+
REAGENTS
 
Target genes of NF-kB


  • Cytokines/Chemokines and their modulators
  • Immunoreceptors
  • Proteins involved in antigen presentation
  • Cell adhesion molecules
  • Acute phase proteins
  • Stress response genes
  • Cell-surface receptors
  • Regulators of apoptosis
  • Growth factors, ligands and their modulators
  • Early response genes
  • Transcription factors and Regulators
  • Viruses
  • Enzymes
  • Miscellaneous

  • (*indicates that the gene has a kB site in the promoter but has not clearly been shown to be controlled by NF-kB; or the gene expression is associated with increased NF-kB activity but has not been shown to be a target directly)

    Cytokines/Chemokines and their modulators

    Gene

    Function

    Reference

    Acc #

    Human Gene Name

    BAFF

    B-cell Activating Factor

    Moon & Park , 2007

    NM_006573

    TNFSF13B

    BLIMP-1

    B lymphocyte-induced maturation protein-1

    Calame, 2008

    NM_00198

    BLIMP1 /PRDM1

    CCL5

    T-cell secreted factor

    Wickremasinghe et al, 2004 

    NM_002985

    CCL5

    CCL15/Leukotactin/ SCYA15

    Chemokine for cell attraction

    Shin et al, 2005 

    NM_032965

    CCL15

    CCL17

    Chemokine

    Takegawa et al, 2008 

    NM_002987

    CCL17

    CCL19

    Recruitment of naive T cells to dendritic cells

    Pietila et al, 2007 

    NM_006274

    CCL19

    CCL20

    Ligand of CC chemokine receptor 6

    Lee et al, 2008; Battaglia et al, 2007

    NM_004591

    CCL20

    CCL22

    Epithelial cell chemokine at mucosa

    Nakayama et al, 2004 

    NM_002990

    CCL22

    CCL23/SYA23

    Monocyte chemokine

    Shin et al, 2007

    NM_005064

    CCL23

    CCL28

    Chemokine for T-cell attraction

    Ogawa et al, 2004 

    NM_148672

    CCL28

    CINC-1

    Cytokine-induced neutrophil chemoattractant

    Blackwell et al, 1994 Ohtsuka et al, 1996

    NM_001511

    CXCL1

    *CXCL 11

    Chemokine ligand for CXCR3

    Tensen et al, 1999

    NM_005409

    CXCL11

    Eotaxin

    beta Chemokine, eosinphil-specific

    Hein et al, 1997

    NM_001565. 

    CXCL10

    Fractalkine

    TNF-induced chemokine

    Ahn et al, 2004;Bhavsar et al, 2008

    NP_002987

    CXCL3

    Gro alpha

    Melanoma growth stimulating activity

    Anisowicz et al, 1991

    NM_001511

    CXCL1

    Gro beta

    Chemokine

    Anisowicz et al, 1991

    AAP13104

    GRO-beta

    Gro gamma

    Chemokine

    Anisowicz et al, 1991

    AAP13105. 

    GRO-gamma

    Gro-1

    Growth regulated oncogene; chemokine

    Wood, 1995

    NM_001511

    CXCL1

    *ICOS

    Inducible co-stimulator

    Haaning Anderson et al, 2003

    NM_012092

    ICOS

    IFN-g

    Interferon

    Sica et al, 1992; Sica et al, 1997

    NM_000619

    IFNG

    IL-1a

    Interleukin-1a

    Mori & Prager, 1996

    NM_000575

    IL1A

    IL-1b

    Interleukin-1b

    Hiscott et al, 1993

    NM_000576

    IL1B

    IL-1 receptor antagonist

    Inhibitor of IL-1 activity

    Smith et al, 1994

    NM_173842

    IL1RN

    IL-2

    Interleukin-2

    Serfling et al, 1989; Hoyos et al, 1989; Lai et al, 1995

    NM_000586

    IL2

    IL-6

    Interleukin-6, inflammatory cytokine

    Libermann & Baltimore, 1990; Shimizu et al, 1990;Son et al, 2008

    NM_000600

    IL6

    IL-8

    Interleukin-8, alpha-chemokine

    Kunsch & Rosen, 1993; Kang et al., 2007

    NM_000584

    IL8

    IL-9

    Interleukin-9

    Zhu et al, 1996; Chen et al, 2008

    NM_000590

    IL9

    IL-10

    Interleukin-10

    Xu & Shu, 2002; Cao et al, 2006

    NM_000572

    IL10

    IL-11

    Interleukin-11

    Bitko et al, 1997

    NM_000641

    IL11

    IL-12B (p40)

    Interleukin-12

    Murphy et al, 1995

    NM_002187

    IL12B

    IL-12A (p35)

    Interleukin-12

    Homma et al, 2007

    NM_000882

    IL12A

    IL-13

    Interleukin-13

    Hinz et al, 2002

    NM_002188

    IL13

    *IL-15

    Interleukin-15

    Azimi et al, 1998

    NM_172174

    IL15

    IL-17

    Interleukin-17

    Shen et al, 2006

    NM_002190

    IL17

    IL-23A (p19)

    Interleukin-23 (p19 gene)

    Carmody et al, 2006; Liu et al, 2007

    NM_016584

    IL23A

    IL-27 (p28)

    Interleukin-27 (p28 subunit)

    Liu et al, 2007

    NM_145659

    IL27

    EBI3/IL-27B

    EBV-induced gene 3 (IL-27beta chain)

    Poleganov et al, 2008

    NM_005755

    EBI3

    beta-Interferon

    Interferon

    Hiscott et al, 1989;

     NM_002176

    IFNB1

    Lenardo et al, 1989

    IP-10

    alpha Chemokine

    Ohmori & Hamilton, 1993; Yang et al, 2007

    NM_002994

    CXCL5

    KC

    alpha Chemokine

    Ohmori et al, 1995

    S79767

    KC

    IiGp1

    Cytokine

    Bunting et al, 2007

    NM_021792

    Iigp1

     

     

     

    NM_002994

    CXCL5

    *LIX (mouse); ENA-78 (CXCL5) and GCP-2 (CXCL6) (human)

    LPS-induced CXC chemokines

    Smith et al, 2002

    NM_002993

    CXCL6

    Lymphotoxin a

    TNF-like cytokine

    Worm et al, 1998

    NM_000595

    LTA

    Lymphotoxin b

    Anchors TNF to cell surface

    Kuprash et al, 1996

    NM_002341

    LTB

    MCP-1/JE

    Macrophage chemotactic protein, beta Chemokine

    Ueda et al, 1994; 1997

    NM_002982

    CCL2

     

     

    Teferedegne et al, 2006; Xing & Remnick, 2007; Ishikado et al, 2009

     

    MIG

    Monokine induced by IFN-gamma

    Bunting et al, 2007

    NM_002416

    CXCL9

    MIP-1a,b

    Macrophage inflammatory protein-1, b Chemokine

    Grove & Plumb, 1993; Widmer et al, 1993

    NM_002983

    CCL3

     

     

    NM_002984

    CCL4

    aka (LAG-1)

