PS 333 B1 - Drugs and Behavior
Time:  M, W, F: 2:00-3:00 CAS 316  Instructor:  Prof. Michael Hasselmo, http://people.bu.edu/hasselmo/ 
e-mail: hasselmo@bu.edu (better than calling)  Tel: 353-1397  Office hrs: WF 3-4pm, W10am, Room 105E, 2 Cummington St.  
Prerequisites:  PS 101 only, but Physiol. Psych is helpful.  Text: A Primer of Drug Action (10th Edition)  by Robert M. Julien.  
Grading:	TWO MID-TERM EXAMS  and a FINAL EXAM  each worth 1/3 of grade.  All multiple-choice exams with questions based on lecture materials and reading.  Exam scores posted on PS333 B1 at courseinfo.bu.edu.  Missed exams require medical note for taking make-up exam near end of course (before final).  Attendance is expected at all meetings.  Students should know and understand the CAS Academic Conduct Code available in CAS Rm. 105.  Topic:  Overview of the effect of drugs on neurophysiology and behavior.  Students will learn anatomy and physiology of neurotransmitters, behavioral effects of drugs, and their use in treatment of psychiatric disorders. Lecture notes are distributed via e-mail at regular intervals and before each exam.
Dates:		    Topic:				  	   Reading:  
Sept. 7W	 		Introduction, course overview, sign in students from waiting list				
Sept. 9F			Neuroanatomy and Neuron structure			Chapter 3 
Sept. 12M			Membrane potential				Chapter 3 and handouts
Sept. 14W			Action potentials					handouts
Sept. 16F			Synaptic transmission				handouts
Sept. 19M			Principles of drug action (delivery, lipid solubility)			Chapter 1
Sept. 21W			Drug receptor interaction, metabolism, excretion			Chapter 2
				I.  AMINO ACID NEUROTRANSMITTERS
Sept. 23-F			Brain slice example of excitatory and inhibitory transmission	Chapter 2 
Sept. 26M			Glutamate – AMPA and NMDA receptors			pp. 81-86 (ch3), pp. 613-619 (ch19)
Sept. 28W			GABA, benzodiazepines and barbiturates			Chapter 5
Sept. 30F			Symptoms and treatment of anxiety disorders			Chapter 6, Chapter 17, pp. 540-549 
Oct. 3-M			Alcohol – Effects on GABAA receptor			Chapter 6
Oct. 5W			Summary and review of amino acids			Chapter 4
Oct. 7F			EXAM  #1    (one hour -- all topics covered before this date)
Oct. 10M			Holiday – No class					
Oct. 12W			Marijuana					Chapter 18
				II.  ACETYLCHOLINE.
Oct. 14F			Physiology and anatomy of acetylcholine			pp. 72-74, pp. 432-8
Oct. 17M			Muscarinic drugs, ACh and sleep			pp. 72-74, pp. 432-8
Oct. 19W			ACh and memory			
Oct. 21F			Caffeine					Chapter 8
Oct. 24-M	 		Nicotine 					Chapter 8, pp. 238-9
				III.  CATECHOLAMINES			
Oct. 26W			Anatomy and physiology of catecholamines			pp. 75-78
Oct. 28F 			Anatomy and physiology of catecholamine			Chapter 7, pp. 75-78
Oct. 31M			Parkinson’s disease, cocaine and amphetamines			Chapter 7, pp. 421-432
Nov. 2W			Cocaine and amphetamines, ADHD and Ritalin			Chapter 7, pp. 390-400
Nov. 4F			Schizophrenia – symptoms and treatment			Chapter 11
Nov. 7M			Neurochemical bases of schizophrenia			Chapter 17
Nov. 9W			Typical and atypical antipsychotics			Chapter 17
Nov. 11F			Holiday – classes suspended
Nov. 14M			EXAM  #2    (one hour – on topics covered since Exam #1)
				IV.  SEROTONIN
Nov. 16W			Anatomy and physiology of serotonin			pp. 78-80
Nov. 18F		   Anatomy and physiology of serotonin, Hallucinogens			pp. 78-80
Nov. 21M			Hallucinogens					Chapter 19 
Nov. 23W, 25F	No class – Thanksgiving Holiday			
Nov. 28M			Affective disorders, MAOIs and tricyclic antidepressents			Chapter 9, Chapter 17
Nov. 30W			Selective serotonin reuptake inhibitors			Chapter 9
Dec. 2F			Treatment of bipolar disorder:  lithium			Chapter 10
				V.  NEUROACTIVE PEPTIDES
Dec. 5M	 		Anatomy and physiology and neuropeptides			Chapter 15
Dec. 7W			Opiates and analgesia 				Chapter 15
Dec. 9F			Steriods					Chapter 20
Dec. 12M			Review for final exam				
Dec.     	FINAL EXAM   (one hour – on topics covered since Exam #2 – non-cumulative)   
 The syllabus, course descriptions, handouts created for this course, and all class lectures are copyrighted by Boston University and myself.  Except with respect to enrolled students as set forth below, the materials and  lectures may not be reproduced in any form or otherwise copied, displayed or distributed, nor should works derived from them be reproduced, copied, displayed or distributed without my written permission.  Infringement of the copyright in these materials, including any sale or commercial use of notes, summaries, outlines or other reproductions of lectures, constitutes a violation of the copyright laws and is prohibited.  Students enrolled in the course are allowed to share with other enrolled students  course materials, notes, and other writings based on the  course materials and lectures, but may not do so on a commercial basis or otherwise for payment of any kind. Please note in particular that selling or buying class notes, lecture notes or summaries, or similar materials both violates copyright and interferes with the academic mission of the College, and is therefore prohibited in this class and will be considered a violation of the student code of responsibility that is subject to academic sanctions."