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Schwarzschild MA, Xu K, Oztas E, Petzer JP, Castagnoli K, Castagnoli Jr. N, Chen J-F (2003). Neuroprotection by Caffeine and More Specific A2A Receptor Antagonists in
Animal Models of Parkinsonís Disease. Neurology 61(suppl.6) ss55-s61 (PDF)

Chen J-F, Fredduzzi S, Bastia E, Yu L-Q, Moratalla R, Ongini E, Schwarzschild MA (2003)
Adenosine A2A receptors in neuroadaptation to repeated dopaminergic stimulation:
implications for the treatment of dyskinesia in Parkinsonís disease. Neurology 61(suppl.6) s74-s81 (PDF)

Castagnoli, Jr. N, Petzer JP, Steyn S, Castagnoli KP, Chen J-F, Schwarzschild MA, Van der Schyf CJ (2003) Monoamine Oxidase B Inhibition and Neuroprotection:
Studies on Selective A2A Adenosine Receptor Antagonists. Neurology 61(suppl.6) s62:s68

Day Y-J, Huang L, McDuffie MJ, Rosin D, Ye H, Chen J-F, Schwarzschild, Fink JS, Linden J, Okusa MD (2003) Renal protection from ischemia mediated by A2A adenosine receptors on hematopoietic cells. Journal of Clinical Investigation 112:883-91

Bibbiani F, Oh JD, Petzer JP, Castagnoli, N. Jr, Chen J-F, M.A. Schwarzchild. Chase TN, MD (2003)
A2A antagonists prevents dopamine agonist-induced motor complications in
an animal model of Parkinsonís disease. Experimental Neurology 184:285-94 (PDF)

Fink JS, Kalda A, Ryu H, Stack EC, Schwarzschild MA, Chen J-F*, Ferrante RJ* (2003)
Genetic and pharmacological inactivation of the adenosine A2A receptor attenuates
3-nitropropionic acid-induced striatal damage.
J. Neruoschem. 88:538-544 (*corresponding author) (PDF)

Yu L, Fithin M, Peterfreund RA, Gerean T, Schwarzschild MA, Weng Z, Fink JS, Chen J-F (2004) Identification of alternative promotors with multiple new exons for the adenosine A2A receptor gene by molecular and bioinformatics analyses. Mol. Brain Res. 1000:156-173(PDF)

Chen J-F (2004)
The adenosine A2A receptor as an attractive target for Parkinsonís disease treatment. Drug News Perspective 16:597604.(PDF)

Frith MC, Fu Y, Yu L, Chen J-F, Hansen U, Weng Z. (2004)
Detection of functional DNA motifs via statistical over-representation.
Nucleic Acids Research. 32:1372-81 (PDF)

Lukashev D, Ohta A, Apasov S, Chen J-F, Sitkovsky M (2004)
Physiological attenuation of proinflammatory transcription by the Gs protein-coupled
A2A adenosine receptor in vivo. Journal Immunology 173:21-24 (PDF)

Yu L, Huang Z-H, Mariani J, Wang Y, Moskowitz M, Chen J-F (2004)
Selective inactivation or reconstitution of adenosine A2A receptors in bone marrow cells
reveals their critical role in the development of ischemic brain injury. Nature Medicine 10:1081-1087. (PDF)

Lopes LV, Halldner L, Rebola N, Johansson B, Ledent C, Chen JF, Fredholm BB, Cunha RA. (2004)
Binding of the prototypical adenosine A(2A) receptor agonist CGS 21680 to the
cerebral cortex of adenosine A(1) and A(2A) receptor knockout mice.
British Journal of Pharmacology. 141:1006-14. (PDF)

Stevens B, Ishibashi T, Chen J-F, Fields RD (2004)
Adenosine: an activity-dependent axonal signal regulating MAP kinase and proliferation in developing Schwann cells. Neuron Glia Biology 1:23-34.

