| + |
|
| REAGENTS |
|
|
|
|
||||
|
Gene |
Function |
Reference |
Acc #
|
Human
Gene Name |
|
BAFF |
B-cell
Activating Factor |
TNFSF13B |
||
|
BLIMP-1 |
B lymphocyte-induced maturation protein-1 |
BLIMP1 /PRDM1 |
||
|
CCL5 |
T-cell
secreted factor |
CCL5 |
||
|
CCL15/Leukotactin/
SCYA15 |
Chemokine
for cell attraction |
Shin
et al, 2005 |
CCL15 |
|
|
CCL17 |
Chemokine |
Takegawa
et al, 2008 |
CCL17 |
|
|
CCL19 |
Recruitment
of naive T cells to dendritic cells |
CCL19 |
||
|
CCL20 |
Ligand
of CC chemokine receptor 6 |
CCL20 |
||
|
CCL22 |
Epithelial
cell chemokine at mucosa |
CCL22 |
||
|
CCL23/SYA23 |
Monocyte
chemokine |
CCL23 |
||
|
CCL28 |
Chemokine
for T-cell attraction |
CCL28 |
||
|
CINC-1 |
Cytokine-induced
neutrophil chemoattractant |
Blackwell
et al, 1994 Ohtsuka et al, 1996 |
CXCL1 |
|
|
*CXCL
11 |
Chemokine
ligand for CXCR3 |
CXCL11 |
||
|
Eotaxin |
beta
Chemokine, eosinphil-specific |
CXCL10 |
||
|
Fractalkine |
TNF-induced
chemokine |
Ahn
et al, 2004;Bhavsar
et al, 2008 |
CXCL3 |
|
|
Gro
alpha |
Melanoma
growth stimulating activity |
CXCL1 |
||
|
Gro
beta |
Chemokine |
GRO-beta |
||
|
Gro
gamma |
Chemokine |
GRO-gamma |
||
|
Gro-1 |
Growth
regulated oncogene; chemokine |
CXCL1 |
||
|
*ICOS |
Inducible
co-stimulator |
ICOS |
||
|
IFN-g |
Interferon |
Sica
et al, 1992; Sica et al, 1997 |
IFNG |
|
|
IL-1a |
Interleukin-1a |
IL1A |
||
|
IL-1b |
Interleukin-1b |
IL1B |
||
|
IL-1
receptor antagonist |
Inhibitor
of IL-1 activity |
IL1RN |
||
|
IL-2 |
Interleukin-2 |
Serfling
et al, 1989; Hoyos et al, 1989; Lai et al, 1995 |
IL2 |
|
|
IL-6 |
Interleukin-6,
inflammatory cytokine |
Libermann
& Baltimore, 1990; Shimizu et al, 1990;Son
et al, 2008 |
IL6 |
|
|
IL-8 |
Interleukin-8,
alpha-chemokine |
Kunsch
& Rosen, 1993; Kang et al., 2007 |
IL8 |
|
|
IL-9 |
Interleukin-9 |
IL9 |
||
|
IL-10 |
Interleukin-10 |
Xu
& Shu, 2002; Cao et al, 2006 |
IL10 |
|
|
IL-11 |
Interleukin-11 |
IL11 |
||
|
IL-12B
(p40) |
Interleukin-12 |
IL12B |
||
|
IL-12A
(p35) |
Interleukin-12 |
IL12A |
||
|
IL-13 |
Interleukin-13 |
IL13 |
||
|
*IL-15 |
Interleukin-15 |
IL15 |
||
|
IL-17 |
Interleukin-17 |
IL17 |
||
|
IL-23A
(p19) |
Interleukin-23
(p19 gene) |
Carmody
et al, 2006; Liu et al, 2007 |
IL23A |
|
|
IL-27
(p28) |
Interleukin-27
(p28 subunit) |
IL27 |
||
|
EBI3/IL-27B |
EBV-induced gene 3 (IL-27beta chain) |
EBI3 |
||
|
beta-Interferon |
Interferon |
IFNB1 |
||
|
IP-10 |
alpha
Chemokine |
Ohmori
& Hamilton, 1993; Yang et al, 2007 |
CXCL5 |
|
|
KC |
alpha
Chemokine |
KC |
||
|
IiGp1 |
Cytokine |
Iigp1 |
||
|
|
|
|
