We are interested in the dynamic behavior of glutamate receptors, which mediate neuronal communication in the brain and serve as the molecular substrates for higher brain function (learning, memory, cognition) and dysfunction (neurotoxicity, neurodegeneration, drug addiction and psychiatric disorders).
Alterations in AMPAR localization and turnover are critical mechanisms underpinning synaptic plasticity and higher brain functions.
Homeostatic plasticity is a compensatory regulation in neuronal activity, which is crucial for the maintenance of neuronal and neural circuit stability.
Autism Spectrum Disorder gene mutations discovered in humans have consistently revealed aberrant synaptic function.
The bioenergy sensor, AMPK, plays a crucial role in the regulation of axon initiation, which is crucial for neural network wiring and information processing in the brain.