Regulation of LPS-mediated inflammation in vivo and in vitro by the thiol antioxidant Nacystelyn.

Antonicelli F, Brown D, Parmentier M, Drost EM, Hirani N, Rahman I, Donaldson K, MacNee

References


 

Relevant publications listed by the last name of the first author.

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Aarenstrup L, Flindt EN, Otkjaer K,Kirkegaard M, Andersen JS and Kristiansen K (2007) HDAC activity is required for p65/RelA-dependent repression of PPARdelta-mediated transactivation in human keratinocytes. Journal of Investigative Dermatology in press

 

Aarnisalo P, Palvimo JJ and Janne OA (1998) CREB-binding protein in androgen receptor-mediated signaling. Proceedings of the National Academy of Sciences USA 95 2122-2127

Aarnisalo P, Santti H, Poukka H, Palvimo JJ and Janne OA (1999) Transcription activating and repressing functions of the androgen receptor are differentially influenced by mutations in the deoxyribonucleic acid-binding domain. Endocrinology 140 3097-3105

Abadie A, Besancon F and Wietzerbin J (2004) Type I interferon and TNFalpha cooperate with type II interferon for TRAIL induction and triggering of apoptosis in SK-N-MC EWING tumor cells. Oncogene 23 4911-4920

Aban M, Cinel L, Arslan M, Dilek U, Kaplanoglu M, Arpaci R and Dilek S (2004) Expression of nuclear factor-kB and placental apoptosis in pregnancies complicated with intrauterine growth restriction and preeclampsia: an immunohistochemical study. Tohoku Journal of Experimental Medicine 204 195-202

Abate A, Oberle S and Schroder H (1998) Lipopolysaccharide-induced expression of cyclooxygenase-2 in mouse macrophages is inhibited by chloromethylketones and a direct inhibitor of NF-kB translocation. Prostaglandins and Other Lipid Mediators 56 277-290

Abate A and Schroder H (1998) Protease inhibitors protect macrophages from lipopolysaccharide-induced cytotoxicity: possible role for NF-kB. Life Sciences 62 1081-1088

Abate A, Yang G, Dennery PA, Oberle S and Schroder H (2000) Synergistic inhibition of cyclooxygenase-2 expression by vitamin E and aspirin. Free Radical Biology and Medicine 29 1135-1142

Abate DA, Watanabe S and Mocarski ES (2004) Major human cytomegalovirus structural protein pp65 (ppUL83) prevents interferon response factor 3 activation in the interferon response. Journal of Virology 78 10995-11006

Abayomi EA, Sissolak G and Jacobs P (2007) Use of novel proteosome inhibitors as a therapeutic strategy in lymphomas current experience and emerging concepts. Transfusion and Apheresis Science 37 85-92

Abbadie C, Kabrun N, Bouali F, Smardova J, Stéhelin D, Vandenbunder B and Enrietto PJ (1993) High levels of c-rel expression are associated with programmed cell death in the developing avian embryo and in bone marrow cells in vitro. Cell 75 899-912

Abbas AK, Sen R (2003) The activation of lymphocytes is in their CARMA. Immunity 18 721-722

Abbas S and Abu-Amer Y (2003) Dominant-negative-IkB facilitates apoptosis of osteoclasts by tumor necrosis factor-alpha. Journal of Biological Chemistry 278 20077-20082

Abbas S, Clohisy JC and Abu-Amer Y (2003) Mitogen-activated protein (MAP) kinases mediate PMMA-induction of osteoclasts. Journal of Orthopedic Research 21 1041-1048

Abbate M, Zoja C and Remuzzi G (2006) How does proteinuria cause progressive renal damage? J
ournal of the American Society of Nephrology 17 2974-2984

Abbott DW, Wilkins A, Asara JM and Cantley LC (2004) The Crohn's Disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO. Current Biology 14 2217-2227

Abbott DW, Yang Y, Hutti JE, Madhavarapu S, Kelliher MA nad Cantley LC (2007) Coordinate regulation of Toll-like Receptor and NOD2 signaling by K63-linked polyubiquitin chains. Molecular and Cellular Biology inpress

Abbott KL, Loss JR 2nd, Robida AM and Murphy TJ (2000) Evidence that Galpha(q)-coupled receptor-induced interleukin-6 mRNA in vascular smooth muscle cells involves the nuclear factor of activated T cells. Molecular Pharmacology 58 946-953

Abbott KL, Robida AM, Davis ME, Pavlath GK, Camden JM, Turner JT and Murphy TJ (2000) Differential regulation of vascular smooth muscle nuclear factor kB by G alpha q-coupled and cytokine receptors. Journal of Molecular and Cellular Cardiology 32 391-403

Abboud PA, Hake PW, Burroughs TJ, Odoms K, O'Connor M, Mangeshkar P, Wong HR and Zingarelli B (2007) Therapeutic effect of epigallocatechin-3-gallate in a mouse model of colitis. European Journal of Pharmacology in press

Abboud PA, Lahni PM, Page K, Giuliano Jr JS, Harmon K, Dunsmore KE, Wong HR and Wheeler DW (2008) The role of endogenously produced extracellualr HSP72 in mononuclear cell reprogramming in press 

Abboushi N, El-Hed A, El-Assaad W, Kozhaya L, El-Sabban ME, Bazarbachi A, Badreddine R, Bielawska A, Usta J and Dbaibo GS (2004) Ceramide inhibits IL-2 production by preventing protein kinase C-dependent NF-kB activation: possible role in protein kinase C{theta} regulation. Journal of Immunology 173 3193-3200

Abbracchio MP and Verderio C (2006) Pathophysiological roles of P2 receptors in glial cells. Novartis Found
ation Symposium 276 91-103

Abdallah A, Sato H, Grutters JC, Veeraraghavan S, Lympany PA, Ruven HJ, Van Den Bosch JM, Wells AU, Du Bois RM and Welsh KI (2003) Inhibitor kB-a (IkB-a) promoter polymorphisms in UK and Dutch sarcoidosis. Genes & Immunity 4 450-454

Abdallah BM, Boissy P, Tan Q, Dahlgaard J, Traustadottir GA, Kupisiewicz K, Laborda J, Delaisse JM and Kassem M (2007) DLK1/FA1 regulates the function of human bone marrow mesenchymal stem cells (HMSC) by modulating gene expression of pro-inflammatory cytokines and immune-response-related factors. Journal of Biol
ogical Chemistry 282 7339-7351

Abdel-Latif MM, Kelleher D and Reynolds JV (2008) Potential role of NF-kB in esophageal adenocarcinoma: as an emerging molecular target. Journal of Surgical Research in press

Abdel-Latif MM, O'Riordan JM, Ravi N, Kelleher D and Reynolds JV (2005) Activated nuclear factor-kB and cytokine profiles in the esophagus parallel tumor regression following neoadjuvant chemoradiotherapy. Dis Esophagus 18 246-252

Abdel-Latif MM, O'Riordan J, Windle HJ, Carton E, Ravi N, Kelleher D and Reynolds JV (2004) NF-kB activation in esophageal adenocarcinoma: relationship to Barrett's metaplasia, survival, and response to neoadjuvant chemoradiotherapy. Annals of Surgery 239 491-500

Abdel-Latif MM, Windle HJ, Homasany BS, Sabra K and Kelleher D (2005) Caffeic acid phenethyl ester modulates Helicobacter pylori-induced nuclear factor-kB and activator protein-1 expression in gastric epithelial cells. British Journal of Pharmacology 146 1139-1147

Abdel-Latif MM, Windle H, Terres A, Eidhin DN, Kelleher D and Reynolds JV (2006) Helicobacter pylori extract induces nuclear factor-kB, activator protein-1, and cyclooxygenase-2 in esophageal epithelial cells. J
ournal of Gastrointestinal Surgery 10 551-562

Abdel-Mageed AB (2003) NF-kB-dependent gene expression of proinflammatory cytokines in T24 cells: possible role in interstitial cystitis. Urology Research 31 300-305

Abdel-Mageed AB and Agrawal KC (1998) Activation of nuclear factor kB: potential role in metallothionein-mediated mitogenic response. Cancer Research 58 2335-2338

Abdel-Mageed AB and Ghoniem GM (1998) Potential role of Rel/Nuclear Factor-kB in the pathogenesis of interstitial cystitis. Journal of Urology 160 2000-2003

Abdel-Razzak Z, Garlatti M, Aggerbeck M and Barouki R (2004) Determination of interleukin-4-responsive region in the human cytochrome P450 2E1 gene promoter. Biochemical Pharmacology 68 1371-1381

Abdelli S, Ansite J, Roduit R, Borsello T, Matsumoto I, Sawada T, Allaman-Pillet N, Henry H, Beckmann JS, Hering BJ and Bonny C (2004) Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure. Diabetes 53 2815-2823

Abdou AG, Hanout HM (2007) Evaluation of survivin and NF-kB in psoriasis, an immunohistochemical study. Journal of Cutaneous Pathology in press

Abdouh M, Albert PR, Drobetsky E, Filep JG and Kouassi E (2004) 5-HT(1A)-mediated promotion of mitogen-activated T and B cell survival and proliferation is associated with increased translocation of NF-kB to the nucleus. Brain Behav Immun 18 24-34

Abdouh M, Storring JM, Riad M, Paquette Y, Albert PR, Drobetsky E and Kouassi E (2001) Transcriptional mechanisms for induction of 5-HT1A receptor mRNA and protein in activated B and T lymphocytes. Journal of Biological Chemistry 276 4382-4388

Abdulla D, Goralski KB, Garcia Del Busto Cano E and Rneton KW (2005) The signal transduction pathways involved in hepatic cytochrome P450 regulation in the rat during an LPS-induced model of CNS inflammation. Drug Metabolism and Disposition 33 1521-1531

Abdulla D and Renton KW (2005) beta-Adrenergic receptor modulation of the LPS-mediated depression in CYP1A activity in astrocytes. Biochemical Pharmacology 69 741-750

Abe E, Matsubara K, Oka K, Kusanagi Y and Ito M (2008) Cytokine regulation of intercellular adhesion molecule-1 expression on trophoblasts in preeclampsia. Gyndecologogical and Obstetrics Investigation 66 27-33

Abe JL (2007) Role of PKCs and NF-kB activation in myocardial inflammation: Enemy or ally? Journal of Molecular and Cellular Cardiology in press

Abe K, Whitehead IP, O'Bryan JP and Der CJ (1999)
Involvement of NH(2)-terminal sequences in the negative regulation of Vav signaling and transforming activity. Journal of Biological Chemistry 274 30410-30418

Abe M, Matsuda M, Kobayashi H, Miyata Y, Nakayama Y, Konuro R, Fukuhara A and Shimomura I (2008) Effects of statins on adipose tissue inflammation. Their inhibitory effect on MyD88-independent IRF3/IFNbeta pathway in macrophages. Arterioslerosis, Thrombosis, Vascular Biology
28 871-877

Abe M, Takiguchi Y, Ichimaru S, Tsuchiya K and Wada K (2008) Comparison of the protective effect of N-acetylcysteine by different treatments on rat myocardial ischemia-reperfusion injury. Journal of Pharmacological Sciences 106 571-577

Abe M, Takiguchi Y, Ichimaru S, Tsuchiya K and Wada K (2008) Different effect of acute treatment with rosiglitazone on rat myocardial ischemia/reperfusion injury by administration method. European Journal of Pharmacology in press

Abe M, Tanaka Y, Saito K, Shirakawa F, Koyama Y, Goto S and Eto S (1997) Regulation of interleukin (IL)-1beta gene transcription induced by IL-1beta in rheumatoid synovial fibroblast-like cells, E11, transformed with simian virus 40 large T antigen. Journal of Rheumatology 24 420-429

Abe S, Nakamura H, Inoue S, Takeda H, Saito H, Kato S, Mukaida N, Matsushima K and Tomoike H (2000) Interleukin-8 gene repression by clarithromycin is mediated by the activator protein-1 binding site in human bronchial epithelial cells. American Journal of Respiratory Cell and Molecular Biology 22 51-60

Abeles AM, Marjanovic N, Park J, Attur M, Chan ES, Al-Mussawir H, Dave M, Fisher MC, Stuchin SA, Abramson SB and Pillinger MH (2007) Protein isoprenylation regulates secretion of matrix metalloproteinase 1 from rheumatoid synovial fibroblasts: Effects of statins and farnesyl and geranylgeranyl transferase inhibitors.
Arthritis and Rheumatism 56 2840-2853

Aberle H, Bauer A, Stappert J, Kispert A and Kemler R (1997) b-catenin is a target for the ubiquitin-proteasome pathway. EMBO Journal 16 3797-3804

Abeyama K, Eng W, Jester JV, Vink AA, Edelbaum D, Cockerell CJ, Bergstresser PR, Takashima A (2000) A role for NF-kB-dependent gene transactivation in sunburn. Journal of Clinical Investigation 105 1751-1759

Abeyama K, Kawano K, Nakajima T, Takasaki I, Kitajima I and Maruyama I (1995) Interleukin 6 mediated differentiation and rescue of cell redox in PC12 cells exposed to ionizing radiation. FEBS Letters 364 298-300

Abid MR, Schoots IG, Spokes KC, Wu SQ, Mawhinney C and Aird WC (2004) VEGF-mediated induction of MnSOD occurs through redox-dependent regulation of forkhead and IkB/NF-kB. Journal of Biological Chemistry 279 44030-44038

Abid MR, Shih SC, Otu HH, Spokes KC, Okada Y, Curiel DT, Minami T and Aird WC (2006) A novel class of VEGF-responsive genes that require Forkhead activity for expression. J
ournal of Biological Chemistry 281 35544-35553

Abiru S, Nakao K, Ichikawa T, Migita K, Shigeno M, Sakamoto M, Ishikawa H, Hamasaki K, Nakata K and Eguchi K (2002) Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells. Hepatology 35 1117-1124

Ables GP, Hamashima N and Watanabe T (2001) Analysis of genetic factors associated with nitric oxide production in mice. Biochemical Genetics 39 379-394

Abou-Merhi R, Khoriaty R, Arnoult D, El Hajj H, Dbouk H, Munier S, El-Sabban ME, Hermine O, Gessain A, de The H, Mahieux R and Bazarbachi A (2007) PS-341 or a combination of arsenic trioxide and interferon-alpha inhibit growth and induce caspase-dependent apoptosis in KSHV/HHV-8-infected primary effusion lymphoma cells.
Leukemia
in press

Abraham C and Cho JH (2006) Functional consequences of NOD2 (CARD15) mutations. Inflammatory Bowel Disease 12 641-650

Abraham DJ, Shiwen X, Black CM, Sa S, Xu Y and Leask A (2000) Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts. Journal of Biological Chemistry 275 15220-15225

Abraham E (1997) NF-kB and reactive oxygen intermediates. Shock 7 97

Abraham E (2000) NF-kB activation. Critical Care Medicine 28 N100-N104

Abraham E (2002) The International Sepsis Forum's controversies in sepsis: how will sepsis be treated in 2051? Critical Care 6 277-278

Abraham E (2003) Nuclear factor-kB and its role in sepsis-associated organ failure. Journal of Infectious Diseases 187 S364-S369

Abraham E (2005) Alterations in cell signaling in sepsis. Clinical Infectious Diseases 41 S459-6S464

Abraham E, Arcaroli J and Shenkar R (2001) Activation of extracellular signal-regulated kinases, NF-kB, and cyclic adenosine 5'-monophosphate response element-binding protein in lung neutrophils occurs by differing mechanisms after hemorrhage or endotoxemia. Journal of Immunology 166 522-530 

Abraham E, Carmody A, Shenkar R, Arcaroli J (2000) Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury. American Journal of Physiology: Lung Cell and Molecular Physiology 279 L1137-L1145

Abraham E, Gyetko MR, Kuhn K, Arcaroli J, Strassheim D, Park JS, Shetty S and Idell S (2003) Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activation. Journal of Immunology 170 5644-5651

Abraham E, Nick JA, Azam T, Kim SH, Mira JP, Svetkauskaite D, He Z, Zamora M, Murphy J, Park JS, Overdier K and Dinarello CA (2006) Peripheral blood neutrophil activation patterns are associated with pulmonary inflammatory responses to lipopolysaccharide in humans. J
ournal of Immunology 176 7753-7760

Abraham S, Yaddanapudi K, Thomas S, Damodaran A, Ramireddy B and Manjunath R (2008) Nonclassical MHC-I and Japanese encephalitis virus infection: induction of H-2Q4, H-2T23 and H-2T10. Virus Research in press

Abrahams VM, Aldo PB, Murphy SP, Visintin I, Koga K, WIlson G, Romero R, Sharma S and Mor G (2008) TLR6 modulates first trimester trophoblast responses to peptidoglycan. Journal of Immunology 180 6035-6043

Abrams CC, Chapman DA, Silk R, Liverani E and Dixon LK (2008) Domains involved in calcineurin phosphatase inhibition and nuclear localisation in the African swine fever virus A238L protein. Virology in press

Abramson J, Licht A and Pecht I (2006) Selective inhibition of the FcvarepsilonRI-induced de novo synthesis of mediators by an inhibitory receptor. EMBO Journal 25 323-334

Abrantes EF, Pires EG, Carvalho AF, Costa FF, Savino W and Reis LF (2003) Identification, structural characterization, and tissue distribution of Tsg-5: a new TNF-stimulated gene. Genes and Immunity 4 298-311

Abreu MT, Arnold ET, Thomas LS, Gonsky R, Zhou Y, Hu B and Arditi M (2002) TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells. Journal of Biological Chemistry 277 20431-20437

Abreu MT, Vora P, Faure E, Thomas LS, Arnold ET and Arditi M (2001) Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide. Journal of Immunology 167 1609-1616

Abril E, Mendez RE, Garcia A, Serrano A, Cabrera T, Garrido F and Ruiz-Cabello F (1996) Characterization of a gastric tumor cell line defective in MHC class I inducibility by both alpha- and gamma-interferon. Tissue Antigens 47 391-398

Abroun S, Otsuyama KI, Shamsasenjan K, Islam A, Amin J, Iqbal MS, GOndo T, Asaoku H and Kawano MM (2008) Galectin-1 supports the survival of CD45RA(-) primary myeloma cells in vitro. British Journal of Haematology in press

Abruzzese RV, Godin D, Burcin M, Mehta V, French M, Li Y, O'Malley BW and Nordstrom JL (1999) Ligand-dependent regulation of plasmid-based transgene expression in vivo. Human Gene Therapy 10 1499-1507

Abshagen K, Eipel C, Kalff JC, Menger MD and Vollmar B (2007) Loss of NF-kB activation in Kupffer cell-depleted mice impairs liver regeneration after partial hepatectomy. American Journal of Physiology: Gastrointestinal Liver Physiology in press

Abu-Amer Y (2001) IL-4 abrogates osteoclastogenesis through STAT6-dependent inhibition of NF-kB. Journal of Clinical Investigation 107 1375-1385

Abu-Amer Y, Darwech I and Otero J (2008) Role of the NF-kB axis in immune modulation of osteoclasts and bone loss. Autoimmunity 41 204-211

Abu-Amer Y, Erdmann J, Alexopoulou L, Kollias G, Ross FP and Teitelbaum SL (2000) Tumor necrosis factor receptors types 1 and 2 differentially regulate osteoclastogenesis. Journal of Biological Chemistry 275 27307-27310

Abu-Amer Y and Tondravi MM (1997) NF-kB and bone: the breaking point. Nature Medicine 3 1189-1190

Abu-Amer Y, Ross FP, McHugh KP, Livolsi A, Peyron J-F and Teitelbaum SL (1997) Tumor necrosis factor-a activation of nuclear transcription factor-kB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of IkBa. Journal of Biological Chemistry 273 29417-29423

Abu-Zant A, Jones S, Asare R, Suttles J, Price C, Graham J and Kwaik YA (2007) Anti-apoptotic signalling by the Dot/Icm secretion system of L. pneumophila. Cellular Microbiology 9 246-264

Abujamra AL, Spanjaard RA, AKinsheye I, Zhao X, Faller DV and Ghosh SK (2005) Leukemia virus long terminal repeat activates NFkB pathway by a TLR3-dependent mechanism. Virology 345 390-403

Acaria L, Gonzalez B and Castellano B (1998) Stat3 and NF-kB glial expression after excitotoxic damage to the postnatal brain. Neuroreport 9 2869-2873

Acarin L, Gonzalez B and Castellano B (2000) STAT3 and NF-kB activation precedes glial reactivity in the excitotoxically injured young cortex but not in the corresponding distal thalamic nuclei. Journal of Neuropathology and Experimental Neurology 59 151-163

Acarin L, Gonzalez B, Castellano B (2001) 
Triflusal posttreatment inhibits glial nuclear factor-kB, downregulates the glial response, and is neuroprotective in an excitotoxic injury model in postnatal brain. Stroke 32 2394-2402

Acarin L, Gonzalez B and Castellano B (2000) Oral administration of the anti-inflammatory substance triflusal results in the downregulation of constitutive transcription factor NF-kB in the postnatal rat brain. Neuroscience Letters 288 41-44


Accaoui MJ, Enoiu M, Mergny M, Masson C, Dominici S, Wellman M, Visvikis A (2000) Gamma-glutamyltranspeptidase-dependent glutathione catabolism results in activation of NF-kB. Biochemical and Biophysical Research Communications 276 1062-1067 

Acharyya S and Guttridge DC (2007) Cancer cachexia signaling pathways continue to emerge yet much still points to the proteasome. Clinical Cancer Research 13 1356-1361

Acharyya S, Villalta SA, Bakkar N, Bupha-Intr T, Janssen PM, Carathers M, Li ZW, Beg AA, Ghosh S, Sahenk Z, Weinstein M, Gardner KL, Rafael-Fortney JA, Karin M, Tidball JG, Baldwin AS and Guttridge DC (2007) Interplay of IKK/NF-kB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. Journal of Clinical Investigation 117 889-901

Achiron A, Feldman A, Mandel M and Gurevich M (2007) Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse. Annals of the New York Academy of Sciences 1107 155-167

Ackerman H, Udalova I, Hull J and Kwiatkowski D (2002) Evolution of a polymorphic regulatory element in interferon-gamma through transposition and mutation. Molecular Biology and Evolution 19 884-890  

Ackerman IV WE, Rovin BH and Kniss DA (2004) Epidermal growth factor and interleukin-1b utilize divergent signaling pathways to synergistically upregulate cyclooxygenase-2 gene expression in human amnion-derived WISH cells. Biology of Reproduction 71 2079-2086

Ackerman IV WE, Summerfield TL, Vandre DD, Robinson JM and Kniss DA (2007) Nuclear factor-kB regulates inducible prostaglandin E synthase expression in human amnion mesenchymal cells. Biol
ogy of Reproduction in press

Ackerman IV WE, Zhang XL, Rovin BH and Kniss DA (2005) Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFkB signal disruption in human WISH and amnion cells. Biology of Reproduction 73 527-535

Ackermann LW and Denning GM (2004) Nuclear factor-kB contributes to interleukin-4- and interferon-dependent polymeric immunoglobulin receptor expression in human intestinal epithelial cells. Immunology 111 75-85

Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernandoo E and Gil J (2008) Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell in press

Acquaah-Mensah GK, Kehrer JP and Leslie SW (2002) In utero ethanol suppresses cerebellar activator protein-1 and nuclear factor-kB transcriptional activation in a rat fetal alcohol syndrome model. Journal of Pharmacology and Experimental Therapy 301 277-283

Acquaviva R, Campisi A, Murabito P, Raciti G, Avola R, Mangiameli S, Musumeci I, Barcellona ML, Vanella A and Li Volti G (2004) Propofol attenuates peroxynitrite-mediated DNA damage and apoptosis in cultured astrocytes: an alternative protective mechanism. Anesthesiology 101 1363-1371

Acquaviva R, Campisi A, Raciti G, Avola R, Barcellona ML, Vanella A and Li Volti G (2005) Propofol inhibits caspase-3 in astroglial cells: role of heme oxygenase-1. Current Neurovascular Research 2 141-148 

Adachi M, Gazel A, P
intucci G, Shuck A, Shifteh S, Ginsburg D, Rao LS, Kaneko T, Freedberg IM, Tamaki K and Blumenberg M (2003) Specificity in stress response: epidermal keratinocytes exhibit specialized UV-responsive signal transduction pathways. DNA Cell Biology 22 665-677

Adachi M, Sakamoto H, Kawamura R, Wang W, Imai K and Shinomura Y (2007) Nonsteroidal anti-inflammatory drugs and oxidative stress in cancer cells. Histol
ogy and Histopathology 22 437-442

Adachi O, Kawai T, Takeda K, Matsumoto M, Tsutsui H, Sakagami M, Nakanishi K and Akira S (1998) Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9 143-150

Adachi Y and Ohno N (2006) Contribution of dectin-1 to the recognition of fungal cell wall products and the activation of innate immune response [Article in Japanese]. Nippon Ishinkin Gakkai Zasshi
47 185-194

Adam D, Kessler U and Kronke M (1995) Cross-linking of the p55 tumor necrosis factor receptor cytoplasmic domain by a dimeric ligand induces nuclear factor-kB and mediates cell death. Journal of Biological Chemistry 270 17482-17487

Adam D, Kessler U, Kronke MAdam D, Wiegmann K, Adam-Klages S, Ruff A and Kronke M (1996) A novel cytoplasmic domain of the p55 tumor necrosis factor receptor initiates the neutral sphingomyelinase pathway. Jouranl of Biological Chemistry 271 14617-14622

Adam E, Hansen KK, Astudillo Fernandez O, Coulon L, Bex F, Duhant X, Jaumotte E, Hollenberg MD and Jacquet A (2005) The house dust mite allergen DER P 1, unlike DER P 3, stimulates the expression of IL-8 in human airway epithelial cells via a proteinase-activated receptor -2 (PAR2) independent mechanism. Journal of Biological Chemistry 691 6910-6923

Adam E, Quivy V, Bex F, Chariot A, Collette Y, Vanhulle C, Schoonbroodt S, Goffin V, Nguyen TL-A, Gloire G, Carrard G, Friguet B, de Launoit Y, Burny A, Bours V, Piette J and Van Lint C (2003) Potentiation of tumor necrosis factor-induced NF-kB activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of IkBa. Molecular and Cellular Biology 23 6200-6209

Adam L, Black PC, Kassouf W, Eve B, McConkey D, Munsell MF, Benedict WF and Dinney CP (20070 Adenoviral mediated interferon-alpha 2b gene therapy suppresses the pro-angiogenic effect of vascular endothelial growth factor in superficial bladder cancer. J
ournal of Urology 177 1900-1906

Adami C, Bianchi R, Pula G and Donato R (2004) S100B-stimulated NO production by BV-2 microglia is independent of RAGE transducing activity but dependent on RAGE extracellular domain. Biochimica et Biophysica Acta 1742 169-177

Adam-Klages S, Schwandner R, Adam D, Kreder D, Bernardo K and Kronke M (1998) Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor. Journal of Leukocyte Biology 63 678-682

Adamo R, Sokol S, Soong G, Gomez M and Prince A (2003) P. aeruginosa flagella activate airway epithelial cells through asialoGM1 and TLR2 as well as TLR5. American Journal of Respiratory Cell and Molecular Biology 30 627-634

Adamopoulos IE, Danks L, Itonagaa I, Locklin RM, Sabokbar A, Ferguson DJ and Athanasou NA (2006) Stimulation of osteoclast formation by inflammatory synovial fluid. Virchows Arch 449 69-77

Adams AB, Williams MA, Jones TR, Shirasugi N, Durham MM, Kaech SM, Wherry EJ, Onami T, Lanier JG, Kokko KE, Pearson TC, Ahmed R and Larsen CP (2003) Heterologous immunity provides a potent barrier to transplantation tolerance. Journal of Clinical Investigation 111 1887-1895

Adams BS, Leung K, Hanley EW and Nabel GJ (1991) Cloning of RkB, a novel DNA-binding protein that recognizes the interleukin-2 receptor a chain kB site. The New Biologist 3 1063-1073 

Adams CC and Workman JL (1995) Binding of disparate transcriptional activators to nucleosomal DNA is inherently cooperative. Molecular and Cellular Biology 15 1405-1421

Adams DS, Nathans R, Pero SC, Sen A and Wakshull E (2000) Activation of a rel-A/CEBP-beta-related transcription factor heteromer by PGG-glucan in a murine monocytic cell line. Journal of Cellular Biochemistry 77 221-233

Adams DS, Pero SC, Petro JB, Nathans R, Mackin WM and Wakshull E (1997) PGG-Glucan activates NF-kB-like and NF-IL-6-like transcription factor complexes in a murine monocytic cell line. Journal of Leukocyte Biology 62 865-873

Adams J (2001) Proteasome inhibition in cancer: development of PS-341. Seminars in Oncology 28 613-619

Adams J (2004) The proteasome: a suitable antineoplastic target. Nature Reviews Cancer 4 349-360

Adams J (2004) The development of proteasome inhibitors as anticancer drugs. Cancer Cell 5 417-421

Adams J, Kiss E, Arroyo AB, Bonrouhi M, Sun Q, Li Z, Gretz N, Schnitger A, Zouboulis CC, Wiesel M, Wagner J, Nelson PJ and Grone HJ (2005) 13-cis retinoic acid inhibits development and progression of chronic allograft nephropathy. American Journal of Pathology 167 285-298

Adams J and Stein R (1996) Novel inhibitors of the proteasome and their therapeutic use in inflammation. Annual Reports in Medicinal Chemistry 31 279-287

Adams LS and Teegarden D (2004) 1,25-dihydroxycholecalciferol inhibits apoptosis in C3H10T1/2 murine fibroblast cells through activation of nuclear factor kB. Journal of Nutrition 134 2948-2952

Adams S, Pankow S, Werner S and Munz B (2007) Regulation of NF-kB activity and keratinocyte differentiation by the RIP4 protein: implications for cutaneous wound repair. J
ournal of Investigative Dermatology 127 538-544

Adams V, Nehrhoff B, Spate U, Linke A, Schulze PC, Baur A, Gielen S, Hambrecht R and Schuler G (2002) Induction of iNOS expression in skeletal muscle by IL-1beta and NFkB activation: an in vitro and in vivo study. Cardiovascular Research 54 95-104

Adams V, Spate U, Krankel N, Schulze PC, Linke A, Schuler G and Hambrecht R (2003) Nuclear factor-kB activation in skeletal muscle of patients with chronic heart failure: correlation with the expression of inducible nitric oxide synthase. Journal of Cardiovascular Risk 10 273-277

Adamsson J, Lindblad M, Lundqvist A, Kelly D, Holmgren J and Harandi AM (2006) Novel immunostimulatory agent based on CpG oligodeoxynucleotide linked to the nontoxic B subunit of cholera toxin. J
ournal of Immunology 176 4902-4913

Adcock IM (1997) Transcription factors as activators of gene transcription: AP-1 and NF-kB. Monaldi Arch Chest Dis 52 178-186

Adcock IM and Barnes PJ (1996) Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation. Biochemical Society Transactions 24 267S

Adcock IM, Brown CR, Gelder CM, Shirasaki H, Peters MJ and Barnes PJ (1995) Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells. American Journal of Physiology 268 C331-C338

Adcock IM, Brown CR, Kwon O and Barnes PJ (1994) Oxidative stress induces NF-kB DNA binding and inducible NOS mRNA in the human epithelial cell line A549. Biochemical Society Transactions 22 186S

Adcock IM, Brown CR, Kwon O and Barnes PJ (1994) Oxidative stress induces NF kappa B DNA binding and inducible NOS mRNA in human epithelial cells. Biochemical and Biophysical Research Communications 199 1518-1524

Adcock IM and Caramori G (2001) Cross-talk between pro-inflammatory transcription factors and glucocorticoids. Immunology and Cell Biology 79 376-384

Adcock IM and Caramori G (2004) Kinase targets and inhibitors for the treatment of airway inflammatory diseases: the next generation of drugs for severe asthma and COPD? BioDrugs 18 167-180

Adcock IM, Chung KF, Caramori G and Ito K (2006) Kinase inhibitors and airway inflammation. Eur
opean Journal of Pharmacology 533 118-132

Adcock IM, Cosio B, Tsaprouni L, Barnes PJ and Ito K (2005) Redox regulation of histone deacetylases and glucocorticoid-mediated inhibition of the inflammatory response. Antioxidants & Redox Signaling 7 144-152

Adcock IM, Ito K and Barnes PJ (2004) Glucocorticoids: effects on gene transcription. Proceedings of the American Thoracic Society 1 247-354

Adcock IM, Ito K and Barnes PJ (2005) Histone deacetylation: an important mechanism in inflammatory lung diseases. COPD
2 445-455

Adcock IM, Lane SJ, Brown CR, Lee TH and Barnes PJ (1995) Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma. Journal of Experimental Medicine 182 1951-1958

Adcock IM, Nasuhara Y, Stevens DA and Barnes PJ (1999) Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targeting of NF-kB and lack of I-kB involvement. British Journal of Pharmacology 127 1003-1011 

Adcock IM, Newton R and Barnes PJ (1997)
NF-kB involvement in IL-1 beta-induction of GM-CSF and COX-2: inhibition by glucocorticoids does not require I-kB. Biochemical Society Transactions 25 154S

Adcock IM, Peters MJ, Brown CR, Gelder CM and Barnes PJ (1993) Transcription factor interactions in human lung. Biochemical Society Transactions 21 277S

Adcock IM, Shirasaki H, Gelder CM, Peters MJ, Brown CR and Barnes PJ (1994) The effects of glucocorticoids on phorbol ester and cytokine stimulated transcription factor activation in human lung. Life Sciences 55 1147-1153

Adderley SR and Fitzgerald DJ (1999) Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2. Journal of Biological Chemistry 274 5038-5046 

Addo A, Le J, Li W, Aksentijevich I, Balow Jr J, Lee A, Gregersen PK, Kastner DL and Remmers EF (2005) Analysis of CARD15/NOD2 haplotypes fails to identify common variants associated with rheumatoid arthritis susceptibility. Scandinavian Journal of Rheumatology 34 198-203

