James Gilbert and Heng-Ye Man (2016)
The X-linked autism protein KIAA2022/KIDLIA regulates neurite outgrowth via N-cadherin and δ-catenin signaling, eNeuro, 10.1523.

Li-Jun Li, Rong Hu, Brendan Lujan, Juan Chen, Jian-Jian Zhang, Yasuko Nakano, Tian-Yuan Cui, Ming-Xia Liao, Jin-Cao Chen, Heng-Ye Man, Hua Feng, Qi Wan (2016)
Glycine Potentiates AMPA Receptor Function through Metabotropic Activation of GluN2A-containing NMDA Receptors, Front. Mol. Neurosci, 10.3389.

Canal M, Martín-Flores N, Pérez-Sisqués L, Romaní-Aumedes J, Altas B, Man HY, Kawabe H, Alberch J, Malagelada C (2016)
Loss of NEDD4 contributes to RTP801 elevation and neuron toxicity: implications for Parkinson's disease, Oncotarget, 10.18632.

Richie E. Kohman, Susie S. Cha, Heng-Ye Man, Xue Han (2016)
Light-Triggered Release of Bioactive Molecules from DNA Nanostructures, Nano Letters, 16(4):2781-2785.


Gauthier JM, Lin A, Nic Dhonnchadha BÁ, Spealman RD, Man HY, Kantak KM (2015)
Environmental enrichment facilitates cocaine-cue extinction, deters reacquisition of cocaine self-administration and alters AMPAR GluA1 expression and phosphorylation, Addict Biol, In press

Qingming Hou, Hongyu Ruan, James Gilbert, Guan Wang, Qi Ma , Wei-Dong Yao and Heng-Ye Man (2015)
MicroRNA miR124 is required for the expression of homeostatic synaptic plasticity, Nature Communications, 6:10045.

Y S Xiong, F F Liu, D Liu, H Z Huang, N Wei, L Tan, J G Chen, H Y Man, C X Gong, Y M Lu, J Z Wang and L Q Zhu (2015)
Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway. Aging Cell, 14(5): 867-877.

Yuda Huo, Natasha Khatri, Qingming Hou, James Gilbert, Guan Wang and Heng-Ye Man (2015)
The deubiquitinating enzyme (DUB) USP46 regulates AMPA receptor deubiquitination and trafficking. J Neurochemistry, 134(6):1067-80.

Luwen Ning#, Zhoufang Li#, Guan Wang#, Wen Hu#, Qingming Hou, Yin Tong, Meng Zhang, Yao Chen, Li Qin, Xiaoping Chen, Heng-Ye Man†, Pinghua Liu†, Jiankui He† (2015) (# Co-first authors; † Co-correspondence authors)
Quantitative assessment of single-cell whole genome amplification methods for detecting copy number variation using hippocampal neurons. Scientific Reports, 5:11415.

Guan Wang, Stephen Amato, James Gilbert and Heng-Ye Man (2015)
Resveratrol Up-regulates AMPA Receptor Expression via AMP-activated protein kinase-mediated Protein Translation. Neuropharmacology, 95: 144-153.

Liu D, Wei N, Man HY, Lu Y, Zhu LQ, Wang JZ (2015)
The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling. Cell Death & Differentiation, 22:583-596.



Amy Lin and Heng-Ye Man (2014)
Endocytic adaptor epidermal growth factor receptor substrate 15 (Eps15) is involved in the trafficking of ubiquitinated a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. JBC, 289: 24652-24664.

James Gilbert and Heng-Ye Man (2014) (Review)
Translational dysregulation in autism. Cell Dev Biol, 3:2.



Natasha Khatri and Heng-Ye Man (2013) (Review)
Synaptic activity and bioenergy homeostasis: implications in brain trauma and neurodegenerative diseases., Frontiers in Neurology, 4:199.

Van Maldergem L, Hou Q, Kalscheuer VM, Rio M, Doco-Fenzy M, Medeira A, de Brouwer AP, Cabrol C, Haas SA, Cacciagli P, Moutton S, Landais E, Motte J, Colleaux L, Bonnet C, Villard L, Dupont J, Man HY (2013)
Loss of function of KIAA2022 causes mild to severe intellectual disability with an autism spectrum disorder and impairs neurite outgrowth. Human Molecular Genetics , 22(16): 3306-3314.

M.M.H. Ellabaan, Y.S. Ong, S.D. Handoko, C.K. Kwoh, and H. Y. Man (2013)
Discovering unique, low-energy transition states of small, non-cyclic molecules using evolutionary molecular memetic computing. IEEE Comptuational Intelligence, 3: 54-63.

