ENOCH S. HUANG, Ph.D. Head of Computational Sciences, Pfizer Research Centers of Emphasis Adjunct Assistant Professor, Bioinformatics, Boston University EDUCATION STANFORD UNIVERSITY, Stanford, CA Ph.D. in Structural Biology 1997 PRINCETON UNIVERSITY, Princeton, NJ A.B. in Molecular Biology 1992 Certificate of Proficiency in East Asian Studies HONORS AND AWARDS * Pfizer Discovery Recognition Award 2001 * Fellowship of the Jane Coffin Childs Memorial Fund 1997-1999 * National Institutes of Health Training Grant 1995-1996 * National Science Foundation Pre-doctoral Fellowship 1992-1995 * Graduated Magna Cum Laude 1992 * Phi Beta Kappa National Honor Society 1992 * Society of Sigma Xi 1992 * Teagle Foundation Scholarship 1992 * National Science Foundation Summer Research Scholarship 1991 RESEARCH EXPERIENCE Boston University Program in Bioinformatics Adjunct Assistant Professor 2001- Pfizer Research Centers of Emphasis Executive Director, Head of Computational Sciences 2007- Pfizer Research Technology Center Director, Molecular Informatics 2002-2007 Manager/Asst. Director, Molecular Informatics 2001-2002 Senior Research Scientist 2000-2001 Cereon Genomics LLC Bioinformatics Group Computational Biologist 1999-2000 Washington University Dept of Biochemistry & Molecular Biophysics Post-doctoral Fellow 1997-1999 Principal investigator: Prof. Jay W. Ponder Stanford University Department of Structural Biology Pre-doctoral Fellow 1992-1997 Principal investigator: Prof. Michael Levitt Princeton University Department of Chemistry Undergraduate Researcher 1991-1992 Principal investigator: Prof. Michael H. Hecht Exxon Research and Engineering Company Alloys & Inorganics Laboratory Intern 1990-1991 Mentor: Dr. George D. Meitzner Exxon Research and Engineering Company Resource Chemistry Laboratory Intern 1988-1989 Mentor: Dr. Edward I. Stiefel PUBLICATIONS REFEREED JOURNAL ARTICLES Hughes JD, Blagg J, Price DA, Bailey S, DeCrescenzo GA, Devraj RV, Ellsworth E, Fobian YM, Gibbs ME, Gilles RW, Greene N, Huang E, Krieger-Burke T, Loesel J, Wager T, Whitely L, Zhang Y. Physiochemical drug properties associated with in vivo toxicological outcomes. Bioorganic & Medicinal Chemistry Letters, 2008, 18: 4872-4875. Caffrey DR, Dana PH, Mathur V, Ocano M, Hong E, Wang YE, Somaroo S, Caffrey BE, Potluri S, Huang ES. PFAAT version 2.0: A tool for editing, annotating, and analyzing multiple sequence alignments. BMC Bioinformatics 2007, 8: 381. Cheng AC, Coleman RG, Smyth KT, Cao Q, Soulard P, Caffrey DR, Salzberg AC, Huang ES. Structure-based maximal affinity model predicts small-molecule druggability. Nature Biotechnology, 2007, 25: 71-75. Caffrey DR, Somaroo S, Hughes JD, Mintseris J, Huang ES. Are protein-protein interfaces more conserved in sequence than the rest of the protein surface? Protein Science, 2004, 13: 190-202. Huang ES. Construction of a sequence motif characteristic of aminergic G protein-coupled receptors. Protein Science, 2003, 12: 1360-1367. Johnson JM, Mason K, Moallemi C, Xi H, Somaroo S, Huang ES. Protein family annotation in a multiple alignment viewer. Bioinformatics, 2003, 19: 544-545. Samudrala R, Huang ES, Koehl P, Levitt M. Constructing side chains on near-native main chains for ab initio protein structure prediction. Protein Engineering, 2000, 13: 453-457. Xia Y, Huang ES, Levitt M, Samudrala R. Ab initio generation and selection of low resolution protein conformations, J. Mol. Biol., 2000, 300: 171-185. Samudrala R, Xia Y, Huang E, Levitt M: Bona fide ab initio protein structure prediction using a combined hierarchical approach. Proteins Struct. Funct. Genet. (Supplement) 1999, 3: 194-198. Wei L, Huang ES, Altman RB: Are predicted structures good enough to preserve functional sites? Structure Fold. Des., 1999, 7: 643-650. Huang ES, Samudrala R, Ponder JW: Ab initio fold prediction of small helical proteins using distance geometry and knowledge-based scoring functions. J. Mol. Biol. 1999, 290: 267-281. Huang ES, Samudrala R, Ponder JW: Distance geometry generates native-like folds for small helical proteins using the consensus distances of predicted protein structures. Protein Sci., 1998, 7: 1998-2003. Huang ES, Koehl P, Levitt M, Pappu R, Ponder JW: Accuracy of side-chain prediction upon near-native protein backbones generated by ab initio folding methods. Proteins Struct. Funct. Genet., 1998, 33: 204-217. Simons K, Kooperberg, C, Huang E, Baker D. Assembly of protein tertiary structures from fragments with similar local sequences using simulated annealing and Bayesian scoring functions. J. Mol. Biol. 1997, 268: 209-225. Park B, Huang ES, Levitt M. Factors affecting the ability of energy functions to discriminate correct from incorrect folds. J. Mol. Biol. 1997, 266: 831-846. Huang ES, Subbiah S, Tsai J, Levitt M: Using a hydrophobic contact potential to evaluate native and near-native folds generated by molecular dynamics simulations. J. Mol. Biol. 1996. 