Definition:
Mild oxidation of primary and secondary alcohols, promoted by oxalyl chloride activation of dimethyl sulphoxide.
Frequency of appearance:
This bar graph represents all of the online articles that were found to contain this specific name reaction in the title of the article. Tetrahedron letters, Tetrahedron, Synthetic letters, Synthesis, Journal of Organic Chemistry and Journal of the American Chemical Society are represented here. This table by no means represents the periodicity of the name reaction found in the literature.
Original References:
- Mancuso, A.J.; Swern, D. Synthesis, 165-185 (1981).
- Omura, K., Swern, D., Tetrahedron 34, 1651 (1978).
Recent academic references: Click here for more references
- A Lactone-Based Strategy Applied to the Total Synthesis of (8S,21S,22S,23R)- and (8R,21S,22S,23R)-Okinonellin B
- Schmitz, W.D.; Messerschmidt, N.B.; Romo, D.* J. Org. Chem., 1998, 63, 2058-2059.
- Modification of the Swern Oxidation: Use of a Soluble Polymer-Bound, Recyclable, and Odorless Sulfoxide
- Harris, J. M.; Liu, Y.; Chai, S.; Andrews, M. D.; Vederas, J. C.;
J. Org. Chem.; 1998; 63(7); 2407-2409.
Recent process papers:
- Process Development in the Synthesis of the ACE Intermediate MDL 28,726
- Horgan, S. W.; et alOrg. Process Res. Dev.; 1999; 3(4); 241-247.
- Development of a Large-Scale Process for an HIV Protease Inhibitor
- Liu, C.; Ng, J. S.; Behling, J. R.; Yen, C. H.; Campbell, A. L.; Fuzail, K. S.; Yonan, E. E.; Mehrotra, D. V.; Org. Process Res. Dev.; 1997; 1(1); 45-54.
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