    Lymphocyte activation gene-1

    Xu et al, 2002; Modi et al, 2001

    NM_002984

    CCL4

    MIP-2

    Macrophage inflammatory protein-2, b Chemokine

    Widmer et al, 1993; Lee et al, 2005

     NM_002090

    CXCL3

    MIP-3alpha/CCL20

    Macrophage inflammatory protein-3a

    Kwon et al, 2002; Tomimori et al, 2007

    NM_004591

    CCL20

    *mob-1

    A C-X-C chemokine

    Varley et al, 2003

    NM_001565

    CXCL10

    Neutrophil activating peptide-78

    Activates neutrophils

    Keates et al., 2001

    NM_002994

    CXCL5

    RANTES

    Regulated upon Activation Normal T lymphocyte Expressed and Secreted,b Chemokine

    Moriuchi et al, 1997

    NM_002985

    CCL5

    TCA3, T-cell activation gene 3

    T-cell activation gene 3, beta chemokine

    Oh & Metcalfe, 1994

    NM_002981

    CCL1

    TNFalpha

    Tumor necrosis factor alpha

    Shakhov et al, 1990; Collart et al, 1990

    NM_000594

    TNF

    TNFbeta

    Tumor necrosis factor beta

    Paul et al, 1990; Messer et al, 1990

    NM_000595

    LTA

    TRAIL (aka Apo2 ligand)

    Cytokine

    Baetu et al, 2001; Matsuda et al, 2005

    NM_003810

    TNFSF10

    TFF3 (Treefoil factor)

    Peptide in response to gut irritation

    Baus-Loncar et al, 2004

    NM_003226

    TFF3

    VEGI

    Vascular endothelial growth inhibitor

    Xiao et al, 2005

    NM_005118

    TNFSF15

     

    Immunoreceptors

    Gene

    Function

    Reference

     Access #

     Human Gene Name

    B7.1 (CD80)

    Co-stimulation of T cells via CD28 binding

    Fong et al, 1996; Zhao et al, 1996

    NM_005191

    CD80

    BRL-1

    B-cell homing receptor

    Wolf et al, 1998

    NM_001716

    BLR1

    CCR5

    Chemokine receptor

    Liu et al, 1998

    NM_000579

    CCR5

    CCR7

    Chemokine receptor

    Hopken et al, 2002

    NM_001838

    CCR7

    CXCR

    Chemokine receptor

    Maxwell et al, 2007

    NM_000634

    IL8RA

    CXCR2

    Chemokine receptor

    Maxwell et al, 2007

    NM_001557

    IL8RB

    CD137

    TNF-like receptor

    Kim et al, 2003

    NM_001561

    TNFRSF9

    CD154

    CD40 ligand

    Srahna et al, 2001; Schubert et al, 2002; Pham et al, 2005

    NM_000074

    CD40LG

    CD3gamma

    T-cell marker

    Willard-Gallo et al, 2005

    NM_000073

    CD3G

    CD21

    B-cell surface molecule

    Debnath et al, 2007

    NM_001006658

    CR2

    CD38

    NAD to cADP ribose converting molecule

    Kang et al, 2006; Tirumurugaan et al, 2008

    NM_001775

    CD38

    CD40

    TNF-receptor family member

    Hinz et al, 2001

    NM_001250

    CD40

    CD48

    Antigen of stimulated lymphocytes

    Klaman & Thorley-Lawson, 1995

    NM_001778

    CD48

    CD83

    T-cell development molecule

    McKinsey et al, 2000; Berchtold et al, 2002

    NM_004233

    CD83

    CD86

    Dendritic cell development molecule

    Zou & Hu, 2005

    NM_175862

    CD86

    CD98

    Membrane receptor, survival blood cells

    Yan et al, 2006

    NM_001012661

    SLC3A2

    CD134

    TNF-like receptor

    Tone et al, 2007

    NM_003327

    TNFRSF4

    *F11-receptor

    Ig-like receptor for platelet adhesion

    Sobocki et al, 2005

    NM_016946

    F11R

    FcRn

    Neonatal receptor for IgG

    Liu et al, 2007

    NM_004107

    FCGRT

    Fc epsilon receptor II (CD23)

    Receptor for IgE

    Richards & Katz, 1997; Lu et al, 2006; Debnath et al, 2007

    NM_002002

    FCER2

    HLA-G

    Human leukocyte antigen-G

    Langat et al., 2007

     NM_002127

    HLA-G

    *ICOS

    T-cell activation factor

    Shilling et al., 2005

    NM_012092

    ICOS

    IL-2 receptor a-chain

    IL-2 receptor subunit

    Ballard et al., 1988

    NM_000417

    IL2RA

    Immunoglobulin Cgamma1

    IgG heavy chain

    Lin & Stavnezer, 1996

    J00230

    IGHG2

    Immunoglobulin gamma1

    IgG heavy chain

    Dryer & Covey, 2005

     J00228

    IGHG1

    Immunoglobulin gamma4

    IgG heavy chain

    Agresti & Vercelli, 2002

     K01316

    IGHG4

    Immunoglobulin e heavy chain

    IgE heavy chain

    Iciek et al, 1997

     J00222

    IGHE

    Immunoglobulin k light chain

    Antibody light chain

    Sen & Baltimore, 1986

     J00241

    IGKC

    Invariant Chain II

    Antigen presentation

    Pessara & Koch, 1990

     

     

    Kinin B1 Receptor

    Cardiovascular homeostasis; inflammation

    Merino et al, 2005

    NM_000710

    BDKRB1

    MHC class I (H-2Kb)

    Major histocompatibility antigen

    IsraŽl et al, 1989; IsraŽl et al, 1989

     

     

    MHC Class I HLA-B7

    Major histocompatibility antigen

    Johnson & Pober, 1994

    NM_005514

    HLA-B

    b2 Microglobulin

    Chaperone for MHC class I-like molecules

    IsraŽl et al, 1989; IsraŽl et al, 1989; Gobin et al, 2002

    NM_004048

    B2M

    Nod2

    Intracellular pathogen recognition

    Gutierrez et al, 2002

    NM_022162

    NOD2

    Polymeric Ig receptor

    Binds Ig

    Schjerven et al, 2001

     AJ276452

    pIgR

    PGRP-S

    Peptidoglycan recognition protein-S

    Lang et al, 2007

    NM_005091

    PGLYRP1

    T-cell receptor b chain

    T-cell receptor subunit

    Jamieson et al, 1989; McMillan & SIkes, 2008

    NG_001333

    TCRB

    T-cell receptor/CD3gamma

    T-cell receptor subunit

    Badran et al, 2002

    NM_000073

    CD3G

    TLR-2

    Toll-like receptor

    Wang et al, 2001; Johnson & Tapping, 2007

    NM_003264

    TLR2

    TLR9

    Toll-like receptor

    Takeshita et al, 2004

    NM_017442

    TLR9

    *TNF-Receptor, p75/80 (CD120B)

    High-affinity TNF receptor

    Santee & Owen-Schaub, 1996

    NM_001066

    TNFRSF1B

    TREM-1

    Neutrophil/monocyte Ig receptor

    Zeng et al, 2007

    NM_018643

    TREM1

     

    Proteins involved in antigen presentation

    Gene

    Function

    Reference

     Acc #

     Human Gene Name

    Complement B

    Activator of alternative complement pathway

    Huang et al, 2002

    NM_001710

    CFB

    Complement component 3

    Component of complement pathway

    Moon et al, 1999

     NM_000064

    C3

    Complement Receptor 2

    Complement receptor for B-cell response to Ag

    Tolnay et al, 2002

     NM_001006658

    CR2

    Proteasome Subunit LMP2

    Subunit of 26S proteasome,cysteine protease

    Wright et al, 1995; Marques et al, 2004

    NM_002800

    PSMB9

    Peptide Transporter TAP1

    Peptide transporter for ER

    Wright et al, 1995; Marques et al, 2004

     NM_000593

    TAP1

    Tapasin

    MHC class I presentation and assembly

    Herrmann et al, 2003

    NM_003190

    TAPBP

     