CXCL5 |
|
|
*LIX
(mouse); ENA-78 (CXCL5) and GCP-2 (CXCL6) (human) |
LPS-induced
CXC chemokines |
CXCL6 |
||
|
Lymphotoxin
a |
TNF-like
cytokine |
LTA |
||
|
Lymphotoxin
b |
Anchors
TNF to cell surface |
LTB |
||
|
MCP-1/JE |
Macrophage
chemotactic protein, beta Chemokine |
Ueda
et al, 1994; 1997 |
CCL2 |
|
|
|
|
|||
|
Teferedegne
et al, 2006; Xing & Remnick, 2007 |
|
|||
|
MIG |
Monokine
induced by IFN-gamma |
CXCL9 |
||
|
MIP-1a,b |
Macrophage
inflammatory protein-1, b Chemokine |
Grove
& Plumb, 1993; Widmer et al, 1993 |
CCL3 |
|
|
|
|
CCL4 |
||
|
aka
(LAG-1) |
Lymphocyte
activation gene-1 |
Xu
et al, 2002; Modi et al, 2001 |
CCL4 |
|
|
MIP-2 |
Macrophage
inflammatory protein-2, b Chemokine |
Widmer
et al, 1993; Lee et al, 2005 |
CXCL3 |
|
|
MIP-3alpha/CCL20 |
Macrophage
inflammatory protein-3a |
Kwon
et al, 2002; Tomimori et al, 2007 |
CCL20 |
|
|
*mob-1 |
A
C-X-C chemokine |
CXCL10 |
||
|
Neutrophil
activating peptide-78 |
Activates
neutrophils |
CXCL5 |
||
|
RANTES |
Regulated
upon Activation Normal T lymphocyte Expressed and Secreted,b Chemokine |
CCL5 |
||
|
TCA3,
T-cell activation gene 3 |
T-cell
activation gene 3, beta chemokine |
CCL1 |
||
|
TNFalpha |
Tumor
necrosis factor alpha |
Shakhov
et al, 1990; Collart et al, 1990 |
TNF |
|
|
TNFbeta |
Tumor
necrosis factor beta |
Paul
et al, 1990; Messer et al, 1990 |
LTA |
|
|
TRAIL
(aka Apo2 ligand) |
Cytokine |
Baetu
et al, 2001; Matsuda et al, 2005 |
TNFSF10 |
|
|
TFF3
(Treefoil factor) |
Peptide
in response to gut irritation |
TFF3 |
||
|
VEGI |
Vascular
endothelial growth inhibitor |
TNFSF15 |
|
|
||||
|
Gene |
Function |
Reference |
Access
# |
Human
Gene Name |
|
B7.1
(CD80) |
Co-stimulation
of T cells via CD28 binding |
Fong
et al, 1996; Zhao et al, 1996 |
CD80 |
|
|
BRL-1 |
B-cell
homing receptor |
BLR1 |
||
|
CCR5 |
Chemokine
receptor |
CCR5 |
||
|
CCR7 |
Chemokine
receptor |
CCR7 |
||
|
CXCR |
Chemokine
receptor |
IL8RA |
||
|
CXCR2 |
Chemokine
receptor |
IL8RB |
||
|
CD137 |
TNF-like
receptor |
TNFRSF9 |
||
|
CD154 |
CD40
ligand |
Srahna
et al, 2001; Schubert et al, 2002; Pham et al, 2005 |
CD40LG |
|
|
CD3gamma |
T-cell
marker |
CD3G |
||
|
CD21 |
B-cell
surface molecule |
CR2 |
||
|
CD38 |
NAD
to cADP ribose converting molecule |
CD38 |
||
|
CD40 |
TNF-receptor
family member |
CD40 |
||
|
CD48 |
Antigen
of stimulated lymphocytes |
CD48 |
||
|
CD83 |
T-cell
development molecule |
McKinsey
et al, 2000; Berchtold et al, 2002 |
CD83 |
|
|
CD86 |
Dendritic
cell development molecule |
CD86 |
||
|
CD98 |
Membrane
receptor, survival blood cells |
