Introduction:
Condensation of aldehydes or ketones with organozinc derivatives of a-halo esters to yield ß-hydroxy esters:
Frequency of appearance:
This bar graph represents all of the online articles that were found to contain this specific name reaction in the title of the article. Tetrahedron letters, Tetrahedron, Synthetic letters, Synthesis, Journal of Organic Chemistry and Journal of the American Chemical Society are represented here. This table by no means represents the periodicity of the name reaction found in the literature.
Original reference:
- Reformatsky, S. Ber. 20, 1210 (1887).
Recent academic references: Click here for more references
- Highly Diastereoselective Reformatsky-Type Reaction Promoted by Tin Iodide Ate Complex
- Shibata, I.; Suwa, T.; Sakakibara, H.; Baba, A.; Org. Lett.; 2002; 4(2); 301-303.
- Expedient, Stereocontrolled Synthesis of (+)-Compactin Lactone via Intramolecular Reformatsky Reaction
- Reddy, P. P.; Yen, K.-F.; Uang, B.-J.; J. Org. Chem.; 2002; 67(3); 1034-1035.
- Rhodium-Catalyzed Reformatsky-Type Reaction
- Kanai, K.; Wakabayashi, H.; Honda, T.; Org. Lett.; 2000; 2(16); 2549-2551.
Recent process references:
- Process Development on (3S,4S)-[(R)-1'-((tert-Butyldimethylsilyl)oxy)ethyl] 4-[(R)-1-carboxyethyl]-2-azetidinone: 1--Methylcarbapenem Key Intermediate
- Lu, X.; Xu, Z.; Yang, G.; Fan, R.; Org. Process Res. Dev.; 2001; 5(2); 186-188.
- Process Development of Voriconazole: A Novel Broad-Spectrum Triazole Antifungal Agent
- Butters, M.; Ebbs, J.; Green, S. P.; MacRae, J.; Morland, M. C.; Murtiashaw, C. W.; Pettman, A. J.; Org. Process Res. Dev.; 2001; 5(1); 28-36.
Mechanism:
Scope and Limitations:
Synonyms: