Peer reviewed Articles:
"Improved Method for Automatic DNA Synthesis", J. 4th Mil.
Yang J-H and S.M. Chen, "Computational Analysis of Functional
elements in DNA ", J. 4th
Yang J-H, R. Zhang and S. Chen, "Kinetic
Studies on RNA Synthesis of Rat H22 Cancer Cell Promoted by hAFP" J.
Yang J-H and H.Y. Zhang, "Synthetic Probe in
Diagnosis of Renal Syndrome Hemorrh Fever Virus" J. 4th Mil.
Yang J-H and B.Y. Xiang, "Synthesis of A
Poly-cistron of ANF Gene and Its Expression in E.coli." J. 4th Mil.
Xiang XB, Yang J-H, N.C. Chen and C.Z.Su, "Chemical Synthesis and Expression of HIV-env Gene in E.coli", Chinese J. Biological Chemistry (1990) 6(3):229.
*Yang J-H, Perreault JP, Labuda D, Usman N, Cedergren R. Mixed DNA/RNA polymers are cleaved by the hammerhead ribozyme. Biochemistry (1990) 29(51):11156-60.
Perreault JP, Labuda D, Usman N, Yang J-H, Cedergren R. Relationship between 2'-hydroxyls and magnesium binding in the hammerhead RNA domain: a model for ribozyme catalysis. Biochemistry (1991) 30(16): 4020-5.
*Yang J-H, Usman N, Chartrand P, Cedergren R. Minimum ribonucleotide requirement for catalysis by the RNA hammerhead domain. Biochemistry (1992) 31(21): 5005-9.
*Yang J-H and R. Cedergren, "Mechanism of
RNA Catalysis", Doctoral Thesis,
*Yang J.-H, Cedergren R, Nadal-Ginard B. Catalytic activity of an RNA domain derived from the U6-U4 RNA complex. Science. (1994) 263(5143): 77-81.
*Yang J.-H, Sklar P, Axel R, Maniatis T. Editing of glutamate receptor subunit B pre-mRNA in vitro by site-specific deamination of adenosine. Nature. (1995) 374(6517): 77-81.
Annotation: This work was initiated and completed by myself. The discovery of a novel type of cellular editing process sets a foundation for my independent research.
*Yang J.-H, Sklar P, Axel R, Maniatis T. Purification and characterization of a human RNA adenosine deaminase for glutamate receptor B pre-mRNA editing. Proc.Natl. Acad. Sci. USA. (1997) 94(9): 4354-9.
Annotation: This work was initiated and completed by myself. It sets the direction of my future study on the biological function of RNA editing in immune system.
F. Li, J-H
Yang, X Liu, P He, S Ji, J Wang, J Han, N Chen, and L
Annotation: This work is generated from a collaborative study. I am the initiative and the designer of this project. It was performed by postdoc fellow Dr. Li under my guidance. I was heavily involved in data interpretation and manuscript preparation.
F. Li, J-H
Yang, N Chen, and L
Rabinovici R, Kabir K, Luo X, Chen M, Su Y, Zhang D, Yang J.-H, ADAR1 is Involved in the Development of Microvascular Lung Injury. Circ Res (2001) 88: 1066 – 1071.
Annotation: I am the initiative and original designer of this project, completed manuscript writing, submission and rebuttal. I am the co-corresponding author of this paper,
K, K., Gelinas, J. P., Chen, M., Chen, D., Zhang, D., Luo, X., Yang J.-H., Carter, D. Rabinovici, R., Characterizing acute pulmonary inflammation in mouse exposed to endotoxin. Shock (2002) 17(4):300-303.
Rabinovici R, Zhang D, Su Y, Luo X, Zhao Q, Yang J-.H.: mob-1 and TNFa interact to induce microvascular lung injury. Shock (2002) 18(3):261-4.
Jing WU, De Xin Zhang, J.-H. YANG & Dai Ming FAN. Inhibitory efficacy of local angiostatin expression in treatment of human hepatic carcinoma cells. Chinese Journal of Digestive Diseases (2002) 3: 132–137.
J-H Yang, Xiaoxing Luo, Yongzhan Nie, Yingjun Su, Qingchuan Zhao, Koroush Kabir, Dexin Zhang, Reuven Rabinovici. Widespread Inosine-containing mRNA in Lymphocytes Regulated by ADAR1 in Response to Inflammation. Immunology (2003) 109:15-23.
Annotation: As the first and corresponding author, I am the initiative and original designer of this project, performed some of the experiments, completed manuscript writing and submission, and rebuttal.
Y. Nie, K. Wu, J-H. Yang, F. Tian, D. Fan. Induction of T lymphocytes specific to gastric cancer using HLA-A matched allogeneic gastric tumor cells. J. Immunotherapy (2003) 26(5) 403-411.
J. Wu, Y. Shi, K. Wu, D. Zhang, J-H Yang, D. Fan, Angiostatin up-regulation in gastric cancer cell SGC7901 inhibits tumorigenesis in nude mice. World J Gastroenterology (2003) 9(1): 59-64.
Jing-Hua Yang, Yongzhan Nie, Qingchuan Zhao, Yingjun Su, Marc Pypaert, Haili Su and Reuven Rabinovici. Intracellular Localization of Differentially Regulated ADAR1 Isoforms in Inflammation. J.Biol.Chem. (2003) 278(46):45833-42
Annotation: As the first and corresponding author, I performed some of the experiments and guided the completion of this project.
Yongzhan Nie, Kaichun Wu and Jing-Hua Yang*. Specific cytolysis of tumor cells by xenogenically activated human serum. Clin. Cancer Res.
Annotation: This paper is accepted but held for publication due to a patent application process. I am the corresponding author of this paper.
Yongzhan Nie, Qingchuan Zhao, Yingjun Su and Jinghua Yang* Subcellular distribution of ADAR1 isoforms is synergistically determined by three nuclear discrimination signals and a regulatory motif. J.Biol.Chem. (2004) 279 (13):13249-55.
Shuli Xia, Jing-Hua Yang*, Enbo Ma, Kevin White and Yingyi Xiao and Gabriel Haddad*. Identification of the new targets of Drosophila pre-mRNA deaminase. Physiological Genomics 2005, 20;20(2):195-202
Nie, Y. Ding, L. Kao, P. N. Braun, R. Yang, Jjinghua* ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing. Mol Cell Biol (2005) 25 (16) 6956-63
Yongzhan Nie, Graeme L. Hammond, & Jing-Hua Yang1* Double-stranded RNA editase ADAR1 increases susceptibility to viral infection. (J. Virology, 2007).
1) Nassim Usman, Robert Cedergren, J.P. Perreault, Jing-Hua
Yang, Alexander Rich. The Nuceozyme I;
2) Nassim Usman, Alexander Rich, Robert Cedergren, J.P. Perreault, Jing-Hua Yang. The Nuceozyme II; US Patent 6,140,491 (2000).
3) Nassim Usman, Robert Cedergren, J.P. Perreault, Jing-Hua Yang, Alexander Rich. The Nuceozyme III; US Patent 6,713,456 (2003).
in "Practical Protocols In Molecular Biology", Jing-Hua
Yang, RNA Synthesis and Processing, (1996). Science Press &
Science Press New Yok, Ltd.,
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