SLC3A2 |
||
|
CD134 |
TNF-like
receptor |
TNFRSF4 |
||
|
*F11-receptor |
Ig-like
receptor for platelet adhesion |
F11R |
||
|
FcRn |
Neonatal
receptor for IgG |
FCGRT |
||
|
Fc
epsilon receptor II (CD23) |
Receptor
for IgE |
Richards
& Katz, 1997; Lu et al, 2006; Debnath et al, 2007 |
FCER2 |
|
|
HLA-G |
Human
leukocyte antigen-G |
HLA-G |
||
|
*ICOS |
T-cell
activation factor |
ICOS |
||
|
IL-2
receptor a-chain |
IL-2
receptor subunit |
IL2RA |
||
|
Immunoglobulin
Cgamma1 |
IgG
heavy chain |
IGHG2 |
||
|
Immunoglobulin
gamma1 |
IgG
heavy chain |
IGHG1 |
||
|
Immunoglobulin
gamma4 |
IgG
heavy chain |
IGHG4 |
||
|
Immunoglobulin
e heavy chain |
IgE
heavy chain |
IGHE |
||
|
Immunoglobulin
k light chain |
Antibody
light chain |
IGKC |
||
|
Invariant
Chain II |
Antigen
presentation |
|
|
|
|
Kinin
B1 Receptor |
Cardiovascular
homeostasis; inflammation |
BDKRB1 |
||
|
MHC
class I (H-2Kb) |
Major
histocompatibility antigen |
Israël
et al, 1989; Israël et al, 1989 |
|
|
|
MHC
Class I HLA-B7 |
Major
histocompatibility antigen |
HLA-B |
||
|
b2
Microglobulin |
Chaperone
for MHC class I-like molecules |
Israël
et al, 1989; Israël et al, 1989; Gobin et al, 2002 |
B2M |
|
|
Nod2 |
Intracellular
pathogen recognition |
NOD2 |
||
|
Polymeric
Ig receptor |
Binds
Ig |
pIgR |
||
|
PGRP-S |
Peptidoglycan
recognition protein-S |
PGLYRP1 |
||
|
T-cell
receptor b chain |
T-cell
receptor subunit |
TCRB |
||
|
T-cell
receptor/CD3gamma |
T-cell
receptor subunit |
CD3G |
||
|
TLR-2 |
Toll-like
receptor |
Wang
et al, 2001; Johnson & Tapping, 2007 |
TLR2 |
|
|
TLR9 |
Toll-like
receptor |
TLR9 |
||
|
*TNF-Receptor,
p75/80 (CD120B) |
High-affinity
TNF receptor |
TNFRSF1B |
||
|
TREM-1 |
Neutrophil/monocyte
Ig receptor |
TREM1 |
Proteins involved in antigen presentation
|
|
||||
|
Gene |
Function |
Reference |
Acc
# |
Human
Gene Name |
|
Complement
B |
Activator
of alternative complement pathway |
CFB |
||
|
Complement
component 3 |
Component
of complement pathway |
C3 |
||
|
Complement
Receptor 2 |
Complement
receptor for B-cell response to Ag |
CR2 |
||
|
Proteasome
Subunit LMP2 |
Subunit
of 26S proteasome,cysteine protease |
Wright
et al, 1995; Marques et al, 2004 |
PSMB9 |
|
|
Peptide
Transporter TAP1 |
Peptide
transporter for ER |
Wright
et al, 1995; Marques et al, 2004 |
TAP1 |
|
|
Tapasin |
MHC
class I presentation and assembly |
TAPBP |
|
Gene |
Function |
Reference |
Acc
# |
Human
Gene Name |
|
CD44 |
Cell-surface receptor for hyaluronic acid |
CD44 |
||
|
DC-SIGN |
Dendritic
cell surface C-type lectin |