    Cell adhesion molecules

    Gene

    Function

    Reference

     Acc #

     Human Gene Name

    CD44

    Cell-surface receptor for hyaluronic acid

    Hinz et al, 2002

    NP_000601

    CD44

    DC-SIGN

    Dendritic cell surface C-type lectin

    Liu et al, 2003

    NM_021155

    CD209

    ELAM-1 (CD62E, E-selectin)

    E-selectin, endothelial cell leukocyte adhesion molecule

    Whelan et al, 1991; Schindler & Baichwal, 1994

    NM_000450

    SELE

    Endoglin

    Endothelial cell membrane glycoprotein

    Botella et al, 2002

    NM_000118

    ENG

    Fibronectin

    Extracellular attachment

    Lee et al, 2002; Norton et al, 2004

     NM_002026

    FN1

    ICAM-1

    Intercellular adhesion molecule-1

    van de Stolpe et al., 1994' Bunting et al, 2007

    NM_000201

    CD54

    MadCAM-1

    Mucosal addressin cell adhesion molecule

    Takeuchi & Baichwal, 1995

     NM_130760

    MADCAM1

    NCAM

    Neural cell adhesion molecule

    Simpson & Morris, 2000

    NM_000615

    NCAM

    P-selectin

    Platelet adhesion receptor

    Pan & McEver, 1995

     NM_003005

    SELP

    Tenascin-C

    ECM protein controls cell attachment and migration, cell growth

    Mettouchi et al, 1997

    NM_002160

    TNC

    VCAM-1

    Vascular cell adhesion molecule

    Iademarco et al, 1992

    NM_001078

    VCAM1

     

    Acute phase proteins

    Gene

    Function

    Reference

     Acc #

     Human Gene Name

    Angiotensinogen (Angiotensin II)

    Angiotensin precursor, regulates blood pressure

    Brasier et al, 1990; Ron et al, 1990

    NM_000029

    AGT

    beta-defensin-2

    Anti-microbial peptide

    Diamond et al, 2000; Tsutsumi-Ishii & Nagaoka, 2002; Kao et al, 2008

     AF040153

    DEFB2

    C4b binding protein

    Complement binding protein

    Moffat & Tack, 1992

    NM_000715

    C4BPA

    Complement factor B

    Complement factor

    Nonaka & Huang, 1990

    NM_001710

    CFB

    Complement factor C4

    Activates extrinsic pathway of complement activation

    Yu et al, 1989

     NM_007293

    C4A

    C-reactive protein

    Host defense protein

    Zhang et al, 1995; Agrawal et al, 2003

     NM_000567

    CRP

    Hepcidin

    Acute phase protein

    Liao et al, 2006

    NM_021175

    HAMP

    Lipopolysaccharide binding protein

    Binds to LPS receptor (CD14) with LPS

    Schumann, 1995

    NM_004139

    LBP

    Pentraxin PTX3

    Pentraxin

    Basile et al, 1997

    NM_002852

    PTX3

    Serum amyloid A proteins (SAA1, SAA2, SAA3)

    Serum components

    Edbrooke et al, 1991; Li & Liao, 1991; Thorn & Whiteside, 2002; Son et al, 2004

    NM_000331

    SAA1

    Serum amyloid A proteins (SAA1, SAA2, SAA3)

    Serum components

     

    NM_030754

    SAA2

    Serum amyloid A proteins (SAA1, SAA2, SAA3)

    Serum components

     

    S73444

    SAA3

    Tissue factor-1

    Activates extrinsic pathway of complement activation

    Mackman et al, 1991

    NM_001993

    F3

    Urokinase-type plasminogen activator

    Activates fibrinogen for fibrin clot lysis

    Novak et al, 1991

    NM_002658

    PLAU

     

    Stress response genes

    Gene

    Function

    Reference

     Acc #

     Human Gene Name

    *CYP2E1

    Cytochrome p450

    Abdel-Razak et al, 2004

     NM_000773

    CYP2E1

    CYP2C11

    Cytochrome p450

    Morgan et al, 2002

    X79081

    CYP2C11

    CYP7b

    Cytochrome p450

    Dulos et al, 2005

    NM_004820

    CYP7B1

    COX-2

    Cyclooxygenase, prostaglandin endoperoxide synthase

    Yamamoto et al, 1995;Ackerman et al, 2007; Kaltschmidt et al, 2002

     NM_000963

    PTGS2

    Ferritin H chain

    Iron storage protein

    Kwak et al, 1995

    NM_002032

    FTH1

    Glutamate-cysteine ligase

    GSH biosynthesis

    Peng et al, 2010

    GCLC

    Glutamate-cysteine ligase modifier

    GCLC modifier protein

    Peng et al, 2010

    GCLM

    HSP90-alpha

    Heat shock protein

    Ammirante et al, 2007

    NM_001017963

    HSP90AA1

    *5-Lipoxygenase (guinea pig)

    Arachidonic acid metabolic enzyme, leukotriene synthesis

    Chopra et al, 1992

    XM_001127464

    ALOX5

    12-Lipoxygenase

    Arachidonic acid metabolic enzyme

    Arakawa et al, 1995

     NM_000697

    ALOX12

    Inducible NO-Synthase

    NO synthesis

    Geller et al, 1993

    NM_000625

    NOS2A

    *MAP4K1

    Activator of stress-induced protein kinase pathway

    Carter et al, 2002

    NM_001042600

    MAP4K1

    SENP2

    SUMO-specific protease

    S Miyamoto, pers commun

    NC_0000013.10

    SENP2

     Cu/Zn SOD

    Superoxide dismutase

    Rojo et al, 2004

    NM_000454

    SOD1

    SOD1

    Manganese uperoxide dismutase

    Das et al, 1995

    NM_000454

    SOD1

    SOD2

    Manganese superoxide dismutase

    Xu et al, 1999; 2007

    NM_000636

    SOD2

    *Mx1

    Viral resistance gene

    Gerardin et al, 2004

    NM_002462

    MX1

    NAD(P)H quinone oxidoreductase (DT-diaphorase)

    Bioreductive enzyme

    Yao & O'Dwyer, 1995

    NM_000903

    NQO1

    Phospholipase A2

    Fatty acid metabolism

    Morri et al, 1994

    AF058921

    PLA2

    SEPS1

    Involved in cytokine production

    Gao et al, 2006

     NM_018445

    SELS

     