Addya S, Shiroto K, Turoczi T, Zhan L, Kaga S, Fukuda S, Surrey S, Duan LJ, Fong GH, Yamamoto F and Maulik N (2005) Ischemic preconditioning-mediated cardioprotection is disrupted in heterozygous Flt-1 (VEGFR-1) knockout mice. Journal of Molecular and Cellular Cardiology 38 345-351

Adelson ME, Martinand-Mari C, Iacono KT, Muto NF and Suhadolnik RJ (1999) Inhibition of human immunodeficiency virus (HIV-1) replication in SupT1 cells transduced with an HIV-1 LTR-driven PKR cDNA construct. European Journal of Biochemistry 264 806-815

Adhami VM, Afaq F and Ahmad N (2003) Suppression of ultraviolet B exposure-mediated activation of NF-kB in normal human keratinocytes by resveratrol. Neoplasia 5 74-82

Adhami VM, Malik A, Zaman N, Sarfaraz S, Siddiqui IA, Syed DN, Afaq F, Pasha FS, Saleem M and Mukhtar H (2007) Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo. Clin
ical Cancer Res
earch 13 1611-1619

Adhikari N, Charles N, Lehmann U and Hall JL (2006) Transcription factor and kinase-mediated signaling in atherosclerosis and vascular injury. Current Atherosclerosis Reports 8 252-260

Adhirkari A, Xu M and Chen ZJ (2007) Ubiquitin-mediated activation of TAK1 and IKK. Oncogene. 26 3214-3226

Adib-Conquy M, Adrie C, Moine P, Asehnoune K, Fitting C, Pinsky MR, Dhainaut JF and Cavaillon JM (2000) NF-kB expression in mononuclear cells of patients with sepsis resembles that observed in lipopolysaccharide tolerance. American Journal of Respiratory and Critical Care Medicine 162 1877-1883

Adib-Conquy M, Asehnoune K, Moine P and Cavaillon JM (2001) Long-term-impaired expre
ssion of nuclear factor-kB and IkBa in peripheral blood mononuclear cells of trauma patients. Journal of Leukocyte Biology 70 30-38

Adib-Conquy M and Cavaillon JM (2002) IFNg and GM-CSF prevent endotoxin tolerance in human monocytes by promoting IRAK expression and its association to MyD88, and not by modulating TLR4 expression. Journal of Biological Chemistry 277 27927-27934

Adib-Conquy M, Petit AF, Marie C, Fitting C and Cavaillon JM (1999) Paradoxical priming effects of IL-10 on cytokine production. International Immunology 11 689-698 

Adler AS, Sinha S, Kawahara TL, Zhang JY, Segal E and Chang HY (2007) Motif module map reveals enforcement of aging by continual NF-kB activity. Genes & Development in press

Adler V and Kraft AS (1995) Regulation of AP-3 enhancer activity during hematopoietic differentiation. Journal of Cell Physiology 164 26-34

Adli M and Baldwin AS (2006) IKK-i/IKKe controls constitutive, cancer cell-associated NF-kB activity via regulation of Ser-536 p65/RelA phosphorylation. Journal of Biological Chemistry 281 26976-26984

Adolph KW, Liska DJ and Bornstein P (1997) Analysis of the promoter and transcription start sites of the human thrombospondin 2 gene (THBS2). Gene 193 5-11

Adorini L (2005) Intervention in autoimmunity: The potential of vitamin D receptor agonists. Cellular Immunology 233 115-124

Adorini L, Penna G, Giarratana N, Roncari A, Amuchastegui S, Daniel KC and Uskokovic M (2004) Dendritic cells as key targets for immunomodulation by Vitamin D receptor ligands. Journal of Steroid Biochemistry and Molecular Biology 89-90 437-441

Adraansen J, Fallaux FJ, de Cortie CJ, Vervoordeldonk MJ and Tak PP (2007) Local delivery of beta interferon using an adeno-associated virus type 5 effectively inhibits adjuvant arthritis in rats. J
ournal of General Virology 88 1717-1721

Adriaenssens E, Mougel A, Goormachtigh G, Loing E, Fafeur V, Auriault C and Coll J (2004) A novel dominant-negative mutant form of Epstein-Barr virus latent membrane protein-1 (LMP1) selectively and differentially impairs LMP1 and TNF signaling pathways. Oncogene 23 2681-2693

Adya R, Tan BK, Chen J and Randeva HS (2008) Nuclear factor kB induction by visfatin in human vascular endothelial cells: role in MMP-2/9 production and activation. Diabetes Care in press

Adzic M, Niciforovic A, Vucic V, Neskovic-Konstantinovic Z, Spasic SD, Jones DR, Radjcic MB and Spasic MB (2006) Systemic NF-kB activation in blood cells of breast cancer patients. Redox Reports 11 39-44

Adzic M, Niciforovic A, Zaric B, Neskovic-Konstantinovic Z, Spasic SD, Jones DR, and Radjcic MB (2008) Cell culture conditions potentiate differences in the response to ionising radiation of peripheral blood leukocytes isolated from breast cancer patients and healthy subjects. Redox Reports 13 17-22

Aeberli D, Yang Y, Mansell A, Santos L, Leech M and Morand EF (2006) Endogenous macrophage migration inhibitory factor modulates glucocorticoid sensitivity in macrophages via effects on MAP kinase phosphatase-1 and p38 MAP kinase. FEBS Letters 580 974-981

Afaq F, Ahmad N and Mukhtar H (2003) Suppression of UVB-induced phosphorylation of mitogen-activated protein kinases and nuclear factor kB by green tea polyphenol in SKH-1 hairless mice. Oncogene 22 9254-9264

Afaq F, Adhami VM, Ahmad N and Mukhtar H (2003) Inhibition of ultraviole
t B-mediated activation of nuclear factor kB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate. Oncogene 22 1035-1044

Afaq F, Malik A, Syed D, Maes D, Matsui MS and Mukhtar H (2004) Pomegranate fruit extract modulates UVB-mediated phosphorylation of mitogen activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes. Photochemistry and Photobiology 81 38-45

Afaq F, Saleem M, Aziz MH, Mukhtar H (2004) Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion markers in CD-1 mouse skin by oleandrin. Toxicology and Applied Pharmacology 195 361-369

Afaq F, Saleem M, Krueger CG, Reed JD and Mukhtar H (2004) Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kB pathways and inhibits skin tumorigenesis in CD-1 mice. International Journal of Cancer 113 423-433

Afford SC, Ahmed-Choudhury J, Randhawa S, Russell C, Youster J, Crosby HA, Eliopoulos A, Hubscher SG, Young LS and Adams DH (2001) CD40 activation-induced, Fas-dependent apoptosis and NF-kB/AP-1 signaling in human intrahepatic biliary epithelial cells. FASEB Journal 15 2345-2354

Afonso PV, Ozden S, Prevost MC, Schmitt C, Seilhean D, Weksler B, Couraud PO, Gessain A, Romero IA and Ceccaldi PE (2007) Human blood-brain barrier disruption by retroviral-infected lymphocytes: role of myosin light chain kinase in endothelial tight-junction disorganization. Journal of Immunology 179 2576-2583

Aga M, Johnson CJ, Hart AP, Guadarrama AG, Suresh M, Svaren J, Bertics PJ and Darien BJ (2002) Modulation of monocyte signaling and pore formation in response to agonists of the nucleotidereceptor P2X(7). Journal of Leukocyte Biology 72 222-232

Aga M, Watters JJ, Pfeiffer ZA, Wiepz GJ, Sommer JA and Bertics PJ (2003) Evidence for nucleotide receptor modulation of the cross talk between MAP kinase and NF-kB signaling pathways in murine RAW 264.7 macrophages. American Journal of Physiology: Cell Physiology 286 C923-C930

Agaisse H, Petersen UM, Boutros M, Mathey-Prevot B and Perrimon N (2003) Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Developmental Cell 5 441-450

Agami R (2007) All roads lead to IKKepsilon. Cell 129 1043-1045

Agapova OA, Kaufman PL and Hernandez MR (2006) Androgen receptor and NFkB expression in human normal and glaucomatous optic nerve head astrocytes in vitro and in experimental glaucoma. Experimental Eye Research 82 1053-1059

Agarwal A, Das K, Lerner N, Sathe S, Cicek M, Casey G and Sizemore N (2004) The AKT/IkB kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kB and beta-catenin. Oncogene 24 1021-1031

Agarwal C, Dhanalakshmi S, Singh RP and Agarwal R (2003) Inositol hexaphosphate inhibits constitutive activation of NF-kB in androgen-independent human prostate carcinoma DU145 cells. Anticancer Research 23 3855-3861

