: 1) to characterize the formation of
I-mRNA in HeLa cells, and 2) to identify
site-specific interactions in A-to-I RNA editing complex BCTR0707230,
Yang (PI), 07/01/2007 – 6/31/2010 $(298,000, direct) Susan G. Komen
for the Cure Title: Activating innate immunity
to fight breast cancer
This
support is to study a tumor specific complement activator (tsCA) that activates human complement system to kill
cancer cells. Instrument
Grant, Yang (PI),
07/01/2007 ($500,000
direct) ShEEP, VA This support
is to purchase instruments for clinic proteomics including 1) Nano-LC QSTARŪ Elite Hybrid LC/MS/MS (nanoLC Q-TOF mass
spectrometer), 2) Voyager-DE™ STR Biospectrometry
Workstation (MALDI TOP mass spectrometer, and 3) multi-dimensional HPLC
with spotting system. Pending: R21
CA124944-01, Yang (PI),
NIH/NIAID This
support is to identify serum markers for chemosensitivity
of pancreatic cancer. Concept
Award on PTSD, Yang (PI),
DoD This
support is to the study on PTSD entitled “PTSD is triggered by
traumatic stress-induced Rbrain RNA editing”. Completed: 1. Hellman fellowship, Date: 1/1/00- P.I.: Jinghua YANG; Title: “The role of A-to-I RNA editase in inflammation.” 2. OHSE Fellowship; Date: 1/1/02 – 12/31/03.
P.I.: Helen Su. Title:
Complement activator specific for tumor cells; 3. OHSE Fellowship, 1/1/03 – 12/31/03 P.I.: Yingjun
Su. Title:
Complement activator specific for tumor cells 4. OHSE Fellowship, 1/1/00
– 12/31/00 P.I.:
Xiaoxing Luo. Title:
A-to-I RNA editase in inflammation. 5.
NSFC # 39625023, 10/1/97 – 9/31/98 P.I.: Jinghua
YANG. BIBLIOGRAPHY Peer-reviewed original research: *Yang J-H, Perreault
JP, Labuda D, Usman N, Cedergren R. Mixed DNA/RNA polymers are cleaved by the
hammerhead ribozyme. Biochemistry 29(51):11156-60 (1990). Annotation: This work was done as a
graduate student in Dr Cedergen’s lab. Xiang
XB, Yang J-H, N.C. Chen and C.Z.Su,
"Chemical Synthesis and Expression of HIV-env
Gene in E.coli", Chinese J. Biological Chemistry 6(3):229 (1990). Perreault JP, Labuda D, Usman N, Yang J-H, Cedergren
R. Relationship between 2'-hydroxyls and magnesium binding in the hammerhead
RNA domain: a model for ribozyme catalysis. Biochemistry
30(16): 4020-5 (1991). Annotation: This work was done as
a graduate student in Dr Cedergen’s lab. Yang
J-H, Usman N, Chartrand P, Cedergren R. Minimum ribonucleotide
requirement for catalysis by the RNA hammerhead domain. Biochemistry
31(21): 5005-9 (1992). Annotation: This work was done as
a graduate student in Dr Cedergen’s lab. Yang
J-H and R. Cedergren, "Mechanism of RNA Catalysis",
Doctoral Thesis, Annotation: This work was done as
a graduate student in Dr Cedergen’s lab. Yang
J.-H, Cedergren R, Nadal-Ginard B.
Catalytic activity of an RNA domain derived from the U6-U4 RNA complex. Science
263(5143): 77-81 (1994). Annotation: This work was done as
a postdoc under Dr. Bernado
Nadal-Ginard. Yang J.-H, Sklar
P, Axel R, Maniatis T. Editing of glutamate
receptor subunit B pre-mRNA in vitro by site-specific deamination
of adenosine. Nature 374(6517): 77-81 (1995). Annotation:
This work was done as a postdoc under Dr. Tom Maniatis and Richard Axel. Yang J.-H, Sklar
P, Axel R, Maniatis T. Purification and
characterization of a human RNA adenosine deaminase
for glutamate receptor B pre-mRNA editing. Proc.Natl.