    Cell-surface receptors

    Gene

    Function

    Reference

     Acc #

     Human Gene Name

    ABCA1

    ATP-binding cassette transporter

    Gerbod-Giannone et al, 2006

    NM_005502

    ABCA1

    ABCC6

    ATP-binding, multidrug resistance-associated protein 6 transporter

    Jiang et al, 2005

    NM_001171

    ABCC6

    A1 adenosine receptor

    Pleiotropic physiological effects

    Nie et al, 1998; Jhaveri et al, 2007

    NM_000674

    ADORA1

    A2A

    Adenosine receptor

    Morello et al, 2006

     NM_000675

    ADORA2A

    *ADAM19

    Dendritic cell marker

    Ehrnsperger et al, 2005

     NM_023038

    ADAM19

    Amiloride-sensitive sodium channel

    Sodium channel

    Baines et al, 2002; Haddad, 2005

    NM_001038

    SCNN1A

    *alpha2B-adrenergic receptor

    adrenergic receptor

    Cayla et al, 2004

    NM_000682

    ADRA2B

    Bradykinin B1-Receptor

    Pleiotropic physiological effects

    Ni et al, 1998

    NM_000710

    BDKRB1

    *CD23

    Cell-surface molecule

    Tinnell et al, 1998

     NM_002002

    FCER2/CD23

    CD69

    Lectin mainly on activated T cells

    Lopez-Cabrera et al, 1995

    NM_001781

    C69

    DOR

    Delta opiod receptor

    Chen et al, 2005, 2006

     NM_000911

    OPRD1

    Epidermal Growth Factor Receptor

    Receptor for EGF

    Nishi et al, 2003; Thornburg & Raab-Traub, 2007

    NM_005228

    EGFR

    ErbB2

    EGF-like receptor

    Kitamura et al, 2005

    NM_001005862

    ERBB2

    Gal1 Receptor

    Galanin receptor, neuroendocrine peptide

    Lorimer et al, 1997

     NM_002256

    KISS1

    Lox-1

    Receptor for Oxidized low density lipoprotein

    Nagase et al, 1998

    NM_002543

    OLR1

    Ly49

    Receptor on NK cells

    Pascal et al, 2007

     NM_006611

    KLRA1

    Mdr1

    Multiple drug resistance mediator (P-glycoprotein)

    Zhou & Kuo, 1997; Wang et al, 2007

    NM_018849

    ABCB4

    Mu-opioid receptor

    Opioid Receptor

    Kraus et al, 2003

    EU360599

    OPRM1

    mGlu2

    Metabotropic glutamate receptor 2

    Chiechio et al, 2006

    NM_000839

    GRM2

    Neuropeptide Y-Y1 receptor

    Pleiotropic physiological effects

    Musso et al, 1997

    NM_000909

    NPY1R

    *NMDA receptor subunit 2A (rat)

    Neural receptor for N-methyl-D-aspartate

    Richter et al, 2002

    NM_000833

    GRIN2A

    *NMDA receptor subunit NR-1 (GRIN1 gene)

    Subunit of neural receptor for N-methyl-D-aspartate

    Begni et al, 2003

    NM_021569

    GRIN1

    Oxytocin receptor

    Oxytocin receptor

    Terizidou et al, 2006

    NM_000916

    OXTR

    PAF receptor 1

    Platelet activator receptor

    Mutoh et al, 1994

    NM_000952

    PTAFR

    P-gp

    P-glycoprotein-Drug resistance

    Wang et al, 2007

    NM_000927

    ABCB1

    RAGE- receptor for advanced glycation end products

    Receptor for Advanced Glycation End products

    Li & Schmidt, 1997

    NM_001136

    AGER

     

    Regulators of apoptosis

    Gene

    Function

    Reference

     Acc #

     Human Gene Name

    ASC

    Apoptosis-associated speck-like protein containing a CARD

    Sun et al, 2007

    NM_013258

    PYCARD

    Bax

    Pro-apoptotic Bcl-2 homologue

    Grimm et al, 2004

    NM_004324

    BAX

    Bfl1/A1

    Pro-survival Bcl-2 homologue

    Grumont et al, 1999; Zong et al, 1999

     NM_004049

    BCL2A1

    Bcl-xL

    Pro-survival Bcl-2 homologue

    Chen et al, 1999; Lee et al, 1999

    NM_138578

    BCL2L1

    Bcl-2

    Pro-survival factor

    Catz & Johnson, 2001

    NM_000633

    BCL2

    Bim

    Pro-apoptotic Bcl-2 homolog

    Wang et al, 2008

    NM_138621

    BCL2L11

    B7-H1

    Programmed cell death ligand 1

    Lee et al, 2005

    NM_014143

    CD274

    BNIP3

    Hypoxia-inducible death factor

    Baetz et al, 2005; Shaw et al, 2006

     NM_004052

    BNIP3

    Caspase-11

    Caspase

    Schauvliege et al, 2002

    NM_001225

    CASP4

    Nr13

    Pro-survival Bcl-2 homologue

    Lee et al, 1999

     

     

    c-FLIP

    Pro-survival factor

    Kreuz et al, 2001

    NM_003879

    CFLAR

    CD95 (Fas)

    Pro-apoptotic receptor

    Chan et al, 1999; Zhou et al, 2005; Singh et al, 2006

    NM_000043

    FAS

    CIDEA

    Cell death-inducing DFFA-like effector A

    Pettersson et al, 2008

    NP_001270.1; NP_938031.1

    CIDEA

    *Fas-associated phosphatase-1

    Protein phosphatase

    Irie et al, 2001

     NM_006264

    PTPN13

    Fas-Ligand

    Inducer of apoptosis

    Matsui et al, 1998; Singh et al, 2006

    NM_000639

    FASLG

    IAPs

    Inhibitors of Apoptosis

    You et al, 1997; Stehlik et al, 1998a, 1998b

     

     

    IEX-1L

    Immediate early gene

    Wu et al, 1998

     NM_052815

    IER3

    TRAF-1

    TNF-receptor associated factor

    Schwenzer et al, 1999

     NM_005658

    TRAF1

    TRAF-2

    TNF-receptor associated factor

    Wang et al, 1998

    NM_021138

    TRAF2

    *TRAF-2 binding protein (Carp)

    TRAF2 binding protein

    Chang et al, 2005

    NM_052864

    TIFA

    XIAP

    X-linked inhibitor of apoptosis

    Turner et al, 2007

    NM_001167

    XIAP

     

    Growth factors, ligands, and their modulators

    Gene

    Function

    Reference

     Acc #

     Human Gene Name

    Activin A

    TGF-beta-like factor

    Alexander et al, 2007

    NM_002192

    INHBA

    Angiopoietin

    Tie-2 receptor ligand

    Scott et al, 2005

     NM_001146

    ANGPT1

    BCAP

    B-cell Adaptor for Phosphoinositide 3-kinase

    Gupta et al, 2008

    NM_152309

    PI3KAP1

    BDNF

    Brain-derived neurotrophic factor

    Saha et al, 2007

    NM_001709

    BDNF

    BLyS

    B-lymphocyte stimulator

    Fu et al, 2006

    NM_006573

    TNFSF13B

    BLNK

    B-cell linker

    Gupta et al, 2008

    NM_013314

    BLNK

    BMP-2

    Bone Morphogenic Protein-2

    Feng et al, 2003; Fukui et al, 2006

     NM_001200

    BMP2

    BMP-4

    Bone Morphogenic Protein-4

     Zhu et al, 2007

    NM_001202

    BMP4

    CGRP

    Calcitonin gene-related peptide

    Bowen et al, 2005

    NM_000728

    CALCB

    FGF8

    Fibroblast Growth Factor 8

    Armstrong et al, 2006

    NM_006119

    FGF8

    FLRG

    Follistatin-related gene

    Bartholin et al, 2007

    NM_005860

    FSTL3

    G-CSF

    Granulocyte Colony Stimulating Factor

    Nishizawa & Nagata, 1990

    NM_000759

    CSF3

    GM-CSF

    Granulocyte Macrophage Colony Stimulating Factor

    Schreck & Baeuerle, 1990; Bunting et al, 2007

     NM_000758

    CSF2

    *HGF/SF

    Hepatocyte growth factor/scatter factor

    Harrison & Farzaneh, 2000

    NM_000601

    HGF

    EPO

    Erythropoietin

    Figueroa et al, 2002

    NM_000799

    EPO

    *IGFBP-1

    Insulin-like growth factor binding protein-1

    Lang et al, 1999

    NM_001013029

    IGFBP1

    IGFBP-2

    Insulin-like growth factor binding protein-2

    Cazals et al, 1999

    NM_000597

    IGFBP2

    M-CSF (CSF-1)