CD209 |
||
|
ELAM-1
(CD62E, E-selectin) |
E-selectin,
endothelial cell leukocyte adhesion molecule |
Whelan
et al, 1991; Schindler & Baichwal, 1994 |
SELE |
|
|
Endoglin |
Endothelial
cell membrane glycoprotein |
ENG |
||
|
Fibronectin |
Extracellular
attachment |
Lee
et al, 2002; Norton et al, 2004 |
FN1 |
|
|
ICAM-1 |
Intercellular
adhesion molecule-1 |
van
de Stolpe et al., 1994' Bunting et al, 2007 |
CD54 |
|
|
MadCAM-1 |
Mucosal
addressin cell adhesion molecule |
MADCAM1 |
||
|
NCAM |
Neural
cell adhesion molecule |
NCAM |
||
|
P-selectin |
Platelet
adhesion receptor |
SELP |
||
|
Tenascin-C |
ECM
protein controls cell attachment and migration, cell growth |
TNC |
||
|
VCAM-1 |
Vascular
cell adhesion molecule |
VCAM1 |
|
|
||||
|
Gene |
Function |
Reference |
Acc
# |
Human
Gene Name |
|
Angiotensinogen
(Angiotensin II) |
Angiotensin
precursor, regulates blood pressure |
Brasier et al, 1990; Ron et al, 1990 |
AGT |
|
|
beta-defensin-2 |
Anti-microbial
peptide |
Diamond et al, 2000; Tsutsumi-Ishii & Nagaoka, 2002 |
DEFB2 |
|
|
C4b
binding protein |
Complement
binding protein |
C4BPA |
||
|
Complement
factor B |
Complement
factor |
CFB |
||
|
Complement
factor C4 |
Activates
extrinsic pathway of complement activation |
C4A |
||
|
C-reactive
protein |
Host
defense protein |
Zhang et al, 1995; Agrawal et al, 2003 |
CRP |
|
|
Hepcidin |
Acute
phase protein |
HAMP |
||
|
Lipopolysaccharide
binding protein |
Binds
to LPS receptor (CD14) with LPS |
LBP |
||
|
Pentraxin
PTX3 |
Pentraxin |
PTX3 |
||
|
Serum
amyloid A proteins (SAA1, SAA2, SAA3) |
Serum
components |
Edbrooke et al, 1991; Li & Liao, 1991; Thorn &
Whiteside, 2002; Son et al, 2004 |
SAA1 |
|
|
Serum
amyloid A proteins (SAA1, SAA2, SAA3) |
Serum
components |
|
SAA2 |
|
|
Serum
amyloid A proteins (SAA1, SAA2, SAA3) |
Serum
components |
|
SAA3 |
|
|
Tissue
factor-1 |
Activates
extrinsic pathway of complement activation |
F3 |
||
|
Urokinase-type
plasminogen activator |
Activates
fibrinogen for fibrin clot lysis |
PLAU |
|
|
||||
|
Gene |
Function |
Reference |
Acc
# |
Human
Gene Name |
|
*CYP2E1 |
Cytochrome
p450 |
CYP2E1 |
||
|
CYP2C11 |
Cytochrome
p450 |
CYP2C11 |
||
|
CYP7b |
Cytochrome
p450 |
CYP7B1 |
||
|
COX-2 |
Cyclooxygenase,
prostaglandin endoperoxide synthase |
Yamamoto et al, 1995;Ackerman et al, 2007 |
PTGS2 |
|
|
Ferritin
H chain |
Iron
storage protein |
FTH1 |
||
|
HSP90-alpha |
Heat
shock protein |
HSP90AA1 |
||
|
*5-Lipoxygenase
(guinea pig) |
Arachidonic
acid metabolic enzyme, leukotriene synthesis |
ALOX5 |
||
|