Agarwal S, Deschner J, Long P, Verma A, Hofman C, Evans CH and Piesco N (2004) Role of NF-kB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals. Arthritis and Rheumatism 50 3541-3548

Agarwal S, Long P, Seyedain A, Piesco N, Shree A and Gassner R (2003) A central role for nuclear factor-kB pathway in the antiinflammatory and proinflammatory actions of mechanical strain. FASEB Journal 17 899-901

Agarwal SK, Lee Burns A, Sukhodolets KE, Kennedy PA, Obungu VH, Hickman AB, Mullendore ME, Whitten I, Skarulis MC, Simonds WF, Mateo C, Crabtree JS, Scacheri PC, Ji Y, Novotny EA, Garrett-Beal L, Ward JM, Libutti SK, Richard Alexander H, Cerrato A, Parisi MJ, Santa Anna-A S, Oliver B, Chandrasekharappa SC, Collins FS, Spiegel AM and Marx SJ (2004) Molecular pathology of the MEN1 gene. Annals of the New York Academy of Science 1014 189-198

Agbottah E, Yeh WI, Berro R, Klase Z, Pedati C, Kehn-Hall K, Wu W and Kaschanchi F (2008) Two specific drugs, BMS-345541 and Purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kB and cell cycle pathways. AIDS Research and Therapy in press

Aggarwal AK (1995) A gripping end to NF-kB. Nature Structural Biology 2 184-186

Aggarwal BB (2000) Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kB. Annals of Rheumatoid Disease 59 6-16

Aggarwal BB (2000) Apoptosis and nuclear factor-kB: a tale of association and dissociation. Biochemical Pharmacology 60 1033-1039

Aggarwal BB (2004) Nuclear factor-kB: The enemy within. Cancer Cell 6 203-208

Aggarwal BB (2007) Nuclear factor-kB: a transcription factor for all seasons. Expert Opinion on Therapeutic Targets 11 109-110

Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S and Takada Y (2004) Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Research 24 2783-2840

Aggarwal BB, Bhardwaj U and Takada Y (2004) Regulation of TRAIL-induced apoptosis by ectopic expression of antiapoptotic factors. Vitamins and Hormones 67 453-483

Aggarwal BB and Higuchi M (1997) Role of ceramide in tumour necrosis factor-mediated apoptosis and nuclear factor-kB activation. Biochemical Society Transactions 25 1166-1171

Aggarwal BB and Ichikawa H (2005) Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle 4 1201-1215

Aggarwal BB, Ichikawa H, Garodia P, Weerasinghe P, Sethi G, Bhatt ED, Pandey MK, Shishodia S and Nair MG (2006) From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer.
Expert Opin
ion in Therapeutic Targets 10 87-118

Aggarwal BB, Kunnumakkara AB, Harikumar KB, Tharakan ST, Sung B and Anand P (2008) Potential of spice-derived phytochemicals for cancer prevention. Planta Medica in press

Aggarwal BB and Shishodia S (2004) Suppression of the nuclear factor-kB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Annals of the New York Academy of Sciences 1030 434-441

Aggarwal BB and Shishodia S (2006) Molecular targets of dietary agents for prevention and therapy of cancer. Biochemical Pharmacology 71 1397-1421

Aggarwal BB, Shishodia S, Ashikawa K and Bharti AC (2002) The role of TNF and its family members in inflammation and cancer: lessons from gene deletion. Current Drug Targets of Inflammation and Allergy 1 327-341

Aggarwal BB, Shishodia S, Sandur SK, Pandey MK and Sethi G (2006) Inflammation and cancer: How hot is the link? Biochem
ical Pharmacology 72 1605-1621

Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE and Price JE (2005) Curcumin suppresses the paclitaxel-induced nuclear factor-kB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clinical Cancer Research 11 7490-7498

Aggarwal BB, Shishodia S, Takada Y, Jackson-Bernitsas D, Ahn KS, Sethi G and Ichikawa H (2006) TNF blockade: an inflammatory issue.
Ernst Schering Research Foundation Workshop 56 161-186

Aggarwal BB, Takada Y and Oommen OV (2004) From chemoprevention to chemotherapy: common targets and common goals. Expert Opinion on Investigational Drugs 13 1327-1338

Aggarwal BB, Takada Y, Shishodia S, Gutierrez AM, Oommen OV, Ichikawa H, Baba Y and Kumar A (2004) Nuclear transcription factor NF-kB: role in biology and medicine. Indian Journal of Experimental Biology 42 341-353

Aggarwal BB, Totpal K, LaPushin R, Chaturvedi MM, Pereira-Smith OM and Smith JR (1995) Diminished responsiveness of senescent normal human fibroblasts to TNF-dependent proliferation and interleukin production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kB. Experimental Cell Research 218 381-388

Aggarwal K and Silverman N (2007) Peptidoglycan recognition in Drosophila. Biochemical Society Transactions 35 1496-1500

Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S and Aggarwal BB (2006) Curcumin (diferuloylmethane) downregulates expression of cell proliferation, antiapoptotic and metastatic gene products through suppression of IkBa kinase and AKT activation. Molecular Pharmacology 69 195-201

Aggarwal S, Takada Y, Mhashilkar AM, Sieger K, Chada S and Aggarwal BB (2004) Melanoma differentiation-associated gene-7/IL-24 gene enhances NF-kB activation and suppresses apoptosis induced by TNF. Journal of Immunology 173 4368-4376

Aggarwal S, Takada Y, Singh S, Myers JN and Aggarwal BB (2004) Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kB signaling. International Journal of Cancer 111 679-692 [Erratum published in Int J Cancer in press 2004]

Aghai ZH, Kode A, Saslow JG, Nakhala T, Farhath S, Stahl GE, Eydelman R, Strande L, Leone P and Rahman I (2007) Azithromycin suppresses activation of nuclear factor-kB and synthesis of pro-inflammatory cytokines in tracheal aspirate cells From premature infants. Pediatric Research in press

Aghai ZH, Kumar S, Farhath S, Kumar MA, Saslow J, Nakhla T, Eydelman R, Strande L, Stahl G, Hewitt C, Nesin M and Rahman I (2005) Dexamethasone suppresses expression of nuclear factor-kB in the cells of tracheobronchial lavage fluid in premature neonates with respiratory distress. Pediatrics Research 59 811-815

Aghajanian C (2004) Clinical update: novel targets in gynecologic malignancies. Seminars in Oncology 31 22-26

Agou F, Courtois G, Chiaravalli J, Baleux F, Coic YM, Traincard F, Israel A and Veron M (2004) Inhibition of NF-kB activation by peptides targeting NEMO oligomerisation. Journal of Biological Chemistry 279 54248-54257

Agou F, Ye F, Goffinont S, Courtois G, Yamaoka S, Israel A and Veron M (2002) NEMO trimerizes through its coiled-coil C-terminal domain. Journal of Biological Chemistry 277 17464-17475

Agius LM (2003) A concept of essentially secondary factors central to definitive subtype characterization of Hodgkin's disease. Medical Hypotheses 61 297-302

Agostini M, Di Marco B, Nocentini G and Delfino DV (2002) Oxidative stress and apoptosis in immune diseases. International Journal of Immunopathology & Pharmacology 15 157-164

Agou F, Courtois G, Chiaravalli J, Baleux F, Coic YM, Traincard F, Israel A and Veron M (2004) Inhibition of NF-kB activation by peptides targeting NF-kB essential modulator (nemo) oligomerization. Journal of Biological Chemistry 279 54248-54257

Agou F, Traincard F, Vinolo E, Courtois G, Yamaoka S, Israel A and Veron M (2004) The trimerization domain of NEMO is comprised of the interacting C-terminal CC2 and LZ coiled-coil subdomains. Journal of Biological Chemistry 279 27861-27869

Agouni A, Sourbier C, Danilin S, Rothhut S, Lindner V, Jacqmin D, Helwig JJ, Lang H and Massfelder T (2007) Parathyroid hormone-related protein induces cell survival in human renal cell carcinoma through the PI3K/Akt pathway: evidence for a critical role for integrin-linked kinase and nuclear factor kB. Carcinogenesis
in press

Agrawal A, Cha-Molstad H, Samols D and Kushner I (2001) Transactivation of C-reactive protein by IL-6 requires synergistic interaction of CCAAT/enhancer binding protein beta (C/EBP beta) and Rel p50. Journal of Immunology 166 2378-2384 

Agrawal A, Cha-Molstad H, Samols D and Kushner I (2003) Overexpressed nuclear factor-kB can participate in endogenous C-reactive protein induction, and enhances the effects of C/EBPbeta and signal transducer and activator of transcription-3. Immunology 108 539-547

Agrawal A, Samols D and Kushner I (2003) Transcription factor c-Rel enhances C-reactive protein expression by facilitating the binding of C/EBPbeta to the promoter. Molecular Immunology 40 373-380