    Macrophage Colony Stimulating Factor

    Brach et al, 1991; Hohensinner et al, 2007

    NM_000757

    CSF1

    Midkine (neurite growth promoting factor-2)

    Heparin Binding Growth Factor

    You et al, 2008

    NM_001012334

    MDK

    NGF

    Nerve Growth Factor

    Heese et al, 2006

    NM_002506

    NGFB

    NK-1R

    Neurokinin-1 Receptor

    Simeonidis et al, 2003; Ramkissoon et al, 2007

    NM_015727

    TACR1

    NK4

    Hepatocyte growth factor

    Zhou et al, 2003

    NM_001012635

    NK4

    Nrg1

    Neuregulin

    Frensing et al, 2007

    NM_004495

    NRG1

    OPN

    Osteopontin

    Samant et al, 2007

     NM_001040058

    SPP1

    PDGF B chain

    Platelet-derived Growth Factor

    Khachigian et al, 1995; Au et al, 2005

    NM_002608

    PDGFB

    PlGF

    Placenta Growth Factor

    Cramer et al, 2005

    NM_002643

    PIGF

    Proenkephalin

    Hormone

    Rattner et al, 1991

    NM_006211

    PENK

    Prolactin

    Pituitary hormone

    Friedrichsen et al, 2005

    NM_000948

    PRL

    Stem Cell Factor

    Mast Cell Growth Factor

    Da Silva et al, 2003; 2005

    NM_000899

    KITLG

    *Thrombospondin-1 (TSP-1)

    Matrix glycoprotein t

    Yang et al, 2003

    NM_003246

    THBS1

    *Thrombospondin-2 (THBS2)

    Matrix glycoprotein t

    Adolph et al, 1997

    NM_003247

    THBS2

    VEGF C

    Vascular Endothelial Growth Factor

    Chilov et al, 1997

    NM_005429

    VEGFC

    *WNT10B

    Secreted glycoprotein

    Katoh & Katoh, 2007

     NM_003394

    WNT10B

     

    Early response genes

    Gene

    Function

    Reference

     Acc #

     Human Gene Name

    *B94

    Early response gene

    Zhou et al, 2003

    NM_006291

    TNFAIP2

    *Egr-1

    Mitogen-induced early response gene; zinc finger 

    Zhou et al, 2003

    NM_001964

    EGR1

    p22/PRG1

    Rat homologue of IEX

    Schafer et al, 1998

    NM_052815

    IER3

    *p62

    Non-proteasomal multi-ubiquitin chain binding protein

    Vadlamudi & Shin, 1998

    NM_016221

    DCTN4

    *TIEG

    TGF-b early response gene; zinc finger protein

    Zhou et al, 2003

     NM_001032282

    KLF10

     

    Transcription factors and their modulators

    Gene

    Function

    Reference

     Acc #

     Human Gene Name

    A20

    TNF-inducible zinc finger

    Krikos et al, 1992

    NM_006290

    TNFAIP3

    ABIN-3

    NF-kB inhibitor

    Verstrepen et al, 2007

    NM_024873

    TNIP3

    Androgen receptor

    Hormone receptor

    Zhang et al, 2004

    NM_000044

    AR

    Bcl-3

    Coactivator for NF-kB p50 and p52

      Brocke-Heidrich et al, 2006

    NM_005178

    BCL3

    BMI-1

    Polycomb chromatin modifier

    Dutton et al, 2006

    NM_005180

    BMI1

    CDX1

    Homeobox protein

    Wong et al, 2005

    NM_001804

    CDX1

    *c-fos (fish gene)

    Proto-oncogene

    Li et al, 2004

    NM_005252

    FOS

    c-myb

    Proto-oncogene

    Toth et al, 1995

    NM_005375

    MYB

    c-myc

    Proto-oncogene

    Duyao et al, 1990

     NM_002467

    MYC

    c-rel

    Proto-oncogene

    Hannink & Temin, 1990; Capobianco & Gilmore, 1991

    NM_002908

    REL

    C/EBPdelta

    Transcription factor

    Liu et al, 2007

    NM_005195

    CEBPD

    *DC-SCRIPT

    Dendritic cell zinc finger protein

    Triantis et al, 2006

    NM_152625

    ZNF366

    Dmp1

    Myb-like transcription factor

    Taneja et al, 2007

    NM_001079911

    DMP1

    E2F3a

    Cell cycle regulator

    Cheng et al, 2003

    NM_001949

    E2F3

    Elf3

    Ets family transcription factor

    Hou et al, 2004

    NM_004433

    ELF3

    *ELYS

    Embryonic large molecule derived from yolk sac

    Okita et al, 2003

    NM_015446

    AHCTF1

    *ETR101

    TPA-inducible, Jun-like transcription factor

    Zhou et al, 2003

    NM_004907

    IER2

    Gata-3

    T-cell differentiation Factor

    Corn et al, 2005

     NM_001002295

    GATA3

    *Glucocorticoid receptor

    Promoter 1B of the GR

    Schaff & Cidlowski, 2002

    NM_000176

    NR3C1

    HIF-1alpha

    Hypoxia-inducible factor

    Bonello et al, 2007; Belaiba et al, 2007; van Uden et al, 2008; Gorlach & Bonello, 2008

    NM_001530

    HIF1A

    HOXA9

    Homeobox protein

    Trivedi et al, 2007

    NM_152739

    HOXA9

    IRF-1

    Interferon regulatory factor-1

    Harada et al, 1994; Robinson et al, 2006 

    NM_002198

    IRF1

    IRF-2

    Interferon regulatory factor-2

    Harada et al, 1994

    NM_002199

    IRF2

    IRF-4

    Interferon regulatory factor-4

    Grumont & Gerondakis, 2000; Saito et al, 2007

     NM_002460

    IRF4

    IRF-7

    Interferon regulatory     factor -7

    Lu et al, 2002

    NM_001572

    IRF7

    IkB-a

    Inhibitor of Rel/NF-kB

    Haskill et al, 1991;

