JASON T. LOWE

Brookline, MA 02445

 

 

Objective                  Research position in pharmaceutical industry that provides opportunity for independent research development and career growth

 

Education

2002 – present              Ph.D. Candidate in Organic Chemistry, Boston University

1999 – 2001                  M.S. in Organic Chemistry, University of Rhode Island, Kingston, RI

1994 – 1998                  B.A. in Chemistry and Geology, University of Rhode Island, Kingston, RI

 

Research Experience

2002 – present              Ph.D. thesis research with Professor James S. Panek, Boston University

-        Synthesized three natural products:  kendomycin (in progress), bistramide A (completed), and neopeltolide (completed)

-        Developed methodology for expanding the scope of Panek Group’s [4+2]-annulation chemistry

1999 – 2001                  Masters research with Professor William Rosen, U. of Rhode Island

-        Explored the utility of dipotassium nitroacetate as a viable nucleophilic reagent

1998 – Summer             Lawrence Livermore National Laboratory internship

-        Attended Actinide Sciences Summer School Program, sponsored by the Department of Energy, supported education in the fields of experimental Nuclear and Radio Chemistry

1998 – Spring                Sensors and Surface Technology Fellowship, U. of Rhode Island

-        Investigated structural manipulations of an electrically conductive polymer

1997 – Summer             Department of Energy Nuclear Chemistry Field Camp, San Jose State University

-        Studied and applied theoretical and laboratory techniques in Nuclear and Radio Chemistry

1997 – Spring                Pfizer Student Fellowship Award, U. of Rhode Island,

-        Investigated the nitration of simple organic compounds using ultrasound

 

Work Experience

2000 – 2002                  Rhodes Technologies (subsidiary of Purdue Pharmaceutical) Coventry, RI

-        Research and development chemist responsible for synthesis and scale-up of a variety of pharmaceutical intermediates

 

Publications

 

  1. Total Synthesis and Biological Evaluation of a 35-Member Stereoisomer Library of Bistramide A. Design and Preparation of Chiral Organosilanes as Reagents in Natural Product Synthesis: Wrona, I. E.; Lowe, J. T.; Panek, J. S. J. Am. Chem. Soc. 2007 (Manuscript in Preparation).
  2. Synthesis of a Select Set of Stereoisomers of Bistramide A. Probing Actin Skeleton Dynamics: Lowe, J. T.; Wrona, I. E.; Beignet, J.; Panek, J. S. Angew. Chem., Int. Ed. 2007 (Manuscript in Preparation).
  3. Total Synthesis and Stereochemical Reassignment of (+)-Neopeltolide: Youngsaye W.; Lowe, J. T.; Pohlki, F.; Ralifo, P.; Panek, J. S. Angew. Chem., Int. Ed. 2007, 46, 9211.
  4. Ruthenium (III) Chloride (RuCl3): Lowe, J. T. Synlett 2007, 12, 1974.
  5. Total Synthesis of Bistramide A: Lowe, J. T.; Wrona, I. E.; Panek, J. S. Org. Lett. 2007, 9, 327.
  6. Mild Reductive Opening of Aryl Pyranosides Promoted by Scandium (III) Triflate: Qin, H. Lowe, J. T.; Panek, J. S. J. Am. Chem. Soc. 2007, 129, 38.
  7. A Convenient Multi-Gram Synthesis of Highly Enantioenriched Methyl 3-Silyl Glycidates: Lowe, J. T.; Youngsaye, W.; Panek, J. S. J. Org. Chem. 2006, 71, 3639.
  8. Synthesis and [4+2]-Annulation of Enantioenriched (Z)-Crotylsilanes: Preparation of the C1-C13 Fragment of Bistramide A: Lowe, J. T.; Panek, J. S. Org. Lett 2005, 7, 3231.
  9. Stereocontrolled [4+2]-Annulation Accessing Dihydropyrans: Synthesis of the C1a-C10 Fragment of Kendomycin: Lowe, J. T.; Panek, J. S. Org. Lett 2005, 7, 1529.
  10. Se,Se'-Diphenyl carbonodiselenoate: preparation and characterization of its molecular structure and thermal reactivity. Lowe, J.T.; Chandrasekaran, A.; Day, R.O.; Rosen, W. Chem. Comm. 2001 15, 1390.

 

Accomplishments and Awards

Present        Merck Graduate Fellowship Winner 2007-2008

                    Division of Organic Chemistry, Fellowship Winner 2006-2007.

                    http://www.organicdivision.org/fellowship_awardee_bios_05.html#Lowe

                    Created (and maintain) Panek Group website. http://people.bu.edu/panek/

                    Created name reactions website to assist undergraduate/graduate students with basic organic transformations

                    http://people.bu.edu/jaylowe/Named%20reactions/Named%20reactions.htm

1997             “Student of the Year” in chemistry and Chemistry Department Representative, U. of Rhode Island

1994           Freshmen class president, Castleton State College