nf-kb.org

REAGENTS

Target genes of NF-kB

Cytokines/Chemokines and their modulators

Immunoreceptors

Proteins involved in antigen presentation

Cell adhesion molecules

Acute phase proteins

Stress response genes

Cell-surface receptors

Regulators of apoptosis

Growth factors, ligands and their modulators

Early response genes

Transcription factors and Regulators

Viruses

Enzymes

Miscellaneous

(*indicates that the gene has a kB site in the promoter but has not clearly been shown to be controlled by NF-kB; or the gene expression is associated with increased NF-kB activity but has not been shown to be a target directly)

Cytokines/Chemokines and their modulators


Gene	Function	Reference	Acc #	Human Gene Name
BAFF	B-cell Activating Factor	Moon & Park , 2007	NM_006573	TNFSF13B
BLIMP-1	B lymphocyte-induced maturation protein-1	Calame, 2008	NM_00198	BLIMP1 /PRDM1
CCL5	T-cell secreted factor	Wickremasinghe et al, 2004	NM_002985	CCL5
CCL15/Leukotactin/ SCYA15	Chemokine for cell attraction	Shin et al, 2005	NM_032965	CCL15
CCL17	Chemokine	Takegawa et al, 2008	NM_002987	CCL17
CCL19	Recruitment of naive T cells to dendritic cells	Pietila et al, 2007	NM_006274	CCL19
CCL20	Ligand of CC chemokine receptor 6	Lee et al, 2008; Battaglia et al, 2007	NM_004591	CCL20
CCL22	Epithelial cell chemokine at mucosa	Nakayama et al, 2004	NM_002990	CCL22
CCL23/SYA23	Monocyte chemokine	Shin et al, 2007	NM_005064	CCL23
CCL28	Chemokine for T-cell attraction	Ogawa et al, 2004	NM_148672	CCL28
CINC-1	Cytokine-induced neutrophil chemoattractant	Blackwell et al, 1994 Ohtsuka et al, 1996	NM_001511	CXCL1
*CXCL 11	Chemokine ligand for CXCR3	Tensen et al, 1999	NM_005409	CXCL11
Eotaxin	beta Chemokine, eosinphil-specific	Hein et al, 1997	NM_001565.	CXCL10
Fractalkine	TNF-induced chemokine	Ahn et al, 2004;Bhavsar et al, 2008	NP_002987	CXCL3
Gro alpha	Melanoma growth stimulating activity	Anisowicz et al, 1991	NM_001511	CXCL1
Gro beta	Chemokine	Anisowicz et al, 1991	AAP13104	GRO-beta
Gro gamma	Chemokine	Anisowicz et al, 1991	AAP13105.	GRO-gamma
Gro-1	Growth regulated oncogene; chemokine	Wood, 1995	NM_001511	CXCL1
*ICOS	Inducible co-stimulator	Haaning Anderson et al, 2003	NM_012092	ICOS
IFN-g	Interferon	Sica et al, 1992; Sica et al, 1997	NM_000619	IFNG
IL-1a	Interleukin-1a	Mori & Prager, 1996	NM_000575	IL1A
IL-1b	Interleukin-1b	Hiscott et al, 1993	NM_000576	IL1B
IL-1 receptor antagonist	Inhibitor of IL-1 activity	Smith et al, 1994	NM_173842	IL1RN
IL-2	Interleukin-2	Serfling et al, 1989; Hoyos et al, 1989; Lai et al, 1995	NM_000586	IL2
IL-6	Interleukin-6, inflammatory cytokine	Libermann & Baltimore, 1990; Shimizu et al, 1990;Son et al, 2008	NM_000600	IL6
IL-8	Interleukin-8, alpha-chemokine	Kunsch & Rosen, 1993; Kang et al., 2007	NM_000584	IL8
IL-9	Interleukin-9	Zhu et al, 1996; Chen et al, 2008	NM_000590	IL9
IL-10	Interleukin-10	Xu & Shu, 2002; Cao et al, 2006	NM_000572	IL10
IL-11	Interleukin-11	Bitko et al, 1997	NM_000641	IL11
IL-12B (p40)	Interleukin-12	Murphy et al, 1995	NM_002187	IL12B
IL-12A (p35)	Interleukin-12	Homma et al, 2007	NM_000882	IL12A
IL-13	Interleukin-13	Hinz et al, 2002	NM_002188	IL13
*IL-15	Interleukin-15	Azimi et al, 1998	NM_172174	IL15
IL-17	Interleukin-17	Shen et al, 2006	NM_002190	IL17
IL-23A (p19)	Interleukin-23 (p19 gene)	Carmody et al, 2006; Liu et al, 2007	NM_016584	IL23A
IL-27 (p28)	Interleukin-27 (p28 subunit)	Liu et al, 2007	NM_145659	IL27
EBI3/IL-27B	EBV-induced gene 3 (IL-27beta chain)	Poleganov et al, 2008	NM_005755	EBI3
beta-Interferon	Interferon	Hiscott et al, 1989;	NM_002176	IFNB1
beta-Interferon	Interferon	Lenardo et al, 1989	NM_002176	IFNB1
IP-10	alpha Chemokine	Ohmori & Hamilton, 1993; Yang et al, 2007	NM_002994	CXCL5
KC	alpha Chemokine	Ohmori et al, 1995	S79767	KC
IiGp1	Cytokine	Bunting et al, 2007	NM_021792	Iigp1
			NM_002994	CXCL5
*LIX (mouse); ENA-78 (CXCL5) and GCP-2 (CXCL6) (human)	LPS-induced CXC chemokines	Smith et al, 2002	NM_002993	CXCL6
Lymphotoxin a	TNF-like cytokine	Worm et al, 1998	NM_000595	LTA
Lymphotoxin b	Anchors TNF to cell surface	Kuprash et al, 1996	NM_002341	LTB
MCP-1/JE	Macrophage chemotactic protein, beta Chemokine	Ueda et al, 1994; 1997	NM_002982	CCL2

		Teferedegne et al, 2006; Xing & Remnick, 2007
MIG	Monokine induced by IFN-gamma	Bunting et al, 2007	NM_002416	CXCL9
MIP-1a,b	Macrophage inflammatory protein-1, b Chemokine	Grove & Plumb, 1993; Widmer et al, 1993	NM_002983	CCL3
			NM_002984	CCL4
aka (LAG-1)	Lymphocyte activation gene-1	Xu et al, 2002; Modi et al, 2001	NM_002984	CCL4
MIP-2 </

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