    NM_020529

    NFKBIA

    Sun et al, 1993

    de Martin et al, 1993

    IkB-e

    Inhibitor of Rel/NF-kB

    Tian et al, 2005

    NM_004556

    NFKBIE

    junB

    Proto-oncogene

    Brown et al, 1995

     NM_002229

    JUNB

    jmjD3

    Histone lysine demethylase

    G Natoli, pers comm

    XM_043272

    JMJD3

    Lef1

    Transcription factor in Wnt/b-catenin pathway

    Yun et al, 2007

    NM_016269

    LEF1

    LZIP

    Leukocyte cell mobility

    Jang et al, 2007

    NM_006368

    CREB3

    Mail

    IkB-like protein

    Shiina et al, 2001; Ito et al, 2004

    NM_001005474

    NFKBIZ

    nfkb2

    NF-kB p100 precursor

    Lombardi et al, 1995

    NM_001077493

    NFKB2

    nfkb1

    NF-kB p105 precursor

    Ten et al, 1992

    NM_003998

    NFKB1

    NLRP2

    NF-kB pathway inhibitor

    Fontalba et al, 2007

    NM_017852

    NLRP2

    NURR1

    Nuclear orphan receptor

    McEvoy et al, 2002

     NM_006186

    NR4A2

    Osterix

    Bone transcription factor

    Lu et al, 2006

    AF477981

    Osterix

    p53

    TF, Tumor suppressor

    Wu & Lozano, 1994; Schumm et al, 2006

    NM_000546

    TP53

    Progesterone receptor

    Transcription factor

    Condon et al, 2005

    NM_000926

    PGR

    PU.1

    Transcription factor

    Bonadies et al, 2009

    NM_001080547.1

    SPI1

    relb

    Transcription factor

    Bren et al, 2001

     NM_006509

    RELB

    Snail

    Transcription factor

    Barbera et al, 2004; Julien et al, 2007

    NM_005985

    SNAI1

    Sox9

    Transcription factor

    Murakami et al, 2000

    NM_000346

    SOX9

    Stat5a

    Transcription factor

    Hinz et al, 2002

    NM_003152

    STAT5A

    Tfec

    Transcription factor

    Rehli et al, 2005

     NM_001018058

    TFEC

    Twist

    Transcription repressor

    Horikawa et al, 2007; Pham et al, 2007

    NM_000474

    TWIST1

    WT1

    Zinc finger transcription factor

    Dehbi et al, 1998; Chen & Williams, 2000

    NM_000378

    WT1

    YY1

    Transcription factor

    Wang et al, 2007

     NM_003403

    YY1

     

    Enzymes

    Gene

    Function

    Reference

     Acc #

     Human Gene Name

      *ABC Transporters

    ATP-binding membrane transporters

    Mutch et al, 2003

    NM_019625

    ABCB9

      *N-acetylglucosaminyltransferase I (rat gene)

    N-acetylglucosaminyltransferase

    Fukuda et al, 2003

    NM_001097634

    GCNT1

      ADH

    Liver alcohol dehydrogenase

    Potter et al, 2002

    NM_000667

    ADH1A

      AID

    Activation-induced cytidine deaminase

    Gourzi et al, 2007; Endo et al, 2007

    NM_020661

    AICDA

      AMACR

    alpha-methylacyl-CoA racemase

    Chen et al, 2007

    NM_014324

    AMACR

      ARF-related protein-1

    GTPase

    Mueller et al, 2007

    NM_003224

    ARFRP1

      Argininosuccinate synthetase

    Arginine synthesis

    Fan et al, 2005; Brasse-Lagnel et al, 2007

    NM_000050

    ASS1

      Aromatase (promoter II)

    Estrogen synthesis

    Brasse-Lagnel et al, 2004

    NM_000103

    CYP19A1

      ART2.1

    Ecto-ADP-ribosyltransferase

     Hong et al, 2007

    NM_004314

    ART1

      alpha 1ACT

    Anti-chymotrypsin

    Kiss et al, 2005

    NM_001085

    SERPINA3

      BACE-1

    beta site APP cleaving enzyme

    Sambamurti et al, 2004; Rossner et al, 2006: Bourne et al, 2007; Bruggia-Prevot et al, 2008

    NM_012104

    BACE1

    Btk

    Bruton's Tyrosine kinase

    Yu et al, 2008

    NM_000061

    BTK

    Cathepsin B

    Lysosomal cysteine protease

    Bien et al, 2004

    NM_001908

    CTSB

    *Cathepsin L

    Lysosomal cysteine protease

    Seth et al, 2003

    NM_001912

    CTSL1

    cdk6

    Cell-dependent kinase 6

    Iwanaga et al, 2008

    CDK6

    *Ceramide glycosyltransferase

    Glycosphingolipid

    Ichikawa et al, 1998

    NM_020120

    UGCGL1

    Chitinase 3-like protein

    Chitinase

    Recklies et al, 2005

    NM_001276

    CHI3L1

    *cis-retinoid/androgen dehydrogenase type 1 (CRAD1)

    Short chain dehydrogenase

    Chai et al, 2001

    NM_080436

    Rdh1

    *cis-retinoid/androgen dehydrogenase type 2 (CRAD2)

    Short chain dehydrogenase

    Tomita et al, 2000

     NM_017473

    Rdh7

    Collagenase 1

    Matrix metalloproteinase

    Vincenti et al, 1998

    NM_002421

    MMP1

    *Dihydrodiol dehydrogenase

    Oxidoreductase, oxidation of trans-hydodiols

    Ciaccio et al, 1996

    NM_00135

    AKR1C1

    *DYPD

    Dihydropyrimidine dehydrogenase

    Ukon et al, 2005

    NM_000110

    DPYD

    DNASIL2

    DNAse-like endonuclease

    Shiokawa et al, 2004

    NM_001374

    DNASE1L2

    EL

    Endothelial lipase

    Kempe et al, 2005

    NM_006033

    LIPG

    *ENO2

    Enolase 2 gamma

    Carter et al, 2002

    NM_001975

    ENO2

    *GAD67

    Glutamic acid decarboxylase

    Szabo et al, 1996

    NM_000817

    GAD1

    GD3-synthase

    Sialyltransferase

    Zeng et al, 1998: Kang et al, 2007

    NM_003034

    ST8SIA1

    gp91 phox

    Subunit of NADPH oxidase

     Anrather et al, 2006

    NM_007052

    NOX1

    Gelatinase B

    Matrix metalloproteinase

    He, 1996

    NM_004994

    MMP9

    GSTP1-1

    Glutathione S-transferase

    Xia et al, 1996

    NM_000852

    GSTP1

    Glutamate-cysteine ligase 

    Glutathione S-transferase synthesis enzyme

    Yang et al, 2001; Nagashima et al, 2007

    NM_001498

    GCLC

    GCLC 

    Glutamate-cysteine ligase catalytic subunit

    Yang et al, 2005

    NM_001498

    GCLC

    *Glutamate-cysteine ligase modifier

    Glutathione S-transferase synthesis enzyme

     Yang et al, 2001

    NM_002061

    GCLM

    *gamma glutamylcysteine synthetase

    Glutatamylcysteine synthesis

    Cheng et al, 2005

    NM_001498

    GCLC

    *Glucose l-6-phosphate dehydrogenase

    Hexose monophosphate

    Garcia-Nogales et al, 1999

    NM_000402

    G6PD

    Glucose-6-phosphatase

    Hexose phosphatase

     Xu et al, 2007

    NM_000151

    G6PC

    GnRH II

    Gonadotropin-releasing hormone II

    Hoo et al, 2007

    NM_001501

    GNRH2

    Granzyme B

    NK cell cytotoxicity

    Huang et al, 2006

    NM_004131

    GZMB

    *Soluble Guanylyl cyclase alpha (1) 

    Receptor for NO

    Vazquez-Padron et al, 2004

    NM_000855

    GUCY1A2

    *Heparanase 

    Cleaves heparin

    Cao et al, 2005

    NM_006665

    HPSE

    HO-1

    Hemeoxygenase

    Lavrovsky et al, 1994; Rushworth & O'Connell, 2004; Wu et al, 2004; Lin et al, 2007

