Definition:
The alkylation or acylation of aromatic compounds catalyzed by aluminum chloride or other Lewis acids:
Frequency of appearance:
This bar graph represents all of the online articles that were found to contain this specific name reaction in the title of the article. Tetrahedron letters, Tetrahedron, Synthetic letters, Synthesis, Journal of Organic Chemistry and Journal of the American Chemical Society are represented here. This table by no means represents the periodicity of the name reaction found in the literature.
Original references:
- C. Friedel, J. M. Crafts, Compt. Rend. 84, 1392, 1450 (1877).
Recent academic references: Click here for more references
- The First Intermolecular Friedel-Crafts Acylation with b-Lactams
- Anderson, K. W.; Tepe, J. J.; Org. Lett.; 2002; 4(3); 459-461.
- 1-Dodecyloxy-4-perfluoroalkylbenzene as a Novel Efficient Additive in Aldol Reactions and Friedel-Crafts Alkylation in Supercritical Carbon Dioxide
- Komoto, I.; Kobayashi, S.; Org. Lett.; 2002; 4(7); 1115-1118.
- Acylation of Indole under Friedel-Crafts Conditions-An Improved Method To Obtain 3-Acylindoles Regioselectively
- Ottoni, O.; et al.,Org. Lett.,; 2001; 3(7); 1005-1007.
Recent process papers:
- Automated Process Research. An Example of Accelerated Optimization of the Friedel-Crafts Acylation Reaction, a Key Step for the Synthesis of Anti-HIV (+)-Calanolide A
- Zhang, J.; Kirchhoff, E. W.; Zembower, D. E.; Jimenez, N.; Sen, P.; Xu, Z.-Q.; Flavin, M. T.;
Org. Process Res. Dev.; 2000; 4(6); 577-580.
- Industrially Viable Alternative to the Friedel-Crafts Acylation Reaction: Tamoxifen Case Study
- Smyth, T. P.; Corby, B. W.; Org. Process Res. Dev.;1997; 1(4); 264-267.
Mechanism:
Scope and Limitations:
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