Agrawal A, Shukla S and Kale RK (2003) Role of Ca2+ in radiation-induced damage in murine splenocytes. International Journal of Radiation Biology 79 733-746

Agrawal DK, Ariyarathna K and Kelbe PW (2004) (S)-Albuterol activates pro-constrictory and pro-inflammatory pathways in human bronchial smooth muscle cells. J Allergy Clin Immunol 113 503-510

Agarwal R, Agarwal C, Ichikawa H, Singh RP and Aggarwal BB (2006) Anticancer potential of silymarin: from bench to bed side.
Anticancer Res
earch 26 4457-4498

 

Agarwal R, Campbell RC and Warnock DG (2004) Oxidative stress in hypertension and chronic kidney disease: Role of angiotensin II. Seminars in Nephrology 24 101-114

Agresti A, Lupo R, Bianchi ME and Muller S (2003) HMGB1 interacts differentially with members of the Rel family of transcription factors. Biochemical and Biophysical Research Communications 302 421-426

Agresti A and Vercelli D (2002) c-Rel is a selective activator of a nove
l IL-4/CD40 responsive element in the human Ig gamma4 germline promoter. Molecular Immunology 38 849-859

Aguiar RC, Chase A, Oscier DG, Carapeti M, Goldman JM and Cross NC (1997) Characterization of a t(10;12)(q24;p13) in a case of CML in transformation. Genes, Chromosomes & Cancer 20 408-411


Aguilar JL, Rojas P, Marcelo A, Plaza A, Bauer R, Reininger E, Klaas CA and Merfort I (2002) Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae). Journal of Ethnopharmacology 81 271-276

Aguilar-Quesada R, Munoz-Gamez JA, Martin-Oliva D, Peralta-Leal A, Quiles-Perez R, Rodrigues-Vargas JM, de Almodaovar MR, Conde C, Ruiz-Extremera A and Oliver FJ (2007) Modulation of transcription by PARP-1: consequences in carcinogenesis and inflammation. Curr
ent Medicinal Chemistry 14 1179-1187

 

Aguilera C, Fernandez-Majada V, Ingles-Esteve J, Rodilla V, Bigas A and Espinosa L (2006) Efficient nuclear export of p65-IkBa complexes requires 14-3-3 proteins. Journal of Cell Science 119 3695-3704

 

Aguilera C, Hoya-Arias R, Haegeman G, Espinosa L and Bigas A (2004) Recruitment of IkBa to the hes1 promoter is associated with transcriptional repression. Proceedings of the National Academy of Sciences USA 101 16537-16542

Agusti A, Morla M, Sauleda J, Saus C and Busquets X (2004) NF-kB activation and iNOS upregulation in skeletal muscle of patients with COPD and low body weight. Thorax 59 483-487

 

Ahmad M, Marui N, Alexander RW and Medford RM (1995) Cell type-specific transactivation of the VCAM-1 promoter through an NF-kB enhancer motif. Journal of Biological Chemistry 270 8976-8983

Ahmad M, Theofanidis P and Medford RM (1998) Role of activating protein-1 in the regulation of the vascular cell adhesion molecule-1 gene expression by tumor necrosis factor-alpha. Journal of Biological Chemistry 273 4616-4621


Ahmad N, Gupta S and Mukhtar H (2000) Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kB in cancer cells versus normal cells. Archives of Biochemistry and Biophysics 376 338-346

A
hmad R, El Bassam S, Cordeiro P and Menezes J (2008) Requirement of TLR2-mediated signalling for the induction of IL-15 gene expression in human monocytic cells by HSV-1. Blood in press

 

Ahmad R, Riana D, Meyer C, Kharbanda S and Kufe D (2006) Triterpenoid CDDO-Me blocks the NF-kB pathway by direct inhibition of IKKb on Cys-179. Journal of Biological Chemistry 281 35764-35769

 

Ahmad R, Raina D, Trivedi V, Ren J, Rajabi H, Kharbanda S and Kufe D (2007) MUC1 oncoprotein activates the IkB kinase beta complex and constitutive NF-kB signalling. Nature Cell Biology in press

Ahmad SR, Lidington EA, Ohta R, Okada N, Robson MG, Davies KA, Leitges M, Harris CL, Haskard DO and Mason JC (2003) Decay-accelerating factor induction by tumour necrosis factor-alpha, through a phosphatidylinositol-3 kinase and protein kinase C-dependent pathway, protects murine vascular endothelial cells against complement deposition. Immunology 110 258-268

Ahmed F, Adsule S, Ali AS, Banerjee S, Ali S, Kulkarni S, Padhye S adn Sarkar FH (2006) A novel copper complex of 3-benzoyl-alpha methyl benzene acetic acid with antitumor activity mediated via cyclooxygenase pathway. Int
ernational Journal of Cancer 120 734-742

 

Ahmed KM, Cao N and Li JJ (2006) HER-2 and NF-kB as the targets for therapy-resistant breast cancer. Anticancer Research 26 4235-4243

 

Ahmed KM, Dong S, Fan M and Li JJ (2006) Nuclear Factor-kB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells. Molecular Cancer Research 4 945-955

Ahmed KM and Li JJ (2007) ATM-NF-kB connection as a target for tumor radiosensitization. Current Cancer Drug Targets 7 335-342

 

Ahmed KM and Li JJ (2008) NF-kB-mediated adaptive resistance to ionizing radiation. Free Radical Biology and Medicine 44 1-13

 

Ahmed MM (2004) Regulation of radiation-induced apoptosis by early growth response-1 gene in solid tumors. Current Cancer Drug Targets 4 43-52

 

Ahmed S, Pakozdi A and Koch AE (2006) Regulation of interleukin-1beta-induced chemokine production and matrix metalloproteinase 2 activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts. Arthritis and Rheumatism 54 2393-2401

 

Ahmed S, Wang N, Hafeez BB, Cheruvu VK and Haqqi TM (2005) Punica granatum L. extract inhibits IL-1beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-kB in human chondrocytes in vitro. Journal of Nutrition 135 2096-2102

Ahmed S, Wang N, Lalonde M, Goldberg VM and Haqqi TM (2003) Green tea polyphenol Epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1{beta}-induced expression of matrix metalloproteinases-1 and -13 in human chondrocytes. Journal of Pharmacology and Experimental Therapeutics 308 767-773

Ahn D, Crawley S, Hokari R, Kato S, Yang S, Li J, Kim Y (2005) TNF-a activates MUC2 transcription via NF-kB but inhibits via JNK activation. Cell Physiology and Biochemistry 15 29-40

Ahn E, Lee H and Yun Y (2006) LIME acts as a transmembrane adapter mediating BCR-dependent B cell activation. Blood 107 1521-1527

Ahn HJ, Hernandez CM, Levenson JM, Lubin FD, Liou HC and Sweatt JD (2008) c-Rel, an NF-kB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation. Learning and Memory 15 539-549

 

Ahn J, Feldman G, Terry L, Shore EM and Kaplan FS (2003) Exoneration of NF-kB dysregulation in fibrodysplasia ossificans progressiva. Clinical Orthopedics 406 205-213

Ahn JH, Park SM, Cho HS, Lee MS, Yoon JB, Vilcek J and Lee TH (2001) Non-apoptotic signaling pathways activated by soluble Fas ligand in serum-starved human fibroblasts. Mitogen-activated protein kinases and NF-kB-dependent gene expression. Journal of Biological Chemistry 276 47100-47106 

Ahn JH, Park TJ, Jin SH and Kang HY (2008) Human melanocytes express functional Toll-like receptor 4. Experimental Dermatology 17 412-417

 

Ahn JY, Choi IS, Shim JY, Yun EK, Yun YS, Jeong G and Song JY (2005) The immunomodulator ginsan induces resistance to experimental sepsis by inhibiting Toll-like receptor-mediated inflammatory signals. European Journal of Immunology 36 37-45

Ahn KS and Aggarwal BB (2005) Transcription factor NF-kB: a sensor for smoke and stress signals. Annals of the New York Academy of Sciences 1056 218-233

 

Ahe KS, Gong x, Sethi G, Chaturvedi MM, Jaiswal AK and Aggarwal BB (2007) Deficiency of NRH:quinone oxidoreductase 2 differentially regulates TNF signaling in keratinocytes: up-regulation of apoptosis correlates with down-regulation of cell survival kinases. Cancer Research 67 10004-10011

Ahn KS, Hahn BS, Kwack K, Lee EB and Kim YS (2006) Platycodin D-induced apoptosis through nuclear factor-kB activation in immortalized keratinocytes. European Journal Pharmacology 

537 1-11

 

