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REAGENTS
 
Target genes of NF-kB


  • Cytokines/Chemokines and their modulators
  • Immunoreceptors
  • Proteins involved in antigen presentation
  • Cell adhesion molecules
  • Acute phase proteins
  • Stress response genes
  • Cell-surface receptors
  • Regulators of apoptosis
  • Growth factors, ligands and their modulators
  • Early response genes
  • Transcription factors and Regulators
  • Viruses
  • Enzymes
  • Miscellaneous

  • (*indicates that the gene has a kB site in the promoter but has not clearly been shown to be controlled by NF-kB; or the gene expression is associated with increased NF-kB activity but has not been shown to be a target directly)

    Cytokines/Chemokines and their modulators

    Gene

    Function

    Reference

    Acc #

    Human Gene Name

    BAFF

    B-cell Activating Factor

    Moon & Park , 2007

    NM_006573

    TNFSF13B

    BLIMP-1

    B lymphocyte-induced maturation protein-1

    Calame, 2008

    NM_00198

    BLIMP1 /PRDM1

    CCL5

    T-cell secreted factor

    Wickremasinghe et al, 2004 

    NM_002985

    CCL5

    CCL15/Leukotactin/ SCYA15

    Chemokine for cell attraction

    Shin et al, 2005 

    NM_032965

    CCL15

    CCL17

    Chemokine

    Takegawa et al, 2008 

    NM_002987

    CCL17

    CCL19

    Recruitment of naive T cells to dendritic cells

    Pietila et al, 2007 

    NM_006274

    CCL19

    CCL20

    Ligand of CC chemokine receptor 6

    Lee et al, 2008; Battaglia et al, 2007

    NM_004591

    CCL20

    CCL22

    Epithelial cell chemokine at mucosa

    Nakayama et al, 2004 

    NM_002990

    CCL22

    CCL23/SYA23

    Monocyte chemokine

    Shin et al, 2007

    NM_005064

    CCL23

    CCL28

    Chemokine for T-cell attraction

    Ogawa et al, 2004 

    NM_148672

    CCL28

    CINC-1

    Cytokine-induced neutrophil chemoattractant

    Blackwell et al, 1994 Ohtsuka et al, 1996

    NM_001511

    CXCL1

    *CXCL 11

    Chemokine ligand for CXCR3

    Tensen et al, 1999

    NM_005409

    CXCL11

    Eotaxin

    beta Chemokine, eosinphil-specific

    Hein et al, 1997

    NM_001565. 

    CXCL10

    Fractalkine

    TNF-induced chemokine

    Ahn et al, 2004;Bhavsar et al, 2008

    NP_002987

    CXCL3

    Gro alpha

    Melanoma growth stimulating activity

    Anisowicz et al, 1991

    NM_001511

    CXCL1

    Gro beta

    Chemokine

    Anisowicz et al, 1991

    AAP13104

    GRO-beta

    Gro gamma

    Chemokine

    Anisowicz et al, 1991

    AAP13105. 

    GRO-gamma

    Gro-1

    Growth regulated oncogene; chemokine

    Wood, 1995

    NM_001511

    CXCL1

    *ICOS

    Inducible co-stimulator

    Haaning Anderson et al, 2003

    NM_012092

    ICOS

    IFN-g

    Interferon

    Sica et al, 1992; Sica et al, 1997

    NM_000619

    IFNG

    IL-1a

    Interleukin-1a

    Mori & Prager, 1996

    NM_000575

    IL1A

    IL-1b

    Interleukin-1b

    Hiscott et al, 1993

    NM_000576

    IL1B

    IL-1 receptor antagonist

    Inhibitor of IL-1 activity

    Smith et al, 1994

    NM_173842

    IL1RN

    IL-2

    Interleukin-2

    Serfling et al, 1989; Hoyos et al, 1989; Lai et al, 1995

    NM_000586

    IL2

    IL-6

    Interleukin-6, inflammatory cytokine

    Libermann & Baltimore, 1990; Shimizu et al, 1990;Son et al, 2008

    NM_000600

    IL6

    IL-8

    Interleukin-8, alpha-chemokine

    Kunsch & Rosen, 1993; Kang et al., 2007

    NM_000584

    IL8

    IL-9

    Interleukin-9

    Zhu et al, 1996; Chen et al, 2008

    NM_000590

    IL9

    IL-10

    Interleukin-10

    Xu & Shu, 2002; Cao et al, 2006

    NM_000572

    IL10

    IL-11

    Interleukin-11

    Bitko et al, 1997

    NM_000641

    IL11

    IL-12B (p40)

    Interleukin-12

    Murphy et al, 1995

    NM_002187

    IL12B

    IL-12A (p35)

    Interleukin-12

    Homma et al, 2007

    NM_000882

    IL12A

    IL-13

    Interleukin-13

    Hinz et al, 2002

    NM_002188

    IL13

    *IL-15

    Interleukin-15

    Azimi et al, 1998

    NM_172174

    IL15

    IL-17

    Interleukin-17

    Shen et al, 2006

    NM_002190

    IL17

    IL-23A (p19)

    Interleukin-23 (p19 gene)

    Carmody et al, 2006; Liu et al, 2007

    NM_016584

    IL23A

    IL-27 (p28)

    Interleukin-27 (p28 subunit)

    Liu et al, 2007

    NM_145659

    IL27

    EBI3/IL-27B

    EBV-induced gene 3 (IL-27beta chain)

    Poleganov et al, 2008

    NM_005755

    EBI3

    beta-Interferon

    Interferon

    Hiscott et al, 1989;

     NM_002176

    IFNB1

    Lenardo et al, 1989

    IP-10

    alpha Chemokine

    Ohmori & Hamilton, 1993; Yang et al, 2007

    NM_002994

    CXCL5

    KC

    alpha Chemokine

    Ohmori et al, 1995

    S79767

    KC

    IiGp1

    Cytokine

    Bunting et al, 2007

    NM_021792

    Iigp1

     

     

     

    NM_002994

    CXCL5

    *LIX (mouse); ENA-78 (CXCL5) and GCP-2 (CXCL6) (human)

    LPS-induced CXC chemokines

    Smith et al, 2002

    NM_002993

    CXCL6

    Lymphotoxin a

    TNF-like cytokine

    Worm et al, 1998

    NM_000595

    LTA

    Lymphotoxin b

    Anchors TNF to cell surface

    Kuprash et al, 1996

    NM_002341

    LTB

    MCP-1/JE

    Macrophage chemotactic protein, beta Chemokine

    Ueda et al, 1994; 1997

    NM_002982

    CCL2

     

     

    Teferedegne et al, 2006; Xing & Remnick, 2007

     

    MIG

    Monokine induced by IFN-gamma

    Bunting et al, 2007

    NM_002416

    CXCL9

    MIP-1a,b

    Macrophage inflammatory protein-1, b Chemokine

    Grove & Plumb, 1993; Widmer et al, 1993

    NM_002983

    CCL3

     

     

     

    NM_002984

    CCL4

    aka (LAG-1)

    Lymphocyte activation gene-1

    Xu et al, 2002; Modi et al, 2001

    NM_002984

    CCL4

    MIP-2 </