12-Lipoxygenase |
Arachidonic
acid metabolic enzyme |
ALOX12 |
||
|
Inducible
NO-Synthase |
NO
synthesis |
NOS2A |
||
|
*MAP4K1 |
Activator
of stress-induced protein kinase pathway |
MAP4K1 |
||
|
Cu/Zn
SOD |
Superoxide
dismutase |
SOD1 |
||
|
SOD1 |
Manganese
uperoxide dismutase |
SOD1 |
||
|
SOD2 |
Manganese
superoxide dismutase |
Xu et al, 1999; 2007 |
SOD2 |
|
|
*Mx1 |
Viral
resistance gene |
MX1 |
||
|
NAD(P)H
quinone oxidoreductase (DT-diaphorase) |
Bioreductive
enzyme |
NQO1 |
||
|
Phospholipase
A2 |
Fatty
acid metabolism |
PLA2 |
||
|
SEPS1 |
Involved
in cytokine production |
SELS |
|
Gene |
Function |
Reference |
Acc
# |
Human
Gene Name |
|
ABCA1 |
ATP-binding
cassette transporter |
ABCA1 |
||
|
ABCC6 |
ATP-binding,
multidrug resistance-associated protein 6 transporter |
ABCC6 |
||
|
A1
adenosine receptor |
Pleiotropic
physiological effects |
Nie et al, 1998; Jhaveri et al, 2007 |
ADORA1 |
|
|
A2A |
Adenosine
receptor |
ADORA2A |
||
|
*ADAM19 |
Dendritic
cell marker |
ADAM19 |
||
|
Amiloride-sensitive
sodium channel |
Sodium
channel |
Baines et al, 2002; Haddad, 2005 |
SCNN1A |
|
|
*alpha2B-adrenergic
receptor |
adrenergic
receptor |
ADRA2B |
||
|
Bradykinin
B1-Receptor |
Pleiotropic
physiological effects |
BDKRB1 |
||
|
*CD23 |
Cell-surface
molecule |
FCER2/CD23 |
||
|
CD69 |
Lectin
mainly on activated T cells |
C69 |
||
|
DOR |
Delta
opiod receptor |
Chen et al, 2005, 2006 |
OPRD1 |
|
|
Epidermal
Growth Factor Receptor |
Receptor
for EGF |
Nishi et al, 2003; Thornburg & Raab-Traub, 2007 |
EGFR |
|
|
ErbB2 |
EGF-like
receptor |
ERBB2 |
||
|
Gal1
Receptor |
Galanin
receptor, neuroendocrine peptide |
KISS1 |
||
|
Lox-1 |
Receptor
for Oxidized low density lipoprotein |
OLR1 |
||
|
Ly49 |
Receptor
on NK cells |
KLRA1 |
||
|
Mdr1 |
Multiple
drug resistance mediator (P-glycoprotein) |
Zhou & Kuo, 1997; Wang et al, 2007 |
ABCB4 |
|
|
Mu-opioid
receptor |
Opioid
Receptor |
OPRM1 |
||
|
mGlu2 |
Metabotropic
glutamate receptor 2 |
GRM2 |
||
|
Neuropeptide
Y-Y1 receptor |
Pleiotropic
physiological effects |
NPY1R |
||
|
*NMDA
receptor subunit 2A (rat) |
Neural
receptor for N-methyl-D-aspartate |
GRIN2A |
||
|
*NMDA
receptor subunit NR-1 (GRIN1 gene) |
Subunit
of neural receptor for N-methyl-D-aspartate |
GRIN1 |
||
|
Oxytocin
receptor |
Oxytocin
receptor |
OXTR |
||
|
PAF
receptor 1 |
Platelet
activator receptor |
PTAFR |
||
|
P-gp |
P-glycoprotein-Drug
resistance |
ABCB1 |
||
|
RAGE-
receptor for advanced glycation end products |
Receptor
for Advanced Glycation End products |
AGER |
|
Gene |
