Welcome to Yang Lab            

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Jinghua YANG, Ph.D.

Associate Professor
Director

Surgical Oncology Laboratory

Clinic Proteomics Facilities

Boston VA Medical Center

Boston University School of Medicine

 

670 Albany St. Pathology 404 

Boston, MA 02118

Tel: (617) 414-7075   

jyang@bu.edu     

 

150 S. Huntington Ave. 1A-320

Boston, MA 02130 

Tel: (857) 364-5611

Fax: (857)364-5627 

Jinghua.yang@va.gov

 

 

Current/former laboratory members:

Bingguan Chen (Lab Manager); John Cao

 

Zhou FEI, Visiting Scholar

 

Yong Liu, Postdoc

 

Yongzhan Nie, Yingjun Su, Fanmin Zhang, Haili Su

 

Dexin Zhang, Xiaoxing Luo, Meihong Chen, Koroush Kabir, Qingchuan Zhao, Jinghua Yang

 

 

Research project 1   

 

dsRNA & dsRNA-binding Proteins

We are studying the biological function of dsRNA and dsRNA-binding proteins. These include the dsRNA editing enzyme ADAR1, ADAR2 and ADAR3.    ADAR1 is ubiquitously expressed particularly in immune organs; ADAR2 is found in all tissues but dominant in neuronal system; and ADAR3 is exclusively in the brain.  Currently our interest is focused on the function of ADAR1 in viral infection/stress, and ADAR2 in traumatic stress.

 

Research project 2

 

Clinic Proteomics

 

Our laboratory is pleased to provide facilities to investigators of Boston University Medical Campus and Boston VA Medical Center in clinic application of proteomics with expert, accurate, and collaborative interactions.  These include i) Fluorescence-assistant Autoimmune Display (FaAD) to identify autoimmune responses against tumors, infectious diseases and autoimmune diseases, ii)  Differential Gel Electrophoresis (DiGE) to identify differentially expressed proteins in blood/tissue samples, iii) Fluorescence-assistant Multi-dimensional HPLC (FaMD-HPLC) to differentially profile protein expression in patient biopsies, iv) LC-MALDI-TOF and nanoLC-Q-TOF (LC-MS/MS) for protein identification, protein profiling, and marker discovery, and v) Liquid protein array (xMAP from Luminex) to validate protein markers in patients.

 

 

  Research project 3

 

  Tumor Immunology

Another focus of our laboratory is to identify the tumor specific complement activator (tsCA).  This factor is found to activate human complement to kill different tumor cells in vitro.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Jinghua on Tom’s birthday

 

 

The RNA group on Tom Maniatis’ 60th birthday

 

James Waston on Tom’s birthday