Amy Lin and Heng-Ye Man (2013) (Review)
Ubiquitination of neurotransmitter receptors and postsynaptic scaffolding proteins. Neural Plasticity, 2013: 432057.

BÁ Nic Dhonnchadha, A Lin, KA Leite-Morris, GB Kaplan, HY Man and KM Kantak (2013)
Alterations in expression and phosphorylation of GluA1 receptors following cocaine-cue extinction learning. Behavioural Brain Research, 238: 119-123.



Qingming Hou and Heng-Ye Man (2012)
Input-specific homeostatic regulation of AMPA receptor accumulation at central synapses. Communicative & Integrative Biology, 2012, 5 (6).

Heng-Ye Man (2012) (Editorial)
The sodium pump: novel functions in the brain, Biochemistry and Analytical Biochemistry, 2012, 1: e116.

Hakryul Jo, Mondal, Subhanjan, Dewar Tan, Eiichiro Nagata, Alok K. Sharma, Qingming Hou, Kumaran Shanmugasundaram, Joe Tung, Alexander O. Tejeda, Heng-Ye Man, Alan C. Rigby, Hongbo R. Luo (2012)
Small molecule- induced cytosolic activation of Akt rescues ischemia-induced neuronal death, Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (26): 10581-10586.

Katrina Foo, Laura Blumenthal and Heng-Ye Man (2012)
Regulation of neuronal bioenergy homeostasis by glutamate, J Neurochem Int., 2012, 61: 389-396.

Nic Dhonnchadha BA, Lovascio BF, Shrestha N, Lin A, Leite-Morris KA, Man HY, Kaplan GB, Kantak KM (2012)
Changes in expression of c-Fos protein following cocaine-cue extinction learning, 2012, Behav Brain Res. 234: 100-106.

Heng-Ye Man, Xin-Ming Ma (2012) (Invited Editorial Highlight)
A role for neuroserpin in neuron morphological development, J Neurochem, 2012, 121(4):495-6.

Guan Wang, James Gilbert and Heng-Ye Man (2012) (Invited Review)
AMPA Receptor Trafficking in Homeostatic Synaptic Plasticity: Functional Molecules and Signaling Cascades, Neural Plasticity, Vol. 2012: 825364.

M. Ellabaan, Y. S. Ong, S. D. Handoko, C.K. Kwoh, S. Bahnassy, and H.Y. Man (2012)
A Tree-structured Covalent-bond-driven Molecular Memetic Algorithm for Optimization of Ring-deficient Molecules. Computers and Mathematics with Applications, 2012, 64(12): 3792-3804.

Larissa Jarzylo and Heng-Ye Man (2012)
Parasynaptic NMDA receptor signaling couples neuronal glutamate transporter function to AMPA receptor synaptic distribution and stability. J Neurosci, 32(7):2552-2563.

James Gilbert, Guan Wang and Heng-Ye Man (2012) (Book chapter)
Homeostatic synaptic plasticity: cellular mechanisms and implications in neurological diseases. in Book ''Synaptic Plasticity: Cell Biology, Regulation and Role in Disease'', Nova Science Publishers, Inc.

Steve Amato and Heng-Ye Man (2012) (Invited Review)
AMPK signaling in neuronal polarization: putting the brakes on axonal traffic of PI3-Kinase. Communicative and Integrative Biology, volume 5, issue 2.



Qingming Hou, James Gilbert and Heng-Ye Man (2011)
Homeostatic regulation of AMPA receptor trafficking and degradation by light-controlled single synaptic activation. Neuron. 72(5): 806-818.

Stephen Amato, Xiuxin Liu, Bin Zheng, Lewis Cantley, Pasko Rakic and Heng-Ye Man (2011)
AMP-Activated Protein Kinase Regulates Neuronal Polarization by Interfering with PI 3-Kinase Localization. Science. 332(6026): 247-51.

Stephen Amato and Heng-Ye Man (2011, Review)
Bioenergy sensing in the brain: the role of AMP-activated protein kinase in neuronal metabolism, development and neurological diseases. Cell Cycle. Volume 10, Issue 20.

Stephen Amato and Heng-Ye Man (2011, Review)
AMPK links cellular bioenergy status to the decision making of axon initiation in neurons. Cellular Logistics. 1(3): 103-105.

Amy Lin, Qingming Hou, Larissa Jarzylo, Steve Amato, James Gilbert, Fu Shang, Heng-Ye Man (2011)
Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking. J Neurochemistry.119(1):27-39.

Heng-Ye Man (Review) (2011)
GluA2-lacking, calcium-permeable AMPA receptors — inducers of plasticity? Current Opinion in Neurobiology. 21(2): 291-298.