Function |
Reference |
Acc
# |
Human
Gene Name |
|
ASC |
Apoptosis-associated
speck-like protein containing a CARD |
PYCARD |
||
|
Bax |
Pro-apoptotic
Bcl-2 homologue |
BAX |
||
|
Bfl1/A1 |
Pro-survival
Bcl-2 homologue |
Grumont et al, 1999; Zong et al, 1999 |
BCL2A1 |
|
|
Bcl-xL |
Pro-survival
Bcl-2 homologue |
Chen et al, 1999; Lee et al, 1999 |
BCL2L1 |
|
|
Bcl-2 |
Pro-survival
factor |
BCL2 |
||
|
Bim |
Pro-apoptotic Bcl-2 homolog |
BCL2L11 |
||
|
B7-H1 |
Programmed
cell death ligand 1 |
CD274 |
||
|
BNIP3 |
Hypoxia-inducible
death factor |
Baetz et al, 2005; Shaw et al, 2006 |
BNIP3 |
|
|
Caspase-11 |
Caspase |
CASP4 |
||
|
Nr13 |
Pro-survival
Bcl-2 homologue |
|
|
|
|
c-FLIP |
Pro-survival
factor |
CFLAR |
||
|
CD95
(Fas) |
Pro-apoptotic
receptor |
Chan et al, 1999; Zhou et al, 2005; Singh et al, 2006 |
FAS |
|
|
CIDEA |
Cell death-inducing DFFA-like effector A |
CIDEA |
||
|
*Fas-associated
phosphatase-1 |
Protein
phosphatase |
PTPN13 |
||
|
Fas-Ligand |
Inducer
of apoptosis |
Matsui et al, 1998; Singh et al, 2006 |
FASLG |
|
|
IAPs |
Inhibitors
of Apoptosis |
You et al, 1997; Stehlik et al, 1998a, 1998b |
|
|
|
IEX-1L |
Immediate
early gene |
IER3 |
||
|
TRAF-1 |
TNF-receptor
associated factor |
TRAF1 |
||
|
TRAF-2 |
TNF-receptor
associated factor |
TRAF2 |
||
|
*TRAF-2
binding protein (Carp) |
TRAF2
binding protein |
TIFA |
||
|
XIAP |
X-linked
inhibitor of apoptosis |
XIAP |
Growth factors, ligands, and their modulators
|
|
||||
|
Gene |
Function |
Reference |
Acc
# |
Human
Gene Name |
|
Activin
A |
TGF-beta-like
factor |
INHBA |
||
|
Angiopoietin |
Tie-2
receptor ligand |
ANGPT1 |
||
|
BCAP |
B-cell Adaptor for Phosphoinositide 3-kinase |
PI3KAP1 |
||
|
BDNF |
Brain-derived
neurotrophic factor |
BDNF |
||
|
BLyS |
B-lymphocyte
stimulator |
TNFSF13B |
||
|
BLNK |
B-cell linker |
Gupta et al, 2008 |
BLNK |
|
|
BMP-2 |
Bone
Morphogenic Protein-2 |
Feng et al, 2003; Fukui et al, 2006 |
BMP2 |
|
|
BMP-4 |
Bone
Morphogenic Protein-4 |
BMP4 |
||
|
CGRP |
Calcitonin
gene-related peptide |
CALCB |
||
|
FGF8 |
Fibroblast
Growth Factor 8 |
FGF8 |
||
|
FLRG |
Follistatin-related
gene |
FSTL3 |
||
|
G-CSF |
Granulocyte
Colony Stimulating Factor |
CSF3 |
||
|
GM-CSF |
Granulocyte
Macrophage Colony Stimulating Factor |
Schreck & Baeuerle, 1990; Bunting et al, 2007 |
CSF2 |
|
|
*HGF/SF |
Hepatocyte
growth factor/scatter factor |
HGF |
||
|
EPO |
Erythropoietin |
EPO |
||
|
*IGFBP-1 |
Insulin-like
growth factor binding protein-1 |
IGFBP1 |
||
|
IGFBP-2 |
Insulin-like
growth factor binding protein-2 |