Ahn KS, Moon KY, Lee J and Kim YS (2003) Downregulation of NF-kB activation in human keratinocytes by melanogenic inhibitors. Journal of Dermatological Science 31 193-201

Ahn KS, Noh EJ, Cha KH, Kim YS, Lim SS, Shin KH and Jung SH (2006) Inhibitory effects of Irigenin from the rhizomes of Belamcanda chinensis on nitric oxide and prostaglandin E(2) production in murine macrophage RAW 264.7 cells. Life Sciences 78 2336-2342

 

Ahn KS, Noh EJ, Zhao HL, Jung SH, Kang SS and Kim YS (2005) Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kB activation in RAW 264.7 cells. Life Sciences 76 2315-2328

Ahn KS, Sethi G and Aggarwal BB (2007) Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kB (NF-kB) signaling pathway leading to suppression of NF-kB-regulated anti-apoptotic and metastatic gene products. Molecular Pharmacology
71 209-219

 

Ahn KS, Sethi G and Aggarwal BB (2007) Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kB-dependent antiapoptotic gene products: role of IkBa kinase and TGF-beta-activated kinase-1. Journal of Immunology 178 2507-2516

Ahn KS, Sethi G and Aggarwal BB (2007) Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-kB pathway. Biochemical Pharmacology in press

Ahn KS, Sethi G and Aggarwal BB (2007) Nuclear factor-kB: from clone to clinic. Current Molecular Medicine 7 619-637

 

Ahn KS, Sethi G, Chaturvedi MM, Palladino MA, Younes A and Aggarwal BB (2007) Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through downmodulation of NF-kB-regulated gene products. Blood 110 2286-2295

Ahn KS, Sethi G, Jain Ak, Jaiswal AK and Aggarwal BB (2006) Genetic deletion of NAD(PPH:quinone oxidoreductase 1 abrogates activation of nuclear factor-kB, IkBa kinase c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and protentiates apoptosis. Journal of Biological Chemistry 281 19798-19808

 

Ahn KS, Sethi G, Krishnan K and Aggarwal BB (2007) gamma -tocotrienol inhibits nuclear factor-kB signaling pathway through inhibition of RIP and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. Journal of Biological Chemistry 282 809-820

Ahn KS, Sethi G, Shishodia S, Sung B, Arbiser JL and Aggarwal BB (2006) Honokiol potentiates apoptosis, suppresses Osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kB activation pathway. Molecular Cancer Research 4 621-633

Ahn KY, Kim BH, Lee YR, Hwang DH, Chung EY, Min K and Kim Y (2005) Dual inhibitory effects of furonaphthoquinone compound on enzyme activity and lipopolysaccharide-induced expression of cyclooxygenase-2 in macrophages. Biochemical and Biophysical Research Communications 336 93-99

Ahn SC, Kim GY, Kim JH, Baik SW, Han MK, Lee HJ, Moon DO, Lee CM, Kang JH, Kim BH, Oh YH and Park YM (2004) Epigallocatechin-3-gallate, constituent of green tea, suppresses the LPS-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and NF-kB. Biochemical and Biophysical Research Communications 313 148-155

Ahn SK, Choe TB and Kwon TJ (2003) The gene expression profile of human umbilical vein endothelial cells stimulated with lipopolysaccharide using cDNA microarray analysis. International Journal of Molecular Medicine 12 231-236

 

Ahn SY, Cho CH, Park KG, Lee HJ, Lee S, Park SK, Lee IK and Koh GY (2004) Tumor necrosis factor-alpha induces fractalkine expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha-induced fractalkine expression. American Journal of Pathology 164 1663-1672

 

Ahtoniemi T, Goldsteins G, Keksa-Goldsteine V, Malm T, Kanninen K, Salminen A and Koistinaho J (2007) Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis. Molecular Pharmacology 71 30-37

 

Ahuja J, Lepoutre V, Wigdahl B, Khan ZK and Jain P (2007) Induction of pro-inflammatory cytokines by human T-cell leukemia virus type-1 Tax protein as determined by multiplexed cytokine protein array analyses of human dendritic cells. Biomedicine & Pharmacotherapy 61 201-208

Aiamkitsumrit B, Zhang X, Block TM, Norton P, Fraser NW and Su YH (2007) Herpes simplex virus type 1 ICP4 deletion mutant virus d120 infection failed to induce apoptosis in nerve growth factor-differentiated PC12 cells. Journal of Neurovirology 13 305-314

Aifantis I, Gounari F, Scorrano L, Borowski C, von Boehmer H (2001) Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kB and NFAT. Nature Immunology 2 403-409

Aihara M, Azuma A, Takizawa H, Tsuchimoto D, Funakoshi Y, Shindo Y, Ohmoto Y, Imagawa K, Kikuchi M, Mukaida N and Matsushima K (1998) Molecular analysis of suppression of interleukin-8 production by rebamipide in Helicobacter pylori-stimulated gastric cancer cell lines. Digestive Diseases and Sciences 43 174S-180S

Aihara M, Tsuchimoto D, Takizawa H, Azuma A, Wakebe H, Ohmoto Y, Imagawa K, Kikuchi M, Mukaida N and Matsushima K (1997) Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line, MKN45. Infection & Immunity 65 3218-3224

Aihara N, Yamaguchi M and Kasai K (2006) Low-energy irradiation stimulates formation of osteoclast-like cells via RANK expression in vitro. Lasers Med Sci
21 24-33

 

Aikawa Y, Yamamoto M, Yamamoto T, Morimoto K, Tanaka K (2002) An anti-rheumatic agent T-614 inhibits NF-kB activation in LPS- and TNF-alpha-stimulated THP-1 cells without interfering with IkBa degradation. Inflammation Research 51 188-194

Aillet F, Gougerot-Pocidalo MA, Virelizier JL and Israel N (1994) Appraisal of potential therapeutic index of antioxidants on the basis of their in vitro effects on HIV replication in monocytes and interleukin 2-induced lymphocyte proliferation. AIDS Research and Human Retroviruses 10 405-411

Aimbire F, Santos FV, Albertini R, Castro=Faria-Neto HC, Mittmann J and Pacheco-Soares C (2008) Low-level laser therapy decreases levels of lung neutrophils anti-apoptotic factors by a NF-kB dependent mechanism. International Immunopharmacology 8 613-605

Ainbinder E, Amir-Zilberstein L, Yamaguchi Y, Handa H and Dikstein R (2004) Elongation inhibition by DRB sensitivity-inducing factor is regulated by the A20 promoter via a novel negative element and NF-kB. Molecular and Cellular Biology 24 2444-2454

Ainbinder E, Revach M, Wolstein O, Moshonov S, Diamant N and Dikstein R (2002) Mechanism of rapid transcriptional induction of tumor necrosis factor alpha-responsive genes by NF-kB. Molecular and Cellular Biology 22 6354-6362

Airoldi I, Gri G, Marshall JD, Corcione A, Facchetti P, Guglielmino R, Trinchieri G and Pistoia V (2002) Expression and function of IL-12 and IL-18 receptors on human tonsillar B cells. Journal of Immunology 165 6880-6888

Ait-Ali D, Turquier V, Tanguy Y, Thouennon E, Ghzili H, Mourien L, Derambure C, Jegou S, Salier JP, Vaudry H, Eiden LE and Anouar Y (2008) TNF-a persistently activates NF-{kappa}B signaling through the TNF-R2 in chromaffin cells. Implications for long-term regulation of neuropeptide gene expression in inflammation. Endocrinology in press

Ait-Ghezala G, Mathura VS, Laporte V, Quadros A, Paris D, Patel N, VOlmar CH, Kolippakkam D, Crawford F and Mullan M (2005) Genomic regulation after CD40 stimulation in microglia: Relevance to Alzheimer's disease. Brain Research Molecular Brain Research 140 73-85

Ait-Ghezala G, VOlmar CH, Frieling J, Paris D, Tweed M, Bakshi P and Mullan M (2007) CD40 promotion of amyloid beta production occurs via the NF-kB pathway. Eur
opean Journal of Neuroscience 25 1685-1695

 

Ait-Said F, Elalamy I, Werts C, Gomard MT, Jacquemin C, Couetil JP and Hatmi M (2003) Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway. Biochimica et Biophysica Acta 1631 77-84

Aitken CJ, Hodge JM, Nishinaka Y, Vaughan T, Yodoi J, Day CJ, Morrison NA and Nicholson GC (2004) Regulation of human osteoclast differentiation by thioredoxin binding protein-2 and redox-sensitive signaling. Journal of Bone and Mineral Research 19 2057-2064

Aizawa K, Suzuki T, Kada N, Ishihara A, Kawai-Kowase K, Matsumura T, Sasaki K, Munemasa Y, Manabe I, Kurabayashi M, Collins