Acad. Sci. USA. 94(9): 4354-9 (1997).
Annotation:
This work was done as a postdoc under Dr. Tom Maniatis and Richard Axel. F. Li, J-H
Yang, X Liu, P He, S Ji, J Wang, J Han, N Chen,
and L Annotation: This work is generated
from a collaborative study. I am the initiative and the designer of this
project. It was performed by postdoc fellow Dr. Li
under my guidance. I was heavily involved in data interpretation and
manuscript preparation. F. Li, J-H
Yang, N Chen, and L Annotation: This work is generated
from the collaborative study as above. I am the initiative and the original
designer and heavily involved in data interpretation and manuscript
preparation. Rabinovici R, Kabir K, Luo
X, Chen M, Su Y, Zhang D, Yang J.-H*, ADAR1
is Involved in the Development of Microvascular
Lung Injury. Circ Res 88:
1066 – 1071 (2001). Annotation: I am the
co-corresponding author of this paper. I am the initiative and the original
designer of this project, guided the research by providing daily
trouble-shooting and data interpretation to postdoctoral fellows, and
directly performed some of the experiments. I completed manuscript writing
and submission, and rebuttal all by myself.
K, K., Gelinas, J. P., Chen, M., Chen, D., Zhang, D., Luo, X., Yang J.-H., Carter, D. Rabinovici, R., Characterizing acute pulmonary
inflammation in mouse exposed to endotoxin. Shock
17(4):300-303 (2003). Rabinovici R, Zhang D, Su Y, Luo X, Zhao
Q, Yang J-.H.: mob-1 and TNFa
interact to induce microvascular lung injury. Shock
18(3):261-4 (2002). Jing WU, De Xin Zhang, J.-H. YANG
& Dai Ming FAN. Inhibitory efficacy of local angiostatin
expression in treatment of human hepatic carcinoma cells. Chinese Journal
of Digestive Diseases 3: 132–137 (2002). J-H
Yang*, Xiaoxing Luo, Yongzhan Nie, Yingjun Su, Qingchuan Zhao, Koroush Kabir, Dexin Zhang, Reuven Rabinovici.
Widespread Inosine-containing mRNA in
Lymphocytes Regulated by ADAR1 in Response to Inflammation. Immunology 109:15-23 (2003). Annotation: As the first and
corresponding author, I am the initiative and original designer of this
project, and also performed some of the experiments. I completed manuscript
writing and submission, and rebuttal by myself. Y. Nie, K. Wu, J-H. Yang, F. Tian,
D. Fan. Induction of T lymphocytes
specific to gastric cancer using HLA-A matched allogeneic
gastric tumor cells. J.
Immunotherapy 26(5) 403-411 (2003). J. Wu, Y.
Shi, K. Wu, D. Zhang, J-H Yang, D. Fan, Angiostatin
up-regulation in gastric cancer cell SGC7901 inhibits tumorigenesis
in nude mice. World J Gastroenterology 9(1): 59-64 (2003). Jing-Hua Yang*, Yongzhan Nie, Qingchuan Zhao, Yingjun Su,
Marc Pypaert, Haili Su
and Reuven Rabinovici.
Intracellular Localization of Differentially Regulated ADAR1 Isoforms in Inflammation.
J.Biol.Chem. 278(46):45833-42
(2003). Annotation: As the first and
corresponding author, I performed some of the experiments and guided the
completion of this project. The original thought development, data
interpretation and manuscript writing, submission and rebuttal were done by myself. Yongzhan Nie, Kaichun
Wu and Jing-Hua Yang*. Specific
cytolysis of tumor cells by xenogenically activated
human serum. Clin. Cancer
Res. Annotation: This paper is accepted
but held by us due to a patent application process. I am the corresponding author and
independent PI of this paper. Yongzhan Nie, Qingchuan
Zhao, Yingjun Su and Jinghua
Yang* Subcellular distribution of ADAR1 isoforms is synergistically determined by three nuclear
discrimination signals and a regulatory motif. J.Biol.Chem.