Bastia E, Xu Y-H, Scibelli A, Day Y-J, Linden J, Chen J-F, Schwarzschild MA(2004)
Amphetamine sensitization requires brain adenosine A2A receptor activation.
Neuropsychopharmacology 30(5):891-900(PDF)

Yaar R, Jones MR, Chen J-F, Ravid K (2005)
Animal models for the study of adenosine receptor function. Journal Cellular Physiology 202:9-20 (PDF)

Fredholm BB, Chen J-F, Masino SA, Vaugeois J-M (2005)
Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs.
Annual Review of Pharmacology & Toxicology. 45:385-412 (PDF)

Huang Z. L., Qu W. M., Eguchi N., Chen J-F., Schwarzschild M. A., Fredholm B. B., Urade Y, Hayaishi O (2005)
Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine.
Nature Neuroscience. 8:858-859. (PDF)

Fredholm BB, Chen J-F, Cunha R, Svenningsson P, Vaugeois J-M (2005)
Adenosine and brain function. International Review of Neurobiology. 63:191-270

Yu L, Haverty P, Mariani J, Schwarzschild MA, Weng Z, Chen J-F (2005)
Egr-2-mediated transcriptional regulatory network in striatum by genetic and
pharmacological inactivation of the adenosine A2A receptor
as revealed by microarray and bioinformatics analyses.
Physiology Genomics 23(1):89-102 (PDF)

Saura J, Angulo E, Ejarque A, Casado V, Tusell JM, Moratalla R, Chen J-F, Schwarzschild MA, Lluis C, Franco R, Serratosa J (2005)
Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia.
Journal of Neurochemistry 95(4):919-29

Xu K, Xu Y-H, Brown-Jermyn D, Chen J-F, Ascherio A, Dluzen DE, Schwarzschild MA (2005)
Neuroprotection by caffeine is prevented by estrogen in the mouse MPTP model of Parkinsonís disease. Journal of Neuroscience 26:535-41 (PDF)

Tebano MT, Martire A, Rebola N, Pepponi R, Domenici MR, Gro MC, Schwarzschild MA, Chen JF, Cunha RA, Popoli P (2005).
Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and
functionally interact in the hippocampus: a possible key mechanism in the
modulation of N-methyl-D-aspartate effects. Journal of Neurochemistry. 95:1188-200 (PDF)

Saura J, Angulo E, Ejarque A, Casado V, Tusell JM, Moratalla R, Chen JF, Schwarzschild MA, Lluis C, Franco R, Serratosa J. (2005)
Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia.
Journal of Neurochemistry. 95:919-29

Shen H-Y, He J-C, Wang Y, Huang Q-Y, Chen J-F (2005)
Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice. Journal of Biological Chemistry 280:39962-39969. (PDF)

Yu L-Y, Schwarzschild MA, Chen J-F (2005)
Cross-sensitization between Caffeine- and L-dopa-induced Behaviors in Hemiparkinsonian Mice. Neuroscience Letters 393:31-35 (PDF)

Kachroo A, Orlando LR, Grandy DK, Chen J-F, Young AB, Schwarzschild MA (2005)
Interactions between glutamate mGlu5 and adenosine A2A receptors in normal and parkinsonian mice. Journal of Neuroscience 25:10414-10419 (PDF)

Bilbao A, Cippitelli A, Martin AB, Granado N, Ortiz O, Bezard E, Chen JF, Navarro M, Rodriguez de Fonseca F, Moratalla R. (2006)
Absence of quasi-morphine withdrawal syndrome in adenosine A2A receptor knockout mice. Psychopharmacology (Berl). 185:160-168.

Lee H, Kim M, Joo JD, Gallos G, Chen JF, Emala CW. (2006)
A3 Adenosine Receptor Activation Decreases Mortality, Renal and Hepatic Injury in Murine Septic Peritonitis. Am J Physiol Regul Integr Comp Physiol. 291(4):R959-69.

Kalda A, Yu L-Y, Emin Oztas E,Chen, J-F (2006)
Novel neuroprotection by caffeine and adenosine A2A receptor antagonists in
animal models of Parkinson's disease. Journal of Neurological Science 248:9-15 (PDF)

Seeman P, Schwarz J, Chen JF, Szechtman H, Perreault M, McKnight GS, Roder JC, Quirion R, Boksa P, Srivastava LK, Yanai K, Weinshenker D, Sumiyoshi T. (2006)
Psychosis pathways converge via D2(High) dopamine receptors. Synapse. 60:319-346. (PDF)

