Most of the genes encoding the transcription factors (Rel/NF-kB), inhibitors (IkB), and kinases (IKK) in the Rel/NF-kB signal transduction pathway have been disrupted in mice.These gene knockouts lead to a variety of phenotypes, which are summarized in the table below.There are also links to the primary references for this information, as on PubMed.
 

Gene	Phenotype	Reference
rela	Embryonic lethal; liver apoptosis; sensitivity to TNF	Beg & Baltimore, 1996
c-rel	Impaired T and B cell activation; systemic arthritis resistance	Kontgen et al, 1995 Grumont et al, 1998 Campbell et al, 2000
relb	Defects in acquired and innate immunity; T-cell infiltration of organs; skin inflammation	Burkly et al, 1995 Weih et al, 1995 Freyschmidt et al, 2007
nfkb1	Immune response defects due to abnormal B-cell response; resistance to arthritis; neural degeneration; sleep irregularities	Sha et al, 1995 Campbell et al, 2000 Lu et al, 2006; Jhaveri et al, 2006
nfkb2	Abnormal spleen and lymph node architecture; defective T-cell response	Caamano et al, 1998 Franzoso et al, 1998
c-rel delta C	Lymphoid cell hyperplasia	Carrasco et al, 1998
nfkb1 delta C	Splenomegaly; enlarged lymph nodes; infiltrations of lung & liver; susceptibility to pathogens	Ishikawa et al, 1998
nfkb2 delta C	Multiple post-natal organ defects	Ishikawa et al, 1997
nfkb1/relb	Lethal 3-4 weeks post-natal; Increased organ inflammation	Weih et al, 1997
nfkb1/nfkb2	Reduced growth; cranofacial abnormalities; bone defects; B-cell defects	Franzoso et al, 1997 Iotsova et al, 1997
nfkb1/c-rel	Decreased humoral immunity	Pohl et al, 2002
c-rel/rela	Embryonic lethal early liver apoptosis; skin epidermus development	Grossmann et al, 1999; Gugasyan et al., 2004
ikba	Early neonatal lethal inflammatory dermatitis and granulocytosis	Beg et al, 1995 Klement et al, 1996
ikbb
ikbe	Reduction in number of CDD44-CD25+ T cells	Memet et al, 1999
bcl-3	Defects in B- and T-cell responses to antigens	Franzoso et al, 1997 Schwartz et al, 1997
IKKa	Early neonatal lethal; Skin defects	Hu et al, 1999 Takeda et al, 1999
IKKb	Embryonic lethal; Liver apoptosis; Sensitivity to TNF; B-cell survival (conditional)	Li et al, 1999 Takeda et al, 1999 Li et al., 2003
IKKa/IKKb	Embryonic lethal;  Liver apoptosis; Sensitivity to TNF; Neural defects	Li et al, 2000
IKKg (NEMO)	Embryonic lethal;  Liver apoptosis; Sensitivity to TNF; Heterozygotes are model for incontinentia pigmenti	Rudolph et al, 2000 Makris et al, 2000