    NM_002133

    HMOX1

    Hyaluronan synthase

    Synthesizes hyaluronic acid

    Ohkawa et al, 1999; Kim, 2006; Saavalainen et al, 2007

    NM_001523

    HAS1

    11bHSD2

    11beta-hydroxysteroid dehydrogenase type 2

     Kostadinova et al, 2005

    NM_000196

    HSD11B2

    *17bHSD

    17beta-hydroxysteroid dehydrogenase

    Villar et al, 2007

    NM_014234

    HSD17B8

    H+-K+ATPase alpha2

    Role in potassium homeostasis

    Zhang & Kone, 2002;Saha et al, 2008

    NM_000702

    ATP1A2

    Iodothyronine deiodinase (type 2)

    Converts T4 to T3

    Fekete et al, 2003; Zeold et al, 2006 

    NM_000793

    DIO2

    *Indoleamine 2,3-dioxygenase

    Enzyme for Trp synthesis

    Ogasawara et al, 2009

    NM_002164

    IDO1

    Lipocalin-type prostaglandin D synthase (L-PGDS)

    Prostaglandin D2 synthase in brain

    Fujimori et al, 2003

    NM_000954

    PTGDS

    Lysozyme

    Hydrolyzes bacterial cell walls

    Phi van, 1996

    NM_000239

    LYZ

    Mthfr

    Methylenetetrahydrofolate reductase

    Pickell et al, 2005

    NM_005957

    MTHFR

    *MKP-1

    MAP kinase phosphatase

    Zhou et al, 2003

    NM_004417

    DUSP1

    MMP-3, matrix metalloproteinaase-3

    Secreted collagenase involved in metastasis

    Borghaei et al, 2004

    NM_002422

    MMP3

    MMP-9, matrix metalloproteinaase-9

    Secreted collagenase involved in metastasis

    Bond et al, 1998; Farina et al, 1999; Yan et al, 2004

    NM_004994

    MMP9

    MLCK

    (Long) Myosin light chain kinase

    Graham et al, 2006

    NM_053025

    MYLK

    iNOS

    Inducible nitric oxide synthase

    Morris et al, 2003; Guo et al, 2006; Hughes et al, 2008

    NM_000625

    NOS2A

    n-NOS

    Neuronal nitric oxide synthase

    Nakata et al, 2006; Li et al, 2007

    NM_000620

    NOS1

    *PDE7A1

    Phosphodiesterase 7A1

    Torras-Llort, & Azorin, 2003

    NM_002603

    PDE7A

    PIM-1

    Ser/Thr kinase

    Zhu et al, 2002

    NM_002648

    PIM1

    Plk3

    Polo-like (Ser/Thr) kinase 3

    Li et al, 2005

    NM_004073

    PLK3

    PIK3CA

    Phosphatidylinositol 3-kinase catalytic subunit

    Yang et al, 2008

    NM_006218

    PIK3CA

    *PP5

    Protein phosphatase 5

    Matsuda et al, 2003

    NM_006247

    PPP5C

    PKAalpha

    Protein kinase A isoform

    Kaltschmidt et al, 2006

    NM_002730

    PRKACA

    PKCdelta

    Protein kinase D isoform

    Suh et al, 2003

    NM_006254

    PRKCD

    PLCdelta 1

    Phospholipase C isoform

    Kim et al, 2003

    NM_006225

    PLCD1

    *PTGIS, prostaglandin synthase

    Prostaglandin synthase

    Yokoyama et al, 1996

    NM_000961

    PTGIS

    *PGES, prostaglandin E synthase

    Prostaglandin synthase

    Zhou et al, 2003

    NM_004878

    PTGES

    PTP1B

    Protein tyrosine phosphatase 1B

    Zabolotny et al, 2008

    NM_002827

    PTPN1

    PTHrP

    Parathryroid hormone related protein

    Nadella et al, 2007

    NM_002820

    PTHLH

    RACK1

    Receptor for Activated C kinase

    Choi et al, 2003

    NM_006098

    GNB2L1

    *REV3

    DNA polymerase zeta

    Yu et al, 2004

    NM_002912

    REV3L

    Slfn-2

    Schlafen-2 DNA/RNA helicase

    Sohn et al, 2007

    NM_011408

    Slfn2

    Serpin 2A

    Serine protease

    Hampson et al, 2001

    XM_372532

    SERPINA2

    SIAT1

    Sialyltransferase

    Lo & Lau, 1999

    NM_173216

    ST6GAL1

    SNARK

    SNF1/AMPK-related kinase

    Legembre et al, 2004

    NM_030952

    NUAK2

    SSAT

    Spermidine/spermine N1-acetyltransferase

    Babbar et al, 2006

    NM_002970

    SAT1

    *SUV3

    ATP-dependent RNA and DNA helicase

    Minczuk et al, 2005

    NM_003171

    SUPV3L1

    TERT

    Telomerase catalytic subunit

    Yin et al, 2000: Hrdlickova et al, 2006

    NM_198253

    TERT

    Transglutaminase

    Forms isopeptide bonds

    Mirza et al, 1997

    NM_000359

    TGM1

    TTG

    Tissue transglutaminase

    Chen et al, 2008

    NM_004613

    TGM2

    Type II-secreted phospholipase A2

    Proinflammatory phospholipase

    Couturier et al, 1999

    NM_000437

    PAFAH2

    Uridine phosphorylase

    5-fluorouracil and capecitabine metabolism

    Wan et al, 2006

    NM_003364

    UPP1

    *Xanthine Dehydrogenase

    Oxidative metabolism of purines

    Xu et al, 1996

    NM_000379

    XDH

     

    Miscellaneous

    Gene

    Function

    Reference

     Acc #

     Human Gene Name

    *ABCG5 (bovine)

    ATP-binding cassette sterol transporters

     Viturro et al, 2006

    NM_022436

    ABCG5

    ABCG8 (bovine)

    ATP-binding cassette sterol transporters

     Viturro et al, 2006

    NM_022437

    ABCG8

    AbetaH-J-J

    Tripartite gene: aspartyl-beta-hydroxylase, junctin), junctate

    Feriotto et al, 2005

    NM_004318

    ASPH

    alpha-1 acid glycoprotein

    Serum protein

    Mejdoubi et al, 1999

    NM_000607

    ORM1

    alpha-fetoprotein

    Liver cancer marker

    Cavin et al, 2004

    NM_001134

    AFP

    AMH

    Anti-Mullerian hormone

    Lukas-Croisier et al, 2003

    NM_000479

    AMH

    *beta-amyloid

    Alzheimer's precursor

    Song & Lahiri, 1998

    NM_000484

    A4

    APOBEC2

    Apolipoportein B mRNA-editing enzyme catalytic subunit 2

    Matsumoto et al, 2006

    NM_006789

    APOBEC2

    Apolipoprotein C III

    Apoprotein of HDL

    Gruber et al, 1994

    NM_000040

    APOC3

    Apolipoprotein D

    Plasma lipocalin

    Do Carmo et al, 2007

    NM_001647

    APOD

    Apolipoprotein E

    Protein assoc. with Alzheimers

    Lahiri, 2004; Du et al, 2005

    NM_000041

    APOE

    AQP4

    Aquaporin 4

    Ito et al, 2006

    NM_001650

    AQP4

    *Biglycan

    Connective tissue proteoglycan

    Ungefroren & Krull, 1996

    NM_001711

    BGN

    BRCA2

    Breast Cancer Susceptibility protein-2

    Wu et al, 2000

    NM_000059

    BRCA2

    Calsarcin-1

    Muscle cell calcineurin-interacting protein

    Wang et al, 2007

    NM_021245

    MYOZ1

    *Caveolin-1

    Lipid raft protein

    Deregowski et al, 2002

    NM_001753

    CAV1

    *Clone 330

    Possible secreted protein

    Matsuda et al, 2003

     