257: 716-725. Huang ES, Subbiah S, Levitt M: Recognizing native folds by the arrangements of hydrophobic and polar residues. J. Mol. Biol. 1995, 252: 709-720. Huang ES, Rock EP, Subbiah S: Automatic and accurate method for analysis of proteins that undergo hinge-mediated domain and loop movements. Current Biology, 1993, 3: 740-748. Brunet AP, Huang ES, Huffine ME, Loeb JE, Weltman RJ, Hecht MH: The role of turns in the structure of an alpha-helical protein. Nature 1993, 364: 355-358. Meitzner GD, Iglesia E, Baumgartner JE, Huang ES: The chemical state of gallium in working alkane dehydrocyclodimerization catalysts. In situ gallium K-edge X-ray absorption spectroscopy. J Catal 1993, 140: 209-225. Meitzner GD, Huang ES: Analysis of mixtures of compounds of copper using K-edge X-ray absorption spectroscopy. Fresenius J Anal Chem 1992, 342: 61-64. REVIEW ARTICLES Slater T, Bouton C, Huang ES. Beyond Data Integration. Drug Discovery Today. 2008, 13: 584-589. Huang ES. Predicting ligands for orphan GPCRs. Drug Discovery Today. 2005, 10: 69-73. Levitt M, Gerstein M, Huang E, Subbiah S, Tsai J. The end game of protein folding. Ann. Rev. Biochem. 1997, 66: 549-579. REFEREED CONFERENCE PAPERS Samudrala R, Xia Y, Levitt M, Huang ES. A combined approach for ab initio construction of low resolution protein tertiary structures from sequence. In Altman R, Dunker K, Hunter L, Klein T, Lauderdale K, eds. Proceedings of the Pacific Symposium on Biocomputing, 505-516, 1999. Samudrala R, Xia Y, Levitt M, Cotton NJ, Huang ES, Davis R: Probing structure-function relationships of the DNA-polymerase alpha- associated zinc-finger protein using computational approaches. Proceedings of the Pacific Symposium in Biocomputing, 2000. INVITED BOOK CHAPTERS Frieden C, Huang ES, Ponder JW: Turn Scanning: Experimental and theoretical approaches to the role of turns. In _Protein Structure, Stability, and Folding_ (K. Murphy, Ed.) 2001, Humana Press: Totowa, NJ, pp. 133-158. Huang ES, Samudrala R, Park BH: Scoring functions for ab initio protein structure prediction. In _Predicting Protein Structure: Methods and Protocols_ (D. Webster, Ed.) 2000, Humana Press: Totowa, NJ, pp. 223-245. Huang ES: An automatic and accurate method for comparing structures that undergo conformational changes. In _Protein Motions_ (S. Subbiah, Ed.) 1996, R.G. Landes: Austin, Texas, pp. 31-58. CONFERENCE ABSTRACTS Huang ES, Samudrala R, Ponder JW: Folding proteins with distance geometry and predicted inter-residue distances. Third Meeting on the Critical Assessment of Techniques for Protein Structure Prediction 1998, p. 5. Xia Y, Huang ES, Levitt M, Samudrala R: A combined method for low- resolution ab initio tertiary structure prediction of small proteins. Third Meeting on the Critical Assessment of Techniques for Protein Structure Prediction 1998, p. 20. Wei, L, Huang ES, Altman R: Are predicted structures good enough to preserve functional sites? Third Meeting on the Critical Assessment of Techniques for Protein Structure Prediction 1998, p. 109. Huang ES, Samudrala R, Ponder JW. Distance geometry generates native-like folds for small helical proteins using the consensus distances of predicted protein structures. 12th Annual Symposium of the Protein Society, Protein Sci. 1998, 7 (supplement), p. 77. Huang ES, Rock EP, Subbiah S: Automatic and accurate method of comparing two alternative structures of a protein. American Crystallographic Association annual meeting, 1994, p. 45. MULTIMEDIA PUBLICATIONS Park B, Huang ES, Subbiah S. ProToons: Plausible Movies of Conformational Changes in Biological Macromolecules. In CD-ROM format. Published with _Protein Motions_ (Subbiah, S., Ed.) 1996, R.G. Landes: Austin, Texas. OTHER WRITTEN MATERIAL Huang, ES. Native and near-native fold recognition: hydrophobicity, energy functions and fold representations. Ph.D. Thesis, Stanford University, 1997. Huang ES: The role of turns in the folding and stability of cytochrome b-562. Senior Thesis, Princeton University, 1992. PROFESSIONAL SERVICE Open Source Project Manager Protein Family Alignment Annotation Tool (http://pfaat.sourceforge.net) Editorial Advisory Boards Chemical Biology & Drug Design Drug Discovery Today Advisory Board Rochester Institute of Technology, Bioinformatics Program Program Committee New York Academy of Sciences, Systems Biology Discussion Group NIH Study Sections ZRG1 BST-D (51) Special Emphasis Panel ZRG1 BPC-Q (03) Special Emphasis Panel Reviewer Protein Science Journal of Molecular Biology Proteins: Structure Function and Bioinformatics Bioinformatics Physical Biology Journal of Chemical Information and Modeling Human Mutation