279 (13):13249-55 (2004). Annotation: I am the corresponding
author and independent PI of this paper. Shuli Xia, Jing-Hua Yang*, Enbo Ma, Kevin White and Yingyi
Xiao and Gabriel Haddad*.
Identification of the new targets of Drosophila pre-mRNA deaminase. Physiological Genomics 20;20(2):195-202 (2005). Annotation: I am the corresponding
author of this paper. The work was done under my supervising in collaboration
with Dr. Haddad. Nie, Y. Ding, L. Kao, P. N. Braun, R. Jinghua,
Yang* ADAR1 interacts with NF90
through double-stranded RNA and regulates NF90-mediated gene expression
independently of RNA editing. Mol
Cell Biol 25 (16) 6956-63 (2005). Annotation: I am the corresponding
author and independent PI of this paper. Yongzhan Nie, Graeme L. Hammond, & Jing-Hua Yang1* Double-stranded RNA editase
ADAR1 increases susceptibility to viral infection. J. Virology, 81(2):917-923 (2007). Annotation: I am the corresponding
author and independent PI of this paper. Patents: 1.
Nassim Usman, Robert Cedergren, J.P. Perreault, Jing-Hua Yang, Alexander
Rich. 2.
Nassim Usman, Alexander Rich, Robert Cedergren, J.P. Perreault, Jing-Hua Yang. Assignee: Ribozyme
Pharmaceuticals. Nuceozymes II; US Patent
6,140,49. (10/31/2000). 3.
Nassim Usman, Robert Cedergren, J.P. Perreault, Jing-Hua Yang, Alexander
Rich. Assignee: MIT. Nuceozymes III.
US Patent 7074601. (7/11/2006). Book Chapter: in "Practical Protocols In
Molecular Biology", Jing-Hua
Yang, RNA Synthesis and Processing, (1996). Science Press &
Science Press New Yok, Ltd., LECTURES and COURSES: Invited speech:
“Role of ADAR1 in host response during viral infection”, Research
Conference, Boston VA Medial Center, West Invited
speaker and panelist: The 1st annual symposium of ACMS, Invited
speech: The 15th World Congress of
Pharmacology, Xian Satellite Meeting, Xian, Invited
speech: “RNA editing enzyme ADAR1 in host defense “Department of
Biochemistry, Brandeis University, Session
Chair: Comparative and Functional Genomics Workshop, Hinxton,
Cambridgeshire, U.K, November 2-5, 2003. Chair and
Organizer: Bio-Pharmaceutical Sciences, the Tri-state chapter of SCBA, Invited
speech: Beyond Identification and Transcription and Sequences, A-to-I RNA
editing diversifies gene expression, 12nd BITS,
DOE. Invited
speech: “Strategies in Disease-related Proteomics”, Biomedicine
and Biotechnology Association. Organizer
and keynote speaker: “Discovery of New Drug Targets with Proteomic Mass
Spectrometry”. Symposium on Proteomics. Xian, Invited
speech: “RNA editing and inflammation”. Invited
speech: “Modifying the genetic information”, 90th Anniversary of TsingHua University, Organizer
and keynote speaker: “RNA editing and function”; 4th Symposium on
Frontier of Life Science. NSF of Invited
speech: "Identification of A-I Editing in Mammalian Messenger RNAs", Gordon
Research Conferences, Invited
speech: "Purification/Characterization of human RNA adenosine deaminase",
EMBO Workshop, Speaker:
"In vitro editing of glutamate receptor B pre-mRNA by Deamination of Adenosine", The first RNA Editing Workshop, |
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