     

    *Clone 156

    Unknown NF-kB inducer

    Matsuda et al, 2003

     

     

    *Clone 68

    Unknown NF-kB inducer

    Matsuda et al, 2003

     

     

    *p21-CIP1

    Cyclin-dependent kinase inhibitor

    Hinata et al, 2003

    NM_000389

    CDKN1A

    *Claudin-2

    Gap junction protein

    Yamamoto et al, 2004

    NM_020384

    CLDN2

    a2(I) collagen

    Type I collagen

    Novitskiy et al, 2004; Nieto, 2007

    NM_000089

    COL1A2

    *Connexin32

    Gap junction protein

    Yamamoto et al, 2004

    NM_000166

    GJB1

    Cyclin D1

    Cell-cycle regulation

    Guttridge et al, 1999; Hinz et al, 1999; Toualbi-Abed et al, 2008

    NM_053056

    CCND1

    Cyclin D2

    Cell-cycle regulation

    Huang et al, 2004; Iwanaga et al, 2008

    NM_001759

    CCND2

    *Cyclin D3

    Cell-cycle regulation

    Wang et al, 1996

    NM_001760

    CCND3

    DIF2

    Monocyte differentiation gene

    Witcher et al, 2007

    NM_003897

    IER3

    DMT1

    Divalent metal ion transporter

    Paradkar et al, 2005

    NM_000617

    SLC11A2

    Elafin

    Proteinase inhibitor

    Bingle et al, 2001

    NM_002638

    SKALP, PI3

    Endothelin 1

    Vasoconstrictor peptide/mitogen

    Quehenberger et al, 2000

    NM_001955

    EDN1

    Ephrin-A1

    Cell-cycle regulation

    Deregowski et al, 2002

    NM_005232

    EPHA1

    Factor VIII

    Hemostasis

    Figueiredo & Brownlee, 1995

    NM_000132

    F8

    Ferritin Heavy Chain

    Anti-oxidant

    Kwak et al, 1995

    NM_002032

    FTH1

    Gadd45beta

    DNA repair/cell cycle

    De Smaele et al, 2001; Qiu et al, 2004

    NM_015675

    GADD45B

    Galpha i2

    G protein

    Arinze & Kawai, 2005

    NM_002070

    GNAI2

    *GIF

    Cys-rich metal binding protein

    Hinata et al, 2003

    NM_005954

    MT3

    Galectin 3

    b-galactosidase-binding lectin

    Hsu et al, 1996

    NR_003225

    LGALS3

    GBP-1

    GTPase guanylate binding protein

    Naschberger et al, 2004

    NM_002053

    GBP1

    epsilon-Globin

    Globin protein

    Hou et al, 2002, 2004

    NM_005330

    HBE1

    zeta-Globin

    Globin protein

    Wang & Liebhaber, 1999

    NM_005332

    HBZ

    *GS3686

    Homology to microtubule aggregating protein

    Carter et al, 2002

    NM_006820

    IFI44L

    Hair K5 keratin

    Hair keratin protein

    Gilon et al, 2007

    NM_000424

    KRT5

    *HCCS1

    Hepatocarcinoma suppressor 1

    Zhu et al, 2006

    NM_018289

    VPS53

    HMG14

    High mobility group 14

    Walker & Enrietto, 1996

    NM_004965

    HMGN1

    IBABP

    Ileal bile acid binding protein

    Fang et al, 2007

    NM_001445

    FABP6

    IMP2

    Insulin-like growth factor-II mRNA binding protein

    Cleynen et al, 2007

    NM_000597

    IGFBP2

    K3 Keratin

    Intermediate filament protein

    Wu et al, 1994

    NM_057088

    KRT3

    K6b Keratin

    Intermediate filament protein

    Komine et al, 2000

    NM_005555

    KRT6B

    K15 Keratin

    Intermediate filament protein

    Radoja et al, 2004

    NM_002275

    KRT15

    *Lactoferrin

    Milk protein

    Zheng et al, 2005

    NM_002343

    LTF

    Laminin B2 Chain

    Basement membrane protein

    Richardson et al, 1995

    NM_002292

    LAMB2

    Lipocalin-2

    Iron-siderophore-binding protein

    Fujino et al, 2005

    NM_005564

    LCN2

    Mts1

    Multiple tumor suppressor

    Tulchinsky et al, 1997

    NM_002961

    S100A4

    Mir125b

    Micro-RNA TNFa

    Tili et al, 2007

     

     

    Mir146a, b

    Micro-RNA for IRAK and Traf6

    Taganov et al, 2006

     

     

    Mir155

    Micro-RNA for FADD, IKKe, Ripk1

    Tili et al, 2007

     

     

    MNE1

    Monocyte/neutrophil elastase inhibitor

    Zeng et al, 2000

    NM_030666

    SERPINB1

    Mucin (MUC-2)

    Airway defense glycoprotein

    Jono et al, 2002; Lee et al, 2000

    NM_002457

    MUC2

    Myelin basic protein

    Neural sheath

    Paez et al, 2006

    NM_001025081

    MBP

    MCT1

    Monocarboxylate transporter isoform 1

    Borthakur et al, 2007

    NM_003051

    SLC16A1

    Naf1

    Associates with HIV Nef

    Tian et al, 2005

    NM_006058

    TNIP1

    Neutrophil gelatinase-associated lipocalin

    Anti-microbial protein in lung

    Cowland et al, 2003

    NM_005564

    LCN2

    NLF1

    IL-1beta induced

    Warton et al, 2004

    NM_207322

    FAM148A

    *p11

    Annexin II ligand

    Huang et al, 2003

    NM_002966

    S100A10

    PA28 alpha

    Proteasome activator

    Ossendorp et al, 2005

    NM_006263

    PSME1

    PA28 beta

    Proteasome activator

    Ossendorp et al, 2005

    NM_002818

    PSME2

    PAI-1

    Plasminogen activator inhibitor

    Hou et al, 2004

    NM_000602

    SERPINE1, PAI-1

    *Pax8

    Paired box gene

    Okladnova et al, 1997

    NM_003466

    PAX8

    *PCBD

    6-pyruvoyl-tetrahydropterin synthase

    Carter et al, 2002

    NM_000317

    PTS

    Perforin

    Pore-forming effector molecule

    Zhou et al, 2002

    NM_005041

    PRF1

    *PGK1

    Phosphoglycerate kinase 1

    Carter et al, 2002

    NM_000291

    PGK1

    POMC

    Proopiomelanocortin

    Karalis et al, 2004; Asaba et al, 2006

     NM_000939

    POMC

    Pregnancy-specific glycoprotein rnCGM3

    Placental expression

    Wang et al, 2001

    NM_019126

    CGM3

    Prodynorphin

    Neuropeptide

    Bakalkin et al, 1994

    NM_024411

    PDYN

    Prostate-specific antigen

    Serum protein in prostate cancer

    Chen & Sawyers, 2002