Before 2010

Dawei Zhang, Qingming Hou, Amy Lin, Larissa Jarzylo, Allison Navis, Aram Raissi, Fang Liu, Heng-Ye Man (2009)
Na,K-ATPase Activity Regulates AMPA Receptor Turnover through Proteasome-Mediated Proteolysis. Journal of Neuroscience. 29(14):4498-4511.

Oberlander JG, Lin AW, Man HY, Erskine MS. (2009)
AMPA receptors in the medial amygdala are critical for establishing a neuroendocrine memory in the female rat. Eur J Neurosci., 29(1):146-60.

Qingming Hou, Yunfei Huang, Steve Amato, Solomon H. Snyder, Richard L. Huganir, Heng-Ye Man (2008)
Regulation of AMPA receptor localization in lipid rafts. Molecular and Cellular Neuroscience, 38(2): 213 - 223.

Qingming Hou, Dawei Zhang, Larissa Jarzylo, Richard L. Huganir, Heng-Ye Man (2008)
Homeostatic regulation of AMPA receptor expression at single hippocampal synapses. Proceedings of the National Academy of Sciences of the United States of America, 105(2): 775-80.

Andken BB, Lim I, Benson G, Vincent JJ, Ferenc MT, Heinrich B, Jarzylo LA, Man HY, Deshler JO (2007)
3'-UTR SIRF: a database for identifying clusters of whort interspersed repeats in 3' untranslanted regions. BMC Bioinformatics, 30; 8:274.

Man HY, Sekine-Aizawa Y, Huganir RL (2007)
Regulation of {alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking through PKA phosphorylation of the Glu receptor 1 subunit. Proceedings of the National Academy of Sciences of the United States of America, 104(9):3579-84.

Y Huang, H Y Man, Y Sekine-Aizawa, Y Han, K Juluri, H Luo, J Cheah, C Lowenstein, R L Huganir and S H Snyder (2005)
S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors. Neuron, 46(4):533-40.

H Y Man, Q H Wang, W Y Lu, W Ju, G Amardian, S D’Souza, L D Liu, T P Wong, LE Becker, L Pai, F Liu, MP Wymann, JF MacDonald and YT Wang (2003)
Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons. Neuron, 38(4), 611-624

H Y Lee, K Takamiya, J S Han, H Y Man, C H Kim, G Rumbaugh, S Yu, L Ding, C He, R S Petralia, R J Wenthold, M Gallagher and R L Huganir (2003)
Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell, 112, 631-643

W Y Lu*, H Y Man*, W Ju, W Trimble, Y T Wang and John F MacDonald (2001)
Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons. (* Equal contribution) Neuron, 29, 243–254

R Q Hu, M A Cortez, H Y Man, J Roder, Y T Wang and O C Snead III (2001)
Alteration of GluR2 expression in the rat brain following absence seizures induced by ?-hydroxybutyric acid. Epilepsy Research, 44(1), 41-51

R Q Hu, M A Cortez, H Y Man, J Roder, Z P Jia, Y T Wang and O C Snead III (2001)
Gamma-hydroxybutyric acid-induced absence seizures in GluR2 null mutant mice. Brain Research, 897 (1-2): 27-35

H Y Man, J Lin, W Ju, G Ahmadian, L Liu, L E Becker, M Sheng and Y T Wang (2000)
Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization. Neuron, 25:649-662.

H Y Man, W Ju, G Ahmadian and Y T Wang (2000)
Intracellular trafficking of AMPA receptors in synaptic plasticity (Review). Molecular and Cellular Life Science, 57: 1526-1534

Q Wan, H Y Man, F Liu, J Braunton, H B Niznik, S F Pang, G M Brown and Y T Wang (1999)
Differential modulation of GABAA receptor function by Mel1a and Mel1b receptors. Nature Neuroscience, 2 (5):401-403

H Y Man, E Ted, L E Becker and Y T Wang (1998)
Modulation of baroreflex sensitivity by the state of tyrosine phosphorylation in the brainstem of rat. Brain Research, 792:141-148

Z B Pristupa, F McConkey, F Liu, H Y Man, F J S Lee, Y T Wang and H B Niznik (1998)
Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter. Synapse, 30:79-87

Q Wan, H Y Man, J Braunton, W Wang, M W Salter, L Becker and Y T Wang (1997)
Modulation of GABAA receptor function by tyrosine phosphorylation of b subunits. J Neurosci, 17(13): 5062-5069

Q Wan, ZG Xiong, H Y Man, CA Ackerley, J Braunton, W Y Lu, LE Becker, JF MacDonald, Y T Wang. (1997)
Recruitment of functional GABA(A) receptors to postsynaptic domains by insulin. Nature, 388(6643):686-90






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