Huang Q-Y, Wei C, Yu L-Q, Coelho J.E, Shen H-Y, Kalda A, Linden J, Chen J-F (2006)
Adenosine A2A receptors in bone marrow-derived cells but not in forebrain neurons are important contributors to 3-nitropropionic acid-induced striatal damage as revealed
by cell-type selective inactivation. Journal of Neuroscience. 26(44):11371-8 (PDF)

Chan ES, Montesinos MC, Fernandez P, Desai A, Delano DL, Yee H, Reiss AB, Pillinger MH, Chen JF, Schwarzschild MA, Friedman SL, Cronstein BN (2006)
Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis. British Journal of Pharmacology. 148:1144-55

Ohta A, Gorelik E, Prasad SJ, Ronchese F, Lukashev D, Wong MK, Huang X, Caldwell S, Liu K, Smith P, Chen JF, Jackson EK, Apasov S, Abrams S, Sitkovsky M.(2006)
A2A adenosine receptor protects tumors from antitumor T cells.
Proc Natl Acad Sci U S A. 103:13132-13127

Chan ES, Fernandez P, Merchant AA, Montesinos MC, Trzaska S, Desai A, Tung CF, Khoa DN, Pillinger MH, Reiss AB, Tomic-Canic M, Chen JF, Schwarzschild MA, Cronstein BN. (2006)
Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts
and in a murine model of scleroderma. Arthritis Rheum. 54:2632-42.

Schwarzschild MA, Agnati L, Fuxe K, Chen JF, Morelli M.(2006)
Targeting adenosine A(2A) receptors in Parkinson's disease.
Trends in Neuroscience. 29(11):647-54.

Xiao D, Bastia E, Xu YH, Benn CL, Cha JH, Peterson TS, Chen JF, Schwarzschild MA. (2006)
Forebrain adenosine A2A receptors contribute to L-3,4-dihydroxyphenylalanine-induced dyskinesia in hemiparkinsonian mice. Journal of Neuroscience. 26(52):13548-55. (PDF)

Huang Q-Y, Yu L-Q, Ferrante RJ, Chen J-F (2007)
Mutant SOD1G93A in bone marrow-derived cells exacerbates 3-nitropropionic acid induced striatal damage in mice. Neuroscience Letter. 418(2):175-80(PDF)

Kalda A, Heidmets L-T, Shen H-Y, Zharkovsky A, Chen J-F (2007)
Histone Deacetylase Inhibitors Modulate the Induction and Expression of
Amphetamine-induced Behavioral Sensitization Partially Through an
Environment Association Learning in Mice. Behavioral Brain Research. 181(1):76-84.

Haschemi A, Wagner O, Marculescu R, Wegiel B, Robson SC, Gagliani N, Gallo D, Chen J-F, Fritz H. Bach FH, Leo E. Otterbein, LE (2007)
Cross Regulation of Carbon Monoxide and The Adenosine A2A Receptor in Macrophages. Journal of Immunology. 178(9):5921-9 (PDF)

Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC. (2007)
Adenosine Generation Catalyzed by CD39 and CD73 Expressed on Regulatory T cells
Mediates Immune Suppression. Journal of Experimental Medicine 204:1257-1265 (PDF)

Cunha RA, Chen J-F, Sitkovsky MV(2007)
Opposite modulation of peripheral inflammation and neuroinflammation by adenosine A2A receptors.

Coelho JE, Shen H-Y, Kenneth Roy Goldstein KR, Chen J-F (2007)
What animal models have taught us about adenosine receptor function. Current Opinion in Medicinal Chemistry 7:328-340 (PDF)

Chen J-F, Sonsalla P, Pedata F, Melani A, Domenici MR, Popoli P, Geiger J, Lopes LV, de MendonÁa, A (2007)
Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multi-faced actions
and ďfine tuningĒ modulation. Progress in Neurobiology. (in press)

Yu L-Y, Huang Q-Y, Rebola N, Shen H-Y, Rapp EK, Day Y-J, Ferrara J, Coelho J, Canas PM, Huang Z-H, Taylor D, Moskowitz M, Schwarzschild MA, Linden J, Cunha RA, Chen J-F (2006)
Adenosine A2A receptors modulate psychomotor activity and acute brain injury by distinct cellular mechanisms (revision, Annual Neurology)

© 2007. Molecular Neuropharmacology Lab at BU School of Medicine . All Rights Reserved.
Comments and questions to
Yu Chen.